ALZHEIMER DISEASE

This study is testing if a drug called brivaracetam, normally used for epilepsy, can help people with early Alzheimer's disease or mild memory problems. Researchers suspect some memory loss might be linked to hidden seizure-like activity in the brain. Participants will have brain…

This study aims to see if a nutritional supplement called tricaprilin can help slow down memory and thinking problems in people with mild to moderate Alzheimer's disease. About 535 participants will take either the supplement or a placebo (dummy pill) twice daily for 26 weeks. Re…

This extension study allows 9 people with mild to moderate Alzheimer's disease who previously received a single stem cell injection to receive up to six additional injections every two months. The main goal is to check if repeated doses are safe when delivered directly into the b…

This early-stage study aims to see if a pill called NPC-1 (containing parthenolide and ipriflavone) is safe and can change certain markers of Alzheimer's disease in the blood over six months. It will involve 40 adults aged 55+ who have early memory concerns or mild Alzheimer's an…

This early-stage study aims to find out if stem cells from a donor's fat tissue are safe to give to people with mild to moderate Alzheimer's disease. Nine participants will receive the cells through an IV, starting with a low dose to check for side effects. The main goal is to se…

This study is testing if a pill called oral semaglutide, currently used for diabetes, is safe and might help slow Alzheimer's disease. It will involve 60 people with mild Alzheimer's to see if the drug protects the brain's communication points. The main goal is to check safety, w…

This study is testing whether tadalafil (commonly known as Cialis) can help slow down Alzheimer's disease in its early stages. Researchers will give 244 people with mild memory problems or early Alzheimer's either tadalafil or a placebo pill daily for one year to see if it's safe…

This study is testing whether deep brain stimulation can improve memory and thinking skills in people with early Alzheimer's disease. Researchers will implant small electrodes in the brain to deliver mild electrical pulses to areas involved in memory. The study will measure chang…

This study is testing whether the drug donanemab can reduce the buildup of a harmful protein called amyloid in the brains of adults with Down syndrome. About 60 participants, aged 35-50, will receive monthly infusions of either donanemab or a placebo for one year, followed by an …

This study is testing whether repeated injections of a patient's own fat-derived stem cells directly into the brain can slow the progression of mild to moderate Alzheimer's disease. About 115 participants will receive either the stem cell treatment or a placebo injection every tw…

This small pilot study will test whether fisetin, a natural compound found in fruits and vegetables, is safe and well-tolerated in older adults with mild Alzheimer's disease or mild cognitive impairment. The research aims to gather initial safety data before larger studies. It wi…

This clinical trial aims to test whether new drugs that target tau protein in the brain can slow Alzheimer's disease progression, either alone or combined with existing amyloid-targeting treatments. It will enroll 750 adults aged 50-80 who have early signs of Alzheimer's but mini…

This early study is exploring whether daily near-infrared light therapy can help control symptoms of mild to moderate Alzheimer's disease. It will involve 40 patients who will receive light therapy at home for 96 weeks while researchers track changes in memory and thinking skills…

This study is testing whether a gentle, non-invasive electrical brain stimulation can help people with early-stage Alzheimer's disease or memory problems caused by Alzheimer's. The treatment involves wearing a cap that delivers a mild electrical current to the scalp. Researchers …

This early study is testing whether a robotic surgical system can safely perform delicate neck surgery on people with Alzheimer's disease. The goal is to improve the brain's natural drainage system to help clear harmful proteins linked to memory loss. The study will enroll 15 peo…

This study is testing a vaccine called AADvac1, designed to target a harmful protein called tau in the brain. It aims to see if the vaccine, given alone or with another Alzheimer's drug, can reduce tau buildup and slow disease progression in adults aged 50-80 with very early sign…

This large Phase 3 trial will test if adding an experimental oral drug called masitinib to standard Alzheimer's medications can safely slow down the progression of the disease. The study will involve 600 people with mild Alzheimer's who are already taking stable doses of their cu…

This study aims to determine if a simple blood test can help doctors diagnose Alzheimer's disease at an early stage during routine primary care visits. Researchers will enroll 1,000 adults aged 55 and older who have concerns about their memory or thinking abilities. The study wil…

This study is testing a new artificial intelligence (AI) tool designed to improve brain scans used to diagnose Alzheimer's disease. The goal is to see if the AI can maintain scan quality even when using a lower radiation dose or a shorter scan time. This could make the diagnostic…

This study aims to develop a better method for spotting early signs of Alzheimer's disease in community-dwelling adults. Researchers will test a new digital screening strategy that analyzes changes in a person's walking patterns, facial expressions, and speech, combined with bloo…

This early-stage study aims to test the safety of an experimental vaccine called AV-1980R in older adults who show early biological signs of Alzheimer's disease but don't yet have memory problems. The study will enroll 48 participants aged 65-80 who will receive either the vaccin…

This study aims to prevent serious complications after major heart and vascular surgery in adults 65 and older. Researchers will test whether personalized pre-surgery training (including physical exercise, brain games, and social support) and special monitoring during surgery can…

This early-stage study will test the safety of an experimental Alzheimer's vaccine called DUVAX in 24 healthy adults aged 40-65. Participants will receive either the vaccine or a placebo injection to see how well it's tolerated and whether it triggers an immune response against A…

This study is testing whether a non-contact sleep monitor can help improve sleep for people with Alzheimer's living in long-term care. For 100 participants, the monitor will track sleep for four weeks. Researchers want to see if sharing this sleep data with care staff leads to be…

This study is testing whether a special exercise program that combines physical movement with mental tasks can help improve thinking skills and daily function in people with mild Alzheimer's disease. Sixty participants will be randomly assigned to either this combined training or…

This study aims to see if art therapy helps people with mild to moderate Alzheimer's disease. Researchers will test whether creative activities like painting and clay modeling can improve memory, thinking skills, and hand coordination. The study will involve 50 participants who w…

This study is testing a culturally adapted online program called Tele-Savvy for Latino caregivers of people with Alzheimer's or dementia. The program aims to help caregivers build skills and confidence through weekly group video sessions and instructional videos. Researchers want…

This study is testing whether giving home health aides extra training in dementia care helps reduce difficult behaviors in older adults with memory problems and improves their quality of life, as well as the well-being of their family caregivers. It will involve 60 pairs of patie…

This study aims to see if wearable technology can help manage sleep and daily rhythm problems in people with Alzheimer's disease. Researchers will first check if patients can comfortably use activity-tracking wristbands. Then, they will test if a special wearable light therapy de…

This study aims to see if a gentle, non-invasive stimulation of the vagus nerve can help improve memory formation in healthy older adults. Researchers will compare the effects in older adults (65-80) to younger adults (18-30) and investigate whether the results are connected to t…

This study follows older adults over time to understand how they make decisions about staying in their homes or moving to care facilities as they age, particularly if they develop Alzheimer's disease or memory loss. Researchers will track how factors like health changes, family s…

This study aims to find new ways to spot the earliest signs of Alzheimer's disease long before memory problems begin. Researchers will test 100 healthy older adults, using special brain scans and detailed eye-tracking tests to look for subtle changes linked to Alzheimer's risk. T…

This study aims to understand how learning your Alzheimer's disease biomarker test results affects your emotional well-being, daily behaviors, and future health decisions. Researchers will follow 240 adults aged 50+ who are at risk for Alzheimer's and have completed brain scans. …

This study aims to see if taking an oral probiotic supplement is safe and practical for people who have early Alzheimer's disease or are at risk for it. Researchers will enroll 40 participants, some with mild memory problems and some without, to take the supplement for up to a ye…