AGING

This study is testing whether two different exercise programs—cardio-dance fitness versus strength, flexibility, and balance training—can improve brain health and reduce Alzheimer's disease risk in older African Americans. Researchers will enroll 280 sedentary adults aged 60+ to …

This study is testing whether a daily probiotic/prebiotic supplement can help slow bone loss in women aged 60 and older. Researchers will compare the supplement against a placebo in 220 women over 18 months to see if it improves bone density and strength. The study focuses on die…

This study is testing whether a smartphone app can help older adults who have mild memory problems remember to take their blood pressure medication. Researchers will enroll 100 adults aged 60 and over. Participants will use an app that provides reminders and educational informati…

This study is testing whether the weight-loss medication tirzepatide might slow down the body's aging process. It will involve 90 adults aged 55-70 who are eligible for weight-loss treatment. Participants will either receive a weekly injection of tirzepatide or no drug for 24 wee…

This study investigates whether fasting, exercise, or both can slow biological aging in healthy adults over 65. 240 participants will be randomly assigned to different groups for one year. Researchers will measure aging markers in blood, fitness, and body composition to see which…

This pilot study is testing a 3-month personalized program to see if it can improve physical, mental, and immune health in older adults. The program combines lifestyle changes like exercise and diet with specific medications and supplements. Researchers will enroll about 20 seden…

This study is testing whether a simple, at-home arm cuff exercise can protect the tiny blood vessels of frail older adults from damage caused by physical stress. Researchers want to see if repeatedly inflating a blood pressure cuff on the arm for two weeks makes these vessels mor…

This study is testing whether a special computer-based 'brain training' program can help improve memory and thinking skills in older adults who have persistent cognitive problems after a viral infection like COVID-19. Researchers will compare the brain training program to other c…

This early-stage study aims to find safe and effective doses of two drugs, rapamycin and everolimus, for healthy adults aged 65-90. Researchers want to see if these drugs can safely reduce a specific cellular activity linked to aging to levels seen in young, healthy people. The s…

This study is testing whether a daily supplement made from fruit and vegetable compounds (polyphenols) can make exercise more effective for improving strength and physical function in adults over 60. For 12 weeks, 40 participants will follow a supervised exercise program while ta…

This study is testing if a daily soluble corn fiber supplement can help older men absorb calcium better and improve bone health. Researchers believe the fiber works by changing the community of bacteria in the gut. They will enroll 30 male Veterans over 60 to compare the fiber su…

This study is testing whether taking oral capsules containing healthy donor stool (fecal microbiota transplantation) can help control aging-related decline in older adults. Researchers will enroll 210 people aged 70-85 to receive either the treatment or a placebo, then track chan…

This study is looking at whether an 8-week aerobic exercise program can help lower high blood pressure in middle-aged adults who binge drink. Researchers will compare blood pressure, small blood vessel function, and nerve activity in binge drinkers, moderate drinkers, and non-dri…

This study is testing whether specific leg exercises can improve blood circulation and walking ability in older adults who have poor leg circulation or chronic wounds. Researchers will compare three different exercise programs over 12 weeks to see which works best. The goal is to…

This study is testing if adding a special home-visit care team to standard Medicare wellness visits improves care for older adults with multiple health problems. The goal is to see if this combined approach leads to better patient and caregiver experiences and fewer hospital stay…

This study is testing if a short, daily breathing exercise can lower high blood pressure and improve blood vessel health as effectively as standard aerobic exercise in postmenopausal women. Researchers will compare a 5-minute breathing regimen against a 150-minute weekly walking …

This study is testing whether a drug called sirolimus can slow down aging-related decline in healthy older adults. Researchers will give the drug to a small group of participants aged 65-80 and measure changes in their physical abilities and cellular aging markers over one year. …

This study is testing whether a special breathing training program can improve blood flow to the brain and thinking skills in older adults with type 2 diabetes. Researchers will compare 80 participants, half with diabetes and half without, to see if repeated, brief sessions of lo…

This study is testing whether a daily food supplement containing ketones can help improve muscle strength, mobility, and immune function in adults aged 65 and older who are starting to experience physical decline. About 180 participants will be randomly assigned to take either th…

This small pilot study is exploring whether a combination of counseling to reduce alcohol use and taking a probiotic supplement can improve thinking skills and brain metabolism in older adults who are heavy drinkers. Researchers will measure changes in memory, attention, and how …

This study is testing whether a supplement called MitoQ can help frail older adults who have trouble walking or thinking. Researchers want to see if MitoQ improves blood vessel function, which could lead to better walking speed and memory. The trial will enroll 60 participants ag…

This study is exploring if a 12-week program can help older adults who are starting to feel weaker and less sharp. Forty participants, aged 50-80, will take a special nutritional supplement drink and do supervised exercise. Researchers will check if this combination improves musc…

This study is testing three different approaches to help older adults living with HIV become more physically active. Researchers will compare physical activity coaching, therapy to address common barriers like pain or low motivation, and a social support program using Fitbit devi…

This study is testing if a medication called empagliflozin, usually used for diabetes, can make stiff arteries more flexible in healthy older adults. It will involve 80 men and women aged 60-80 who already have some artery stiffening but do not have diabetes. Participants will ta…

This study is testing whether a daily natural supplement can improve the health of blood vessels and reduce markers in the blood linked to aging and future heart disease. Healthy adults will take the supplement for six weeks while researchers measure changes in specific blood mar…

This study is testing whether a ketone supplement drink can protect older adults from the negative health effects of eating too much salt. Researchers want to see if the supplement can prevent high salt from raising blood pressure, harming blood vessels, or causing kidney stress.…

This study is testing whether a guided meditation app on a smartphone or tablet can help slow down memory and thinking problems in adults over 60. Researchers want to find the right amount of meditation needed to see benefits and understand which people it helps most. The goal is…

This study is testing whether a daily natural supplement, when combined with a twice-weekly exercise program, can help improve the immune system, reduce bodily stress, and enhance overall health in adults aged 65 and older. Researchers will compare the supplement to a placebo (a …

This early-stage study aims to find safe weekly doses of two existing drugs, sirolimus and everolimus, that might slow down the fundamental biology of aging. It will enroll 72 healthy adults aged 55-89 who will take one of the drugs once a week for 6 weeks. The main goal is to id…

This study is testing a new computer tool that uses artificial intelligence to help primary care doctors safely reduce or stop high-risk medications for patients aged 65 and older. The tool learns what advice works best for each doctor and provides personalized suggestions in the…

This study is testing a new program called Cafe Move designed to help older adults prevent physical frailty as they age. The program provides personalized feedback about physical function compared to peers and encourages preventive health behaviors. Researchers will enroll 36 ind…

This study is testing whether a special form of Tai Chi exercise, designed to challenge both the mind and body at the same time, can help prevent falls in older adults who have mild memory problems. Researchers will compare this special Tai Chi to standard Tai Chi and a simple st…

This study tests if involving family members in a proven hospital care program is better at preventing delirium (sudden, severe confusion) in older patients. It will compare the standard Hospital Elder Life Program (HELP) with a new version that trains and includes family caregiv…

This study aims to find practical ways to protect older adults from heart strain during dangerous heat waves. Researchers will test simple cooling methods like fans, water spray, or both on 100 healthy seniors aged 65+. Participants will experience simulated heat wave conditions …

This study is testing whether two dietary supplements, Urolithin A and Fisetin, can improve sleep quality and affect biological markers of aging in middle-aged and older adults. Researchers will compare four groups taking either a placebo, one supplement, the other supplement, or…

This study is testing whether a program that combines physical exercise with brain training games can improve memory, thinking speed, and overall brain function in people living with chronic heart failure. Researchers will enroll 216 men and women to compare the combined program …

This study is testing a new technology-assisted block-building training program for older adults. It aims to see if this fun, game-like activity can help improve memory, thinking skills, hand strength, and dexterity. Researchers will enroll 40 adults aged 65 and older who live in…

This study is testing whether a daily liquid dietary supplement can improve memory, focus, and mood in healthy adults aged 55 and older. Participants will take the supplement or a control drink for 45 days and complete memory and mood tests at the start and end. The goal is to se…

This study is testing a special vibration system to see if it can help older adults and people recovering from a stroke. Researchers want to find out if the vibrations can improve muscle strength, balance, walking ability, and reduce pain. The study will involve 80 participants w…

This study is testing a home exercise program delivered over video calls to see if it can help older adults improve their balance, reduce their risk of falling, and sharpen their thinking and sleep. The program involves doing physical and mental tasks at the same time. Researcher…

This study is testing whether a daily natural supplement, when combined with a supervised exercise program, can help improve common challenges during perimenopause. Researchers want to see if it can ease symptoms like mood swings, poor sleep, and brain fog, while also improving p…

This study is testing if adding a specific type of electrical muscle stimulation to standard physical therapy helps people recover better after knee replacement surgery. It will involve over 3,000 patients across two major healthcare systems. The goal is to see if this stimulatio…

This study is testing two already-approved wrinkle-filler products, INNEA and INNEA AQUA, to confirm how well and how safely they work. It will enroll 55 women, aged 35 to 65, who want to reduce wrinkles on their cheeks or upper chest. Participants will receive three injections o…

This study is testing if a small, wearable device that delivers a gentle, undetectable electrical stimulation can help improve balance and make walking easier for older adults who have trouble with stability. Researchers want to see if using the device can increase walking speed …

This study is testing whether a personalized meditation app can help improve sleep and reduce stress in older adults with mild memory problems. Researchers will enroll 90 participants to use the app and measure changes in sleep quality, stress levels, and attention. The goal is t…

This study is testing whether nicotine gum can help reverse age-related difficulties in processing sounds, like understanding speech in noisy places. Researchers will give 48 non-smoking adults, both young and older, nicotine gum or a placebo during separate sessions to measure i…

This study is testing whether a wearable device called Walkasins can help older adults with foot numbness walk more safely. The device provides sensory feedback to the legs, aiming to make walking more automatic and less mentally taxing. Researchers will measure walking performan…

This study is testing whether sitting in a special bathtub that uses low-frequency ultrasound waves can help older adults age more healthily. Twenty participants aged 70 and older will either sit in the ultrasound bath or a regular bath three times a week for eight weeks. Researc…

This study is testing whether two different forms of NMN supplements can help healthy adults aged 60-80 exercise longer and feel less tired. Participants will take either a special NMN blend called EGA® or regular NMN for a period, then switch. Researchers will measure how long p…

This study is testing if adding simple mental tasks to a water aerobics program can boost memory and thinking skills in older women more than water exercise alone. Researchers will compare three groups: one doing water aerobics with brain games, one doing regular water aerobics, …

This study is testing whether a special video game program can help improve balance, hand-eye coordination, and self-confidence in healthy adults aged 60 and older. Researchers will compare a group that plays the games twice a week for six weeks to a group that does not. The goal…

This study is testing whether using a brain-training app on a tablet for 8 weeks can help improve memory and focus in older adults, including those experiencing mild memory problems. Researchers will compare two different training apps to see if they help. Participants will do al…

This study aims to understand how aging and the transition through menopause affect how women's blood vessels respond to low oxygen levels. Researchers will measure blood flow in the arms of 75 healthy women who are premenopausal, perimenopausal, or postmenopausal. The goal is to…

This study aims to understand how the brain ages by looking for early signs of future memory changes. Researchers will use MRI brain scans and eye-tracking tests on 100 healthy volunteers over 60 years old to see if certain measurements can predict who stays sharp and who might d…

This study aims to understand how age-related hearing loss affects a person's ability to separate speech from background noise. Researchers will test different hearing aid technologies on older adults with hearing loss to see which settings work best for understanding speech in n…

This study aims to understand if and how the seasons—specifically summer and winter—affect a person's biological age. Researchers will observe 60 healthy adults over 40 for one year, tracking changes in 'biological age clocks' measured from blood samples. The goal is to gather kn…

This study aims to understand how aging affects muscles in people with Multiple Sclerosis (MS) and how their bodies respond to exercise. Researchers will compare 10 older adults with MS to older adults without MS, measuring muscle health before and after a 4-month exercise progra…

This study aims to understand how stress affects the way older adults plan routes and use memory during navigation. Researchers will use brain scans and virtual reality tasks to compare two groups of healthy adults aged 65-80: one exposed to a mild stress test and one not. The go…

This study is testing a new toolkit designed to help primary care doctors and nurses have better conversations with people living with dementia about their future care wishes. It will compare the toolkit to usual care across 20 clinics to see if it leads to more and higher-qualit…

This study aims to learn more about how blood stem cells work in older adults, especially those with common age-related genetic changes. Researchers will collect bone marrow and blood samples from 24 people aged 65+ who are having hip replacement surgery. They will compare the ac…

This study aims to understand why older adults often have weaker immune responses to pneumonia vaccines compared to younger people. Researchers will examine how a specific type of white blood cell (neutrophils) functions differently with age and how this affects vaccine protectio…

This study aims to understand why some people age healthier than others by measuring how the body processes nutrients like proteins, fats, and sugars over time. Researchers will enroll 100 older adults to track changes in metabolism, physical function, and mental sharpness. The g…

This small pilot study is testing whether a new health monitoring system is practical and easy for older adults to use. The system tracks vital signs and medication use, first in the hospital and then at home. Researchers want to see if patients and doctors find it helpful and if…

This study aims to understand if former competitive athletes, especially those with past knee injuries, face worse health and physical function in middle age. Researchers will compare 450 current athletes, former athletes, and non-athletes by measuring their strength, activity le…

This study aims to understand how older women's bodies handle extreme heat and humidity, which is important as climate change increases heat waves. Researchers will test 12 older female participants in controlled hot environments to find the exact point where their bodies can no …

This study aims to understand how a temporary, experimental pain affects the way healthy older adults learn and remember new walking patterns. Researchers will use a special split-belt treadmill and a safe, short-term pain stimulus. The goal is to gather basic knowledge about how…

This study aims to understand how muscle fatigue affects balance and walking, and whether these effects differ between older and younger adults. Researchers will recruit 140 healthy participants, split into a younger group (20-40 years) and an older group (60-85 years). Participa…

This study aims to understand why some older adults benefit more from strength training than others. Researchers will measure how 300 sedentary adults aged 65+ respond to a supervised weightlifting program. The goal is to identify biological factors that explain differences in im…

This study aims to learn more about how blood flow and the body's nervous system change in women as they get older. Researchers will measure blood flow in the arms of 64 women aged 18 to 70. The goal is to gather basic knowledge about these early changes, not to test a treatment.

This study aims to understand the challenges of aging for people 50 and older who are living with HIV. Researchers will screen 100 participants for signs of frailty and offer a personalized activity and nutrition plan to some. The main goal is to learn more about aging with HIV t…

This long-running study aims to understand the normal aging process by following healthy adults over their entire lives. Participants, who must be at least 20 years old and in good health, undergo comprehensive multi-day check-ups every few years. The goal is to gather detailed i…

This research aims to understand how our sense of touch works by studying nerve signals in healthy people and some amputees. The goal is to use this knowledge to create prosthetic limbs that can provide realistic sensory feedback, like feeling texture or temperature. Researchers …

This study aims to learn if regularly drinking cold water can improve body composition and potentially extend healthy lifespan in older adults. Researchers will compare a group drinking cold water to a group drinking room-temperature water over six months. They will measure body …

This study uses a new type of brain scan to look for a protein called tau in older adults. Researchers want to see how much tau is in the brain and if it relates to changes in memory, thinking, and brain activity. The goal is to better understand how tau might contribute to futur…

This study aims to understand how mild dehydration and then drinking water again affects the body's inflammation, sleep quality, and muscle strength in healthy adults aged 45-65. Participants will go through cycles of controlled hydration, dehydration, and rehydration over severa…

This study is testing whether learning online skills to boost positive emotions can improve well-being and affect markers of biological aging. Researchers will enroll 80 adults aged 40-70 to use a self-guided program focused on gratitude and mindfulness. They will measure changes…

This study aims to understand the complex links between age-related muscle loss (sarcopenia), conditions like diabetes and heart disease, and the overall aging process. Researchers will follow 10,000 adults over time, collecting health data to see how these factors interact and a…

This study aims to understand how a protein called amyloid builds up in the brain as people age and whether this buildup is linked to memory loss or other thinking problems. Researchers will follow 400 adults aged 55 and older who are already part of a long-term aging study, perf…

This study aims to build a detailed research database to help scientists develop better ways to detect, prevent, and treat Alzheimer's disease. It will enroll 1,000 adults aged 60 and older, including those with and without memory problems. Participants will be followed annually …

This study is exploring whether applying common over-the-counter moisturizers can reduce body-wide inflammation in older adults with dry skin. Researchers will enroll 32 participants aged 70+ to apply either Vaseline or CeraVe cream daily for four weeks, comparing it to a period …

This study aims to understand how normal aging connects changes in the brain and kidneys with changes in memory and thinking skills. Researchers will use detailed MRI scans and cognitive tests on healthy adults. The goal is to gather knowledge about the aging process, not to test…

This study aims to understand if a single dose of psilocybin, the compound found in 'magic mushrooms,' can cause lasting changes in the brain structure and function of healthy older adults. Researchers will use brain scans and memory tests to measure changes in 40 participants ag…

This study aims to understand how different types of dietary fat affect brain function and memory in healthy older adults. Researchers will provide all meals for 60 participants aged 65-75 for four weeks, testing two different one-week diets: one high in saturated fat (like a typ…

This study aims to understand if two common heart medications (propranolol and metoprolol) cause older adults to overheat more quickly during extreme heat. Researchers will expose 22 healthy adults aged 65+ to 3 hours of simulated heat while monitoring their body temperature. The…

This small pilot study is exploring whether combining electrical muscle stimulation with light exercise can help older adults activate their muscles more effectively, as this ability often declines with age. Researchers will test if this approach improves measures of strength, ba…

This study aims to understand how obesity and aging affect the body's metabolism, which could lead to better health in later life. Researchers will observe 650 young and older adults, some with and some without obesity, to find biological signs of aging in the blood. The goal is …

This study aims to identify specific temperature and humidity combinations where older adults can no longer cool themselves effectively during exercise, putting them at risk for heat illness. Researchers will have participants exercise in controlled environmental chambers to find…

This study aims to understand why older adults' muscles don't respond well to exercise. Researchers will examine whether inflamed body fat releases substances that interfere with muscle repair and growth after exercise. The study involves 120 younger and older adults who will und…

This study aims to understand how older adults process two drugs (sirolimus and everolimus) that might slow down aging. Researchers will measure drug levels in the blood and check for changes in biological signs of aging over three months in 60 participants aged 65 and older. The…

This study aims to understand why people's physical and mental abilities decline as they age. Researchers will observe 770 healthy adults, collecting detailed health data through questionnaires, physical tests, blood draws, and activity trackers worn for a week. The goal is to le…

This study aims to see if a simple blood test can measure your body's aerobic fitness level as accurately as a complex treadmill test. Researchers will enroll 250 healthy adults, measure their fitness with a standard test, and take a blood sample on the same day. The goal is to c…

This study aims to understand why older adults lose important immune cells (T cells) in their noses and how this makes them more vulnerable to lung infections like pneumonia. Researchers will compare nasal and blood samples from 170 people across three groups: young adults, healt…

This early-stage study aims to understand if a hormone called angiotensin-(1-7) can improve heart and blood vessel health in healthy older adults. Researchers will give 26 participants aged 65-80 an intravenous infusion of the hormone or a placebo saline solution and measure effe…

This study aims to understand how regular reformer Pilates exercises affect women's flexibility, muscle strength, and posture as they age. Researchers will measure 38 women aged 18-65 who already practice Pilates, using physical tests and 3D body scans. The goal is to gather deta…

This study aims to understand if passive heat exposure, like sitting in a warm room, can improve the function of tiny blood vessels in older adults. Researchers will test this in 20 healthy participants aged 18-80 to see if heat can mimic some benefits of exercise for blood vesse…

This study aims to understand how blood flow in fat tissue differs between younger and older healthy adults. Researchers will compare 24 participants aged 18-35 with those aged 65-80, measuring blood flow before and after drinking a sugary drink and taking small fat tissue sample…

This study aims to understand how the brain responds to a non-invasive stimulation technique (TMS) to potentially improve treatments for arm and hand movement problems after a stroke. Researchers are testing if timing the stimulation to match a person's natural brainwave patterns…