Can pressurized oxygen help heal the brain?
NCT ID NCT02407028
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests hyperbaric oxygen therapy—breathing pure oxygen in a pressurized chamber—for people with severe traumatic brain injury. Researchers will compare different oxygen pressures to see which works best. The goal is to improve long-term recovery and reduce brain swelling.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
hyperbaric oxygen
What this could lead to
If successful, this could identify the best way to use hyperbaric oxygen to improve recovery after severe brain injury.
What could go wrong
This is an early-phase trial with only 200 participants, so results may not apply to all patients. The treatment is intense and may not improve outcomes over standard care.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Detroit Receiving Hospital
RECRUITINGDetroit, Michigan, 48201, United States
Contact
Contact Email: •••••@•••••
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Duke University Hospital
RECRUITINGDurham, North Carolina, 27710, United States
Contact
Contact Email: •••••@•••••
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Hamilton Heath Services
COMPLETEDHamilton, Ontario, L8L 2X2, Canada
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Hennepin County Hospital
RECRUITINGMinneapolis, Minnesota, 55415, United States
Contact Email: •••••@•••••
Contact
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St. Mary's Medical Center
RECRUITINGWest Palm Beach, Florida, 33407, United States
Contact
Contact Email: •••••@•••••
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The Ohio State University Wexner Medical Center
COMPLETEDColumbus, Ohio, 43210, United States
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UCSD Medical Center - Hillcrest Hospital
RECRUITINGSan Diego, California, 92103, United States
Contact
Contact Email: •••••@•••••
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University of Iowa Hospitals and Clinics
RECRUITINGIowa City, Iowa, 52242, United States
Contact Email: •••••@•••••
Contact
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University of Kentucky Hospital
RECRUITINGLexington, Kentucky, 40536, United States
Contact
Contact Email: •••••@•••••
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University of Maryland
RECRUITINGBaltimore, Maryland, 21201, United States
Contact
Contact Email: •••••@•••••
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University of Nebraska Medical Center
COMPLETEDOmaha, Nebraska, 68198, United States