AGING

This study investigates whether age-related vision problems are caused by disrupted brain wave patterns. Researchers will use personalized, non-invasive brain stimulation on 240 older adults to try to restore these patterns and improve visual abilities like contrast sensitivity a…

This study aims to see if two common dietary supplements, creatine and HMB, can boost the benefits of exercise for frail, older adults living in nursing homes. Eighty participants will follow a supervised exercise program for 12 weeks while taking either the supplements, a placeb…

This study aims to see if taking a dietary supplement called MitoQ for three months can improve the health and function of blood vessels that supply the brain in healthy women over 60. Researchers will compare the supplement to a placebo (a dummy pill) in 86 participants to see i…

This study is testing a new electronic health check-up tool for adults 65 and older to help doctors spot and track frailty during regular visits. It also includes a sub-study where some participants get a personalized exercise program designed by an expert to see if it can improv…

This study is testing a new computer-based exercise game designed to help prevent dementia in older adults with mild memory problems. Researchers want to see if combining physical movement with mental challenges in a fun, video-game format can improve balance, thinking skills, an…

This study is testing a program where nurses visit older adults in their homes to help them better manage chronic pain and feelings of depression. Over eight weekly visits, nurses will work one-on-one with participants to set personal goals, teach pain and mood management skills,…

This study is testing a non-invasive, drug-free brain stimulation technique to improve memory in healthy older adults. Researchers will use a personalized cap that delivers gentle electrical currents to the brain, aiming to strengthen the brain networks that support memory. The g…

This study is testing a new program called SickleFit, which combines personalized exercise with nutrition counseling for adults aged 35 and older who have sickle cell disease. The main goal is to see if the program is safe, practical, and acceptable to participants. Researchers w…

This study is testing if interactive video game exercises can improve balance, leg strength, and mobility in older adults, potentially reducing the risk of falls. It will compare 40 participants doing either video game exercises or standard balance training for 8 weeks. Researche…

This study is testing an already-approved hyaluronic acid gel called STYLAGE HydroMax to see how well it reduces wrinkles on the cheeks and around the eyes. It will involve 81 healthy adults who want to improve the appearance of facial wrinkles. Participants will be randomly assi…

This study is testing two different phone-based programs to help older adults with HIV who have trouble sleeping. One program focuses on improving sleep habits, while the other teaches mindfulness techniques. Researchers want to see if either program can improve sleep quality and…

This small pilot study is testing whether a free smartphone app is easy and practical for older adults and their caregivers to use. The app offers activities like drawing, Tai-Chi, and prayer reading, which may help with emotional stability, gentle movement, and social connection…

This study is testing whether voice therapy for age-related voice problems works just as well when delivered through video calls (telehealth) as it does in person. Researchers will enroll 30 adults aged 55 and older and randomly assign them to receive four therapy sessions either…

This study is testing a program called VIVE-AT, which uses simple assistive devices and group sessions to help older Latino adults manage physical disabilities. The goal is to see if this culturally tailored approach improves their ability to perform daily tasks and their overall…

This study is testing whether adding whole-body vibration therapy to usual care helps improve muscle mass, strength, and physical function in older adults who are starting to become frail. It will compare two groups: one receiving vibration therapy plus usual care, and one receiv…

This study aims to understand how different types of exercise affect the brain's ability to learn and adapt in older adults and people who have had a stroke. Researchers will compare high-intensity cycling, low-intensity cycling, and a health education group to see how exercise i…

This study aims to see if popular weight loss medications (semaglutide or tirzepatide), when combined with lifestyle coaching, can slow down a person's biological aging. Researchers will follow 440 adults in Singapore who are overweight or obese for six months in a real-world wei…

This study aims to understand if the body's response to phosphate—a mineral common in many foods—changes as people age and differs between men and women. Researchers will give a phosphate drink to 40 healthy volunteers from two age groups (young adults and older adults) and measu…

This study aims to see if a gentle, non-invasive stimulation of the vagus nerve can help improve memory formation in healthy older adults. Researchers will compare the effects in older adults (65-80) to younger adults (18-30) and investigate whether the results are connected to t…

This study aims to discover what allows some people to live past 95 in good health. Researchers will compare 500 very long-lived individuals with 2,000 younger seniors in Hong Kong. By analyzing blood samples and health information, they hope to identify the genetic and lifestyle…

This study aims to understand how the brain's memory system changes with healthy aging. Researchers will compare brain scans of 360 healthy young adults (18-30) and older adults (65-80) while they perform memory tasks. The goal is to see if older adults use different brain strate…

This study aims to see if a 12-week aerobic exercise program can help improve the immune system in older adults living in care facilities. It will involve 40 participants who will either do the exercise program or continue their usual routine. Researchers will measure immune cell…

This study aims to build a detailed health database for adults aged 40 and older in Taiwan. Researchers will collect various health data, including brain scans, sleep patterns, blood tests, and gut bacteria samples, from about 250 participants. The goal is to better understand ho…

This study aims to understand if two safe dietary supplements—a specific probiotic or blueberry extract—can affect markers of immune system aging in people with HIV who drink alcohol. It is a research study, not a treatment trial. Participants will try each supplement for four we…

This long-term study aims to understand why some people develop memory and thinking problems as they age while others do not. Researchers will follow 2,800 adults aged 55 and older, including those with healthy brains and those with early signs of cognitive decline. They will col…

This study aims to understand why older adults often require lower doses of anesthesia during major abdominal surgery compared to younger patients. Researchers will compare 60 younger and older patients, measuring brain activity, anesthesia levels, and blood markers of inflammati…