Sound waves to the brain: a new hope for Alzheimer's?

NCT ID NCT03671889

Recruiting now Disease control Sponsor: InSightec Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a device that uses focused ultrasound to temporarily open the blood-brain barrier in people with Alzheimer's disease. The goal is to see if this is safe and could help treatments reach the brain better. Fifty participants aged 50 to 85 with probable Alzheimer's will be treated and monitored for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: focused ultrasound (ExAblate Neuro device)
What this could lead to: If it works, this could help deliver Alzheimer's treatments more effectively to the brain, potentially slowing memory loss and cognitive decline.
What could go wrong: This is an early-stage safety study with only 50 participants, so it may not show clear benefit. The procedure carries risks like bleeding or swelling in the brain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE

Contacts and locations

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Locations

Advent Health
RECRUITING

Orlando, Florida, 34747, United States
Baptist Health South Florida & Florida International University
RECRUITING

Miami, Florida, 33176, United States
Broward Health Medical Center & The University of Florida
RECRUITING

Fort Lauderdale, Florida, 33316, United States

Contact Email: •••••@•••••
Delray Medical Center & Florida Atlantic University
RECRUITING

Delray Beach, Florida, 33484, United States
Tampa General Hospital
RECRUITING

Tampa, Florida, 33612, United States
The Ohio State University -Wexner Medical Center
ACTIVE_NOT_RECRUITING

Columbus, Ohio, 43210, United States
University of Florida Health Shands
RECRUITING

Gainesville, Florida, 32608, United States
University of Texas Southwestern Medical Center
ACTIVE_NOT_RECRUITING

Dallas, Texas, 75390, United States
Weill Cornell Medicine
ACTIVE_NOT_RECRUITING

New York, New York, 10065, United States
West Virginia University Rockefeller Neuroscience Center
ACTIVE_NOT_RECRUITING

Morgantown, West Virginia, 26506, United States

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