Neck bypass surgery could flush out Alzheimer's brain toxins
NCT ID NCT06965062
First seen Jan 17, 2026 · Last updated Jun 23, 2026 · Updated 25 times
Summary
This early study tests a surgical procedure that connects lymph nodes in the neck to veins, aiming to improve drainage of toxic proteins from the brain in people with mild-to-moderate Alzheimer's disease. Ten participants will undergo the surgery and be followed for two years with cognitive tests, brain scans, and safety checks. The goal is to see if the procedure is safe and might slow or improve memory and thinking problems.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Changi General Hospital
RECRUITINGSingapore, Singapore
Contact Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Deep cervical lymph node to venous bypass surgery
What this could lead to
If this works, it could point toward a new way to slow or even reverse memory loss in Alzheimer's by helping the brain clear out harmful proteins.
What could go wrong
This is a very early, small proof-of-concept study with only 10 people. Surgery on the neck carries risks like infection, nerve injury, or complications from anesthesia. It may not help everyone or work at all.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.