Can pressurized oxygen help heal the brain?

NCT ID NCT02407028

Recruiting now Disease control Sponsor: Gaylan Rockswold Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—for people with severe traumatic brain injury. Researchers will compare different oxygen pressures to see which works best. The goal is to improve long-term recovery and reduce brain swelling.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: hyperbaric oxygen
What this could lead to: If successful, this could identify the best way to use hyperbaric oxygen to improve recovery after severe brain injury.
What could go wrong: This is an early-phase trial with only 200 participants, so results may not apply to all patients. The treatment is intense and may not improve outcomes over standard care.

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Conditions

The condition(s) this trial relates to.

Brain Injuries, Traumatic traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TRAUMATIC BRAIN INJURY

Contacts and locations

Locations

Detroit Receiving Hospital
RECRUITING

Detroit, Michigan, 48201, United States
Duke University Hospital
RECRUITING

Durham, North Carolina, 27710, United States
Hamilton Heath Services
COMPLETED

Hamilton, Ontario, L8L 2X2, Canada
Hennepin County Hospital
RECRUITING

Minneapolis, Minnesota, 55415, United States
St. Mary's Medical Center
RECRUITING

West Palm Beach, Florida, 33407, United States
The Ohio State University Wexner Medical Center
COMPLETED

Columbus, Ohio, 43210, United States
UCSD Medical Center - Hillcrest Hospital
RECRUITING

San Diego, California, 92103, United States
University of Iowa Hospitals and Clinics
RECRUITING

Iowa City, Iowa, 52242, United States
University of Kentucky Hospital
RECRUITING

Lexington, Kentucky, 40536, United States
University of Maryland
RECRUITING

Baltimore, Maryland, 21201, United States
University of Nebraska Medical Center
COMPLETED

Omaha, Nebraska, 68198, United States

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