MILD COGNITIVE IMPAIRMENT

This study tests two types of computerized brain-training exercises in 84 older adults (65+) with mild cognitive impairment. Participants will do 30-minute sessions targeting speed, memory, or executive function. The goal is to see if these exercises improve brain signaling and t…

This study tests whether a daily 240 mg dose of Ginkgo biloba extract can change certain blood markers linked to Alzheimer's disease in people with mild cognitive impairment. Over 6 months, 120 participants will be randomly assigned to receive either Ginkgo biloba or a placebo. T…

This study tests whether a mild electrical stimulation applied to the ear (via a small device) can improve memory and thinking in people with type 2 diabetes who also have mild cognitive impairment. The trial will involve 38 participants who will either receive the active stimula…

This study tests whether a 6-week self-management program, done with a caregiver's help, can improve diabetes control and thinking skills in adults aged 55+ who have both diabetes and mild cognitive impairment. About 309 participants will attend weekly group sessions and provide …

This study will test whether using a virtual reality (VR) headset for cognitive and physical exercises is practical and well-liked by people with mild cognitive impairment. Ten participants will do three supervised VR sessions per week for six weeks. The goal is to see if they ca…

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This study tests whether combining a gentle brain stimulation technique (rTMS) with walking and eye exercises can improve balance and reduce fall risk in 30 adults aged 18-80 with or without mild cognitive impairment. Participants will practice stepping onto targets while their e…

This pilot study will test whether a non-invasive brain stimulation technique called transcranial alternating current stimulation (tACS) can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive low-level electrica…

This study will test whether 8 weeks of group body percussion training (clapping, knee tapping, foot tapping) can improve motor skills, attention, and daily function in 25 adolescents aged 14-18 with mild intellectual disability. Participants are randomly assigned to either the r…

This study tests whether a digital exercise program using video games (exergames) can improve quality of life and physical function in older adults with mild cognitive impairment living in care homes. Thirty-eight participants will either play exergames or do standard physiothera…

This study tests a sleep therapy called SleepSMART for older veterans who have both insomnia and mild cognitive impairment (MCI). The therapy adapts standard insomnia treatment with extra memory and learning support. Researchers will compare SleepSMART to standard therapy in 150 …

This early-phase study tests whether brivaracetam, a seizure medication, can calm overactive brain areas and improve thinking in 25 adults aged 45–70 with mild Alzheimer's or mild cognitive impairment. Participants will have brain activity monitored via scalp and depth electrodes…

This study tests whether using a special blend of essential oils at home can improve mood and behavior in people with mild cognitive impairment or early dementia. It also looks at whether this simple, pleasant treatment can reduce stress for their caregivers. Two hundred patients…

The AHEAD study is testing whether artificial intelligence can help detect early signs of Alzheimer's disease in people who feel their memory is slipping but still test normal. Researchers will use brain scans, eye tests, and blood markers to identify those at highest risk. High-…

This study follows 285 older adults with Alzheimer's or mild cognitive impairment to learn how they make decisions about aging in place or moving to long-term care. Researchers will track planning and preferences over time. No treatment or intervention is being tested.

This study looks at whether a virtual reality (VR) program called CAST can help older adults with mild cognitive impairment (mild memory problems) stay socially and mentally engaged. Researchers will test how easy and enjoyable the VR system is for 312 people aged 65 and older. T…

This study is developing and testing an intelligent software system designed to provide cognitive and social support to older adults with mild cognitive impairment (MCI). The software adapts to each user's abilities and needs. Researchers will enroll 290 participants aged 62 and …

This study aims to develop and test digital assistant tools that help older adults, including those with mild cognitive impairment (MCI), manage healthcare tasks like finding services, handling medical bills, and using Medicare.gov. Researchers will interview 600 participants to …

This study will follow 1,000 older adults from under-resourced communities who have early memory concerns or mild cognitive impairment. Participants will be monitored through phone or video visits, with data collected on thinking skills, brain scans, and blood samples. The goal i…

This study will test if wearable devices like smartwatches and rings can detect early signs of mild cognitive impairment and Alzheimer's disease in 150 adults aged 65 and older. Participants will wear the devices for 30 days while researchers collect data on activity, sleep, and …

This study will follow 2,500 elderly people in Hong Kong for 2-3 years to find early signs of Alzheimer's disease. Researchers will use blood tests, brain scans, and memory assessments to see if a simple blood test can detect the disease before symptoms get worse. The goal is to …

This study tests whether transcranial magnetic stimulation (TMS), a non-invasive brain stimulation technique, can improve the brain's natural waste-clearing system (glymphatic function) in people with mild cognitive impairment. Researchers will give TMS to 20 participants to see …