Zapping the brain to save memories: early trial shows promise

NCT ID NCT05327257

Completed Symptom relief Sponsor: Maria I. Lapid, M.D. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small pilot study tested whether a non-invasive brain stimulation technique called iTBS rTMS could improve memory in 25 adults with mild cognitive impairment (MCI). The main goal was to see if the treatment was feasible and acceptable, while also checking for any memory benefits. Results are still being analyzed, but this early work could lead to larger trials exploring a drug-free way to ease memory symptoms.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: intermittent theta burst stimulation (iTBS) repetitive transcranial magnetic stimulation (rTMS)
What this could lead to: If it works, this could point toward a non-drug treatment to ease memory problems in people with mild cognitive impairment.
What could go wrong: This is a very small, early pilot study with only 25 participants, focused on feasibility. It may not show clear memory benefits, and results may not apply to everyone with MCI.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Cognitive Dysfunction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

Mayo Clinic in Rochester

Rochester, Minnesota, 55905, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.