Neck bypass surgery aimed at flushing out Alzheimer's toxins begins human testing
NCT ID NCT06965062
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early study tests a surgical procedure that reroutes lymphatic vessels in the neck to help the brain drain waste proteins linked to Alzheimer's. Ten people with mild-to-moderate Alzheimer's will undergo the operation and be followed for two years. The main goals are to check safety and see if there are any signs of cognitive improvement.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Deep cervical lymph node to venous bypass surgery (a procedure to reroute lymphatic drainage from the neck to a vein)
- What this could lead to
- If it works, this could point toward a new surgical approach to slow or improve cognitive decline in Alzheimer's by helping the brain clear toxic proteins.
- What could go wrong
- This is a very small, early proof-of-concept study with only 10 participants. Surgery carries risks like infection, nerve injury, or anaesthetic complications. The approach is highly experimental and may not show meaningful benefit.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Changi General Hospital
RECRUITINGSingapore, Singapore
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