MILD COGNITIVE IMPAIRMENT

This small pilot study will test whether adding a single infusion of human mesenchymal stem cells (hMSCs) to standard antibody treatment (like Leqembi or Kisunla) can help stabilize memory and daily function in people with mild Alzheimer's or mild cognitive impairment. Ten adults…

This study tests a 6-week program where older adults with diabetes and mild memory issues work with their caregivers to improve diabetes self-care and thinking skills. About 309 participants will attend weekly sessions and provide feedback. The goal is to see if this team-based a…

This study tests an online educational program called Brain Health PRO that teaches lifestyle changes to lower dementia risk. About 700 adults at risk for dementia will either start the program right away or wait 6 months. The goal is to see if the program helps people adopt heal…

This study tests two computer-based brain-training programs designed to improve thinking and brain health in older adults (65+) with mild cognitive impairment (MCI). Participants will use the programs at home and undergo brain scans to measure changes. The goal is to see if these…

This study tests whether a 6-week program of therapeutic video games (exergames) can improve movement, balance, and quality of life in older adults with mild cognitive impairment living in long-term care. About 38 participants will either play exergames or do standard physiothera…

This study looks at whether the seizure medication brivaracetam can calm overactive brain activity in people with mild Alzheimer's or mild cognitive impairment. About 25 participants aged 45-70 will take the drug for up to a year. Researchers will measure changes in brain waves a…

This study tests a sleep program called SleepSMART for 150 veterans who have both insomnia and mild cognitive impairment (MCI). The therapy adapts standard sleep counseling with extra memory aids to help veterans learn and stick with the treatment. Researchers will compare SleepS…

This study tests if transcranial magnetic stimulation (TMS) can help the brain's natural waste-clearing system remove proteins linked to Alzheimer's disease. Researchers will give TMS to 20 older adults with mild cognitive impairment and measure changes in protein levels and thin…

This study will test whether group-based body percussion training (clapping, tapping, and snapping to a beat) can improve motor skills, attention, and daily functioning in 25 adolescents aged 14-18 with mild intellectual disability. Participants will either take part in 8 weeks o…

This pilot study tests whether a non-invasive brain stimulation technique called tACS can improve working memory in 30 adults with mild cognitive impairment or traumatic brain injury. Participants will receive tACS sessions and undergo memory tests and brain scans to see if the s…

This study looks at whether a carefully planned ketogenic diet can reduce pain and improve thinking in people who have both osteoarthritis and mild cognitive impairment. Ten adults will follow the diet under supervision, and researchers will check their pain, physical function, a…

This study tests whether using a special blend of essential oils at home can improve symptoms like anxiety and depression in people with mild cognitive impairment or early dementia. It also looks at whether patients will stick with the treatment and if it helps reduce stress for …

This study tests a 5-week virtual cognitive training program for people aged 65+ with mild cognitive impairment (MCI). Researchers want to see if the shorter program works as well as the standard 8-week version to improve memory, thinking, daily function, and mood. Participants w…

This study tests whether combining a non-invasive brain stimulation technique called rTMS with gaze and gait training can improve walking and balance in 30 adults aged 18-80 who have mild cognitive impairment. Participants will practice stepping and eye movements while receiving …

This study will test a virtual reality (VR) program called CAST, designed for older adults with mild cognitive impairment. The goal is to see if the program is easy to use, enjoyable, and helpful for staying socially connected. Researchers will track how often participants use th…

This study will see if wearable devices like smartwatches and rings can catch early signs of memory loss and Alzheimer's disease. Researchers will track 150 adults aged 65 and older, comparing data from wearables with brain scans, blood tests, and thinking tests. The goal is to f…

This study aims to develop and test digital assistant tools that help older adults, including those with mild cognitive impairment, manage healthcare tasks like finding services, handling medical bills, and using Medicare.gov. Researchers will interview 600 participants to unders…

This study is creating and testing a smart tablet program designed to help older adults with mild cognitive impairment (MCI) stay mentally and socially engaged. The program adapts to each person's changing needs and includes a feature that records speech to detect early signs of …

This study will follow 1,000 older adults (age 50+) from under-resourced communities who have early memory concerns. Researchers will collect health data, brain scans, and samples over time to better understand how dementia develops. No treatment or medication is given—the goal i…

This study follows 285 older adults (65+) with Alzheimer's or mild cognitive impairment, along with their caregivers, to learn how they make decisions about staying at home or moving to a care facility. Researchers will track their planning over time through simple questions abou…

This study will follow 2,500 elderly people in Hong Kong for 2-3 years to find better ways to detect Alzheimer's disease early. Researchers will use blood tests and brain scans to track changes in memory and thinking. The goal is to create a Chinese-specific resource to improve e…