MILD COGNITIVE IMPAIRMENT

This study looks at whether two different diets—a Mediterranean diet and a modified Mediterranean-ketogenic diet—can improve gut and brain health in older adults living in underserved rural areas. About 61 people aged 55-85, some with mild memory problems and some without, will f…

This study tests whether trazodone, a medication used for sleep, can slow down memory loss and brain changes in people with mild cognitive impairment and obstructive sleep apnea. About 134 participants will take either trazodone or a placebo for one year. Researchers will measure…

This study tests a heart medication, nicorandil, as a possible treatment for hippocampal sclerosis of aging — a brain condition that looks like Alzheimer's but is different. Researchers want to see if the drug is safe and can slow brain shrinkage in people aged 75 and older with …

This study tests a device that delivers light and sound stimulation to people with mild to moderate Alzheimer's disease. About 670 participants will use either the active device or a sham (inactive) device for one hour daily over 12 months. The goal is to see if the stimulation c…

This study tests whether senolytic drugs—which clear out aged, damaged cells—are safe and feasible for people with early Alzheimer's or mild cognitive impairment. About 48 adults aged 60 and older with elevated tau protein will receive either the drug or a placebo. The main goal …

This study tests whether computerized working memory training can slow the progression of mild cognitive impairment (MCI) to dementia. About 205 people with MCI will be randomly assigned to one or two training sessions or an active control group. Researchers will track memory, da…

This study tests a non-invasive brain stimulation technique to boost memory and thinking in 150 older adults with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. The goal is to strengthen the brain's natural ability to compensate for early damage and…

This study tests whether using ultrasound to temporarily open the blood-brain barrier is safe and feasible for people with mild Alzheimer's or mild cognitive impairment who are already receiving standard antibody therapy. The goal is to see if this approach can help more medicati…

This study tests three common diabetes medications (liraglutide, empagliflozin, and linagliptin) to see if they can improve memory and thinking in people with type 2 diabetes who have mild cognitive impairment. About 396 adults aged 40-75 will take one of the drugs for 48 weeks, …

This early-phase study tests whether a non-invasive brain stimulation technique called accelerated rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. The goal is to see if the treatment can reduce heavy drinking and improve t…

This study looks at a new way to analyze brain scans, called Cortical Disarray Measurement (CDM), to see if it can help diagnose Alzheimer's disease more accurately. Researchers will follow 400 people with mild memory or thinking problems over time. The goal is to see if CDM chan…

This study tests a simple, painless eye scan (OCT) to see if it can detect early Alzheimer's disease before dementia sets in. Researchers will compare people with early chemical signs of Alzheimer's to those without any signs. The goal is to find a new way to diagnose Alzheimer's…

This study tests whether metformin, a common diabetes medication, can prevent Alzheimer's dementia in people with mild cognitive impairment. About 326 overweight adults aged 55-90 without diabetes will take either metformin or a placebo for 18 months. Researchers will track memor…

This 7-year study tests whether a combination of gentle brain stimulation (tDCS) and computer-based cognitive training can slow memory loss and prevent Alzheimer's dementia. It involves 375 older adults with mild cognitive impairment or a history of depression. Participants recei…

This study is following older adults for six years to see if using hearing aids can slow down memory loss and thinking problems, and possibly reduce the risk of dementia. It continues a previous 3-year trial where half the participants received hearing aids and the other half rec…

This study is testing a home-based program designed to help prevent long-term memory decline in older adults at risk for Alzheimer's disease. The program combines brain-training exercises with a gentle, non-invasive brain stimulation technique called tDCS, which is delivered by a…

This pilot study tests whether lamivudine, an HIV medication, can reduce brain-damage markers in people with mild cognitive impairment (MCI) and signs of Alzheimer's. 23 participants aged 55-90 will take the drug for 24 weeks. The goal is to see if it lowers certain proteins in t…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a special video game that challenges balance and thinking, while a coach supervises them remotely via telemedicine. The goal is to see if this approach ca…

This study tests a nature-based program led by caregivers for people with mild cognitive impairment or dementia living at home. About 48 pairs (a person with memory issues and their caregiver) will be randomly assigned to either start the program right away or wait. The program i…

This study looks at whether a 12-month nurse-led program can help people with mild cognitive impairment or dementia and their caregivers. About 200 participants from a Stanford research center will either get monthly nurse support or standard care. The goal is to improve symptoms…

This study looks at whether taking vitamin D3, folic acid, and vitamin B12 can help people aged 50 to 70 with mild cognitive impairment (MCI) — a slight but noticeable decline in memory and thinking. Participants are split into three groups: low-dose vitamins, high-dose vitamins,…

This pilot study tests a 12-month lifestyle program (PRISEM) for 45 African American and White adults aged 50+ with mild cognitive impairment. The program includes group and individual activities focused on health education, nutrition, exercise, and stress management. Researchers…

This study compares two virtual symptom management programs for adults aged 60+ who have chronic pain and early cognitive decline. Over 260 participants will try either Active Brains 1 or 2, focusing on physical, mental, and emotional health. Researchers will track improvements i…

This study tests whether shining a special light on the forehead can help people with early Alzheimer's or mild memory problems. About 200 adults aged 65-85 will receive either real or fake light treatments for 8 weeks. Researchers will check if the light improves thinking, memor…

This study tests a computer-based brain-training program designed to improve working memory in people with mild cognitive impairment (MCI), an early stage of Alzheimer's disease. Participants learn to change their brain activity through neurofeedback, which may help slow memory d…

This early study tests whether a combination of two drugs, dasatinib and quercetin, is safe and possible for people with mild cognitive impairment or Alzheimer's disease. The goal is to see if these drugs can clear aging cells from the brain. Twenty participants aged 55 and older…

This study tests a tablet app called the Digital Memory Notebook (DMN) to help older adults with mild memory problems or early Alzheimer's manage everyday tasks like appointments and medications. Twenty participants will learn to use the app in weekly sessions over six weeks, the…

This study tests whether a combination of virtual reality exercises and computer-based brain training can improve memory and thinking skills in older adults with heart failure who have mild cognitive impairment. Researchers will enroll 172 participants aged 55 and older. The goal…

This study looks at whether giving caffeine to adults aged 70 and older after major surgery can reduce their risk of postoperative delirium—a state of sudden confusion that can slow recovery. About 250 participants are being followed to see if caffeine helps them think more clear…

This study tests whether a daily supplement called nicotinamide riboside (a form of vitamin B3) can improve brain energy and reduce stress in people with mild memory problems or early Alzheimer's. Researchers will measure changes in brain chemistry and thinking skills over time. …

This study tests a program that helps people with mild dementia and their family caregivers focus on their strengths and abilities, rather than just the challenges of the disease. The program includes cognitive exercises and support to improve thinking skills, quality of life, an…

This study tests two types of memory training for people with Parkinson's disease and mild memory problems. 120 participants will complete 8 training sessions over 8 weeks and be followed for a year. The goal is to see if these programs improve everyday memory and help people rea…

This study explores whether a 12-week yoga program can improve brain function and thinking skills in people aged 55+ who have both heart failure and mild cognitive impairment. Researchers will use brain scans, memory tests, and blood samples to measure changes. The goal is to see…

This study looks at whether older adults with mild memory problems or early Alzheimer's can use a tablet-based brain-training app at home. Researchers will check if the app is easy to use and acceptable over two weeks. The goal is to see if remote cognitive training is practical,…

This study uses a special brain scan to measure a protein called amyloid in people who may be at risk for Alzheimer's disease. Researchers want to see how and when amyloid builds up, which could help find the best time to start treatments. About 800 volunteers from an Alzheimer's…

This study follows 100 people aged 60–85 over 5 years to see if problems with smell, hearing, or balance speed up memory loss and lower quality of life. Participants will have tests with a neurologist, psychologist, and ear-nose-throat doctor. The goal is to understand which sens…

This study from Stanford University uses cameras and sensors placed in the homes of 25 older adults (65+) to automatically track behaviors like mood changes and agitation. The goal is to see if this technology can help doctors detect early signs of memory problems or dementia. Pa…

This study uses a special brain scan called DaTSCAN to learn more about aging and diseases like dementia, Parkinson's, and mild cognitive impairment. Researchers will compare scan results with clinical diagnoses and other brain images to better understand these conditions. The st…

This study looks at whether treating sleep problems can help reduce mood and behavior issues like anxiety, agitation, and irritability in people with early Alzheimer's or mild cognitive impairment. Researchers will give 150 adults either a sleep therapy program (CBT-I) or a contr…

This early-stage study looks at whether older adults (65+) with type 2 diabetes and mild memory issues can use a continuous glucose monitor shared with a care partner to better manage their diabetes. Fourteen participants and their care partners will use the device for two weeks,…

This study will enroll 100,000 adults aged 45 and older to track early signs of Alzheimer's and Parkinson's disease using phone apps, voice recordings, and movement tests. Researchers aim to create better tools for early diagnosis by combining digital data with genetic and biolog…

This study looks at how a protein called tau builds up in the brain and how it relates to thinning in key memory areas. Researchers will scan 150 older adults, some with mild cognitive impairment and some healthy, using special PET and MRI techniques. The goal is to better unders…

This study is tracking 452 adults with a family history of Alzheimer's or early memory problems to see how personalized medicine approaches affect their thinking and memory over time. Researchers will regularly measure blood markers, genetics, and cognitive test results. The goal…

This study uses a special MRI technique to measure brain stiffness in people with Alzheimer's, mild cognitive impairment, and healthy volunteers. Researchers want to see if brain stiffness can serve as a new marker to detect Alzheimer's disease. The study involves 450 participant…

This study from Yale University looks at how live music affects the brains and bodies of people with early Alzheimer's, dementia, or mild cognitive impairment, along with their caregivers. About 60 pairs (patient and caregiver) will listen to live and recorded music while wearing…

This study looked at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. About 95 participants with mild memory concerns or at risk for cognitive de…

This study looks at how 100 Black and White patients with mild memory problems change their health habits, planning, and research involvement after learning their Alzheimer's risk from brain scans. Researchers want to see if knowing about amyloid and tau buildup leads to positive…

This study looks at how memory and thinking skills change after hip or knee replacement surgery. Researchers will test 505 adults aged 50 and older before and after surgery to see how many experience cognitive decline. The goal is to identify risk factors and better understand ho…

This study looks at whether learning music improvisation can help older adults (60+) better regulate their thoughts and actions. Researchers will compare participants who take improvisation training to those who don't, measuring changes in cognitive skills and brain activity. The…

This study looks at whether a type of brain stimulation called theta-burst stimulation (TBS) can improve thinking and memory in people with mild cognitive impairment (MCI). Researchers will use brain scans to see how the stimulation affects brain activity and to predict who might…

This study is testing whether smartphones and wearable devices can catch early signs of Alzheimer's disease better than standard questionnaires. About 3,500 adults, including healthy volunteers and those with different stages of memory loss, will use these digital tools to track …

This study follows 1,400 people with early-stage Alzheimer's or mild cognitive impairment to track their healthcare use, costs, and quality of life over time. It does not test any new treatment or drug. The goal is to better understand the economic and personal impact of the dise…

This long-term study follows 1,500 adults with normal memory, mild cognitive impairment, or Alzheimer's disease. Researchers use brain scans, memory tests, and genetic data to understand how the disease progresses and to improve future clinical trials. The study also aims to incl…

This study looks at whether giving supplements that boost glutathione, a natural antioxidant, can improve thinking and memory in older adults with mild cognitive impairment. Sixty participants will take either the active supplements or a placebo for 12 weeks, then stop for anothe…