ALZHEIMER DISEASE

This early-stage study tests a new vaccine called DUVAX in 24 healthy adults aged 40-65. The vaccine aims to train the immune system to attack two proteins linked to Alzheimer's disease. The main goal is to check safety and see if the vaccine produces a protective immune response…

This study tests whether a daily dose of tricaprilin, a type of fat that may provide energy to brain cells, can improve memory, thinking, and daily function in people with mild-to-moderate Alzheimer's disease. About 535 participants will receive either tricaprilin or a placebo fo…

This study tests a drug called TML-6 in 210 people with early Alzheimer's disease. Over 52 weeks, researchers will compare those taking TML-6 to those on a placebo to see if the drug can slow or stop memory and thinking problems. The goal is to find a treatment that helps people …

This study tests whether donanemab, given as an IV infusion every 4 weeks, can safely lower amyloid plaques in the brains of 60 adults aged 35–50 with Down syndrome. Participants receive either donanemab or a placebo for 12 months, followed by a 12-month extension where everyone …

This study tests a vaccine called AADvac1, which targets tau tangles in the brain, a hallmark of Alzheimer's. It will be given alone or with another drug (donanemab) to 450 adults aged 50-80 with very early Alzheimer's. The goal is to see if this approach can reduce tau buildup a…

This study tests whether drugs that target tau protein, alone or with donanemab, can reduce tau buildup and slow memory decline in people aged 50-80 with early Alzheimer's. Participants will receive treatment for 30 months and undergo brain scans and cognitive tests. The goal is …

This study tests whether a drug called DAOIB, which boosts brain signaling, combined with omega-3 fatty acids can improve thinking and daily life in people with early Alzheimer's or mild cognitive impairment. 140 participants will receive either the combo or a placebo for 24 week…

This early-stage trial tests whether repeated injections of a patient's own fat-derived stem cells into the brain are safe for people with mild to moderate Alzheimer's. Nine participants who previously received a single dose will now get up to six injections every two months. Res…

This Phase 3 trial tests whether masitinib, a drug that targets immune cells in the brain, can slow cognitive decline in 600 people with mild Alzheimer's. Participants take masitinib or a placebo alongside standard Alzheimer's medications. The study lasts 24 weeks and measures ch…

This Phase 2 trial tests whether repeated injections of a patient's own fat-derived stem cells into the brain can slow the progression of mild to moderate Alzheimer's disease. 115 participants will receive either the stem cells or a placebo every two months for a total of six dos…

This study tests whether oral semaglutide, a drug used for diabetes, is safe and can slow Alzheimer's disease. Sixty people with mild Alzheimer's will take the drug for one year. Researchers will check for side effects and use brain scans to see if the drug protects brain cells.

This study tests whether tadalafil, a drug typically used for erectile dysfunction, is safe and can help people with early Alzheimer's or mild cognitive impairment. Over one year, 244 participants will take either tadalafil or a placebo. Researchers will check for side effects an…

This study tests a wearable insole and ankle device that measures walking patterns to detect early cognitive decline in older adults. Researchers will collect gait data from 150 participants—some healthy, some with mild cognitive impairment or dementia—first in a lab and then dur…

This early-phase trial will test a new radioactive tracer called 18F-FCOB04 in 40 people with neurodegenerative diseases like Alzheimer's or Parkinson's. The tracer targets a brain protein called MAO-B and is used with PET scans to see if it can help diagnose these conditions. Th…

This study tests a special PET probe that targets a protein called DDR2, which is linked to lung scarring in interstitial lung disease. Researchers will scan 50 patients to see if the probe can accurately detect the disease and also check for related cognitive problems. The goal …

This study will check if a blood test can find signs of Alzheimer's disease in people with early memory concerns. Researchers will test 1,000 adults aged 55 and older in primary care. The goal is to see if blood markers for amyloid and tau proteins match those found in spinal flu…

This study will test if combining digital technology (analyzing how people walk, their facial expressions, and speech) with blood markers can better screen for early Alzheimer's disease in community adults aged 50 and older. The goal is to create a more efficient screening method…

This study looks at whether simple eye-tracking tests and brain scans can detect very early signs of Alzheimer's disease in 100 healthy older adults. Half of the participants carry a genetic risk factor (APOE4). The goal is to find biomarkers that could lead to earlier diagnosis,…

This study tests a special device that monitors sleep without any physical contact, designed for people with Alzheimer's or related dementias living in long-term care facilities. About 100 residents will use the device for four weeks. Researchers want to see if sharing sleep data…

This study will test whether silkworm pupa powder, taken daily for 12 weeks, can improve memory, daily living skills, and frailty in 100 people with mild-to-moderate Alzheimer's disease. Participants will take the powder twice a day and visit the clinic every 4 weeks for tests in…

This Phase 2 trial will test whether taking a daily probiotic supplement for six months is safe and practical for people with early Alzheimer's or those at risk. Researchers will enroll 40 participants aged 60 and older. The study does not test whether the probiotic improves memo…

This study tests whether a nasal spray containing two medicines, dexmedetomidine and esketamine, can improve sleep quality and thinking abilities in older adults with mild-to-moderate Alzheimer's-related cognitive impairment and sleep problems. Sixty participants will receive eit…

This study tests whether a virtual cognitive behavioral therapy for insomnia (CBT-I) program, called REPAIR Sleep, can improve sleep and emotional well-being in people with dementia and their live-in caregivers. Over 5 weekly video sessions, participants learn techniques like set…

This study tests whether giving home health aides extra training on dementia care can reduce troubling behaviors in older adults with dementia or mild cognitive impairment and improve quality of life for both patients and their care partners. About 120 patient-care partner pairs …

This study tests a program called FPCI-AL that helps staff in assisted living communities interact more positively with residents who have dementia. Researchers will work with staff for several months to improve care interactions. The goal is to reduce residents' behavioral sympt…

This early-phase study tests whether brivaracetam, a seizure medication, can calm overactive brain areas and improve thinking in 25 adults aged 45–70 with mild Alzheimer's or mild cognitive impairment. Participants will have brain activity monitored via scalp and depth electrodes…

This study tests whether a gentle electrical current applied to the scalp (called tACS) can improve memory and thinking in people with mild Alzheimer's disease. Researchers will compare real stimulation to a sham (fake) version in 160 participants. The goal is to see if this safe…

This early-phase study will test whether shining near-infrared light on the head each day can help people with mild to moderate Alzheimer's disease. Forty participants will receive 30-minute light sessions six times a week for 96 weeks. Researchers will measure changes in thinkin…

This study tests whether doing physical exercises (like walking and balancing) at the same time as mental tasks (like math or memory games) can improve thinking skills in people with mild Alzheimer's disease. Sixty older adults will be randomly assigned to either this dual-task t…

This study tests whether art therapy—like painting, clay modeling, and collage—can improve thinking and hand skills in people with mild to moderate Alzheimer's disease. Fifty adults aged 60 and older will be split into two groups: one does art therapy twice a week for 8 weeks, th…

The AHEAD study is testing whether artificial intelligence can help detect early signs of Alzheimer's disease in people who feel their memory is slipping but still test normal. Researchers will use brain scans, eye tests, and blood markers to identify those at highest risk. High-…

This study will create a computer tool to predict which older adults are at high risk for serious problems after heart or blood vessel surgery. It will also test if special programs before and during surgery can help prevent confusion, heart issues, and death. About 1,200 people …

This study will adapt and test an online communication training program called CHATO for nursing home staff who care for people with dementia. The goal is to improve how staff interact with residents, which may reduce behavioral symptoms like agitation or rejection of care. Resea…

This study follows 285 older adults with Alzheimer's or mild cognitive impairment to learn how they make decisions about aging in place or moving to long-term care. Researchers will track planning and preferences over time. No treatment or intervention is being tested.

This study will check if levels of Alzheimer's-related substances in the blood differ among the main ethnic groups living in central Barcelona. Researchers will also look at how age, income, education, and health conditions affect these levels. The goal is to identify barriers to…

This study will follow 2,800 adults aged 55 and older in China for many years to understand how aging affects the brain and thinking skills. Researchers will collect information on diet, lifestyle, medical history, brain scans, and gut bacteria. The goal is to learn what helps pe…

This Stanford study tests whether a non-invasive device that gently stimulates a nerve in the ear can improve memory formation in healthy older adults (ages 65-80) compared to younger adults (ages 18-30). The stimulation is given during learning tasks, and researchers will also l…