Could a Vitamin-Like pill slow Alzheimer's? new trial seeks answers
NCT ID NCT06223360
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether benfotiamine, a form of vitamin B1, can safely slow memory and thinking decline in people with early Alzheimer's. About 406 adults aged 50-89 with mild symptoms will take the drug or a placebo for up to 72 weeks. Researchers will measure changes in cognition and daily function, and monitor side effects.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AMC Research LLC, dba Flourish Research
Matthews, North Carolina, 28105, United States
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Albany Medical College
Albany, New York, 12208, United States
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Banner Sun Health Research Institute
Sun City, Arizona, 85351, United States
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Blue Medical Research Inc.
Miami, Florida, 33144, United States
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Brain Matters Research
Delray Beach, Florida, 33445, United States
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Brain Matters Research (Kane Center)
Stuart, Florida, 34997, United States
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Brainstorm Research
Miami, Florida, 33176, United States
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CCM Clinical Research Group, LLC
Miami, Florida, 33133, United States
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Case Western Reserve University
Cleveland, Ohio, 44106, United States
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Cedars Sinai, Los Angeles
Los Angeles, California, 90048, United States
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Columbia University Irving Medical Center
New York, New York, 10032, United States
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Conquest Research
Winter Park, Florida, 32789, United States
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Dent Neurologic Institute
Amherst, New York, 14226, United States
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Emory University Goizueta Alzheimer's Disease Research Center(GADRC)
Atlanta, Georgia, 30329, United States
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Froedtert and Medical College of Wisconsin
Milwaukee, Wisconsin, 53226, United States
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Geisinger Memory and Cognition Center
Wilkes-Barre, Pennsylvania, 18711, United States
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Gonzalez MD & Aswad MD Health Services
Miami, Florida, 33135, United States
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Integrative Clinical Trials
Brooklyn, New York, 11229, United States
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JEM Research Institute
Atlantis, Florida, 33462, United States
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KCA Neurology
Tennessee City, Tennessee, 37067, United States
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MedVadis Research
Waltham, Massachusetts, 02451, United States
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Miami Jewish Health
Miami, Florida, 33137, United States
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Mount Sinai School of Medicine
New York, New York, 10029, United States
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Nathan Kline Institute for Psychiatric Research
New York, New York, 10962, United States
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Neuropsychiatric Research Center of Southwest Florida
Fort Myers, Florida, 33912, United States
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Northwestern University Feinberg School of Medicine
Chicago, Illinois, 60611, United States
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Ohio State University
Columbus, Ohio, 43221, United States
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Oregon Health & Science University (OHSU)
Portland, Oregon, 97239, United States
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Pacific Research Network
Lemon Grove, California, 91945, United States
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Perseverance Research Center, LLC
Scottsdale, Arizona, 85253, United States
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Ralph H. Johnson VA Health Care System
Charleston, South Carolina, 29401, United States
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Rhode Island Hospital
Providence, Rhode Island, 02903, United States
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Rush University Medical Center
Chicago, Illinois, 60612, United States
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Rutgers, Robert Wood Johnson Medical School
New Brunswick, New Jersey, 08901, United States
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SUNY Upstate Medical University
Syracuse, New York, 13210, United States
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Sandhill Research, LLC d/b/a Accel Research Sites
Decatur, Georgia, 30030, United States
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Southern Illinois University
Springfield, Illinois, 62702, United States
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St. Joseph's Hospital and Medical Center/Barrow Neurological Institute
Phoenix, Arizona, 85013, United States
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Syrentis Clinical Research
Santa Ana, California, 92705, United States
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The Neuron Clinic
Chula Vista, California, 91910, United States
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University of California, Irvine
Irvine, California, 92697, United States
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University of Iowa
Iowa City, Iowa, 52242, United States
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University of Kentucky
Lexington, Kentucky, 40504, United States
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University of Michigan, Ann Arbor
Ann Arbor, Michigan, 48109, United States
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University of North Texas Health Science Center
Fort Worth, Texas, 76107, United States
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University of Southern California
Los Angeles, California, 90033, United States
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Weill Cornell Medical College
New York, New York, 10021, United States
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