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Can one bike ride reveal how exercise shapes the brain?

NCT ID NCT07883720

Knowledge-focused Sponsor: Brigham and Women's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Oct 20, 2026 · Last updated Oct 21, 2026 · Updated 1 time

Summary

Researchers at Brigham and Women's Hospital are studying how one session of exercise affects brain function and body signals in people with neurological conditions compared with healthy adults. The study includes people with epilepsy, functional neurological disorder, mild cognitive impairment, dementia, Parkinson's disease, concussion, or brain tumors, plus healthy volunteers. Participants complete a single one-day visit with a bike exercise test and brain MRI, blood draws, and nervous system measurements taken before and after the exercise. The goal is to understand differences in fitness and exhaustion, and how exercise changes brain networks, brain chemistry, blood markers, and heart rate variability.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a single session of exercise on a stationary bike
What this could lead to
If exercise reliably shifts brain network activity and blood markers, doctors could use simple fitness tests to track neurological health or tailor exercise advice for people with these conditions.
What could go wrong
This is a one-day observational study with no treatment arm, so it can show associations but not whether exercise causes lasting brain changes. Results may differ by condition and may not translate into new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 240 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2026

Expected to finish

Dec 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18 years or older * Clinical diagnosis of one of the following neurological diseases: epilepsy, functional neurological disorder, mild cognitive impairment, dementia, Parkinson's disease, concussion, brain tumor \[for participants with neurological diseases\] * No diagnosis of neurological disease \[for healthy control participants\] Exclusion Criteria: * Non-english speaking individuals * Exercise contraindications (e.g., physical impairments limiting use of bicycle ergometer, acute infections, severe heart disease, uncontrolled hypertension, exercise associated seizures) * Current use of medications for cardiac rhythm or rate control * Magnetic resonance imaging (MRI) contraindications (e.g., electrical implants, ferromagnetic implants or objects, pregnancy)

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Conditions

The condition(s) this trial relates to.

brain cancer Brain Concussion brain neoplasm Cognitive Dysfunction conversion disorder dementia epilepsy Motor Activity Parkinson disease traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Brain tumor Concussion, brain Dementia Epilepsy Functional neurological disorder Healthy Mild cognitive impairment Parkinson disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Brigham and Women's Hospital

    RECRUITING

    Boston, Massachusetts, 02115, United States

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