Sleep and memory boost? citicoline supplement tested in Alzheimer's prevention trial

NCT ID NCT06029894

Completed Symptom relief Sponsor: Emory University Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed pilot study from Emory University tested whether a daily citicoline supplement could improve sleep quality, daytime sleepiness, and memory in 100 older adults with mild cognitive impairment (MCI). Participants took 1000 mg of citicoline for 3 months and completed sleep questionnaires, cognitive tests, and blood or spinal fluid tests to measure Alzheimer's-related biomarkers. The goal was to see if this well-tolerated supplement might help both sleep and early signs of Alzheimer's disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: citicoline (dietary supplement)
What this could lead to: If it works, this could point toward a simple supplement to improve sleep and slow cognitive decline in people with mild memory problems.
What could go wrong: This is a small, early pilot study with no placebo group, so results may not be reliable. The supplement may have no real effect on sleep or Alzheimer's markers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Alzheimer disease Cognitive Dysfunction dementia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALZHEIMER DISEASE MILD COGNITIVE IMPAIRMENT

Contacts and locations

Locations

Emory University School of Nursing

Atlanta, Georgia, 30322, United States
Goizueta Alzheimer's Disease Research Center

Atlanta, Georgia, 30329, United States

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