MRNA injection aims to turn back the clock on aging
NCT ID NCT07544420
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial tests an mRNA drug called aKL003 that instructs cells to produce alpha klotho, a protein linked to longevity. About 21 healthy adults aged 50-90 will receive two injections four weeks apart. The main goal is to check safety and whether the protein levels rise in the blood.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
alpha klotho mRNA (aKLmRNA, AKL003) in lipid nanoparticles
What this could lead to
If successful, this could point toward a treatment that slows or reverses aspects of aging by increasing alpha klotho protein levels.
What could go wrong
This is a very early Phase 1b safety trial with only 21 healthy volunteers. It is not designed to prove any anti-aging effect, and the treatment may fail to raise protein levels or cause side effects.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for AGING are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
GARM
Roatán, Bay Islands, 34101, Honduras
Contact Phone: •••-•••-•••• Email: •••••@•••••