National Institute Of Neurological Disorders And Stroke (ninds)

This early-stage trial tests a new drug called LMP744 in 40 adults whose glioblastoma (a type of brain cancer) has come back after standard treatment. The drug is given through a vein for 5 days each month for up to a year. The goal is to see if it can shrink tumors or delay canc…

This study tests whether an antiviral drug called brincidofovir is safe for people with progressive multifocal leukoencephalopathy (PML), a rare and often deadly brain infection caused by the JC virus. About 24 adults with PML will receive the drug through an IV twice a week for …

This early-stage trial tests whether a single injection of resiniferatoxin (RTX) can safely reduce severe bone pain caused by cancer that hasn't responded to standard treatments. About 30 adults with advanced cancer will receive the injection into their lower back and be followed…

This early-stage trial tests whether a single dose of pembrolizumab, a cancer drug, is safe for people with long COVID who have brain-related symptoms like headache, dizziness, or trouble thinking. Fifteen adults who had COVID at least 6 months ago will receive the drug and be fo…