New drug sabirnetug aims to slow Alzheimer's decline
NCT ID NCT06335173
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This Phase 2 trial tests whether sabirnetug, given as an IV infusion every four weeks, can slow cognitive and functional decline in people with early Alzheimer's disease. About 542 participants will receive either sabirnetug or a placebo. The main outcome is change in a combined score of memory and daily living skills over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- sabirnetug (given as an intravenous infusion every 4 weeks)
- What this could lead to
- If successful, sabirnetug could become a new treatment option to slow memory loss and functional decline in early Alzheimer's disease.
- What could go wrong
- This is a Phase 2 trial, so it is still early. The drug may not show enough benefit over placebo, and there could be side effects from the infusions.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AMC Research
Matthews, North Carolina, 28105, United States
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Abington Neurological Associates
Abington, Pennsylvania, 19001, United States
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ActivMed Practices and Research
Portsmouth, New Hampshire, 03801, United States
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Alzheimer's Research and Treatment Center - Stuart
Stuart, Florida, 34997, United States
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Alzheimers Research and Treatment Center - Wellington
Wellington, Florida, 33414, United States
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Aqualane Clinical Research
Naples, Florida, 34105-8522, United States
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Boston Center for Memory
Newton, Massachusetts, 02459, United States
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Bradenton Research Center
Bradenton, Florida, 34205, United States
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Brain Matters Research
Delray Beach, Florida, 33445, United States
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Cae Oroitu
Getxo, Spain
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CenExel - Advanced Memory Research Institute of NJ
Toms River, New Jersey, 08755, United States
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CenExel - California Neuroscience Research Medical Group, Inc (CNR)
Sherman Oaks, California, 91403-2131, United States
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CenExel - iResearch Atlanta
Decatur, Georgia, 30030, United States
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Charité - Universitaetsmedizin Berlin
Berlin, Germany
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Charter Research - Lady Lake
The Villages, Florida, 32162, United States
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Charter Research - Winter Park
Winter Park, Florida, 32792, United States
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Cleveland Clinic
Cleveland, Ohio, 44195, United States
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Columbus Memory Center
Columbus, Georgia, 31909, United States
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Conquest Research
Winter Park, Florida, 32789, United States
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Coral Clinical Research
Homestead, Florida, 33032, United States
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Finlay Medical Research
Miami, Florida, 33126, United States
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Fundacio ACE
Barcelona, Spain
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Fundacion Neuropolis - Hospital Viamed Montecanal
Cuarte de Huerva, Zaragoza, Spain
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Gadolin Research, LLC
Beaumont, Texas, 77702, United States
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Gil Fernandez-Yera, MD, PA
Coral Gables, Florida, 33135, United States
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Hattiesburg Clinic - Memory Center
Hattiesburg, Mississippi, 39401-7246, United States
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Healthy Brain Research
Long Beach, California, 90804, United States
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Hippocampe d/b/a Ottawa Memory Clinic
Ottawa, Ontario, Canada
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Hospital Ruber
Madrid, Spain
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Hospital Universitari General de catalunya
Sant Cugat del Vallès, Barcelona, Spain
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Hospital Universitari i Politècnic La Fe
Valencia, Spain
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Hospital Victoria Eugenia
Seville, Spain
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Irvine Medical Research
Irvine, California, 92614, United States
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JEM Research Institute
Atlantis, Florida, 33462, United States
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K2 Medical Research - Tampa
Tampa, Florida, 33607, United States
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K2 Medical Research - Villages
Lady Lake, Florida, 32159, United States
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Kerwin Medical Center
Dallas, Texas, 75231, United States
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Keystone Clinical Research
Norristown, Pennsylvania, 19462, United States
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MoCA Research and Innovations
Greenfield Park, Quebec, Canada
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Neuroclin Glasgow
Motherwell, Lanarkshire, United Kingdom
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Neurological Associates of Albany
Albany, New York, 12208, United States
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Neurology Center of North Orange County
Fullerton, California, 92835, United States
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Neurology Clinic. P.C
Cordova, Tennessee, 38018, United States
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Ocala Health - Family Care Specialists - Ocala I
Ocala, Florida, 34470, United States
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Office of Jeffrey S. Ross, MD
Northbrook, Illinois, 60640, United States
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Okanagan Clinical Trials
Kelowna, British Columbia, Canada
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Panthera Bio-Partners - Preston
Preston, Lancashire, United Kingdom
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Panthera Biopartners - Sheffield
Sheffield, Yorkshire, United Kingdom
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Policlínica Gipuzkoa
Donostia / San Sebastian, Spain
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Progressive Medical Research
Port Orange, Florida, 32127, United States
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Re:Cognition Health - Bristol
Bristol, United Kingdom
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Re:Cognition Health - Fairfax
Washington D.C., District of Columbia, 22031, United States
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Re:Cognition Health - Guildford
Guildford, Surrey, United Kingdom
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Re:Cognition Health - London
London, Greater London, United Kingdom
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Re:Cognition Health - Winchester
Winchester, Hampshire, United Kingdom
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Research Center for Clinical Studies, LLC
Norwalk, Connecticut, 06851-4903, United States
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Rhode Island Mood and Memory
East Providence, Rhode Island, 02914, United States
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Senior Adult Specialty Research
Austin, Texas, 78757, United States
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St. Pancras Clinical Research Ltd.
London, Greater London, United Kingdom
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Summit Research Network
Portland, Oregon, 97210, United States
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Syrentis Clinical Research
Santa Ana, California, 92705, United States
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Technical University of Munich, School of Medicine and Health, Klinikum rechts der Isar
Munich, Germany
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The Alliance for Multispecialty Research LLC (AMR)
Knoxville, Tennessee, 37920-1511, United States
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The Cognitive and Research Center of New Jersey
Springfield, New Jersey, 07081, United States
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The Neurology Center of Southern California - Carlsbad
Carlsbad, California, 92011-4219, United States
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Toronto Memory Program (TMP) (Neurology Research Inc.)
Toronto, Ontario, Canada
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University Hospital of Cologne
Cologne, Germany
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Zentralinstitut für seelische Gesundheit
Mannheim, Germany
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