One shot or several? new trial tests shorter radiation for cancer spread
NCT ID NCT05784428
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study is testing whether a single, high-dose radiation session works as well as multiple sessions for people whose cancer has spread to a few places (oligometastatic disease). About 600 participants will be randomly assigned to receive either one or several radiation treatments. The goal is to see if the single dose causes fewer side effects and maintains quality of life while still controlling the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy (stereotactic ablative radiotherapy)
- What this could lead to
- If it works, this could show that a single, shorter radiation session is just as effective as multiple sessions for controlling limited cancer spread, with fewer side effects and lower costs.
- What could go wrong
- This is a non-inferiority trial, meaning it aims to prove that one session is not worse than multiple. It is still recruiting, and results may show that single sessions are less effective or cause unexpected side effects in some patients.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
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Contact
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Locations
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BC Cancer
RECRUITINGKelowna, British Columbia, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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BC Cancer
RECRUITINGPrince George, British Columbia, V2M 7E9, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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BC Cancer
RECRUITINGSurrey, British Columbia, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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BC Cancer
RECRUITINGVancouver, British Columbia, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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BC Cancer - Victoria
NOT_YET_RECRUITINGVictoria, British Columbia, Canada
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Beacon Hospital
RECRUITINGDublin, Leinster, D18 AK68, Ireland
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Bon Secours Radiotherapy Cork in Partnership with UPMC Hillman Cancer Centre
RECRUITINGCork, Munster, T12 DV56, Ireland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Cork University Hospital
RECRUITINGCork, Munster, T12 DC4A, Ireland
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Health Sciences North Research Institute
RECRUITINGGreater Sudbury, Ontario, P3E 5J1, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Mater Private Hospital
RECRUITINGDublin, Leinster, D07 WKW8, Ireland
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Princess Margaret Cancer Centre | University Health Network
RECRUITINGToronto, Ontario, M5G 1X6, Canada
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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St. Luke's Radiation Oncology Network
RECRUITINGDublin, Dublin, D06 E1C9, Ireland
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UPMC Whitfield Hospital - Waterford
RECRUITINGWaterford, Munster, X91 DH9W, Ireland
Contact
Contact Email: •••••@•••••
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University Hospital Galway
RECRUITINGGalway, Connacht, H91 YR71, Ireland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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