Can a ketogenic supplement boost brain health in older adults?
NCT ID NCT06347315
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial investigates whether a daily supplement containing ketogenic medium-chain triglycerides (a type of fat that produces ketones) and B-vitamins can improve cognitive function in older adults aged 60 and older who have mild cognitive impairment (MCI). Participants take either the active supplement or a placebo for a period, and their memory, executive function, and overall cognition are measured using standard tests. The goal is to see if this nutritional approach can help slow or improve cognitive decline associated with MCI.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
ketogenic medium-chain triglycerides and B-vitamins
What this could lead to
If it works, this could point toward a simple dietary supplement to help slow cognitive decline in people with mild cognitive impairment.
What could go wrong
This is a nutritional intervention, not a drug, so effects may be modest. The trial is still testing whether the supplement improves cognitive scores, and results may not apply to everyone.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AO Card. G. Panico
RECRUITINGTricase, Italy
Contact
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AOU Policlinico Umberto I - Sapienza Università di Roma
RECRUITINGRoma, Italy
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Azienda Ospedaliera SantAndrea
RECRUITINGRoma, Italy
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Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone"
RECRUITINGPalermo, Italy
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CHU de Montpellier - Hôpital Gui de Chauliac
RECRUITINGMontpellier, France
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CHU de Nantes - Hôpital Nord Laennec
RECRUITINGNantes, France
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CHU de Toulouse - Gerontopole
RECRUITINGToulouse, France
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CHUV
RECRUITINGLausanne, Switzerland
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Foundation Institute G.Giglio
RECRUITINGCefalù, Italy
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Fundaciò ACE
RECRUITINGBarcelona, Spain
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HGU Gregorio Marañón
RECRUITINGMadrid, Spain
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Hampshire & Isle of Wight Healthcare NHS Foundation Trust
RECRUITINGSouthampton, United Kingdom
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Hospital Universitari General de Catalunya
RECRUITINGSant Cugat del Vallès, Spain
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Hospital Universitari i Politecnic La Fe
RECRUITINGValencia, Spain
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Hospital Universitario Victoria Eugenia
RECRUITINGSeville, Spain
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Hospital Universitario del Vinalopó
RECRUITINGAlicante, Spain
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Hôpital Pierre Wertheimer
RECRUITINGBron, France
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IRCCS Ospedale Policlinico San Martino
RECRUITINGGenova, Italy
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Klinikum Bayreuth GmbH - Klinik Hohe Warte
RECRUITINGBayreuth, Germany
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Laboratory of Neuropsyichiatry, Fondazione Santa Lucia IRCCS
RECRUITINGRoma, Italy
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Neuro Centrum Science GmbH
RECRUITINGErbach im Odenwald, Germany
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Policlinico Universitario Agostino Gemelli
RECRUITINGRoma, Italy
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Spitalzentrum Centre Hospitalier Biel-Bienne AG (SZB)
RECRUITINGBiel, Switzerland
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Studienzentrum für Neurologie und Psychiatrie
RECRUITINGBöblingen, Germany
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Sussex Partnership NHS foundation Trust
RECRUITINGCrowborough, United Kingdom
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Unidad de Investigación Neurociencias Centro de Salud San Juan
RECRUITINGSalamanca, Spain
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Universitaetsmedizin Ulm
RECRUITINGUlm, Germany
Contact
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Universitare Altersmedizin FELIX PLATTER
RECRUITINGBasel, Basel, 4055, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••