Brain boost? L-Citrulline supplement tested for blood flow in aging
NCT ID NCT05722860
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This completed Phase 1 study tested whether taking L-Citrulline, a dietary supplement, for one week can improve blood vessel function in the brain and eyes of healthy young and older adults. Researchers measured brain activity and blood flow using special imaging techniques. With only 20 participants, this early study aims to gather knowledge about how the supplement affects the aging brain.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
L-Citrulline (a dietary supplement)
What this could lead to
If it works, this could point toward a simple supplement to support brain blood vessel health as we age.
What could go wrong
This is a very small, early Phase 1 study with only 20 people. It measures short-term changes, not long-term health benefits. Results may not apply to everyone.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Andriy Yabluchanskiy
Oklahoma City, Oklahoma, 73117, United States