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Which drug cuts C-Section bleeding best? tranexamic acid vs misoprostol put to the test

NCT ID NCT07712510

Disease control Sponsor: Medicare Hospital (Pvt) Limited Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This trial compares two medicines—intravenous tranexamic acid and rectal misoprostol—for reducing blood loss in women having a planned cesarean section. About 214 women will be randomly assigned to receive one of the drugs before surgery. Researchers will measure blood loss during and two hours after the procedure, as well as changes in hemoglobin levels, to see which treatment is more effective.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
intravenous tranexamic acid or rectal misoprostol
What this could lead to
If one medicine works better, it could become the standard choice to reduce bleeding and prevent anemia after cesarean sections.
What could go wrong
This is a single-hospital study with 214 participants, so results may not apply to all women. Both drugs have side effects, and the trial does not track long-term outcomes.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

214 people

The number who actually took part.

Started

Mar 2025

Finished

Aug 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 37 to 42 weeks of gestation * Planned cesarean section Exclusion Criteria: * Women with pre-eclampsia * Chronic hypertension * Multiple pregnancies * Preterm or postdate pregnancy * Previous cesarean section * Gestational diabetes * Fetal macrosomia * History of bleeding / clotting disorder * On anti-coagulation heparin / warfarin therapy * Non-reassuring cardiotocograph or poor progress of labor

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Conditions

The condition(s) this trial relates to.

Blood Loss, Surgical Postoperative Hemorrhage

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Blood loss, postoperative Blood loss, surgical Cesarean section

Contacts and locations

Locations

  • Medicare Hospital (Pvt) Limited

    Multan, Punjab Province, 60000, Pakistan

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