AGING

This Phase 2 trial is testing whether the drug sirolimus can slow aging in adults aged 65 to 80. Ten participants will be randomly assigned to receive sirolimus or standard care, and researchers will measure aging biomarkers like walking speed and cellular changes after one year.…

Most older Americans eat too much salt, which can raise blood pressure and harm the kidneys. This study tests whether a ketone supplement (a substance the body makes during fasting or exercise) can block those harmful effects. Thirty-five adults aged 60-85 will follow a high-salt…

This study tests whether a gentle electrical current applied to the lower spine can boost the effects of balance training in adults aged 65 to 95 who have trouble walking and balancing. Participants will perform balance exercises while receiving either real or sham spinal stimula…

This early-phase study is testing two drugs, rapamycin and everolimus, in 194 healthy adults aged 65 to 90. The goal is to find a safe dose and timing that can reduce a key aging signal in cells to levels seen in younger people. The researchers also want to see if the best dose d…

This Phase 1 trial tests two drugs, sirolimus and everolimus, given once a week to healthy adults aged 55-89. The goal is to find the safest dose that might slow the aging process. Participants take the drug for 6 weeks and are monitored for side effects and drug levels in the bl…

This phase 2 trial tests whether adding tesamorelin (a growth-hormone-releasing hormone analogue) to a home-based exercise program can improve physical function in 100 adults aged 50-80 with HIV. Participants are randomly assigned to receive tesamorelin or a placebo injection dai…

This Phase 2 study tests whether a Traditional Chinese Medicine (TCM) herbal formula can improve muscle strength and bone health in pre-frail adults aged 65 and older, compared to the nutritional supplement HMB. Over 24 weeks, 90 participants will take either the TCM powder or HM…

This study tests whether taking a daily capsule of nicotinamide mononucleotide (NMN) can reduce biological age in healthy adults aged 40-70. Over 240 participants will take either NMN or a placebo for one year. Researchers will measure aging using blood tests and other markers to…

This study looks at whether a combination of physical exercise and a nutritional supplement (phenylcapsaicin) can improve body composition, metabolism, and overall health in adults aged 50-65 who are overweight but not obese. Participants must have at least two signs of mild meta…

This study looks at whether whole body vibration therapy, added to usual care, can improve muscle mass, strength, and function in older adults who are starting to become frail. About 40 people aged 65 and older will be randomly assigned to receive either vibration therapy plus us…

This study tests whether a daily dose of nicotinamide riboside (a form of vitamin B3) can improve blood flow and activity in the brains of healthy adults aged 60 to 85. Over 8 weeks, 214 participants will take either the supplement or a placebo. Researchers will measure brain blo…

This pilot study tests whether tirzepatide (Zepbound), a drug already used for weight loss, can slow biological aging in adults aged 55 to 70. Ninety participants with a BMI of 27 or higher will be randomly assigned to receive the drug weekly for 24 weeks or no drug, followed by …

This study tests three approaches to help older adults with HIV become more physically active: one-on-one coaching, cognitive behavioral therapy to overcome barriers like low motivation or pain, and a Fitbit-based social support program. About 196 participants will wear a Fitbit …

This study tests a special medical food containing probiotics and prebiotics to see if it can help slow or reverse bone loss in older women. Researchers will measure changes in bone density and strength over 18 months. The goal is to find a safe, dietary approach to manage osteop…

This study tests whether short, controlled sessions of low oxygen (intermittent hypoxia) can improve blood flow to the brain and memory in adults aged 60-85 with type 2 diabetes. Researchers will compare the training to a placebo in 80 participants. The goal is to find a new way …

This study tests whether a dietary fiber supplement (soluble corn fiber) can help older men absorb more calcium and improve bone health. Thirty male veterans aged 60 and older will take the fiber supplement and then have their calcium absorption measured. The goal is to see if ch…

This study tests whether empagliflozin, a drug currently used for diabetes, can reverse the natural stiffening of arteries that happens with age. Researchers will give 80 healthy adults aged 60-80 either the drug or a placebo daily for 12 weeks. The main goal is to see if artery …

This study compares a 5-minute daily breathing exercise (IMST) to brisk walking for lowering blood pressure in postmenopausal women aged 50 and older with above-normal blood pressure. Researchers will measure changes in blood pressure and blood vessel function after 3 months of t…

This study is testing whether taking fecal microbiota transplants (FMT) in capsule form can reduce frailty and improve overall health in people aged 70-85. The researchers believe that restoring a healthy balance of gut bacteria may slow aging and lower the risk of age-related di…

This study tests whether a daily natural supplement combined with a twice-weekly exercise program can improve immune function and reduce inflammation in adults aged 65 and older. Over six months, 60 participants will take either the supplement or a placebo, all while following th…

This study tests whether a smartphone app with reminders and education can help older adults (60+) who have mild memory problems stick to their blood pressure medication schedule. One hundred participants will use either the full app with reminders or just the education part for …

This study tests whether a combined program of exercises, education, and technology support can prevent disability in older adults (over 70) who are already frail. About 288 participants will either receive this program during their hospital stay and at home for 3 months, or get …

This study compares two approaches to prevent delirium in older adults during a hospital stay. One is standard hospital care (HELP), and the other adds daily support from family members (FAM-HELP). Researchers will track 1,900 patients aged 70 and older to see if family involveme…

This study tests a program called Cafe Move, designed to help older adults prevent physical frailty. Participants choose from various physical assessments and receive personalized reports on their performance. The goal is to make health promotion easy and accessible, helping peop…

This study tests whether a type of tai chi that combines movement with a mental task can reduce falls in older adults with mild cognitive impairment. Researchers will compare dual-task tai ji quan, standard tai ji quan, and stretching exercises in 336 people aged 65 and older who…

This study tests a small, TENS-like device that sends a mild electric signal to improve balance and walking in older adults. Researchers will measure walking speed and stability in 120 participants aged 60 and older, as well as younger adults for comparison. Participants will wal…

This study tests whether a powered leg exoskeleton can improve walking speed and ease for older adults aged 65 to 75. Forty participants will walk with and without the device to see if it helps them move faster and more comfortably. The goal is to find new ways to support mobilit…

This early-phase study tests a 4-week training program that uses mixed reality to guide precise movements, like stacking virtual objects. The goal is to see if this can improve walking speed, balance, and thinking in people with multiple sclerosis. Thirty adults with MS will part…

This study tests a device called Walkasins, worn on the legs, that vibrates to give sensory feedback to older adults who have lost some feeling in their feet. The goal is to see if it helps them walk more automatically and with less mental effort. The study involves 30 people age…

This study tests a program called SPARK for adults aged 50 and older who have pain, depressive symptoms, and trouble moving around. Participants receive 8 nurse visits at home to help them cope with pain and improve their mood. The goal is to see if this approach reduces pain int…

This study tests a 12-week exercise and nutrition program called SickleFit in 40 adults aged 35 and older with sickle cell disease. The goal is to see if the program is safe, doable, and liked by participants. It does not aim to cure the disease but to improve fitness and quality…

This study looks at whether a one-year, home-based exercise program can help people aged 60 and older who are undergoing cancer treatment. Participants will be split into two groups: one doing guided exercises at home, and the other receiving usual care. Researchers will measure …

This study tests a topical cosmetic product to see if it improves skin hydration and reduces wrinkles. About 30 healthy adults aged 45 to 65 with visible facial wrinkles will use the product for 8 weeks. Researchers will measure changes in skin moisture and wrinkle depth.

This study looks at whether a 16-week program combining mindfulness meditation and Nordic walking pole exercise can improve physical function, mood, and sleep in adults aged 55 and older. About 1,500 participants will take part in the program and be assessed at several points. Th…

This study tests two hyaluronic acid gels, INNEA and INNEA AQUA, for treating wrinkles on the cheeks and décolletage. Fifty-five women aged 35 to 65 will receive up to three injections. Researchers will check wrinkle improvement one month after the last injection using the Lemper…

This study tests three different exercise programs—core stabilization, amplitude-based movements (like LSVT BIG), and a combination of both—in healthy adults aged 65 and older. The goal is to see which program best improves dynamic balance and reduces fall risk. Forty-five partic…

This pilot study tests whether fisetin, a natural compound found in strawberries, can reduce aging cells and improve walking ability in 34 people aged 50+ with peripheral artery disease (PAD). Participants will receive either fisetin or a placebo for 4 months. The main goal is to…

This study tests whether a home-based exercise and nutrition program, called prehabilitation, can improve physical function in adults aged 65 and older with breast cancer before they have surgery. The program includes strength, balance, and flexibility exercises tailored to each …

This study tests whether shining a specific red light on the legs each day before a walking session can help people with peripheral artery disease (PAD) walk farther. PAD causes leg pain and difficulty walking due to poor blood flow. The trial will involve 32 adults aged 50 and o…

This study tests whether adding nitrate-rich beetroot juice to exercise helps people with peripheral artery disease (PAD) walk farther and with less pain. 210 adults aged 50+ with PAD will be assigned to either supervised treadmill or home walking, plus either beetroot juice or a…

This study tests whether using a music-based rhythm training app or a word search app for up to 8 weeks can improve working memory and focus in older adults. Participants, including those with mild cognitive impairment, will complete cognitive tests before, after, and 6 months la…

This study is testing whether a single dose of nicotine gum can reverse age-related hearing problems. Researchers will give 48 healthy non-smokers aged 18-85 either nicotine gum or a placebo and measure their hearing and brain responses. The goal is to see if nicotine can improve…

This study tests whether guided imagery—specifically, vividly imagining a future where you are physically active—can help mid-life adults stick to an exercise program. 160 participants will complete an in-person exercise program and be randomly assigned to different imagery exerc…

This study tests an AI chatbot called Aurora that guides people through creating a personal life story to improve emotional well-being and identity. It includes healthy adults, adults with mental health conditions in residential care, and older adults aged 65+. The chatbot is not…

This study tests whether older adults (ages 65-74) can improve their balance, reduce fear of falling, and sleep better by doing combined physical and mental exercises at home via video calls with a physiotherapist. Participants will perform 4 weeks of dual-task exercises—like wal…

This study tests whether a daily ketone supplement can improve muscle strength, mobility, and immune function in adults aged 65 and older who are starting to feel weaker. Over 20 weeks, 180 participants will either take the ketone drink or a placebo. Researchers will measure phys…

This study tests whether playing a special video-based game (BeCure) twice a week for 6 weeks can improve balance, hand-eye coordination, and confidence in people aged 60 and older. Researchers will compare 32 healthy older adults who play the game to a control group that does no…

This pilot study tests whether taking a daily polyphenol supplement (from red leaf lettuce) alongside a 12-week exercise program can improve physical performance in adults over 60. The main goal is to see if the study is feasible—can people stick with it? Researchers will also me…

This pilot study tests whether a personalized digital meditation app called MediTrain can help older adults with mild cognitive impairment (MCI) sleep better and feel less stressed. Participants will use the app for 30 minutes daily over 6 weeks. Researchers will measure changes …

This study tests whether a neuroscience-based computer program can improve memory and thinking in older adults who have had cognitive problems for at least 12 weeks after a COVID-19 infection. Researchers will compare the brain-training program to other computer activities in 75 …

This study is testing a tablet-based meditation game called MediTrain to see if it can help older adults improve their thinking skills and manage stress. Researchers will enroll 4,000 people aged 60 and older to find the best amount of game play needed for benefits. The game adap…

This study tests whether a supplement called nicotinamide mononucleotide (NMN) can improve exercise tolerance in healthy adults aged 60 to 80. Participants will take either the supplement or a placebo and measure how long they can cycle before getting tired. The goal is to see if…

This pilot study tests whether whole-body electrical muscle stimulation (WB-EMS) combined with exercise can improve muscle activation and physical function in healthy older adults aged 65 and older. Participants will use a special suit with electrodes that stimulate major muscle …

This study is testing whether two dietary supplements, urolithin A and fisetin, can improve sleep quality and reduce signs of aging in middle-aged and older adults. Eighty participants aged 30-75 with poor sleep will take one of the supplements, a combination, or a placebo daily …

This study is testing whether a special vibration device, used along with standard rehab, can improve muscle strength, movement, and pain in older adults and stroke survivors. About 80 participants will receive either vibration therapy plus rehab or rehab alone. The goal is to se…

This study tests whether a daily MitoQ supplement for 12 weeks can improve blood vessel function, walking speed, and thinking skills in frail older adults aged 65-80. Researchers will measure changes in blood flow, cognitive tests, and physical performance. The trial involves 60 …

This study looks at whether different exercise programs can improve blood flow in the legs of older adults with poor circulation. About 425 participants will be split into groups doing either mixed exercise, high-intensity rowing, or vibration exercise for 12 weeks. The goal is t…

This study tests whether a technology-assisted block training program can improve thinking skills, hand strength, and dexterity in healthy older adults aged 65 and up. Forty participants will use a special block system and be measured on memory, grip, and fine motor skills. The g…

This study looks at whether a natural supplement combined with a supervised exercise program can improve mood, sleep, thinking skills, and physical function in women going through menopause. About 90 women aged 45-65 will take either the supplement or a placebo daily for 10 weeks…

This study tests whether combining cognitive training (brain games) with physical exercise can improve thinking, memory, and brain blood flow in people with chronic heart failure. Researchers will enroll 216 men and women aged 50 and older with stable heart failure. Participants …

This study tests whether low-frequency ultrasound baths can improve muscle strength, thinking skills, and immune health in healthy adults aged 70 and older. Twenty participants will either receive ultrasound baths three times a week for 8 weeks or sit in a bath without ultrasound…

This study tests whether a daily dietary supplement can improve memory, thinking, and emotional well-being in healthy adults aged 55 and older. Sixteen participants will take the supplement for 45 days and complete memory and mood tests at the start and end. The goal is to see if…

This study tests whether using mild electrical pulses on the thigh muscle can help people regain strength and movement faster after total knee replacement. About 3,250 patients will be randomly assigned to receive either standard physical therapy or standard therapy plus electric…

This study tests whether adding simple mental tasks (like memory games) to water aerobics helps older women improve their thinking and memory more than water aerobics alone. About 98 inactive women aged 60-75 will take part in a 12-week program. Researchers will measure changes i…

This study uses yearly PET scans to track amyloid protein buildup in the brains of 400 adults aged 55 and older over 5 years. Participants are already part of the Baltimore Longitudinal Study of Aging. The goal is to see how these brain changes relate to memory loss and other thi…

This study looks at how 'cognitive reserve' — the brain's built-in resilience built over a lifetime — affects recovery from daily physical and mental fatigue in people aged 65 and older. Researchers will measure cognitive reserve levels in 400 older adults and track how they perc…

This study aims to find the best way to deliver preventive health screenings to people in underserved and rural areas. It will compare different methods, such as interactive health reports, mobile screening units, and even droid-assisted screenings, to see which improves health e…

This study is tracking 2,000 adults over time to understand how obesity and disruptions to the body's internal clock (circadian rhythm) influence aging and heart health. Participants will provide health data, questionnaires, and biological samples during annual check-ups. The goa…

This study is testing the drug sirolimus in 60 healthy adults aged 65 and older to see how the body processes it and how it affects aging-related markers. Participants take sirolimus tablets daily for several weeks, with dose adjustments to reach a target blood level. The goal is…

This study looks at how estrogen levels affect the way women's bodies handle heat stress. Researchers will compare premenopausal and postmenopausal women aged 42-64, using drugs to temporarily adjust estrogen levels. The goal is to understand why older women are at higher risk du…

This study looks at how healthy young and older adults use their brains to make memory decisions. Participants will complete memory tasks while having an MRI scan. Researchers want to see if older adults rely more on combining past experiences to remember. The goal is to better u…

This observational study will enroll up to one million adults to understand how health, environment, and lifestyle affect aging and disease. Researchers will link participants' clinical data with information from public records, such as pollution and social factors, to create a d…

This study, running since 1958, follows healthy adults aged 20 and older for life to understand how people age. Participants undergo physical exams, cognitive tests, imaging, and other assessments every few years. The goal is to characterize the aging process and learn how people…

This study will follow 1,000,000 adults aged 18 and older for the rest of their lives. Researchers will collect health measurements and track who develops diseases, becomes frail, or dies. The goal is to find which tests best predict how well people age, so doctors can one day of…

This study looks at how stroke changes the way the brain handles walking while doing another task, like listening or navigating. Researchers will monitor brain activity in 50 stroke survivors as they walk on different paths and respond to sounds. The goal is to better understand …

This study looks at how binge drinking in mid-life (ages 50-64) affects blood pressure, small blood vessels, and nerve activity. It compares binge drinkers to non-drinkers and moderate drinkers. In a second phase, binge drinkers will try 8 weeks of aerobic exercise to see if it i…

This study will measure how much energy older adults use during mat and equipment-based Pilates sessions. Twenty men and women aged 60+ with Pilates experience will complete both types of Pilates and treadmill walking. Researchers will track calories burned, heart rate, and perce…

This study looks at how different amounts and types of exercise can improve thinking and memory in Veterans aged 65 and older. Researchers will measure changes in cognitive skills and blood markers related to brain health. The goal is to understand which exercise habits work best…

This study looks at whether a community support program called Vefahane helps older adults maintain their thinking skills and quality of life. Researchers will compare 120 people aged 60 and older who take part in activities like exercise, music, and social events with those who …

This study looks at how endurance exercise (like walking or cycling) and resistance exercise (like lifting weights) affect bone health in older veterans aged 60 and over. Researchers want to see if either type of exercise causes bone breakdown and how the body adapts over time. T…

This study compares two groups of healthy adults over 55: those who have exercised regularly for 30 years and those who have not. Researchers will test blood and physical function to see how lifelong activity affects T cell metabolism and overall vitality. The goal is to understa…

This study looks at how different amounts of strength training (low, medium, or high) affect the body's inflammation levels in healthy adults aged 60-75. Participants will train for 4 weeks, then stop for 4 weeks. Researchers will measure changes in blood markers of inflammation …

This study looks at how well people can control their hip muscles and whether that affects their balance and walking. Researchers will compare healthy young, middle-aged, and older adults, as well as people with Parkinson's disease. The goal is to understand why falls happen more…

This study explores whether mild low-oxygen (hypoxic) conditioning, alone or combined with exercise, can improve blood vessel function in the brains of inactive adults aged 60-80. Researchers will measure changes in brain blood flow and other health markers in 64 participants. Th…

This study looks at how sleep quality and physical activity are linked to memory in people living in assisted-living facilities. Researchers will measure sleep using monitors and questionnaires, and assess physical function with walking tests. The goal is to find factors that can…

This study aims to understand whether blood flow in fat tissue changes as we age. Researchers will compare healthy younger adults (18-35) with older adults (65-80) by measuring blood flow and taking small fat samples. Participants will also drink a sugary drink to see how the bod…

This study aims to understand how the brain responds to magnetic stimulation when it is timed with natural brain waves. Researchers will test healthy adults and people who had a stroke at least 6 months ago. The goal is to find ways to make brain stimulation more effective for im…

This study aims to understand why our bodies and minds change as we get older. Researchers will use brain scans, fitness tests, and wearable devices to track health in 770 adults aged 18-85. The goal is to learn how factors like race, sex, and lifestyle affect aging, not to test …

This study looks at why older adults respond differently to the same exercise program. Researchers will have 250 healthy adults aged 60+ do a mix of cycling and strength training three times a week. The goal is to understand what makes exercise more effective for some, so future …

This study looks at how getting older and feeling stressed can change the way we remember places and find our way around. Researchers will have 85 adults aged 65 to 80 do a virtual navigation task while their brains are scanned. Some participants will be put under mild stress to …

This study tests whether a special training toolkit helps doctors and nurses have better conversations about future medical care with people living with Alzheimer's or related dementias. The researchers will compare clinics that use the toolkit to those that continue usual care, …

This study looks at slow brain waves during sleep and wakefulness in 90 people: young adults, healthy seniors, and early-stage Alzheimer's patients. Researchers will measure these waves and test memory and attention. They will also play sounds during sleep to see if it boosts mem…

This study looks at how different blood pressure treatment goals affect artery stiffness in veterans over 60 with high blood pressure. Researchers will measure stiffness caused by blood pressure itself and by changes in the artery wall, and explore genetic factors. The goal is to…

This study compares two online training programs for assisted living staff who care for people with dementia. One program is a self-paced web course called essentiALZ; the other adds a virtual mentoring group called Project ECHO. Researchers will track changes in staff knowledge,…

This study explores how aging affects the ability to learn who to trust. Researchers will use real-time fMRI to give older adults feedback on their brain activity while they practice trust-related tasks. The goal is to see if this brain training can improve their decision-making …

This study looks at how the brain changes as we age and searches for new markers of healthy aging. Researchers will also test whether stem cell-derived exosomes can rejuvenate the brains of aged mice. The goal is to better understand brain aging and find ways to keep the brain he…

This study looks at how a type of immune cell called neutrophils affects the body's response to the pneumococcal vaccine in young (21-40) and older (65+) adults. Researchers will measure how well neutrophils kill pneumonia bacteria after vaccination. The goal is to understand why…

This study looks at how aging and multiple sclerosis (MS) affect muscle and heart health in people over 60. Researchers will compare older adults with MS to those without MS, and test how their bodies respond to a 4-month exercise program. The goal is to understand differences in…

This study looks at how former athletes, current master's athletes, and nonathletes (ages 35-65) experience pain and respond to moderate exercise. Participants will do strength and aerobic exercises while their pain tolerance and sensitivity are measured. The goal is to understan…

This study tests whether a natural supplement from brown seaweed (fucoidan) can improve biological age in 60 pre-frail men aged 50-80. Researchers will measure changes in DNA methylation (a marker of aging) and inflammation. The goal is to see if targeting the aging process itsel…

This study collects bone marrow from 24 adults aged 65+ having hip surgery to understand how common aging-related blood cell mutations (called CHIP) change cell metabolism. Researchers will compare gene activity in mutated versus normal stem cells. The goal is to learn more about…

This study aims to understand frailty in people with HIV who are 50 or older. Researchers will screen participants for signs of weakness or low stamina, then offer a personalized activity plan with strength, balance, and walking goals. The study will track how well people stick w…

This pilot study tests a new system that continuously monitors vital signs in older adults, both in the hospital and at home. The goal is to see if the system is easy to use and reliable, and to gather feedback from patients and clinicians. Only 15 participants will be enrolled, …

This pilot study tests whether a combination of reducing alcohol and taking a probiotic supplement can improve thinking skills and brain metabolism in healthy older adults (ages 65-84) who are heavy drinkers. Twenty participants will receive either a probiotic or a placebo for 30…

This study aims to understand how our sense of touch works by recording nerve signals in healthy volunteers as they touch different surfaces, temperatures, and textures. Researchers will also test how emotions and age affect touch. The goal is to use this knowledge to create pros…

This study looks at whether a 12-week program of a special supplement (with synbiotics) plus supervised exercise can improve muscle, gut health, immunity, and thinking in 40 pre-frail adults aged 50-80. The goal is to see if these changes can be measured together as a single scor…

This pilot study tests whether applying over-the-counter moisturizers (CeraVe or Vaseline) daily for 4 weeks can reduce inflammation in adults aged 70 and older with dry skin. Researchers will measure skin barrier function, blood markers of inflammation, and skin microbes. The ma…

This study looks at how past sports injuries and a sedentary lifestyle may lead to chronic disease, pain, and disability in former athletes. Researchers will compare strength, function, physical activity, and heart health among current and former college athletes and non-athletes…

This study looks at whether a 6-month cardio-dance fitness program can improve brain health and lower Alzheimer's risk in 280 older African Americans (age 60+). Participants will do either dance fitness or strength/flexibility exercises three times a week. Researchers will measur…

This study aims to understand how obesity and aging are connected by looking at blood markers in 650 young and older adults with or without obesity. Participants will provide blood samples and undergo imaging tests to measure biological age and fat distribution. The goal is to la…

This study uses a special PET scan to detect tau protein buildup in the brains of healthy older adults and those with mild cognitive impairment. Researchers will compare scan results with memory tests and brain activity patterns to understand how tau affects thinking. The goal is…

This study looks at how getting older and muscle tiredness affect a person's ability to stand steady and walk. Researchers will measure balance, walking speed, and muscle strength in 140 healthy adults (young and old) after they do exercises that tire out their arms or legs. The …

This study is creating a large, diverse group of 1,000 older adults in Tennessee to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will be followed yearly with tests like brain scans and bl…

This study looks at how well a blood test can predict a person's fitness level, measured by VO₂max. Researchers will collect blood samples and fitness data from 250 healthy adults. The goal is to see if certain molecules in the blood can accurately estimate how fit someone is, an…

This study tests whether combining fasting with exercise can slow the aging process in healthy adults over 65. 240 participants will be split into four groups: exercise only, fasting only, both, or neither. Researchers will measure biological age using DNA markers and other healt…

This study looks at how well older adults can handle heat and humidity. Researchers will have 190 participants exercise in different conditions to find the point where their body can no longer cool itself. The goal is to identify dangerous temperature and humidity combinations to…

This study from Mayo Clinic looks at why older adults' muscles don't respond as well to exercise as younger people's. Researchers will measure how muscles build protein after a single workout session in 120 healthy young and older adults. The goal is to understand if chronic infl…

This study looks at whether adding a special care program (GRACE) to regular annual check-ups can help older adults with multiple health issues avoid hospital stays and feel better. About 6,000 people aged 65 and older who speak English or Spanish will take part. The goal is to s…

This study tests whether drinking cold water (4°C) four times a day for six months can lower body fat and slow aging in healthy adults aged 50-65. Researchers will compare the cold water group to a group drinking warm water (37°C). Participants will undergo body scans and health …

This study tests whether an online program teaching positive emotion skills can improve mental well-being and slow biological aging. Researchers will measure changes in mood and biological age markers in 80 adults aged 40-70 from the Chicago area. The goal is to understand if boo…

This study looks at 100 healthy adults over 60 to see if brain scans and eye-tracking tests can predict memory changes. Researchers focus on a small brain area called the locus coeruleus, which is linked to early Alzheimer's changes. Participants will have MRI scans and do comput…

This study looks at how older adults with hearing loss understand speech in noisy settings, and how hearing aids can help. Researchers will test 121 people, including young and older adults with normal hearing and older adults with hearing loss. They will measure both behavior (l…

This study looks at whether the time of year—summer vs. winter—changes a person's biological age, which is a measure of how fast their body is aging. Researchers will track 60 healthy adults over 40 for 12 months, using blood or saliva tests to calculate aging clocks. The goal is…

This study looks at how short-term pain affects the ability of older adults to learn and remember a new way of walking. Researchers will apply a cream with capsaicin (the stuff that makes chili peppers hot) and a heat pack to one leg to create temporary pain. Participants will wa…

This study looks at how blood flow and the nervous system adapt early in aging women. Researchers will measure forearm blood flow in 64 women aged 18-70. The goal is to better understand these changes, not to test a treatment.

This early-phase study tests whether soaking the lower legs in warm water (42°C) for an hour can improve how small blood vessels widen in response to increased blood flow. Researchers will study 20 healthy adults aged 18-80 to see if this passive heating mimics some benefits of e…

This study tests whether water spray, fans, or both can reduce heat-related stress on the heart and body in older adults. One hundred healthy volunteers aged 65 and older will sit in a hot climate chamber while researchers measure their temperature and heart function. The goal is…

This study looks at whether two common heart medications, propranolol and metoprolol, cause older adults to get hotter than normal during extreme heat. Researchers will measure body temperature and sweat rate in 22 healthy volunteers aged 65 and older over 3 hours of heat exposur…

This early-stage study is looking at how a single dose of psilocybin, the active ingredient in magic mushrooms, might affect brain structure and function in healthy older adults aged 60 to 85. Researchers will use MRI scans to measure changes in brain plasticity and activity. The…

This study aims to understand how aging changes the brain and kidneys in healthy adults. Researchers will use advanced MRI scans and thinking tests to find links between these changes. The study involves 120 English-speaking adults with no major health conditions. Results may hel…

The SMILE study is tracking 10,000 adults aged 18 and older to see how sarcopenia (age-related muscle loss) and metabolic diseases like diabetes influence overall health and lifespan. Researchers will collect data from medical records, tests, and surveys over time. This is an obs…

This study looks at how aging changes the way your body uses energy and nutrients, and how that relates to physical and mental decline. Researchers will track 100 healthy and frail older adults using special tracer infusions to measure metabolism. The goal is to better understand…

This study tests whether a simple, at-home procedure called ischemic conditioning can protect small blood vessels in frail adults aged 65-85. Participants use a blood pressure cuff to briefly restrict blood flow to one arm, then release it, repeating this for two weeks. Researche…

This early-phase study tests whether angiotensin-(1-7), a natural hormone, can improve blood vessel function and lower blood pressure in healthy adults aged 65-80. Researchers will measure nerve activity and blood vessel responses during a short infusion of the hormone compared t…

This study is testing how two different types of dietary fats affect brain function in healthy adults aged 65 to 75. Participants will follow a low-fat diet for one week, then switch to either a Mediterranean-style diet (high in oleic acid) or a typical North American diet (high …

This study looks at why older adults respond differently to strength training. Researchers will enroll 300 people aged 65 and older who are at risk for mobility problems. Participants will either do progressive resistance training three times a week or attend weekly health educat…

This study looks at how mild dehydration (losing 2-3% of body weight through water) and then rehydrating affects inflammation, blood sugar, sleep, and strength in adults aged 45-65. Fifteen healthy participants will follow a 12-day hydration schedule, with five lab visits to meas…

This observational study aims to understand why older adults lose certain immune cells (T cells) from their nasal passages, which may make them more prone to respiratory infections. Researchers will compare young adults (18-30), healthy older adults (65+), and frail older adults …

This study examines how aging and menopause change the way blood vessels widen in response to low oxygen. Researchers will give healthy women either a placebo, a beta-blocker (propranolol), or a bladder medication (gemtesa) to see how these drugs affect blood flow in the forearm.…