New combo sedation aims to calm recovery agitation

NCT ID NCT01544725

Completed Symptom relief Sponsor: Centre Hospitalier Universitaire de Nice Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether combining ketamine with propofol reduces agitation during recovery from sedation, compared to ketamine alone. 150 adults needing sedation for a broken bone or dislocation were randomly assigned to one of the two drug combinations. The main goal was to see how many patients experienced recovery agitation, with secondary checks on breathing problems, blood pressure changes, and sedation duration.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketamine and propofol
What this could lead to: If successful, this combination could make emergency procedures more comfortable for adults by reducing agitation during recovery.
What could go wrong: This is a small, completed Phase 4 trial with 150 participants, so results may not apply to all patients or settings. The combination may also carry its own side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

bone fracture Joint Dislocations

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DISLOCATION FRACTURE

Contacts and locations

Locations

Hôpital St Roch

Nice, 06006, France

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