AGING

This study looks at whether a 12-week Tai Chi program can improve balance in older adults living in the community. 90 participants aged 55 and older with some balance issues will be randomly assigned to either Tai Chi classes or health education. The main goal is to see if Tai Ch…

This study tests whether adding a beetroot juice supplement (rich in nitrates) to a 12-week exercise program helps adults aged 60+ gain more fitness and muscle strength. 226 participants will be randomly assigned to receive either the active supplement or a placebo. The goal is t…

This study tests whether TA-65, a dietary supplement that activates telomerase, can improve small blood vessel function in healthy older adults and people with coronary artery disease. Researchers will measure blood vessel responses and blood pressure in 180 participants. The goa…

This early-stage trial tests an mRNA drug called aKL003 that instructs cells to produce alpha klotho, a protein linked to longevity. About 21 healthy adults aged 50-90 will receive two injections four weeks apart. The main goal is to check safety and whether the protein levels ri…

This study tests whether two safe dietary supplements—a probiotic and blueberry extract—can reduce signs of accelerated aging in people with HIV who drink alcohol. Researchers will measure changes in immune cells and biological age markers. The trial involves 160 participants age…

This study tests whether age-related vision problems are caused by disrupted brain signals and if a noninvasive brain stimulation technique can fix them. Researchers will use brain scans and personalized electrical stimulation in 240 older adults to try to improve contrast sensit…

This study tests a new cognitive-motor training program for older adults with mild cognitive impairment (MCI), an early stage of dementia. The program combines brain games with balance exercises using computer vision. Researchers want to see if it improves thinking, walking, phys…

This study tests whether motivational text messages can increase physical activity in adults aged 40 and older who are not very active. Participants will wear activity trackers and receive up to 4 texts per day for 3 months, some timed based on their personal habits. The goal is …

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare different combinations of activ…

This study tests whether a short, telephone-delivered insomnia treatment (BBTI) can improve sleep and cognitive function in 214 older adults with HIV, compared to a mindfulness approach (BMT). Participants will complete four weekly phone sessions and attend in-person visits for s…

This pilot study tests whether an 8-week program that mixes exercise with non-immersive virtual reality can improve balance, thinking, and daily activities in adults over 65. Sixty participants will be split into three groups: exercise plus VR, VR alone, or usual care. The goal i…

This study tests a program called VIVE-AT that teaches older Latinos with physical disabilities how to use assistive technology devices, like tools for dressing, cooking, and mobility. Researchers will enroll 76 participants from a low-income clinic in Puerto Rico, randomly assig…

This study tests a non-invasive brain stimulation technique called tACS to improve memory in healthy adults aged 65 and older. Researchers will use a personalized, brain-guided system to strengthen memory networks. The goal is to develop a drug-free way to ease age-related memory…

This study tests whether a smartphone app called utmbHealthyBrain is easy for older adults and their caregivers to use. The app includes drawing, Tai-Chi, meditation, and a sharing feature to help with emotions, movement, and social connection. Forty pairs of adults aged 50+ and …

This study tests whether taking MitoQ, a dietary supplement, for 3 months can improve blood flow in the brain's arteries in healthy women aged 60 and older who have gone through menopause. Participants will take either MitoQ or a placebo daily and have their brain artery function…

This study tests whether interactive video game exercises (exergames) can improve foot muscle activation, balance, and mobility in healthy older adults aged 65-80. Forty participants will be split into two groups: one doing exergame training and the other doing standard balance e…

This study compares voice therapy delivered in-person versus via telehealth for adults aged 55 and older with age-related voice problems. Thirty participants will receive four sessions of PhoRTE® voice exercises either face-to-face or through video calls. Researchers will measure…

This study tests STYLAGE® HydroMax, a gel made of hyaluronic acid, to see how well it reduces superficial wrinkles on the cheeks. About 81 adults aged 35 to 70 with mild to moderate wrinkles will receive three injection sessions over 24 weeks. The main goal is to measure wrinkle …

This study will follow 440 adults aged 40-89 who are starting a weight management program that includes drugs like semaglutide or tirzepatide along with lifestyle coaching. Researchers will measure changes in biological age using a blood-based aging clock over 6 months. The goal …

This early study tests whether a drug called gemtesa (used for overactive bladder) can improve blood vessel function in women aged 18 to 70. Researchers want to see if targeting beta3 receptors in blood vessels can help them relax and improve blood flow. The trial involves 60 hea…

This study will test a device that delivers gentle waist pulls during treadmill walking to improve balance in people who have had a stroke and in older adults with mild balance issues. Fifty participants will undergo nine training sessions over three weeks. The goal is to see if …

This study looks at how personal habits, beliefs, social surroundings, and environment work together to affect health and independence in people aged 55 and older. Participants fill out questionnaires and do simple tests to measure things like daily living skills, physical activi…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study will test an Italian version of a questionnaire called the dynamic Neurocognitive Adaptation (dNA) scale in 265 older adults, including those with normal aging, mild memory complaints, or dementia. The goal is to see if higher scores on the scale—reflecting more engage…

This study looks at how aging changes tiny parts of our cells called mitochondria, which produce energy. Researchers will take small skin samples and blood from 90 healthy adults aged 18-90 to measure inflammation and cell aging markers. The goal is to better understand why we ag…

This study will test a digital platform called MEVA that measures cognitive wellness in healthy adults aged 55 to 75. Participants will complete activities and questionnaires to see how reliable and easy the platform is. The goal is to understand if the tool works well for older …

This study tests different exercise programs to see which one helps older adults stay physically active over the long term. Six hundred people aged 60 and older will be assigned to one of four groups, each with a different approach to exercise. The goal is to find strategies that…

This study tests whether a co-designed exercise program helps seniors stay physically active. 60 participants aged 60+ will choose their own activities from a menu and attend two sessions per week for 12 weeks. Researchers will measure adherence during the program and physical ac…

This study will test a three-session education program for adults aged 65 and older at primary care centers. The program aims to improve their confidence, healthy habits, and ability to understand health information. One group will receive the program, and the other will get usua…

This study tests whether an interactive digital animation program can help older adults in nursing homes learn about health risks like falls, nutrition, and medication safety. Sixty-six participants will be split into two groups: one receives the animation training, the other get…

This study looks at whether wearing an aging simulation suit can improve nursing students' attitudes and compassion toward older adults. About 102 third-year nursing students will be randomly assigned to use the suit or not. The goal is to see if this hands-on experience helps th…

This study looks at how short bursts of aerobic exercise affect brain function in older adults and stroke survivors. Researchers will compare three groups: one doing moderate cycling to raise lactate levels, one doing light cycling, and one receiving health education only. Partic…

This study will check if routinely measuring walking speed in older veterans (age 60+) can act like a vital sign to spot health problems early. Over 10,000 veterans will take part across VA clinics. Some clinics will use the walking speed results to guide care, while others will …

This study looks at fat that builds up inside muscles as people age, which may cause inflammation and damage. Researchers will have 16 older adults (ages 65-80) do a 12-week calf exercise program. Before and after, they will measure muscle strength, take CT scans, and analyze sma…

This study looks at how neck strength affects balance in adults aged 65 and older. Researchers will compare standard balance training with balance training plus neck strengthening exercises. The goal is to understand if stronger neck muscles can improve balance and reduce fall ri…

This study looks at whether a 12-week aerobic exercise program can improve immune function in adults aged 60 and older living in care homes. Forty participants will be split into an exercise group or a control group, with follow-ups after a break and a second exercise period. The…

This study will collect health data from 250 Taiwanese adults aged 40 and older to understand how aging affects the brain, sleep, and thinking skills. Participants will undergo brain scans and wear activity monitors, and answer sleep questionnaires. The goal is to build a compreh…

This study looks at whether inflammation linked to aging affects how much anesthesia older adults need during major abdominal surgery. Researchers will compare younger (18-30) and older (60+) patients by monitoring brain activity, blood markers, and tissue samples. The goal is to…

This study will follow 2,800 adults aged 55 and older in China for many years to understand how aging affects the brain and thinking skills. Researchers will collect information on diet, lifestyle, medical history, brain scans, and gut bacteria. The goal is to learn what helps pe…

This study aims to understand why some people live to 95 and beyond by analyzing their genes, proteins, and lifestyle. Researchers will recruit 2,500 Han Chinese adults aged 95+ in Hong Kong to build a biobank and identify factors that promote healthy aging. The goal is to develo…

This study looks at whether an electronic comprehensive geriatric assessment (eCGA) can be used in primary care for adults aged 65 and older. Researchers will track frailty over 12 months and compare patient self-reports with doctor assessments. A smaller group will also try a pe…

This Stanford study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve memory formation in healthy older adults (ages 65-80) compared to younger adults (ages 18-30). The stimulation is given during learning tasks, and researchers will also l…

This study looks at how age and sex influence the body's ability to manage phosphate after a single oral dose. Forty healthy volunteers in two age groups (18-25 and 63-70) will ingest 558 mg of phosphorus, and researchers will measure phosphate levels in the blood over time. The …