New combo sedation aims to calm recovery agitation
NCT ID NCT01544725
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether combining ketamine with propofol reduces agitation during recovery from sedation, compared to ketamine alone. 150 adults needing sedation for a broken bone or dislocation were randomly assigned to one of the two drug combinations. The main goal was to see how many patients experienced recovery agitation, with secondary checks on breathing problems, blood pressure changes, and sedation duration.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketamine and propofol
What this could lead to
If successful, this combination could make emergency procedures more comfortable for adults by reducing agitation during recovery.
What could go wrong
This is a small, completed Phase 4 trial with 150 participants, so results may not apply to all patients or settings. The combination may also carry its own side effects.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Hôpital St Roch
Nice, 06006, France