Could a common antidepressant stop mental health decline after a broken bone?
NCT ID NCT04850222
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tested whether giving fluoxetine (Prozac) to people with serious bone fractures could prevent or reduce depression, anxiety, and other mental health issues that often follow such injuries. 55 adults with broken bones requiring surgery were randomly assigned to take either fluoxetine or a calcium supplement for 90 days. The goal was to see if a simple medication, prescribed by the surgical team, could improve recovery beyond just physical healing.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
fluoxetine
What this could lead to
If it works, this could point toward a simple, safe way for surgeons to help patients avoid lasting mental health issues after a serious injury.
What could go wrong
This is a very small pilot study with only 55 people, so results may not apply widely. Fluoxetine can cause side effects like nausea or sleep problems, and it may not help everyone.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Florida
Gainesville, Florida, 32608, United States