Simple drug may cut bleeding in broken leg surgery

NCT ID NCT07625709

Completed Disease control Sponsor: Kathmandu University School of Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at whether giving tranexamic acid before surgery can reduce blood loss in people with broken thigh or shin bones. Fifty-four patients received either the drug or a placebo before their operation. Researchers measured blood loss during and after surgery, as well as changes in hemoglobin levels and transfusion needs.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: tranexamic acid
What this could lead to: If it works, this could show that a single dose of tranexamic acid before surgery reduces bleeding and the need for blood transfusions in patients with leg fractures.
What could go wrong: This is a small, completed study with only 54 participants, so results may not apply to everyone. There is also a risk of side effects like blood clots or allergic reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for BLOOD LOSS, POSTOPERATIVE are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

Blood Loss, Surgical bone fracture Femoral Fractures femoral neck fracture Postoperative Hemorrhage tibia fracture

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BLOOD LOSS, POSTOPERATIVE BLOOD LOSS, SURGICAL FEMORAL FRACTURE TIBIAL FRACTURE

Contacts and locations

Locations

Dhulikhel Hospital, Kathmandu University Hospital

Dhulikhel, Bagmati, 45200, Nepal

More trials for these conditions

Other studies related to the condition(s) this trial covers.