Sleep and memory boost? citicoline supplement tested in Alzheimer's prevention trial
NCT ID NCT06029894
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This completed pilot study from Emory University tested whether a daily citicoline supplement could improve sleep quality, daytime sleepiness, and memory in 100 older adults with mild cognitive impairment (MCI). Participants took 1000 mg of citicoline for 3 months and completed sleep questionnaires, cognitive tests, and blood or spinal fluid tests to measure Alzheimer's-related biomarkers. The goal was to see if this well-tolerated supplement might help both sleep and early signs of Alzheimer's disease.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
citicoline (dietary supplement)
What this could lead to
If it works, this could point toward a simple supplement to improve sleep and slow cognitive decline in people with mild memory problems.
What could go wrong
This is a small, early pilot study with no placebo group, so results may not be reliable. The supplement may have no real effect on sleep or Alzheimer's markers.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Emory University School of Nursing
Atlanta, Georgia, 30322, United States
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Goizueta Alzheimer's Disease Research Center
Atlanta, Georgia, 30329, United States