MILD COGNITIVE IMPAIRMENT

This study is testing whether combining two types of drugs works better than one to slow cognitive decline in early Alzheimer's disease or mild cognitive impairment. Researchers will give 80 participants a drug that affects brain signaling (an NMDA-enhancing agent) plus an antiox…

This study is testing whether a smartphone app can help older adults who have mild memory problems remember to take their blood pressure medication. Researchers will enroll 100 adults aged 60 and over. Participants will use an app that provides reminders and educational informati…

This study is testing an oral drug called Senicapoc to see if it can slow down the progression of Alzheimer's disease in people with early memory problems. About 55 participants will take either the drug or a placebo daily for one year. Researchers will measure changes in memory,…

This study is testing a device called Cerogrin, which gently stimulates a nerve in the ear, to see if it can help improve memory and thinking in people with vascular dementia or mild cognitive impairment. Twenty-four participants will use either the real device or a fake one at h…

This study is testing if a weekly injection called mazdutide can slow down or improve memory and thinking problems in people who have both type 2 diabetes and early dementia. Over 76 weeks, 420 participants will receive either the active drug or a placebo (dummy injection) to see…

This study is testing whether a special exercise program can help people with early memory loss due to Alzheimer's disease. Researchers want to see if exercises that combine physical and mental tasks can improve walking, balance, and thinking skills better than regular exercise o…

This is an early safety study testing a new drug designed to stimulate the body's natural immune defenses in people with early Alzheimer's disease or mild cognitive impairment. The trial will enroll 39 participants to receive either the drug or a placebo at different dose levels …

This study is testing whether a dental mouthpiece is as good as a standard CPAP machine at improving memory and thinking skills in people with sleep apnea who also have mild memory problems and heart disease risk. Researchers will enroll 260 adults in Singapore to use one of the …

This study is testing whether a gentle exercise program that also involves thinking tasks can help improve memory and thinking skills in older adults with mild memory concerns. Researchers will recruit 64 participants and randomly assign them to either do the exercise program thr…

This study is testing whether a simple sleep improvement program can help slow down brain changes linked to Alzheimer's disease. Researchers will work with 116 older adults who have mild memory concerns or are at risk for Alzheimer's. For four weeks, participants will follow a sc…

This study is testing whether a simple smell training exercise can help people with early memory problems. Participants with mild cognitive impairment will practice matching scents at home for 10 minutes daily over 3 months. Researchers want to see if this smell training improves…

This 8-week study is testing whether a dietary supplement called Sabroxy® can help improve both blood sugar control and memory in adults. Researchers will enroll 120 adults aged 40-80 who have mild memory concerns and insulin resistance. Participants will take either the suppleme…

This study is testing whether a medical device called Neuclare can temporarily improve planning and problem-solving skills in adults with mild memory loss or very early Alzheimer's disease. Participants will continue their regular memory medications and use the device (or a look-…

This study is testing whether restricting eating to a 10-hour window each day (fasting for 14 hours overnight) can help slow cognitive decline in people with mild cognitive impairment or early Alzheimer's disease. Researchers will enroll 60 older adults to follow this eating patt…

This study is testing whether a supplement called MitoQ can help frail older adults who have trouble walking or thinking. Researchers want to see if MitoQ improves blood vessel function, which could lead to better walking speed and memory. The trial will enroll 60 participants ag…

This study is testing a personalized, non-invasive brain stimulation technique to see if it can improve working memory. Researchers will use magnetic pulses guided by an individual's own brain activity patterns. The goal is to help healthy older adults and those with mild cogniti…

This study is testing whether two different types of exercise can help improve thinking skills and physical fitness in older adults with mild memory problems. Researchers will compare short bursts of high-intensity exercise (HIIT) with longer, moderate-paced exercise (MICT) over …

This study is testing whether a heart procedure called catheter ablation, when added to standard medication, can help improve or stabilize thinking and memory in older adults who have both a persistent irregular heartbeat (atrial fibrillation) and mild cognitive impairment. About…

This study is testing whether specific computer-based brain training exercises can help older adults with mild memory problems maintain their ability to perform daily tasks and delay the onset of dementia. Researchers will compare four different combinations of training exercises…

This study is testing whether playing specific memory-training games on a tablet at home can help improve long-term memory in older adults, including those with mild memory concerns. Researchers will compare two different game apps over 8 weeks to see if they boost memory perform…

This study is testing whether a simple eating schedule is practical and might help women with mild memory problems. Fifteen women will try eating all their daily food within a 10-hour window for eight weeks. Researchers will check if participants can stick to the schedule and see…

This study is testing whether a drug called rapamycin, taken daily for a year, is safe and might help slow down memory and thinking problems in older adults with early-stage Alzheimer's disease or mild cognitive impairment. Researchers will enroll 40 participants to measure chang…

This is a first-in-human safety study testing a new gene therapy approach for early Alzheimer's disease and mild cognitive impairment. Researchers will use a harmless virus to deliver a protective protein called BDNF directly into the brain of 12 participants. The goal is to see …

This study is testing if the diabetes medication metformin can help control mild memory problems in older adults who are overweight or obese. Researchers will enroll 54 participants aged 60-75 and randomly assign them to receive either metformin plus lifestyle advice or lifestyle…

This study is testing whether a 45-minute smell test can help detect early signs of Alzheimer's disease. Researchers want to see if changes in a person's sense of smell can predict who might develop memory problems. Participants will sniff different odors and answer questions abo…

This study is testing if small, in-home cameras and sensors can spot early changes in mood and daily behavior that might signal memory problems or dementia. Researchers at Stanford University are working with 25 older adults to see if this technology can provide clearer, more fre…

This study is testing whether a simple, non-invasive eye-tracking test using a VR headset can help detect early signs of cognitive decline. It will compare the eye responses of 140 adults, including people with Alzheimer's disease, mild memory problems, depression-related impairm…

This study is testing whether a tablet-based memory test helps primary care doctors identify early signs of dementia more effectively than usual care. It will involve about 180,000 patients across 26 clinics, where some clinics will use the tablet tool and others will continue th…

This study tests a new technology called Sense4Safety, designed to help prevent falls in older adults living at home who have mild memory problems. The system uses sensors placed in the home to monitor for signs of increased fall risk and connects participants with a coach to cre…

This study is testing whether a special form of Tai Chi exercise, designed to challenge both the mind and body at the same time, can help prevent falls in older adults who have mild memory problems. Researchers will compare this special Tai Chi to standard Tai Chi and a simple st…

This study tests if involving family members in a proven hospital care program is better at preventing delirium (sudden, severe confusion) in older patients. It will compare the standard Hospital Elder Life Program (HELP) with a new version that trains and includes family caregiv…

This study is testing whether a 12-week, home-based strength training program guided by telehealth is practical and easy to stick with for adults who have both type 2 diabetes and mild cognitive impairment. Researchers want to see if this approach can improve physical function, m…

This study is testing whether a non-invasive brain stimulation technique called rTMS can improve thinking skills in veterans with Parkinson's disease who have mild cognitive problems. Researchers will compare real magnetic stimulation to a sham (fake) treatment in 56 participants…

This study is testing whether a combination of non-invasive brain stimulation and regular aerobic exercise can improve thinking skills and physical mobility in older adults who are experiencing mild cognitive frailty. Researchers will compare different types of stimulation to see…

This study is testing whether playing simple online games like Connect 4 and Uno with family and friends can help older adults feel less lonely and more socially connected. Researchers are enrolling 124 adults aged 50-85, including some with mild memory concerns, to play games th…

This study is testing whether a safe, non-invasive brain stimulation technique can improve memory. It involves healthy young adults, healthy older adults, and older adults with mild memory problems. Researchers will use a device called TMS to stimulate a specific brain area and m…

This study is testing a home-based treatment to improve attention and memory problems in active-duty service members and veterans who have had a mild traumatic brain injury (mTBI). Participants will use a safe, non-invasive brain stimulation device at home while doing computer-ba…

This study aims to see if over-the-counter hearing aids or special communication strategies can make conversations easier for older adults who have both hearing loss and early-stage memory problems. Researchers will compare the two approaches in 50 participants and their communic…

This study is testing a non-invasive brain stimulation treatment for depression in people over 60 who have Alzheimer's disease or mild memory loss. Participants who haven't been helped by antidepressant medications will receive daily magnetic stimulation sessions for four weeks. …

This study is testing whether a program of enjoyable outdoor activities, like gardening or walking a dog, is practical and liked by people with memory challenges and their care partners. Researchers want to see if this 'Green Activity Program' helps people stay active and improve…

This small, early-stage study from Johns Hopkins University is testing whether the psychedelic compound psilocybin, given in a controlled setting with support, can safely reduce depression in people with mild cognitive impairment or early Alzheimer's disease. Up to 20 participant…

This study is testing whether a non-invasive ultrasound treatment can improve symptoms for people with Alzheimer's, Parkinson's, or related brain diseases. Researchers will use focused sound waves to stimulate the brain, aiming to improve movement, memory, and daily life quality.…

This study is testing if a special computer-based program can help reduce anxiety and stress in older adults with early-stage memory loss or mild Alzheimer's disease. It also looks at whether the program helps reduce the strain on their family caregivers. Researchers will compare…

This study aims to better understand brain inflammation in neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Researchers will use PET scans to measure specific inflammation markers in the brains of 184 participants, including both patients and healthy volunteers.…

This study aims to find out if difficulty hearing speech in noisy places is linked to early, mild changes in memory and thinking. Researchers will compare hearing and cognitive test results between 70 adults with mild memory concerns and healthy adults aged 55-80. The goal is to …

This research study aims to understand if amyloid protein deposits in the heart are related to Alzheimer's disease in the brain. Researchers will use special heart scans on 15 people already getting brain scans for Alzheimer's evaluation. The goal is to learn if these heart depos…

This study is testing whether looking at rhythmic, flashing lights can improve brain activity and memory in people with mild cognitive impairment. Twenty participants will have their brain waves measured while they watch different light patterns. The goal is to see if the lights …

This study aims to understand why some people experience thinking and memory problems after a stroke, while others recover better. Researchers will follow 8,000 stroke patients over time, using brain scans, blood tests, and memory assessments. The goal is to identify early signs …

This study aims to understand how early-onset Alzheimer's disease changes over time in people aged 40-64. Researchers will follow about 850 participants with and without memory problems for 2-4 years, using brain scans, memory tests, and fluid samples. The goal is to gather detai…

This research study aims to understand how non-invasive magnetic brain stimulation affects memory and brain function. It involves older adults with mild memory problems and those without cognitive issues. Participants receive repeated brain stimulation sessions while researchers …

This study aims to see if a special, non-invasive eye scan can detect changes in the retina linked to dementia. Researchers will compare scans from 20 people with mild dementia to scans from people without dementia. The goal is to find new ways to identify the disease by looking …

This study aims to create a large database to understand how simple blood tests and digital measurements relate to the buildup of harmful proteins in the brain, as seen on specialized scans. It will enroll 1,200 older adults who are cognitively normal, have mild memory issues, or…

This study aims to understand how a gentle, non-invasive form of electrical brain stimulation affects brain activity and memory. Researchers will enroll 80 older adults, some with mild memory concerns and some without, to see how their brains respond during memory tasks. The goal…

This study uses a new type of brain scan to look for a protein called tau in older adults. Researchers want to see how much tau is in the brain and if it relates to changes in memory, thinking, and brain activity. The goal is to better understand how tau might contribute to futur…

This study aims to understand how the ability to adjust walking patterns relates to memory problems in older adults. Researchers will observe 10 participants with mild cognitive impairment or Alzheimer's disease, using a special treadmill to test walking adaptation. The goal is t…

This study is testing whether improving sleep can help reduce anxiety, depression, and agitation in people with early Alzheimer's disease or memory loss. Researchers will give 150 participants either a proven sleep therapy program or a comparison activity to see if better sleep l…

This study aims to understand how mild cognitive impairment affects the connection between making decisions and controlling movement. Researchers will observe hand movements and measure brain stiffness in 60 participants, including those with and without a diagnosis. The goal is …

This study aims to see if measuring certain proteins in a person's blood can accurately predict who will develop Alzheimer's disease or experience cognitive decline. Researchers will follow 1,800 adults aged 60 and older, some with memory concerns and some without, for several ye…

This study aims to build a detailed research database to help scientists develop better ways to detect, prevent, and treat Alzheimer's disease. It will enroll 1,000 adults aged 60 and older, including those with and without memory problems. Participants will be followed annually …

This study aims to identify what factors help predict whether a person's thinking skills will improve after completing a six-month computerized brain training program. Researchers will enroll 30 adults with a past brain injury and mild thinking difficulties. They will measure cha…

This study aims to understand if Veterans who have had mild to moderate head injuries are at higher risk for developing dementia later in life. Researchers will compare 800 participants—some with past head injuries, some with early memory concerns, and some healthy—by testing the…

This study aims to see if a small, contactless device placed in the bedroom can detect subtle changes in sleep patterns, walking speed, and daily activity in people with mild memory problems or early Alzheimer's disease. About 40 participants will have the device monitor them at …

This study aims to understand how the body's response to stress and a person's genes might predict future memory and thinking problems in people with mild cognitive impairment, a potential early sign of Alzheimer's disease. Researchers will enroll 240 participants to undergo brie…

This study aims to understand if a specific enzyme linked to brain inflammation is higher in people with Alzheimer's disease or mild cognitive impairment. Researchers will use special brain imaging scans (PET and MRI) on 90 participants aged 50 and older, including those with the…

This study aims to see if detailed pictures of the back of the eye (the retina) can reveal early signs of brain diseases like Alzheimer's and Parkinson's. Researchers will use special, non-invasive camera scans on 2000 people, both with and without these conditions. The goal is t…

This study aims to create a better prediction model for how memory and thinking problems worsen over time in people with early dementia or mild cognitive impairment. Researchers will collect blood samples, perform brain scans, conduct memory tests, and gather information from clo…