Can timed lung 'Recruitment' maneuvers protect Preemies' lungs?

NCT ID NCT04289324

First seen Aug 06, 2026 · Last updated Aug 07, 2026 · Updated 1 time

Summary

This trial tests whether performing stepwise, oxygenation-guided lung recruitment maneuvers at regular intervals during high-frequency oscillatory ventilation (HFOV) can improve oxygen levels in extremely preterm infants born before 28 weeks of gestation. The study compares this regular approach to standard care, measuring the oxygen saturation index over up to seven days of ventilation. It also tracks outcomes like days on a ventilator and the development of bronchopulmonary dysplasia, a chronic lung condition common in premature babies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Regular lung recruitment maneuvers (stepwise oxygenation-guided procedure) during high-frequency oscillatory ventilation
What this could lead to
If effective, this approach could improve oxygen levels and reduce lung injury in extremely preterm infants, potentially lowering the risk of chronic lung disease.
What could go wrong
This is a small, early-stage trial, so results may not be conclusive. The procedure itself could cause temporary changes in blood pressure or oxygen levels, and benefits may not persist.

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • Medical University of Vienna

    Vienna, State of Vienna, 1090, Austria

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