MILD COGNITIVE IMPAIRMENT

This study tested whether having a personal health coach helps people with early memory concerns or at risk for them stick to recommended lifestyle changes. For 6 months, some participants worked with a coach on goals like diet and exercise, while others received standard doctor …

This early study is testing whether temporarily opening the protective blood-brain barrier with a focused ultrasound device is safe and feasible when combined with standard Alzheimer's drug infusions. It involves 15 people with mild Alzheimer's or mild cognitive impairment. The g…

This study is testing whether a daily treatment using special light and sound stimulation can slow the progression of Alzheimer's disease. About 670 people with mild to moderate Alzheimer's will use either the active stimulation device or a look-alike sham device at home for a ye…

This early-stage study is testing whether a dietary supplement called nicotinamide riboside (a form of vitamin B3) can improve brain cell energy and reduce harmful stress in people with mild memory problems or early Alzheimer's disease. Researchers will give the supplement to 50 …

This study is testing whether three existing diabetes medications can help reverse mild memory loss in people with type 2 diabetes. It will involve about 400 adults who have both conditions. Participants will take one of the three drugs for nearly a year and a half while research…

This study is testing a non-invasive brain stimulation technique to see if it can help older adults with alcohol use disorder and mild memory problems. Researchers want to see if stimulating specific brain areas can reduce heavy drinking and improve thinking skills at the same ti…

This study is following older adults for six years to see if using hearing aids can slow down memory loss and thinking problems, and reduce the risk of developing dementia. It builds on a previous 3-year trial and involves about 629 participants aged 70-84 who have untreated hear…

This study is testing whether following a Mediterranean diet or a modified ketogenic diet can improve gut health and potentially slow cognitive decline in older adults, some of whom have mild memory problems. Researchers are working with 61 participants from rural communities to …

This study is testing whether a combination of vitamin D, folic acid, and vitamin B12 can help slow down or improve early memory problems in older adults. About 380 participants aged 50-70 with mild cognitive impairment will take either a low or high dose of the vitamins or a pla…

This study is testing whether a non-invasive light therapy, aimed at the forehead, can help improve memory and thinking in older adults with early Alzheimer's disease or mild memory problems. About 196 participants will receive either the real light treatment or a sham (fake) tre…

This pilot study is testing a 12-month lifestyle program designed to help people with mild memory problems. The program focuses on improving diet, physical activity, stress management, and brain health through group and individual activities, delivered both in-person and remotely…

This study is testing if a common sleep medication called trazodone can slow down memory loss in people who have both early-stage memory problems (mild cognitive impairment) and obstructive sleep apnea. Researchers believe treating sleep apnea might help protect the brain. Over o…

This study is testing whether nicorandil, an existing heart medication, is safe and might help slow brain shrinkage in older adults with a dementia type often mistaken for Alzheimer's. It will involve 64 participants aged 75+ who have this specific brain condition. The goal is to…

This study is testing a computer-based brain-training program designed to improve working memory in people with mild cognitive impairment, an early stage of Alzheimer's disease. Participants will complete brain-training sessions twice a week for 12 weeks while researchers measure…

This small, early-stage study is testing whether lamivudine, a drug used for HIV, can lower levels of specific proteins in the blood that are linked to brain changes in Alzheimer's disease. The study involves 23 older adults with mild cognitive impairment who show early signs of …

This small, early-stage study is testing whether two drugs (Dasatinib and Quercetin) can be safely given to people with Alzheimer's disease or mild cognitive impairment. The drugs aim to clear out 'senescent' or aging cells that may contribute to brain decline. Researchers will m…

This study aims to see if a special brain scan called DaTSCAN can help doctors better understand and diagnose conditions like dementia, Parkinson's disease, and mild memory problems. Researchers will scan 500 adults aged 40-90 who have one of these conditions and compare the scan…

This small pilot study is testing whether a simple, caregiver-led nature activity program can improve wellbeing for people living with mild cognitive impairment or dementia and their family caregivers. The program involves 8 weekly sessions of guided nature activities. Researcher…

This study is testing whether a year-long support program led by a nurse can help people with dementia and their caregivers. 200 participants from a Stanford research center are randomly assigned to receive either their usual care or usual care plus monthly phone/video sessions w…

This study is testing two different virtual group programs to help older adults who have both chronic pain and early signs of memory decline. The programs aim to improve physical function, thinking skills, and emotional well-being through guided sessions. Researchers want to see …

This study is testing a new home exercise program for older adults with mild memory loss or dementia. Participants use a special video game system at home to do balance and thinking exercises, which are supervised remotely by a therapist through video calls. The goal is to see if…

This study is testing two different training methods to help people with Parkinson's disease who have mild memory problems. The goal is to improve their ability to remember to do everyday tasks, like taking medication or attending appointments. About 120 participants will complet…

This Yale University study is exploring whether attending live music concerts can help reduce anxiety and improve emotional connection for people in the early stages of Alzheimer's disease and their caregivers. Researchers will measure brain activity, heart rate, and survey respo…

This study is testing whether a combination of virtual reality exercises and computer-based brain training can improve memory, attention, and daily life skills in older adults who have both heart failure and mild thinking problems. Researchers will compare the combined approach t…

This study is creating a large registry to observe people at risk for or living with Alzheimer's disease or other dementias. Researchers will collect health information over time during participants' regular medical care to understand how different approaches to prevention and ca…

This study aims to understand how older adults make decisions about future care, especially if they develop memory problems like Alzheimer's. Researchers gave 293 participants access to a web-based planning tool and followed them for over three years to see what factors influence…

This study is testing whether taking music improvisation classes can help improve thinking skills and self-control in older adults. Researchers want to see if this fun, creative training can help people stay mentally engaged, especially those with mild memory concerns. The study …

This study is exploring if a continuous glucose monitor (CGM) can help older adults with type 2 diabetes and mild memory problems manage their condition better when they share the data with a family member or caregiver. For two weeks, 10 older adults and their 10 helpers will use…

This study looks at how Black and White patients with mild memory problems change their health habits, future planning, and research participation after learning about their Alzheimer's risk through brain scan results. Researchers want to understand if this information helps peop…

This study aims to better understand how Alzheimer's disease develops and progresses over time. It will follow 1,500 older adults, including those with normal memory, mild memory problems, and dementia, for up to five years. Researchers will use memory tests, brain scans, and blo…

This study aims to understand the healthcare use, costs, and quality of life over time for 1,400 people in the early stages of Alzheimer's disease in the United States. It is purely observational research and does not provide any treatment. Participants and their caregivers will …

This large observational study aims to find better ways to detect Alzheimer's and Parkinson's diseases at their earliest stages, before significant symptoms develop. Researchers will enroll up to 100,000 participants aged 45 and older, using smartphone apps and wearable devices t…

This study is testing a non-invasive brain stimulation technique called theta-burst stimulation (TBS) in 80 people with mild cognitive impairment (early memory problems). The main goal is to understand how the stimulation works and if it affects thinking skills, not to provide a …

This study uses specialized brain scans to understand how a protein called tau relates to memory problems in older adults. Researchers will scan 150 people, some with normal memory and some with mild cognitive impairment, to see how tau buildup connects to brain structure changes…

This study aims to find out if smartphones, wearables, and home sensors can detect very early signs of Alzheimer's disease by measuring changes in a person's daily activities. It will enroll 3,500 people, including healthy volunteers and those with different stages of memory prob…

This study aims to understand how often and why patients experience memory and thinking problems after hip or knee replacement surgery. Researchers are following 505 patients aged 50+ to track their cognitive function before and after surgery for several months. The goal is to id…

This study aims to see if measuring brain stiffness with a special, non-invasive MRI scan can serve as a new sign, or biomarker, for Alzheimer's disease. Researchers will enroll 450 people, including those with Alzheimer's, mild memory problems, and healthy individuals, to compar…

This study is testing whether a safe, painless eye scan can detect early signs of Alzheimer's disease before memory problems begin. Researchers will compare scans from people with early chemical markers of Alzheimer's to those without any markers. The goal is to understand if cha…

This study uses special brain scans to measure and track a protein called amyloid in the brains of 800 people. It includes adults with and without memory problems who are already part of an Alzheimer's research center. The goal is to understand how amyloid buildup relates to the …