Magnetic brain zaps tailored to each patient may boost memory in Alzheimer's
NCT ID NCT03121066
First seen Jul 21, 2026 · Last updated Jul 22, 2026 · Updated 1 time
Summary
This study investigates whether transcranial magnetic stimulation (TMS) — a non-invasive technique that uses magnetic pulses to stimulate brain areas — can improve thinking, mood, and daily function in people with Alzheimer's disease. Unlike standard TMS, this approach personalizes the stimulation targets based on each person's unique brain connectivity. The trial involves 45 participants aged 60–75 with mild Alzheimer's, who will receive either active TMS, a sham (placebo) treatment, or a conventional non-personalized TMS over two weeks. Researchers will track changes in cognition, mood, and brain activity for up to six months after treatment.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- personalized transcranial magnetic stimulation (TMS) using intermittent theta burst stimulation (iTBS)
- What this could lead to
- If successful, this approach could offer a non-drug treatment to slow cognitive decline and improve mood in Alzheimer's disease.
- What could go wrong
- This is a small, early-stage trial with only 45 participants, so results may not apply broadly. The benefits may be modest or temporary.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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