Could a common blood pressure pill help african americans with memory loss?

NCT ID NCT04522739

Completed Symptom relief Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether spironolactone, a blood pressure medication, is safe for older African Americans with mild memory and thinking problems. Twenty-five participants took either the drug or a placebo daily for one year. The main goal was to check safety and tolerability, with a secondary look at memory test performance.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Spironolactone (a blood pressure medication)
What this could lead to: If successful, this could point toward a safe way to potentially help memory in African Americans with early Alzheimer's.
What could go wrong: This is a small, early safety study with only 25 participants. It may not show any benefit for memory, and side effects are possible.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE MILD COGNITIVE IMPAIRMENT

Contacts and locations

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Locations

Emory Clinic at Executive Park

Atlanta, Georgia, 30329, United States

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