Can a ketogenic supplement boost brain health in older adults?

NCT ID NCT06347315

Recruiting now Disease control Sponsor: Société des Produits Nestlé (SPN) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This trial investigates whether a daily supplement containing ketogenic medium-chain triglycerides (a type of fat that produces ketones) and B-vitamins can improve cognitive function in older adults aged 60 and older who have mild cognitive impairment (MCI). Participants take either the active supplement or a placebo for a period, and their memory, executive function, and overall cognition are measured using standard tests. The goal is to see if this nutritional approach can help slow or improve cognitive decline associated with MCI.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ketogenic medium-chain triglycerides and B-vitamins
What this could lead to: If it works, this could point toward a simple dietary supplement to help slow cognitive decline in people with mild cognitive impairment.
What could go wrong: This is a nutritional intervention, not a drug, so effects may be modest. The trial is still testing whether the supplement improves cognitive scores, and results may not apply to everyone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

AO Card. G. Panico
RECRUITING

Tricase, Italy
AOU Policlinico Umberto I - Sapienza Università di Roma
RECRUITING

Roma, Italy
Azienda Ospedaliera SantAndrea
RECRUITING

Roma, Italy
Azienda Ospedaliera Universitaria Policlinico "Paolo Giaccone"
RECRUITING

Palermo, Italy
CHU de Montpellier - Hôpital Gui de Chauliac
RECRUITING

Montpellier, France
CHU de Nantes - Hôpital Nord Laennec
RECRUITING

Nantes, France
CHU de Toulouse - Gerontopole
RECRUITING

Toulouse, France
CHUV
RECRUITING

Lausanne, Switzerland
Foundation Institute G.Giglio
RECRUITING

Cefalù, Italy
Fundaciò ACE
RECRUITING

Barcelona, Spain
HGU Gregorio Marañón
RECRUITING

Madrid, Spain
Hampshire & Isle of Wight Healthcare NHS Foundation Trust
RECRUITING

Southampton, United Kingdom
Hospital Universitari General de Catalunya
RECRUITING

Sant Cugat del Vallès, Spain
Hospital Universitari i Politecnic La Fe
RECRUITING

Valencia, Spain
Hospital Universitario Victoria Eugenia
RECRUITING

Seville, Spain
Hospital Universitario del Vinalopó
RECRUITING

Alicante, Spain
Hôpital Pierre Wertheimer
RECRUITING

Bron, France
IRCCS Ospedale Policlinico San Martino
RECRUITING

Genova, Italy
Klinikum Bayreuth GmbH - Klinik Hohe Warte
RECRUITING

Bayreuth, Germany
Laboratory of Neuropsyichiatry, Fondazione Santa Lucia IRCCS
RECRUITING

Roma, Italy
Neuro Centrum Science GmbH
RECRUITING

Erbach im Odenwald, Germany
Policlinico Universitario Agostino Gemelli
RECRUITING

Roma, Italy
Spitalzentrum Centre Hospitalier Biel-Bienne AG (SZB)
RECRUITING

Biel, Switzerland
Studienzentrum für Neurologie und Psychiatrie
RECRUITING

Böblingen, Germany
Sussex Partnership NHS foundation Trust
RECRUITING

Crowborough, United Kingdom
Unidad de Investigación Neurociencias Centro de Salud San Juan
RECRUITING

Salamanca, Spain
Universitaetsmedizin Ulm
RECRUITING

Ulm, Germany
Universitare Altersmedizin FELIX PLATTER
RECRUITING

Basel, Basel, 4055, Switzerland

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