New Alzheimer's drug injected into spine shows promise in early safety trial

NCT ID NCT06297590

Recruiting now Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage study tests a new drug called LY3954068 in 48 people with mild Alzheimer's symptoms. The drug is given directly into the spinal fluid, either once or twice, to see if it is safe and how it affects Alzheimer's markers. The study lasts up to 100 weeks and includes a placebo group.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease brain disorder central nervous system disorder cognitive disorder Cognitive Dysfunction dementia nervous system disorder neurodegenerative disease Pick disease psychiatric disorder tauopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

Locations

CenExel AMRI
RECRUITING

Toms River, New Jersey, 08755, United States
CenExel iResearch, LLC (CenExel iRA)
RECRUITING

Decatur, Georgia, 30030, United States
Charter Research, LLC
RECRUITING

The Villages, Florida, 32162, United States
Duke University
RECRUITING

Durham, North Carolina, 27710, United States
K2 Medical Research, LLC
RECRUITING

Maitland, Florida, 32751, United States
Massachusetts General Hospital (MGH)
NOT_YET_RECRUITING

Charlestown, Massachusetts, 02129, United States
National Hospital for Neurology and Neurosurgery (UCLH)
RECRUITING

London, WC1N 3BG, United Kingdom
Royal Hallamshire Hospital
NOT_YET_RECRUITING

Sheffield, S10 2JF, United Kingdom
The University of Tokyo Hospital
RECRUITING

Bunkyō City, 113-8655, Japan
University Hospital Southampton
NOT_YET_RECRUITING

Southampton, SO16 6YD, United Kingdom

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