Brain boost? L-Citrulline supplement tested for blood flow in aging

NCT ID NCT05722860

Completed Knowledge-focused Sponsor: University of Oklahoma Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed Phase 1 study tested whether taking L-Citrulline, a dietary supplement, for one week can improve blood vessel function in the brain and eyes of healthy young and older adults. Researchers measured brain activity and blood flow using special imaging techniques. With only 20 participants, this early study aims to gather knowledge about how the supplement affects the aging brain.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: L-Citrulline (a dietary supplement)
What this could lead to: If it works, this could point toward a simple supplement to support brain blood vessel health as we age.
What could go wrong: This is a very small, early Phase 1 study with only 20 people. It measures short-term changes, not long-term health benefits. Results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AGING

Contacts and locations

Locations

Andriy Yabluchanskiy

Oklahoma City, Oklahoma, 73117, United States

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