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Could intensive rehab help trauma survivors walk again? a feasibility trial begins

NCT ID NCT05652790

Knowledge-focused Sponsor: Manchester University NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 17, 2026 · Last updated Jul 17, 2026

Summary

This study explores whether an enhanced rehabilitation program (ERP) is practical for people recovering from major trauma, such as severe leg injuries or multiple injuries. Participants receive at least two sessions per week of therapies like exercise, manual therapy, and cognitive support, while a comparison group receives standard care. The main goal is to see if patients can be recruited and retained, and to identify barriers for a future larger trial.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Enhanced Rehabilitation Programme (ERP) including manual therapy, hydrotherapy, exercise, and cognitive rehabilitation
What this could lead to
If successful, this could pave the way for a larger trial to determine whether an intensive rehab program improves recovery after major trauma.
What could go wrong
This is a small feasibility study, not designed to prove the program works. Results may not apply to all trauma patients, and travel requirements could limit participation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

55 people

The number who actually took part.

Started

Feb 2023

Finished

Jan 2026

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants over 18 years old * Registered GP in Greater Manchester or Greater Manchester Resident. * Polytrauma or one or more complex /severe isolated injury * Rehabilitation goals (e.g., mobility, function, job retention/ return to work) identified using shared decision-making process * Patient able to enter programme 6-30 months post injury. * For the ERP patients willing to travel to the MIHP for their evaluation and treatment twice a week. * Participants with lower limb injuries that continue to have functional impairment. * Participants deemed well and safe enough to participate by clinical teams. * Normal ECG if previously reported to have abnormal ECG * Participants willing to consent to follow up over 12 months * Participants with the capacity to consent to the study. * Fully healed wounds and bone healed sufficiently to allow at least partial weight bearing Exclusion Criteria: * Participants under the age of 18 * Participants unable to provide informed consent * Participants with multiple pre-existing comorbidities that affect ability to participate in enhanced rehabilitation such as cognitive impairment, unstable angina. * Central motor neurological impairment affecting ability to participate in an enhanced rehab programme * Absence of functional disability affecting gait and / or function. * Plans for further surgery that will impact on gait or function.

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Conditions

The condition(s) this trial relates to.

injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Major trauma

Contacts and locations

Locations

  • Manchester University NHS Foundation Trust - St Mary's

    Manchester, Greater Manchester, M13 9WL, United Kingdom

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