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Why some seniors get more from exercise: study seeks answers

NCT ID NCT07093216

Knowledge-focused Sponsor: University of Alabama at Birmingham Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 14, 2026 · Last updated Jul 15, 2026 · Updated 1 time

Summary

This study investigates why older adults respond so differently to the same exercise program. Researchers will track 304 adults aged 60 and older through a 6-month exercise intervention, measuring changes in overall health and function. The goal is to identify factors that predict who benefits most, paving the way for personalized exercise prescriptions.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a 6-month exercise program
What this could lead to
If successful, this could lead to personalized exercise plans that help older adults maintain health and independence longer.
What could go wrong
This is an observational-style study focused on understanding variability, not testing a new treatment. Results may not directly translate to practical guidelines.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 304 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2028

An estimate. Start dates often move.

Expected to finish

Apr 2035

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

60 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Written informed consent prior to any study procedure * 60+ years of age * \<120 min/wk of self-reported moderate physical activity as assessed by Community Health Activities Model Program for Seniors (CHAMPS) physical activity questionnaire13 * Evidence of impairment in one or more Intrinsic Capacity domains (see section 3.2) * Passage of a physical exam and diagnostic, graded exercise test with 12-lead ECG reviewed by a cardiologist or otherwise credentialed clinician. Exclusion Criteria: * End-stage disease and/or a life expectancy less than one year * Resistant hypertension, defined as BP \> 140/90, despite the use of three or more anti-hypertensive drugs * Chronic kidney disease * Serum creatinine \>2.5 mg/dL in men or \>2.0 mg/dL in women * Serum potassium \>5.0 mEq/L * Urinary protein \> 1 on dipstick * Abnormal liver enzymes (AST, ALT, or alkaline phosphatase \> 2.5 times the upper limit of normal) * Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina * Acute myocardial infarction identified by ECG * Current treatment for malignancy * Known diagnosis of dementia * Any other disease or condition that would preclude completion of all testing and exercise training * Any other condition that would interfere with testing or increase risk of complications during exercise * Any other condition or events considered exclusionary by the PIs and/or study clinicians.

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Conditions

The condition(s) this trial relates to.

Motor Activity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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