Short bursts of low oxygen may boost breathing after spinal injury

NCT ID NCT06011876

Recruiting now Knowledge-focused Sponsor: University of Florida Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether short episodes of breathing low-oxygen air can improve breathing strength in people with chronic spinal cord injury. Participants will try three different breathing sessions (low oxygen, low oxygen with extra carbon dioxide, and normal air) to see which works best. Researchers will also look for genetic differences that might explain why some people respond better than others.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Acute Intermittent Hypoxia (AIH) and Acute Intermittent Hypercapnic-Hypoxia (AIHH)
What this could lead to: If successful, this could point toward a personalized breathing therapy for people with spinal cord injury based on their genetics.
What could go wrong: This is an early, small study (62 people) focused on short-term changes, not long-term outcomes. Results may not apply to everyone with spinal cord injury.

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Conditions

The condition(s) this trial relates to.

Respiratory Aspiration spinal cord injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

SPINAL CORD INJURIES

Contacts and locations

Locations

Brooks Rehabilitation
RECRUITING

Jacksonville, Florida, 32216, United States

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