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Turmeric compound tested as spray for sore gums after tooth pull

NCT ID NCT07874789

Symptom relief Sponsor: Istanbul University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 15, 2026 · Last updated Oct 16, 2026 · Updated 1 time

Summary

Researchers at Istanbul University are testing whether a topical spray made from curcumin, a compound in turmeric, helps extraction wounds heal and reduces pain after a lower molar is removed. The trial enrolls 54 healthy adults aged 18 to 40 who need a first molar extracted. Participants are randomly assigned to use curcumin spray, a chlorhexidine spray, or standard care alone twice daily for seven days. The team measures healing with a standard index, tracks pain on a 0 to 10 scale, and checks saliva for inflammatory markers.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a topical spray containing curcumin, a compound from turmeric
What this could lead to
If curcumin spray helps, it could offer a plant-based option for easing pain and supporting healing after tooth extraction.
What could go wrong
This is a small, single-center study of 54 healthy adults, so results may not apply to people with health conditions or to other types of dental surgery. Curcumin can stain and may irritate some people.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 54 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Sep 2026

An estimate. Start dates often move.

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy individuals aged 18-40 years with ASA physical status I. * Patients scheduled for extraction of a mandibular first molar. * Individuals who voluntarily agree to participate and provide written informed consent. * Individuals without chronic systemic disease and who do not use regular medication. * Patients with no oral health condition that would contraindicate the surgical procedure. Exclusion Criteria: * Pregnant or breastfeeding individuals. * Patients with systemic diseases or immunosuppression. * Individuals with a history of previous surgery or trauma in the same region. * Individuals with a known allergy or hypersensitivity to turmeric (curcumin), chlorhexidine spray, or any component of the study products. * Individuals who smoke or consume alcohol. * Individuals who regularly use medications, particularly anti-inflammatory or anticoagulant drugs.

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Conditions

The condition(s) this trial relates to.

alveolar periostitis Inflammation injury Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Alveolitis of jaw Curcumin Tooth extraction Wound healing

How to take part

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  1. The places running it

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  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Istanbul University Faculty of Dentistry, Department of Oral and Maxillofacial Surgery

    RECRUITING

    Istanbul, Istanbul, 34452, Turkey (Türkiye)

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