Brain scan may reveal early clues to Alzheimer's
NCT ID NCT04251130
First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 1 time
Summary
This study is looking at how a protein called tau builds up in the brains of older adults with mild cognitive impairment (MCI) or who are cognitively normal. Researchers will use a special PET scan with a tracer called [18F]PI-2620 to take detailed pictures of the brain's memory center. The goal is to see if tau buildup is linked to thinning of brain tissue in areas important for memory. This is a knowledge-gathering study, not a treatment trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
[18F]PI-2620 (a radioactive tracer for PET imaging)
What this could lead to
If successful, this could help doctors better understand and detect early signs of Alzheimer's disease using brain scans.
What could go wrong
This is an observational study, not a treatment trial. It may not lead to any direct benefit for participants, and the imaging technique may not prove useful in routine care.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of Pennsylvania, School of Medicine
Philadelphia, Pennsylvania, 19104, United States