ALZHEIMER DISEASE

This early-stage study aimed to test the safety of a potential Alzheimer's treatment using a patient's own stem cells. The plan was to give 24 participants with early Alzheimer's four infusions of these cells. Researchers wanted to see if the treatment was safe and if it could re…

This early-stage study is testing a new, personalized cell therapy designed to train the body's immune system to fight Alzheimer's disease. Doctors take a patient's own immune cells, load them with a modified Alzheimer's-related protein, and inject them back to potentially trigge…

This study is testing a new oral medication called ONO-2020 to see if it is safe and can help improve memory and thinking in people with mild to moderate Alzheimer's disease. About 240 participants will take either the drug or a placebo (a dummy pill) daily for 26 weeks. The main…

This study aims to improve care for people living with dementia and their caregivers after an emergency room visit. It tests different coaching programs to help connect families with community support and services. The goal is to improve care quality, satisfaction, and reduce fut…

This study is testing whether a daily treatment using special light and sound stimulation can slow the progression of Alzheimer's disease. About 670 people with mild to moderate Alzheimer's will use either the active stimulation device or a look-alike sham device at home for a ye…

This small study is testing whether a non-invasive brain stimulation technique called theta burst stimulation can help improve thinking skills in people with early Alzheimer's disease. Researchers will compare the real stimulation treatment to a sham (fake) procedure in 6 partici…

This study is testing whether shining a special near-infrared light on the head can help people with mild to moderate Alzheimer's disease. It will compare the light treatment to a fake treatment in 38 participants over 16 weeks, measuring changes in memory, thinking, and daily fu…

This is the first study in people for a new drug called ADEL-Y01, which is designed to target a harmful protein in the brain linked to Alzheimer's disease. The study will first test single and multiple doses in healthy volunteers to check for safety, and then test multiple doses …

This study is testing an investigational drug called sabirnetug to see if it can slow down the worsening of memory and daily function in people with early Alzheimer's disease. About 542 participants will receive either the drug or a placebo as a monthly intravenous infusion. The …

This study aims to identify which Alzheimer's patients are most likely to benefit from the approved medication memantine. Researchers will test whether a simple brain function measurement after a single dose can predict who will show the best cognitive improvement over six months…

This study is testing whether following a Mediterranean diet or a modified ketogenic diet can improve gut health and potentially slow cognitive decline in older adults, some of whom have mild memory problems. Researchers are working with 61 participants from rural communities to …

This study is testing whether an experimental drug called mevidalen is safe and can help control symptoms in people with mild to moderate Alzheimer's disease. About 300 participants will take the drug or a placebo for 26 weeks to see if it improves their memory, thinking, and abi…

This study is testing whether a non-invasive light therapy, aimed at the forehead, can help improve memory and thinking in older adults with early Alzheimer's disease or mild memory problems. About 196 participants will receive either the real light treatment or a sham (fake) tre…

This study is testing whether an investigational drug called JNJ-63733657 can slow the progression of early Alzheimer's disease. The drug is an antibody designed to target and clear tau protein, one of the key abnormal proteins that builds up in the Alzheimer's brain. About 523 p…

This study is testing whether a daily fasting schedule can help improve brain function and overall health in older adults who are overweight and noticing memory problems. For 24 weeks, participants will either follow a time-restricted eating plan (fasting for about 16 hours each …

This clinical trial is testing whether a daily pill called Xanamem can help control symptoms in people with mild to moderate Alzheimer's disease dementia. The study involves 247 participants who will take either the medication or a placebo for 36 weeks, followed by an optional ex…

This large, late-stage study is testing whether a new oral medication called AR1001 can slow the progression of early Alzheimer's disease. Over 1,500 participants with mild memory problems will take either the drug or a placebo for one year. Researchers will measure changes in me…

This small, early-stage study is testing whether two drugs (Dasatinib and Quercetin) can be safely given to people with Alzheimer's disease or mild cognitive impairment. The drugs aim to clear out 'senescent' or aging cells that may contribute to brain decline. Researchers will m…

This study is testing a new, lower-cost eye scanner to see if it can take pictures of the back of the eye (retina) as well as a standard commercial machine. Researchers want to see if this device can detect changes in the retina that might be linked to Alzheimer's disease. They a…

This study aims to find ways to diagnose Chronic Traumatic Encephalopathy (CTE), a brain disease linked to repeated head impacts, in living people. It will enroll 350 participants, including former college and professional football players, healthy controls, and people with Alzhe…

This study is testing whether the drug memantine can help prevent Alzheimer's disease in people who are at high risk but don't yet have symptoms. It involves 32 adults aged 50-65 who have a family history of Alzheimer's and carry a specific genetic risk factor. The main goal is t…

This large, late-stage study is testing whether the drug donanemab can prevent or significantly delay the onset of Alzheimer's disease in people who are at risk but do not yet show clear symptoms. It involves nearly 3,000 participants who have early biological signs of Alzheimer'…

This study aims to find the ideal weekly schedule of dance or music appreciation classes to help support memory and heart/lung fitness in older adults who are worried about their memory but do not yet have a diagnosis. Researchers will enroll 165 adults aged 62+ and assign them t…

This study is testing a personalized website called 'Small Steps' that helps older adults make lifestyle changes to reduce their risk of developing dementia. Participants aged 65 and over use the website to plan small, manageable changes to sit less, move more, and improve their …

This small, early-stage study is testing whether a liquid CBD solution placed under the tongue can help reduce anxiety and agitation in older adults with mild memory problems or early Alzheimer's disease. The 12 participants will take the solution for eight weeks while researcher…

This study is testing whether a special training program for caregivers makes a visual mapping technology more helpful for people with Alzheimer's or other dementias. The technology uses picture-based schedules to help with daily tasks and independence. Researchers want to see if…

This Yale University study is exploring whether attending live music concerts can help reduce anxiety and improve emotional connection for people in the early stages of Alzheimer's disease and their caregivers. Researchers will measure brain activity, heart rate, and survey respo…

This study explores whether doing rhythmic music activities together can improve social attention and feelings of connection for people with mild to moderate frontotemporal dementia or Alzheimer's disease and their caregivers. Researchers will compare groups doing synchronized mu…

This study is creating a large database to understand how different medical care and lifestyle approaches affect Alzheimer's disease risk and progression. It will follow over 450 adults who are either at risk for or already have memory problems, collecting health data over time. …

This study uses specialized brain scans (PET scans) to see if anti-amyloid Alzheimer's drugs also reduce tau protein tangles in the brain. Researchers will follow 135 patients with mild Alzheimer's symptoms who are already receiving these therapies at Mayo Clinic. The goal is to …

This study aims to understand how brain inflammation relates to Alzheimer's disease and Lewy body dementia using specialized PET scans. Researchers will scan 125 adults aged 60 and older to measure inflammation and see how it connects to memory problems and other disease markers.…

This study aims to create a registry to understand how the recently approved Alzheimer's drug lecanemab affects patients and their caregivers in everyday life. Researchers will enroll 20 Alzheimer's patients receiving lecanemab infusions and their caregivers to collect data on th…

This study aims to understand why people with chronic kidney disease (CKD) often develop memory loss and thinking problems. Researchers are following 600 people, with and without CKD, for up to five years, tracking their cognitive function and taking brain scans. The goal is to i…

This study is looking at whether simple blood tests can help doctors diagnose brain diseases like Alzheimer's, dementia, depression, and schizophrenia more quickly and accurately. Researchers will analyze blood samples from about 1,800 people who already have these conditions, al…

This study aims to compare and standardize two different types of brain scans used to measure tau protein tangles, a key marker of Alzheimer's disease. It involves 822 participants with varying levels of cognitive function, from no impairment to Alzheimer's dementia. Participants…

This study aims to understand how older adults make decisions about future care, especially if they develop memory problems like Alzheimer's. Researchers gave 293 participants access to a web-based planning tool and followed them for over three years to see what factors influence…

This study is creating a global registry to track how Alzheimer's treatments work in real-world settings. It will follow 2,000 patients with Alzheimer's or related conditions during their regular doctor visits. The goal is to understand the long-term safety and effectiveness of s…

This study aims to find biological markers, or 'fingerprints,' for Parkinson's disease using easy-to-collect samples like blood and nasal tissue. Researchers will analyze samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers, to see if spe…

This study looks at how Black and White patients with mild memory problems change their health habits, future planning, and research participation after learning about their Alzheimer's risk through brain scan results. Researchers want to understand if this information helps peop…

This study aims to better understand how Alzheimer's disease develops and progresses over time. It will follow 1,500 older adults, including those with normal memory, mild memory problems, and dementia, for up to five years. Researchers will use memory tests, brain scans, and blo…

This study aims to understand the healthcare use, costs, and quality of life over time for 1,400 people in the early stages of Alzheimer's disease in the United States. It is purely observational research and does not provide any treatment. Participants and their caregivers will …

This large observational study aims to find better ways to detect Alzheimer's and Parkinson's diseases at their earliest stages, before significant symptoms develop. Researchers will enroll up to 100,000 participants aged 45 and older, using smartphone apps and wearable devices t…

This study examines how sharing personalized 5-year Alzheimer's disease risk estimates affects healthy older adults. Researchers gave 450 participants without memory problems risk reports based on their brain scans, blood tests, and genetics. They measured how this information im…

This study uses special brain scans to look for early signs of Alzheimer's disease in older African American adults who are currently thinking clearly. Researchers want to understand the difference between normal aging and the very early stages of Alzheimer's. Participants get de…

This study is evaluating a training program for volunteers who visit and support older adults with memory loss, dementia, or Alzheimer's. The program is being tested in a real-world setting by a social service organization in Minnesota. Researchers are analyzing data to see if th…

This study aims to better understand how two proteins, amyloid and tau, build up in the brains of people with different forms of Alzheimer's disease. Researchers will use brain scans to track 60 participants with typical or unusual Alzheimer's symptoms over one year. The goal is …

This study aims to gather feedback from patients with neurological diseases like Alzheimer's and Parkinson's about their experience using the MemorEM head device. About 1,000 patients and their caregivers will share their thoughts through monthly surveys to help improve the devic…

This study aims to understand how blood tests for Alzheimer's disease work differently in men and women. Researchers will analyze blood samples from over 13,000 older adults to see if these tests predict dementia risk differently based on sex and other health factors. The goal is…

This large European study aims to understand how social and economic factors—like income, education, and social support—affect mental health and brain biology. Researchers will follow over 1,300 adults, including people with conditions like depression, schizophrenia, Alzheimer's,…

This study aims to see if measuring brain stiffness with a special, non-invasive MRI scan can serve as a new sign, or biomarker, for Alzheimer's disease. Researchers will enroll 450 people, including those with Alzheimer's, mild memory problems, and healthy individuals, to compar…

This program aims to build a large pool of volunteers to help speed up Alzheimer's disease research. It enrolls healthy adults aged 50-90 to collect a genetic sample, which is used to match them to future prevention studies. The program itself is not a treatment trial; it's a rec…

This study is testing whether a safe, painless eye scan can detect early signs of Alzheimer's disease before memory problems begin. Researchers will compare scans from people with early chemical markers of Alzheimer's to those without any markers. The goal is to understand if cha…

This study aims to understand if being frail is linked to a faster loss of daily abilities in older adults living at home with Alzheimer's disease. Researchers will follow 130 participants for up to 5 years, checking their function and frailty to see if it predicts needing more c…

This study uses special brain scans to measure and track a protein called amyloid in the brains of 800 people. It includes adults with and without memory problems who are already part of an Alzheimer's research center. The goal is to understand how amyloid buildup relates to the …