MILD COGNITIVE IMPAIRMENT

This trial investigates whether a daily supplement containing ketogenic medium-chain triglycerides (a type of fat that produces ketones) and B-vitamins can improve cognitive function in older adults aged 60 and older who have mild cognitive impairment (MCI). Participants take eit…

This study tests whether cannabidiol (CBD) can slow the progression of Alzheimer's disease in people aged 55-85 with mild cognitive impairment (early memory loss). Over 236 participants will receive either CBD or a placebo for a period, and researchers will measure changes in mem…

This study tests whether adding a single infusion of human stem cells to standard antibody therapy can slow memory and thinking decline in people with mild Alzheimer's or mild cognitive impairment. Ten participants aged 55-90 who are already on antibody treatment will receive one…

This study tests whether 6 months of supervised aerobic exercise can improve fitness, brain health, and memory in adults aged 65 and older with mild cognitive impairment or early Alzheimer's disease. Participants will exercise, undergo memory tests, and have MRI scans over a year…

The BEAT-AD study is testing whether a low-carb, high-fat ketogenic diet can improve thinking and memory in 120 adults with mild cognitive impairment, a precursor to Alzheimer's. Participants are randomly assigned to either a ketogenic diet or a low-fat diet for 16 weeks, with fo…

This Phase 2 trial tests whether adding an antioxidant to an NMDA-enhancing drug (DAOIB) improves thinking and memory more than the drug alone in people with early Alzheimer's or mild cognitive impairment. Eighty participants will take the combination or a placebo for 24 weeks. R…

This 76-week study tests whether mazdutide, a weekly injection already used for diabetes, can slow memory and thinking decline in 420 adults aged 50-75 with type 2 diabetes and early dementia. Half receive the drug, half a placebo. Researchers will measure changes in thinking ski…

This study tests whether metformin, a diabetes drug, can improve memory and thinking in overweight adults aged 60-75 with mild cognitive impairment. Half of the 54 participants will take metformin daily for 26 weeks, while the other half will receive lifestyle advice only. Resear…

This study tests an experimental drug called senicapoc in people with mild Alzheimer's or mild cognitive impairment. The goal is to see if it can reduce brain inflammation and slow down memory loss. About 55 participants will take either the drug or a placebo for 52 weeks, with r…

This study tests whether a heart procedure called catheter ablation can slow down memory loss in people with mild cognitive impairment who also have a common heart rhythm problem called atrial fibrillation. 120 participants will be randomly assigned to get either the ablation plu…

This early-stage trial tests a drug called CpG1018, which aims to stimulate the immune system to fight Alzheimer's disease. It involves 18 people with mild cognitive impairment or mild Alzheimer's. The main goal is to check safety, not yet to see if it works.

This study is testing different combinations of computerized brain exercises (cognitive training) to see which works best to delay dementia in older adults with mild cognitive impairment. About 1,300 participants aged 55–89 will complete 40 sessions of either cognitive training o…

This early study tests a gene therapy that delivers a protein called BDNF directly into the brain. The goal is to see if it is safe and can slow or prevent brain cell loss in people with early Alzheimer's or mild cognitive impairment. Only 12 participants will be enrolled in this…

This study tests whether a smartphone app with reminders and education can help older adults (60+) who have mild memory problems stick to their blood pressure medication schedule. One hundred participants will use either the full app with reminders or just the education part for …

This study tests a new PET imaging method that uses 10 to 100 times less radiation than current scans to detect Alzheimer's disease and other dementias. Researchers will scan 200 adults (including healthy volunteers) after injecting a radioactive tracer, aiming to see if shorter …

This study is testing whether new blood tests can accurately diagnose the cause of memory loss or dementia, potentially replacing the need for a spinal tap. Researchers will compare blood test results with standard spinal fluid tests in 1,200 people at a memory clinic. If success…

This study aims to make it easier for family doctors to detect early signs of Alzheimer's and other dementias. Researchers will test 1,200 adults with memory or thinking problems using blood tests and brain scans. The goal is to see if these tools can accurately identify who has …

This study tests whether artificial intelligence can predict cognitive test scores by analyzing how people tell a story. 150 adults aged 50 and older will describe a picture while their speech is recorded. The AI will look for patterns in voice and language, and researchers will …

This study explores whether a simple, at-home smell test can help detect early signs of Alzheimer's and other memory disorders. Researchers will ask 250 adults with mild memory or behavior concerns, as well as healthy older adults, to take a 45-minute scratch-and-sniff test using…

This study is testing whether a simple tablet-based assessment can help primary care doctors spot early signs of cognitive impairment or dementia in older adults. The tool, called TabCAT, is easy to use and automatically scores results. Researchers will compare detection rates ac…

This study tests an online educational program called Brain Health PRO in 700 Canadians at risk for dementia. Participants are randomly assigned to start the 6-month program immediately or after a 6-month delay. The program covers lifestyle factors like diet, exercise, sleep, and…

This study compares two approaches to prevent delirium in older adults during a hospital stay. One is standard hospital care (HELP), and the other adds daily support from family members (FAM-HELP). Researchers will track 1,900 patients aged 70 and older to see if family involveme…

This study tests a pressure-sensor exercise mat and software designed to improve memory, balance, and physical fitness in adults 65 and older. Participants stand on the mat and follow on-screen games and exercises led by a coach. Researchers will compare results with a control gr…

This study tests whether a type of tai chi that combines movement with a mental task can reduce falls in older adults with mild cognitive impairment. Researchers will compare dual-task tai ji quan, standard tai ji quan, and stretching exercises in 336 people aged 65 and older who…

This study explores whether group drumming or music listening can improve pain, stress, and brain function in people with early Alzheimer's, mild dementia, or mild cognitive impairment, as well as their caregivers. Over 8 weeks, 60 participants will attend weekly sessions while r…

This study tests a 5-week virtual cognitive training program for people aged 65-85 with mild cognitive impairment (MCI). Participants attend weekly two-hour group sessions online, learning memory strategies, mindfulness, and planning skills. Researchers want to see if the shorter…

This study is testing whether a special flickering light therapy can improve memory and sleep in people with mild cognitive impairment or early Alzheimer's disease. About 120 participants will be randomly assigned to one of four light conditions and use the light at home for two …

This study tests whether restricting eating to a 10-hour daytime window (fasting 14 hours overnight) can reduce sleep problems and cognitive decline in people with mild cognitive impairment or early-to-moderate Alzheimer's disease. Sixty older adults will try the diet for 3 or 6 …

This study tests whether different hand exercises—using both hands, just fingers, or virtual reality games—can improve thinking and memory in people with mild cognitive impairment. 106 adults aged 50-75 will do 40-minute sessions three times a week for 8 weeks. Researchers will m…

This study looks at whether a 12-week home-based strength training program, supported by technology and telehealth, is practical for 20 adults aged 55-80 with type 2 diabetes and mild cognitive impairment. Participants will start with supervised sessions and gradually exercise on…

This study tests a new device that uses focused ultrasound waves on the brain to see if it can safely improve movement problems in people with Parkinson's disease. About 60 adults with Parkinson's will receive either real or fake (sham) ultrasound treatments. Researchers will mea…

This study tests a 12-week program for people with mild cognitive impairment (early memory loss) and their main family caregiver. The program includes professional-led sessions and caregiver support to improve thinking, memory, and quality of life for both. Researchers will track…

This study tests whether personalized virtual music therapy can boost memory and mood in people with mild cognitive impairment or early Alzheimer's disease. Sixty participants will receive two 30-minute online music therapy sessions each week for 8 weeks, led by a certified thera…

This study tests a new kind of talk therapy called Smart Virtual Reminiscence (SVR) for older adults with mild cognitive impairment or early dementia. The therapy uses artificial intelligence to guide conversations about past memories, aiming to reduce troubling symptoms like agi…

This study tests whether a gentle electrical brain stimulation technique called tDCS can improve cognitive problems in people with Parkinson's disease who have mild memory or thinking issues. About 36 participants will receive the stimulation while their brain activity and cognit…

This study tests whether playing soft sounds during deep sleep can improve the effects of a home-based brain training program for people with Parkinson's disease and mild memory problems. Fifty participants will use a sleep device at night and complete cognitive exercises for fiv…

This study tests whether a brain-computer interface (BCI) that reads your brain waves while you play a video game can deliver targeted magnetic stimulation to improve focus and thinking. Researchers will enroll 180 adults, including those with mild cognitive impairment, to compar…

This study tests whether short sessions of breathing air with slightly less oxygen (intermittent hypoxia training) can safely improve memory and thinking in adults aged 55-79 with mild cognitive impairment. Participants will be assigned to either the real treatment or a sham (fak…

This study tests whether a non-invasive brain stimulation technique called rTMS can safely improve mild thinking problems in veterans with Parkinson's disease. Researchers will give real or fake rTMS sessions to 56 veterans and measure changes in executive function (like planning…

This study tests a non-invasive technique called Low Intensity Focused Ultrasound Pulsation (LIFUP) to see if it can safely increase brain activity and improve memory in people with mild cognitive impairment or mild Alzheimer's disease. Participants will receive ultrasound to a k…

This study tests whether exercising before a mild brain stimulation session can improve memory in people with mild cognitive impairment linked to heart or blood vessel problems. 64 adults aged 50 and older will be randomly assigned to receive either real or sham brain stimulation…

This study looks at whether a simple home-based walking program can boost memory, thinking skills, and brain structure in older adults (over 55) who have both chronic kidney disease and mild cognitive impairment. Over 6 months, participants will either walk regularly or receive h…

This small pilot study tests whether repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, can reduce apathy in people with dementia or mild cognitive impairment. Ten participants will receive rTMS, some also taking the medication methyl…

This pilot study tests whether doing simple eye exercises on a touchscreen for 30 minutes every other day can improve attention and thinking speed in people aged 60 and older with mild cognitive impairment. Forty participants will either do the visual exercises or watch a TV prog…

This study aims to find the best dose of a safe, non-invasive brain stimulation technique called accelerated TMS to improve both depression and thinking skills in people aged 60-85 with mild cognitive impairment and depression. About 60 participants will receive different doses o…

This study tests whether playing a digital navigation game can improve long-term memory in healthy older adults and those with mild cognitive impairment. About 150 participants will play the game or a control game for up to 8 weeks at home. Researchers will measure memory and thi…

This study tests whether a virtual reality (VR) app used at home with remote therapist guidance can improve memory, attention, and social skills in people with early memory decline (Subjective Cognitive Decline and Mild Cognitive Impairment). 480 adults aged 40-80 will either use…

This study is testing whether a Memory Support System (MSS) is practical and helpful for people with mild cognitive impairment (MCI) and their care partners. About 40 participants will try the MSS and report on their daily function, memory confidence, mood, and quality of life. T…

This study tests whether combining a gentle brain stimulation technique (called iTBS and cTBS) with aerobic exercise can improve thinking, walking, and daily function in older adults who are frail and have mild memory issues. Researchers will compare this combo to exercise alone …

This pilot study tests whether a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) can improve memory in healthy adults and in older adults with amnestic mild cognitive impairment (aMCI), a condition that often leads to Alzheimer's. Researche…

This study tests whether a simple smell training program can improve memory, thinking, and daily function in people with mild cognitive impairment (MCI), a condition that often precedes Alzheimer's disease. Thirty participants will either do smell exercises or visual memory exerc…

This study tests a program called Sense4Safety to help older adults with mild cognitive impairment reduce their risk of falling. The program includes a home assessment, personalized education and exercise, and passive monitoring using sensors. Researchers will enroll 200 particip…

This pilot study is testing whether psilocybin, the active ingredient in magic mushrooms, can safely help depression in people with mild cognitive impairment or early Alzheimer's disease. Twenty participants will receive one or two doses under supportive conditions. Researchers w…

This study tests whether a computer-based program can reduce anxiety in older adults with mild cognitive impairment or early Alzheimer's disease, and also help their care partners feel less burdened. About 388 pairs (patient and care partner) will take part. The program involves …

This study looks at whether simple, low-intensity exercise can improve memory and thinking in older adults with mild cognitive impairment (MCI), a condition that raises dementia risk. Researchers will have 64 participants do combined physical and mental exercises three times a we…

This 8-week study tests whether a daily supplement called Sabroxy® (made from Oroxylum indicum bark) can improve insulin resistance and memory in adults aged 40-80 with mild cognitive impairment and insulin resistance. About 140 participants will receive either Sabroxy® or a plac…

This study tests whether a dental mouthpiece (MAD) works as well as a CPAP machine to improve thinking and memory in people with sleep apnea who also have mild memory problems. About 260 adults aged 45 and older will be randomly assigned to use either device for one year. Researc…

This study tests whether combining aerobic, strength, and balance exercises with cognitive training (dual-tasking) can improve gait, balance, and cognition in people with mild cognitive impairment due to Alzheimer's. Forty-five participants will be split into three groups: one do…

This study tests whether a daily MitoQ supplement for 12 weeks can improve blood vessel function, walking speed, and thinking skills in frail older adults aged 65-80. Researchers will measure changes in blood flow, cognitive tests, and physical performance. The trial involves 60 …

This study will test whether women with mild cognitive impairment can follow a time-restricted eating plan, where they eat all their food within a 10-hour window each day. The goal is to see if this approach is practical and acceptable for this group. If it works, it could lead t…

This study tests whether playing online games like Connect 4 and Uno with a partner three times a week for 12 weeks can help older adults (ages 50-85) with and without mild cognitive impairment feel less lonely and more socially engaged. Participants will play via a special onlin…

This study tests a device called Neuclare that is placed on the head to see if it can temporarily improve planning and problem-solving skills in people with mild cognitive impairment or very early Alzheimer's disease. About 138 adults aged 55 to 90 who are already on memory medic…

This study tests a small device called Cerogrin that gently stimulates a nerve in the ear, aiming to improve thinking and memory in people with vascular dementia or mild cognitive impairment. Twenty-four participants will use the device at home for 30 minutes daily over four week…

This study tests a safe, non-invasive brain stimulation technique (tDCS) that people can use at home while doing computer-based attention exercises. The goal is to see if it can improve complex attention in 160 active-duty service members and veterans who had a mild traumatic bra…

This study tests a non-invasive brain stimulation technique called deep transcranial magnetic stimulation (dTMS) in 28 adults over 60 who have Alzheimer's disease or mild cognitive impairment along with depression that hasn't improved with medication. Participants receive daily d…

This study tests a program called the Green Activity Program, designed for people aged 45+ with mild memory problems. The program encourages enjoyable nature activities like walking, gardening, or outdoor yoga, with a partner. Researchers want to see if the program is easy to do …

This study looks at whether over-the-counter hearing aids can improve communication for older adults with mild cognitive impairment and mild to moderate hearing loss. Fifty participants and their communication partners will be randomly assigned to try hearing aids first or receiv…

This study tests a new radioactive tracer to see if it can measure brain inflammation in people with Alzheimer's disease or mild cognitive impairment. Researchers will compare scans from 90 volunteers (patients and healthy older adults) to understand how inflammation relates to m…

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases. Researchers will compare these scans to those from healthy volunteers to see if inflammation levels differ. The goal is to d…

This study tests whether combining brain training with aerobic exercise for 12 weeks can improve brain function in people with mild cognitive impairment (MCI), a condition that can lead to dementia. Researchers will measure changes in brain structure, blood flow, and thinking ski…

This study is testing whether playing an immersive virtual reality game can help improve memory in older adults with mild cognitive impairment. Researchers will measure changes in memory recall and brain activity using MRI scans. The goal is to see if this non-drug approach can r…

This study tests whether a non-invasive technique called repetitive Transcranial Magnetic Stimulation (rTMS) can improve memory and brain function in older adults with mild cognitive impairment or early Alzheimer's. Over 30 participants will receive both real and sham (placebo) s…

This study looks at whether a history of mild traumatic brain injury (like a concussion) is linked to biological changes in people with mild memory problems. Researchers will use a gentle brain stimulation technique and blood tests to explore this connection. The study involves 7…

This Mayo Clinic study uses a safe, noninvasive light-based device called fNIRS to measure brain activity in 200 adults with major depression, bipolar disorder, or mild cognitive impairment. By comparing brain blood flow patterns across these groups, researchers hope to better un…

This study is creating a large database of blood tests, digital assessments (like smartphone tasks), and brain scans from 1,200 older adults. Participants may have normal memory, mild memory problems, or mild-to-moderate Alzheimer's. The goal is to see if simple, non-invasive tes…

This study is testing a web-based platform called LEAD that helps people in the early stages of Alzheimer's or dementia talk about and document their end-of-life care preferences. The goal is to make it easier for them and their care partners to feel confident in making future me…

This study is looking for early warning signs of Alzheimer's disease in 800 cognitively healthy adults aged 50 to 80. Researchers will use blood tests, brain scans, and memory assessments over about 4 years to see how Alzheimer's-related changes develop. The goal is to find a way…

This study follows nearly 3,000 people, including healthy adults and those with memory or movement problems, to learn how brain diseases like Alzheimer's and Parkinson's develop. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve ear…

This study is testing whether neighborhood pharmacies can help identify older adults with early memory problems and guide them to the right support. Over 1,000 participants aged 60 and older will take a digital memory test at their pharmacy. If the test shows concerns, the pharma…

This study is tracking 850 adults with normal cognition or early memory problems, some of whom have prediabetes. Researchers will monitor memory, brain scans, and spinal fluid over time to see how blood sugar issues might affect Alzheimer's risk. The goal is to better understand …

This study tests whether a gentle, non-invasive brain stimulation technique can improve memory and brain function in older adults with mild cognitive impairment. Researchers will use brain scans to measure changes in brain activity and chemical levels. The goal is to understand h…

This study looks at how people with mild cognitive impairment (MCI) and Alzheimer's disease adjust their walking when conditions change, like walking on different surfaces. Researchers will measure walking patterns, memory, and thinking skills in 10 older adults. The goal is to b…

This study uses virtual reality and eye-tracking to measure how pupils react during memory tasks. Researchers hope to find a simple, non-invasive way to detect early cognitive decline in Alzheimer's disease, mild cognitive impairment, and depression. 140 adults will be tested at …

This study follows 850 people aged 40-64 with early-onset cognitive impairment to understand how Alzheimer's disease progresses. Participants undergo cognitive tests, brain scans, and genetic analysis, but no experimental treatment is given. The goal is to gather data that could …

This study uses a special PET scan to detect tau protein buildup in the brains of healthy older adults and those with mild cognitive impairment. Researchers will compare scan results with memory tests and brain activity patterns to understand how tau affects thinking. The goal is…

This study is creating a large, diverse group of 1,000 older adults in Tennessee to help researchers better understand Alzheimer's disease. Participants, who may be healthy, have mild memory problems, or have Alzheimer's, will be followed yearly with tests like brain scans and bl…

This study uses non-invasive eye scans (OCT and OCTA) to look for changes in the retina that might be linked to brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers aim to find early markers that could help diagnose or track these conditions. The stud…

This study looks at how stress hormones and genes linked to Alzheimer's affect memory and thinking in older adults with mild cognitive impairment. Participants undergo a stress test and provide blood and saliva samples, then return after 2 years for follow-up. The goal is to unde…

This study aims to see if proteins in the blood can predict who will develop Alzheimer's disease or memory problems. Researchers will follow 1,800 older adults, some with mild forgetfulness or dementia, and track their cognitive health over time. The goal is to develop and valida…

This study explores whether hearing tests, especially in noisy settings, can reveal early signs of mild cognitive impairment (MCI). Researchers will compare 70 adults aged 55–80—some with MCI, some healthy—on how well they hear soft sounds and process speech in noise. The goal is…

This study tests whether spending less time in bed for four weeks can deepen sleep and boost memory in adults aged 65-85 who have poor sleep and are at risk for Alzheimer's. Researchers will measure brain activity, memory, and blood markers. The goal is to see if a simple behavio…

This study is looking for 500 people with early dementia or mild cognitive impairment to help develop a way to predict how their disease will progress. Researchers will use blood tests and other models to better understand each person's outlook. The goal is to give patients and d…

This study tests whether a radio-wave sensor placed in the home can measure sleep, movement, and walking speed in 40 people with mild cognitive impairment or mild Alzheimer's who are taking nicotinamide riboside (a form of vitamin B3). The goal is to find digital biomarkers that …

This study follows 8,000 adults who have had a stroke to learn why some develop memory and thinking problems afterward. Researchers will track changes in cognition, brain scans, and blood samples over time. The goal is to help doctors identify who is at risk for dementia and pave…

This study looks at how mild cognitive impairment (MCI) affects the link between making decisions and moving. Researchers will track hand movements and brain changes in 60 adults aged 45-90, half with MCI and half without. The goal is to find early signs of disease that could lea…

This study uses a noninvasive technique called transcranial magnetic stimulation (TMS) to try to improve working memory in healthy older adults and people with mild cognitive impairment (MCI). Researchers will use brain scans to personalize the stimulation and measure its effects…

This study is looking at 800 veterans to see if mild traumatic brain injury (concussion) increases the risk of dementia later in life. Researchers will test memory, brain waves, brain scans, and proteins in blood and spinal fluid. The goal is to find early warning signs of diseas…

This study is testing whether special eye scans can detect signs of Alzheimer's disease and dementia. Researchers will use two non-invasive imaging devices to look for blood vessel changes and protein deposits in the retina. The study involves 20 participants, including people wi…

This study looks at whether people with Alzheimer's disease also have amyloid deposits in their hearts, which can cause heart problems. Researchers will use special PET scans—normally used to see amyloid in the brain—to also scan the heart. The goal is to better understand if the…