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Could a common vitamin speed burn recovery?

NCT ID NCT01749371

Disease control Sponsor: The University of Texas Medical Branch, Galveston Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 20, 2026 · Last updated Jul 21, 2026 · Updated 1 time

Summary

This trial investigates whether high-dose vitamin E (alpha-tocopherol) can reduce oxidative stress and improve outcomes in adults with severe burns covering at least 40% of their body. Participants receive vitamin E drops after surgery, and researchers measure vitamin levels, lung function, and markers of healing. The goal is to see if this simple supplement can lessen complications like lung injury and slow wound healing, potentially shortening hospital stays.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vitamin E (alpha-tocopherol) given as oral drops
What this could lead to
If it works, this could lead to a simple, safe vitamin supplement that helps burn patients heal faster and spend less time in the hospital.
What could go wrong
This is a small, early-phase trial with only 27 participants, so results may not apply to all burn patients. High-dose vitamin E slightly increases bleeding risk.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

27 people

The number who actually took part.

Started

Feb 2013

Finished

Sep 2017

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

16 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age: 16 - 85 years * ≥40% total body surface area burn Exclusion Criteria: * Septic shock * Bleeding disorders * Diabetes, or on diabetes medications or anti-lipidemic agents * Arthritis * Known kidney/renal disease, endocrine disease, cancer, heart disease, osteoporosis, liver disease * Congestive heart failure * Positive hepatitis or HIV screens * Pregnancy (women)

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Conditions

The condition(s) this trial relates to.

burn Inflammation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Burn

Contacts and locations

Locations

  • Memorial Hermann Hospital Burn Intensive Care Unit

    Houston, Texas, 77030, United States

  • University of Texas Medical Branch: Blocker Burn Unit and Shriners Hospitals for Children

    Galveston, Texas, 77555, United States

  • University of Texas Southwestern Medical Center, Parkland Health and Hospital System

    Dallas, Texas, 75390, United States

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