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Can a gentle leg workout with blood flow restriction spare the nervous system?

NCT ID NCT07722403

Knowledge-focused Sponsor: Egas Moniz - Cooperativa de Ensino Superior, CRL Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 23, 2026 · Last updated Jul 24, 2026 · Updated 1 time

Summary

This trial investigates how the body's nervous system reacts to two types of leg exercise: low-intensity exercise with a cuff that partially restricts blood flow, and traditional high-intensity weight training. Researchers will measure heart rate, blood pressure, and heart rate variability in young adults (18-24) and older adults (60+) during and after each session. The goal is to see which approach is less stressful on the nervous system and whether age affects recovery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
low-intensity resistance training with blood flow restriction (LIRT-BFR) and high-intensity resistance training (HIRT)
What this could lead to
If low-intensity exercise with blood flow restriction proves gentler on the nervous system, it could offer a safer alternative to heavy weight training for older adults or those with limited mobility.
What could go wrong
This is a small, early-stage study with only 48 participants, so results may not apply broadly. The blood flow restriction technique may cause discomfort or rare complications like bruising or blood clots.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Young adults aged 18-24 years * Older adults aged 60 years and above * Willing and able to provide written informed consent * Able to comply with study procedures and visit schedule Exclusion Criteria: * Medications affecting cardiac activity (e.g., beta-blockers, calcium channel blockers, antiarrhythmics) * Tobacco use * Sleep apnea * Body mass index (BMI) greater than 30 kg/m² * Regular exercise training (more than 150 minutes per week for more than 6 months) * History of coronary heart disease * History of stroke * History of oncological disease * History of major cardiovascular events * Peripheral vascular disease * Uncontrolled hypertension * Diabetes mellitus * Unstable angina * Active kidney or liver disease * Chronic obstructive pulmonary disease (COPD) * Recent surgical procedure (within the last two months) * Neurological impairments affecting exercise capacity * Orthopedic impairments affecting exercise capacity * Sensory impairments affecting exercise capacity

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Aging Blood flow restriction exercise

How to take part

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  1. The places running it

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  2. The official record

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    Open the record ↗

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Contacts and locations

Locations

  • Egas Moniz School of Health and Science

    Almada, Monte Da Caparica, 2829-511, Portugal

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