MILD COGNITIVE IMPAIRMENT

This phase 2 trial tests whether leuprolide (Eligard), a drug that lowers certain hormones, can slow memory and thinking decline in 180 women with mild Alzheimer's or mild cognitive impairment. All participants are already taking donepezil. The study compares leuprolide injection…

This study tests whether the drug rapamycin is safe and tolerable for older adults with mild memory problems or early Alzheimer's disease. About 40 participants will take rapamycin for 12 months while researchers monitor side effects and changes in memory and thinking. The goal i…

This study follows 629 older adults for 3 years to see if using hearing aids and getting hearing rehab can slow down memory loss and lower the risk of dementia. Participants were already in an earlier trial and now continue with hearing care or a delayed treatment. The goal is to…

This early-stage trial tests a drug called NIO752 in 38 people with mild Alzheimer's or mild cognitive impairment due to Alzheimer's. The drug is given as one or two injections into the spinal fluid to see if it can lower levels of tau protein, a key marker of Alzheimer's damage.…

This study tests a device that delivers specific light and sound patterns to the brain, aiming to slow the progression of mild-to-moderate Alzheimer's disease. About 670 participants will use the device at home for an hour daily over a year, with half receiving a sham (inactive) …

This study tests whether computerized memory training can slow mental decline in people with mild cognitive impairment (MCI), a stage between normal aging and dementia. About 205 participants from Norwegian memory clinics will do brain exercises on a computer or play a simple gam…

This study tests whether a home-based program combining cognitive exercises (like puzzles) with mild brain stimulation can improve thinking and memory in older adults with mild cognitive impairment or late-life depression. About 40 participants will use the program at home with h…

This early-phase study tests whether a type of brain stimulation called rTMS can help older adults (ages 60-85) who have both alcohol use disorder and mild cognitive impairment. Participants receive 50 sessions of stimulation over one week. Researchers will measure changes in thi…

This phase 2 trial is testing whether a combination of two drugs, dasatinib and quercetin, is safe and feasible for people with early-stage Alzheimer's or mild cognitive impairment. The drugs aim to clear aging 'senescent' cells that may contribute to brain damage. 48 participant…

This study tests whether using focused ultrasound to temporarily open the blood-brain barrier can safely help standard antibody therapy reach the brain in people with mild Alzheimer's or mild cognitive impairment. About 15 participants will receive the combined treatment. The goa…

This study tests whether the sleep medication trazodone can slow memory loss in people with mild cognitive impairment and obstructive sleep apnea. Researchers will measure changes in blood markers and thinking skills over one year. 134 participants are enrolled in this double-bli…

This study tests whether three diabetes medications—liraglutide, empagliflozin, and linagliptin—can help reverse mild cognitive impairment (early memory and thinking problems) in people with type 2 diabetes. About 396 participants will take one of the drugs for 48 weeks, with an …

This study tests whether nicorandil, a drug currently used for heart conditions, can help people with a type of dementia called hippocampal sclerosis of aging. This condition is often mistaken for Alzheimer's but has no approved treatments. The trial includes 64 older adults and …

This pilot study tests whether lamivudine, an antiviral drug used for HIV, can lower levels of brain-damage-related proteins in the blood of people with mild cognitive impairment (MCI) who also have early signs of Alzheimer's disease. Twenty-three participants will take lamivudin…

This study explores whether a self-administered digital test called eSAGE, combined with information from electronic health records and machine learning, can help detect early signs of cognitive impairment, including dementia and Alzheimer's disease. Researchers will analyze data…

This early-phase study tests whether a single injection of pramlintide, a diabetes drug, can temporarily increase levels of Alzheimer's-related proteins in the blood, potentially revealing early signs of the disease. Researchers will measure changes in beta-amyloid and tau protei…

This study uses a special brain scan called DaTscan to look at how certain brain diseases affect the brain. Researchers will scan 500 adults with conditions like Parkinson's disease, dementia, mild cognitive impairment, or REM sleep behavior disorder. The goal is to see if DaTsca…

Researchers at Mayo Clinic are testing whether measuring brain stiffness with a special MRI scan (magnetic resonance elastography) can serve as a new biomarker for Alzheimer's disease. The study will enroll 450 adults, including healthy volunteers, people with mild cognitive impa…

This study tests whether metformin, a drug used for diabetes, can prevent Alzheimer's dementia in people with mild cognitive impairment (MCI). Over 18 months, 326 overweight adults aged 55-90 with MCI will receive either metformin or a placebo. Researchers will track memory, brai…

This 7-year study tests whether a combination of mild electrical brain stimulation (tDCS) and computer-based memory exercises can slow mental decline and prevent Alzheimer's dementia. It involves 375 older adults with mild cognitive impairment or depression (both risk factors for…

This study tests whether a structured conversation between people with dementia or mild cognitive impairment and their care partners can reduce difficult symptoms like agitation and depression. The idea is that when care partners better understand the person's everyday preference…

This study tests whether 12 weeks of piano improvisation training can improve thinking skills and self-control in adults aged 60 and older, including those with mild cognitive impairment. Participants will either take piano improvisation lessons or listen to music with an instruc…

This study looks at whether physical exercise can improve working memory in older women with mild cognitive impairment (MCI). Researchers will compare the effects of a single exercise session and a 12-week program on memory and muscle strength. The goal is to find a simple, drug-…

This study tests a home-based exercise program for older adults with mild cognitive impairment or dementia. Participants play a specially designed game while a therapist supervises them remotely via telemedicine. The goal is to see if this approach can improve balance and thinkin…

This study tests whether a non-invasive brain stimulation technique called paired associative stimulation (PAS) can improve memory and thinking in 150 older adults with mild cognitive impairment (MCI), a condition that often leads to Alzheimer's. Participants receive daily sessio…

This study tests whether giving caffeine to adults aged 70 and older after major surgery can lower their risk of postoperative delirium—a state of sudden confusion. Researchers will compare low-dose and high-dose caffeine against a placebo in 250 participants. The goal is to see …

This study tests an 8-week program that helps people with mild dementia and their caregivers identify and use their strengths. The program includes workshops and a biography activity led by trained volunteers. Researchers will measure changes in thinking skills and caregiver conf…

This study tests whether a 12-week yoga program can improve thinking and brain health in people aged 55+ who have both heart failure and mild cognitive impairment. Participants will be split into a yoga group and a control group to compare changes in brain scans, memory tests, an…

This study tests a tablet-based app called the Digital Memory Notebook (DMN) to help older adults with mild memory problems or early Alzheimer's manage everyday tasks like appointments and medications. Twenty participants will learn to use the app over six weekly sessions, then c…

This study tests whether a combination of virtual reality exercises and computer-based cognitive training can improve memory and thinking in 172 older adults (55+) who have both heart failure and mild cognitive impairment. Participants will use VR and computer programs designed t…

This study looks at whether taking vitamin D3 with folic acid and vitamin B12 can help people with mild memory and thinking problems. About 380 adults aged 50 to 70 will take either a low or high dose of these vitamins or a placebo for 6 months. Researchers will check if the vita…

This study tests two types of memory training in 120 people with Parkinson's disease and mild cognitive impairment. Participants complete 8 weekly sessions of either process or strategy training. The goal is to see if these exercises improve remembering to do tasks in daily life,…

This study tests whether monthly nurse-led coaching sessions over a year can help people with mild cognitive impairment or dementia and their caregivers. Researchers will track symptoms, quality of life, and how well care plans are documented. The goal is to improve supportive ca…

This study from Yale University will test whether listening to live music can reduce anxiety and improve brain activity in people with early Alzheimer's disease, dementia, or mild cognitive impairment, along with their caregivers. Sixty pairs (patient and caregiver) will attend b…

This study tests a computer-based brain-training program called neurofeedback in 112 people with mild cognitive impairment, an early stage of Alzheimer's disease. Participants learn to control their brain activity through visual or audio cues, aiming to improve working memory. Th…

This early-stage study tests whether two drugs, dasatinib and quercetin, are safe and practical for people with mild cognitive impairment or Alzheimer's disease. The drugs aim to clear aging cells that may contribute to brain decline. Twenty participants aged 55 and older will be…

This study tests a new, non-invasive treatment called transcranial photobiomodulation (t-PBM) for people with mild cognitive impairment or early Alzheimer's disease. 196 participants aged 65-85 will receive either real or fake light therapy to the forehead for 8 weeks. The goal i…

This early-phase study looks at whether older adults (65+) with type 2 diabetes and mild cognitive impairment can better manage their blood sugar by sharing continuous glucose monitor data with a care partner via a mobile app. Fourteen participants and their care partners will us…

This pilot study tests a caregiver-led nature-based intervention for people with mild cognitive impairment or dementia and their caregivers. 48 pairs (dyads) will be randomly assigned to either receive the 8-week nature activity manual immediately or join a waitlist. The goal is …

This study looks at whether intensive computer-based brain exercises can improve memory, attention, and problem-solving in people who have had a brain injury. Thirty adults aged 25-65 with mild cognitive problems will train on a computer for 45-60 minutes a day, five days a week,…

This study follows 1,500 volunteers with normal memory, mild cognitive impairment, or Alzheimer's over several years. Researchers use brain scans, memory tests, and blood samples to track how the disease progresses. The goal is to find better ways to diagnose and treat Alzheimer'…

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This study follows 640 adults with normal cognition, mild cognitive impairment, or Alzheimer's disease to track brain changes over time. Researchers use advanced brain scans and genetic tests to understand how Alzheimer's develops. The goal is to find better ways to diagnose and …

This pilot study looks at whether a simple, non-invasive eye scan (OCT-A) can detect early signs of memory decline in people with atrial fibrillation, a common heart rhythm disorder. Researchers will compare retinal blood vessel patterns in 40 patients with and without mild cogni…

This study looks at whether improving sleep through cognitive behavioral therapy (CBT-I) can reduce neuropsychiatric symptoms like anxiety, depression, and agitation in 150 older adults with mild cognitive impairment or early Alzheimer's. Participants are randomly assigned to CBT…

This Stanford study is testing whether non-intrusive sensors placed in the home can automatically track neuropsychiatric symptoms like mood changes and agitation in older adults. Researchers will enroll 25 participants with or at risk of mild cognitive impairment or dementia, alo…

This study is testing a new way to analyze MRI brain scans, called Cortical Disarray Measurement (CDM), to see if it can help diagnose Alzheimer's disease more accurately. Researchers will follow 400 people with mild memory or thinking problems over time, comparing CDM results wi…

This study follows 100 people aged 60-85 with mild memory or movement problems to see if losing smell, hearing, or balance speeds up cognitive decline. Researchers will test these senses and track thinking skills and quality of life for 5 years. The goal is to understand which se…

This study is creating a registry of 452 adults with a family history of Alzheimer's or early memory problems. Researchers will track their health, blood markers, and thinking skills over time to see if personalized care plans can help prevent or treat the disease. The goal is to…

This study looks at whether taking supplements that boost glutathione, a natural antioxidant, can help memory in older adults with mild cognitive impairment. Sixty participants will take either the active supplements or a placebo for 12 weeks, then stop for another 12 weeks to se…

This study looks at whether a non-invasive brain stimulation technique called theta-burst stimulation (TBS) can improve memory in people with mild cognitive impairment (MCI). Researchers will use brain scans and cognitive tests to see who responds best and how the brain changes. …

This observational study will enroll 100,000 people over age 45 to track early signs of Alzheimer's and Parkinson's using smartphone-based tests, genetic data, and brain scans. Researchers aim to develop better ways to identify who is at risk before symptoms worsen. Participants …

This study looks at whether people with mild memory problems change their health habits, make future plans, or join more research after learning about their Alzheimer's-related brain scan results. It includes 100 Black and White adults with amnestic mild cognitive impairment. The…

This study uses a special brain scan to measure amyloid protein buildup in 800 people already enrolled in an Alzheimer's research center. The goal is to understand when amyloid starts accumulating and how fast it builds up, which could reveal a window for early treatment. Partici…

This study uses a safe, painless eye scan called OCT to look at support cells (glia) in the retina, which is part of the brain. Researchers want to see if these cells work differently in people with early signs of Alzheimer's compared to those without. If they find a difference, …

This study looks at whether giving older adults (ages 60-79) personalized advice and extra support helps them follow brain-healthy habits like a Mediterranean diet, exercise, and staying socially active. Participants have mild memory concerns or are at risk for cognitive decline.…

This study follows 1,400 people with early-stage Alzheimer's or mild cognitive impairment to understand how the disease affects healthcare costs and daily life over time. Participants are not given any experimental treatment. The goal is to gather information for research purpose…

This study is testing whether smartphones and wearable devices can detect early signs of Alzheimer's disease better than traditional questionnaires. Researchers will follow 3,500 people with and without memory problems to see if digital tools can spot subtle changes in daily acti…

This study follows 505 adults aged 50 and older who are having hip or knee replacement surgery. Researchers use a simple online card-game test to measure changes in memory, attention, and thinking before and up to 4.5 months after surgery. The goal is to find out how many people …

This study is looking at how a protein called tau builds up in the brains of older adults with mild cognitive impairment (MCI) or who are cognitively normal. Researchers will use a special PET scan with a tracer called [18F]PI-2620 to take detailed pictures of the brain's memory …