Brain scan may reveal early clues to Alzheimer's

NCT ID NCT04251130

Ongoing Knowledge-focused Sponsor: University of Pennsylvania Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study is looking at how a protein called tau builds up in the brains of older adults with mild cognitive impairment (MCI) or who are cognitively normal. Researchers will use a special PET scan with a tracer called [18F]PI-2620 to take detailed pictures of the brain's memory center. The goal is to see if tau buildup is linked to thinning of brain tissue in areas important for memory. This is a knowledge-gathering study, not a treatment trial.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [18F]PI-2620 (a radioactive tracer for PET imaging)
What this could lead to: If successful, this could help doctors better understand and detect early signs of Alzheimer's disease using brain scans.
What could go wrong: This is an observational study, not a treatment trial. It may not lead to any direct benefit for participants, and the imaging technique may not prove useful in routine care.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

University of Pennsylvania, School of Medicine

Philadelphia, Pennsylvania, 19104, United States

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