ALZHEIMER DISEASE

This study tested a non-invasive medical device that uses low-level light and magnetic fields, delivered through a helmet and abdominal panel, to see if it could help people with mild-to-moderate Alzheimer's disease. The goal was to see if this light therapy could slow the declin…

This study tested a twice-daily oral medication called varoglutamstat (PQ912) for people with early Alzheimer's disease. The goal was to see if the drug could safely slow the decline in memory and thinking skills. The trial was designed in two parts, starting with about 180 parti…

This study aimed to check the long-term safety and effects of an experimental drug called XPro1595 in people with Alzheimer's disease. It was an extension for 11 people who had already taken the drug in an earlier trial. Participants received a weekly injection for up to 18 month…

This early-stage study aimed to check the safety and how the body processes a new drug called ION269 in adults with Down syndrome who have brain amyloid, a protein linked to Alzheimer's disease. Only one person was enrolled before the study was stopped. The main goal was to see i…

This study tested whether a drug called simufilam could slow memory and thinking decline in people with mild-to-moderate Alzheimer's disease. About 1,125 participants took either the drug or a placebo pill twice daily for 76 weeks. The trial was terminated early, and researchers …

This study tested an oral medication called REM0046127 in people with mild to moderate Alzheimer's disease. It aimed to see if the drug could affect certain brain fluid markers and brain wave patterns, and to check its safety. The trial was terminated early and only enrolled 14 o…

This study aimed to see if anti-inflammatory drugs could help slow cognitive decline in people with early Alzheimer's disease or mild memory problems due to Alzheimer's. It tested one drug in a small group of participants who also showed signs of body-wide inflammation. The trial…

This study tested a special brain scan (EEG) to see if it could help doctors more accurately diagnose Alzheimer's disease and mild cognitive impairment. Researchers compared the brain scan results to standard memory and thinking tests in 148 participants, including healthy adults…

This study tested a new device called the Dysphagia Detection System (DDS), which is a small sensor worn on the neck. Researchers wanted to see if it could accurately detect unsafe or inefficient swallowing in people with conditions like stroke, Parkinson's, and dementia, compare…

This small pilot study tested whether improving sleep patterns could help people with mild memory problems or early Alzheimer's disease. Researchers developed a program combining bright light therapy and behavioral techniques to regulate daytime and nighttime sleep. They aimed to…

This study aimed to check the long-term safety of AXS-05 for treating agitation in people with Alzheimer's disease. It included 139 participants who had completed previous trials of the same medication. The trial was terminated, meaning it ended early before reaching its planned …

This study tested whether using magnetic pulses to stimulate specific brain areas could improve memory in older adults with very early signs of Alzheimer's disease. Researchers used brain scans to see how the stimulation changed brain network connections and gave memory tests to …