AGING

This study tests whether two safe, over-the-counter supplements can slow the aging of the immune system in people with HIV who drink alcohol. About 160 adults aged 40 and older will receive each supplement in a random order. Researchers will measure changes in aging-related immun…

This early-stage study tests whether an experimental mRNA treatment called aKL003 is safe and tolerable in healthy adults aged 50 to 90. Participants receive two injections of either the active drug or a placebo (saline). The goal is to see if the treatment can safely increase le…

This study tests whether TA-65, a dietary supplement that activates telomerase, can improve small blood vessel function in healthy older adults and people with coronary artery disease. Researchers will measure blood vessel responses in the skin and track blood pressure. The trial…

This study looks at whether adding a nitrate-rich supplement to a standard exercise program can help older adults (60+) gain more fitness and muscle benefits. About 226 healthy but inactive seniors will do 12 weeks of combined endurance and resistance training, with some taking t…

This study tests whether taking MitoQ, a dietary supplement that targets cell powerhouses (mitochondria), for 3 months can improve blood flow to the brain in healthy women aged 60 and older who have gone through menopause. Researchers will compare MitoQ to a placebo to see if it …

This study tests a new program that combines thinking exercises with physical movements to help older adults with mild memory problems. The goal is to improve balance, activity levels, and quality of life, and possibly slow or prevent progression to dementia. 46 people aged 55-90…

This study tests if a brief, phone-delivered insomnia treatment (BBTI) can improve sleep and thinking in older adults with HIV compared to a mindfulness approach. 214 participants aged 50+ with insomnia will complete 4 weeks of therapy and be followed for a year. The goal is to s…

This study tests a program called SPARK for adults aged 50 and older who have ongoing pain, depressive symptoms, and trouble moving around. Participants will receive 8 nurse visits at home to learn ways to cope with pain and improve mood. The goal is to see if this approach reduc…

This study will test whether interactive video-game exercises can improve foot muscle function, balance, and mobility in older adults. Forty healthy seniors aged 65-80 will be randomly assigned to either the exergame program or standard balance exercises for 8 weeks. Researchers …

This pilot study will test whether a program that combines physical exercises with non-immersive virtual reality can improve balance, thinking, and daily activities in adults aged 65 and older. About 60 participants will be split into three groups: one doing combined exercise and…

This study tests a program called VIVE-AT that uses assistive technology to help older Latinos with physical disabilities improve their daily function and quality of life. About 76 participants aged 65 and older from a low-income clinic in Puerto Rico will either receive the prog…

This study tests whether a smartphone app called utmbHealthyBrain is easy for older adults and their caregivers to use. The app includes drawing, Tai-Chi, meditation, and a sharing feature to connect with family. Over six weeks, 40 participants will try the app at home. The goal …

This study tests a noninvasive, drug-free method to improve memory in healthy adults aged 65 and older. Researchers will use a personalized, brain-guided electrical stimulation technique called tACS to strengthen memory-related brain networks. The goal is to see if this approach …

This study tests a gel called STYLAGE HydroMax to see how well it reduces cheek wrinkles. About 81 adults aged 35 to 70 with mild to moderate wrinkles will receive the gel or a control. The main goal is to measure wrinkle improvement after 6 weeks.

This study tests whether voice therapy exercises (PhoRTE®) work as well through video calls as they do in person for adults aged 55 and older with age-related voice problems. Thirty participants will receive four therapy sessions either face-to-face or via telehealth. Researchers…

This study tests if combining a gentle electrical brain stimulation (tDCS) with computer-based memory games can improve thinking and memory in adults over 60 with recurrent depression. Participants will be assigned to one of three groups to compare active stimulation plus targete…

This study looks at whether a 12-week Tai Chi program can improve balance in older adults living in the community. Researchers will compare a Tai Chi group to a health education group and measure balance, physical function, and well-being. They also want to see if a person's 'cir…

This study looks at whether fat that builds up inside muscles as people age causes damage and inflammation. Researchers will have 16 older adults (ages 65-80) do a 12-week calf exercise program. They will measure muscle strength, take CT scans, and analyze small muscle samples to…

This study will check if common weight loss medications (semaglutide or tirzepatide), combined with diet and exercise coaching, can slow or reverse biological aging in adults aged 40 to 89 who are overweight or obese. Researchers will use a special blood test called the LinAge2 c…

This study looks at how well the body handles phosphate from food as people age and whether men and women respond differently. Researchers will give a phosphate drink to 40 healthy adults (young and older) and measure blood levels. The goal is to understand normal changes in kidn…

This study aims to validate an Italian version of the dynamic Neurocognitive Adaptation (dNA) Scale, a questionnaire that measures how much older adults engage in physical, mental, creative, and social activities. Researchers will recruit 265 people aged 65 and older, including t…

This study tests whether a digital training program using animated stories can help older adults in nursing homes learn about common health risks (like falls and medication safety) and become less frail. Sixty-six participants will be split into two groups: one receives the anima…

This early-stage study tests whether age-related vision problems are caused by changes in brain wave patterns. Researchers will use noninvasive brain stimulation to try to restore these patterns and improve how older adults see contrast and 3D motion. The study involves 240 healt…

This study looks at how healthy young adults (ages 18-30) and older adults (ages 65-80) make memory decisions. Participants will do memory tasks inside an MRI scanner so researchers can measure brain activity. The goal is to understand if older adults rely more on combining past …

This study looks at how neck strength affects balance in older adults at risk of falling. Researchers will compare standard balance training to balance training plus neck strengthening exercises in 110 people aged 65 and older. The goal is to help physical therapists design bette…

This study will test a 3-session education program for adults aged 65 and older at primary care centers. The program aims to boost confidence, encourage healthy habits, and improve understanding of health information. About 100 participants will be split into two groups: one gets…

This study looks at whether having nursing students wear an aging simulation suit can improve their attitudes and compassion toward older adults. About 102 third-year nursing students will take part. The goal is to see if this hands-on experience helps them better understand the …

This study will enroll 2500 Chinese adults aged 95 and older in Hong Kong to understand why they live so long. Researchers will collect blood samples and health information to look for genetic, protein, and lifestyle factors linked to healthy aging. The goal is to find ways to he…

This observational study looks at whether age-related inflammation changes how much anesthesia older adults need during major abdominal surgery. Researchers will compare older patients (over 60) with younger adults (18-30) by monitoring brain activity, blood markers, and tissue s…

This study tests whether a non-invasive device that stimulates the vagus nerve can improve memory in healthy older adults aged 65-80. Researchers will compare memory performance with and without stimulation, and also look at how gut health and early Alzheimer's markers affect res…

This study looks at whether a detailed health check-up (called eCGA) can help doctors better understand and manage frailty in adults aged 65 and older. About 120 participants will be followed for 12 months, and some will also get a personalized exercise program. The goal is to se…

This study aims to create a comprehensive health database for middle-aged and elderly people in Taiwan. Researchers will measure brain volume, sleep patterns, and sleep quality in 250 adults aged 40 and older. The goal is to better understand how sleep and brain changes relate to…

This study will follow 2,800 adults aged 55 and older in Hangzhou, China, for many years. Researchers will collect information on diet, lifestyle, thinking skills, brain scans, and gut bacteria. The goal is to learn more about healthy aging and cognitive decline, not to test a tr…

This study looks at how short bursts of aerobic exercise might help the brain learn and adapt better in older adults and stroke survivors. About 48 participants will do cycling at different intensities, then complete memory and movement tasks while their brain activity is measure…

This study looks at whether routinely measuring walking speed in older veterans (age 60+) can act like a vital sign to spot early declines in physical function. The goal is to help doctors make timely referrals to prevent falls, hospital visits, and other health problems. Over 10…

This study looks at whether a 12-week aerobic exercise program can help reverse age-related immune decline in adults aged 60 and older living in care homes. Forty participants will either exercise or continue their usual routine, with blood tests and fitness measures taken at sev…