Persistent atrial fibrillation

This study tests whether adding extra scar lines in the heart, along with the standard vein isolation procedure, helps people with persistent atrial fibrillation stay in normal rhythm longer. About 640 adults aged 18–80 with symptomatic, drug-resistant persistent AFib will be ran…

This study follows 580 adults with atrial fibrillation who are treated with the PulseSelect PFA system, a device that uses electrical pulses to fix irregular heartbeats. Researchers will monitor participants for 36 months to see how well the procedure prevents heart rhythm proble…

This study tests a new device called FARAFLEX that uses electrical pulses to treat atrial fibrillation (AF), a condition where the heart beats irregularly. About 571 adults with AF that hasn't improved with medication will get this procedure. The goal is to see if it safely resto…

This study tests a new catheter called VARIPULSE against an already approved one, FARAWAVE, for people with persistent atrial fibrillation (a long-lasting irregular heartbeat). About 466 participants will receive one of the two treatments to see which is safer and better at resto…

This trial asks whether people with permanent atrial fibrillation (AF) can continue drinking caffeinated coffee without worsening their heart rate control. Half of the participants will keep their usual coffee habit, while the other half will switch to decaf for a month, then swa…

This study is testing a new device called the VARIPULSE catheter system to treat persistent atrial fibrillation, a type of irregular heartbeat. The device uses pulsed field ablation to isolate specific heart veins and may be combined with a procedure to close off a heart pouch to…

This study tests a new catheter system (Sphere-9) for a repeat heart ablation procedure in 400 people whose atrial fibrillation came back after an earlier ablation. The procedure uses radiofrequency and pulsed field energy to correct faulty heart signals. Participants will be fol…

This study is testing the FARAPULSE Pulsed Field Ablation system in 376 people with persistent atrial fibrillation (AFib) who have already had a prior ablation. The device uses electrical pulses to destroy the heart tissue causing the abnormal rhythm. The goal is to see if it is …

This study tests a new procedure using pulsed field energy to treat atrial fibrillation (AFib), a common heart rhythm problem. The procedure isolates the pulmonary veins and the back wall of the left atrium to stop abnormal signals. About 442 adults with symptomatic AFib will be …

This study tests new waveforms delivered by the FARAPULSE PFA system to treat atrial fibrillation, a common heart rhythm problem. About 200 adults with paroxysmal or persistent atrial fibrillation will receive the procedure. The goal is to see if these new waveforms are safe and …

This study is testing a new device called the FARAFLEX system, which uses targeted electrical pulses to treat atrial fibrillation, a common heart rhythm problem. About 250 adults with persistent or paroxysmal atrial fibrillation will take part. The goal is to see if the device is…

This trial compares two catheter ablation strategies for people with persistent atrial fibrillation (AF). One group receives standard pulmonary vein isolation using pulsed-field ablation; the other receives radiofrequency ablation followed by additional map-guided targeting of ab…

This study compares two common procedures—radiofrequency and cryoablation—for treating persistent atrial fibrillation, a heart rhythm disorder that raises stroke risk. Researchers will track 158 adults over 24 months to see which method better prevents strokes, transient ischemic…

This study tests a new device that uses short bursts of electricity to treat atrial fibrillation (AF), a common heart rhythm problem. About 360 adults with AF will receive the procedure to see if it safely restores a normal heartbeat. The goal is to improve symptoms and quality o…

This study tests a new mapping system (CoreMap) to help doctors treat persistent atrial fibrillation (AFib), a type of irregular heartbeat. About 245 adults with persistent AFib will have a standard procedure called ablation, but with the CoreMap system guiding the treatment. The…

This study compares two ablation methods for people with persistent atrial fibrillation (AFib), a heart rhythm problem. One group gets standard treatment (isolating the pulmonary veins), while the other gets that plus extra ablation on the back wall of the heart and a nearby vein…

This study tests doing two procedures at once for people with atrial fibrillation (AFib): a catheter ablation to restore normal heart rhythm and a device implant to close off a part of the heart where clots form. The goal is to see if this combined approach is safe and effective …

This study is testing a new system (VARIPULSE catheter and TRUPULSE generator) with updated software to treat atrial fibrillation, a condition where the heart beats irregularly. The goal is to see how well the system works in a real-world setting, measuring procedure times and sa…

This registry tracks 20,000 people with atrial fibrillation or ventricular arrhythmias who undergo catheter ablation using advanced CARTO mapping technologies. The goal is to see how safe and effective these procedures are in everyday medical practice. Researchers will monitor he…

This pilot study tests whether using a noninvasive global mapping system to guide catheter ablation can improve outcomes for people with persistent atrial fibrillation. Thirty participants will receive standard pulmonary vein isolation plus personalized ablation of up to three ad…

This study tests a new system (VARIPULSE catheter and TRUPULSE generator) with updated software for treating persistent atrial fibrillation, a long-lasting irregular heartbeat. About 50 adults aged 18-75 who have not responded to medication will undergo a heart ablation procedure…

This study tests a new two-step procedure for people with long-standing persistent atrial fibrillation (AFib), a type of irregular heartbeat. The procedure combines a minimally invasive surgery on the outside of the heart with a standard catheter ablation inside the heart. Resear…

This study is testing a new procedure called pulsed-field ablation to treat persistent atrial fibrillation, a common heart rhythm problem. The procedure uses non-thermal energy to isolate the pulmonary veins, aiming to stop abnormal heart signals. Researchers will follow 60 parti…

This study is tracking 300 people with paroxysmal or persistent atrial fibrillation (AFib) who are treated with the Volt PFA System, a balloon-based device that uses pulsed field ablation to correct irregular heart rhythms. Researchers are monitoring safety—looking for serious si…

This study tests whether using a special radiofrequency ablation device during open-heart surgery can safely stop persistent atrial fibrillation (AFib). About 160 people with long-lasting AFib who need heart surgery for other reasons will receive the ablation. The goal is to see …

This study tests a personalized approach to catheter ablation for persistent atrial fibrillation (AF), a common heart rhythm disorder. Researchers will identify specific areas in the heart that drive AF and target them with ablation, aiming to improve success rates. The trial inv…

This study tests whether treating extra scar tissue in the heart's upper chamber, along with the standard vein isolation, can better control atrial fibrillation (AF) in people with persistent AF. About 204 adults with moderate scarring will be randomly assigned to standard treatm…

This study tests a digital toolkit called the Corrie Virtual Atrial Fibrillation Management Program, designed to help people with atrial fibrillation learn about treatment options, stick to therapies, and manage episodes. Researchers will enroll 248 adults with AFib and a BMI of …

This study is testing a procedure called pulsed field ablation (PFA) to treat atrial fibrillation, a common heart rhythm problem, in patients from racial and ethnic minority groups. About 275 participants will receive the standard PFA treatment using FDA-approved catheters, and r…

This study tests if people with atrial fibrillation (an irregular heartbeat) can use a smartwatch to decide when to take blood thinners, instead of taking them every day. About 5,350 adults with a low-to-moderate stroke risk will be randomly assigned to either standard daily bloo…

This study tests whether Qidong Yixin Granules, an herbal medicine, can reduce the chance of atrial fibrillation returning within a year after a standard heart ablation procedure. About 846 adults with persistent atrial fibrillation will be randomly assigned to receive either the…

This study tests whether a catheter ablation procedure can reduce severe mitral valve leakage in people with persistent atrial fibrillation (a type of irregular heartbeat). About 146 adults aged 18-80 with both conditions will either get the ablation plus standard care or just st…

This study tests a new way to treat persistent atrial fibrillation (AFib) by targeting specific high-frequency areas in the heart that may be driving the condition. Researchers will compare this new ablation method to standard treatment in 78 adults with long-lasting AFib or recu…

This study tests whether a heart procedure called catheter ablation can slow down memory loss in people with mild cognitive impairment who also have a common heart rhythm problem called atrial fibrillation. 120 participants will be randomly assigned to get either the ablation plu…

This pilot study tests whether a non-invasive global mapping system can help doctors personalize catheter ablation for people with persistent atrial fibrillation (AF). The standard approach isolates the pulmonary veins, but this study adds up to three extra targets based on where…

This study looks at whether combining a heart procedure called ablation with a 12-week home exercise program can improve how well the body uses oxygen in people with a type of heart failure (HFpEF) and a common heart rhythm problem (atrial fibrillation). About 40 participants wil…

This early study tests a new catheter that changes shape to better treat persistent atrial fibrillation (AF), a type of irregular heartbeat. The catheter can switch between a large 'petal' shape for quick vein isolation and a small 'bud' shape for precise linear ablation. Forty a…

This study looks at whether a lower daily dose of the heart medication amiodarone can keep the heart in a normal rhythm as well as the standard dose, but with fewer side effects. About 312 adults with persistent atrial fibrillation who have had a successful electrical shock to re…

This study tests whether adding a kidney nerve-zapping procedure (renal artery denervation) to the standard heart ablation procedure can better control persistent atrial fibrillation (AF). About 50 adults with persistent AF and controlled or no high blood pressure will be randoml…

This study tests whether a newer, two-step hybrid ablation procedure works better than standard catheter ablation for people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 participants will be randomly assigned to one of the two p…

This study compares two approaches for people with permanent atrial fibrillation and heart failure with preserved ejection fraction. One group gets a pacemaker plus a procedure to ablate (destroy) the heart's AV node, while the other group continues with standard heart rate medic…

This study looks at whether screening for and treating sleep apnea can reduce the burden of atrial fibrillation (AFib) in patients who are candidates for heart ablation. Fifty adults with paroxysmal or persistent AFib that hasn't responded to medication will be screened for sleep…

This trial compares three different catheter ablation strategies for people with persistent atrial fibrillation (AFib), a heart rhythm problem. Sixty adults aged 18-80 will be randomly assigned to one of three approaches using a special catheter that can switch between two energy…

This study compares two procedures for treating persistent atrial fibrillation (AF): catheter ablation (which scars tiny areas in the heart to block faulty signals) and DC cardioversion (an electric shock to restore normal rhythm). Researchers want to see which one better prevent…

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This study evaluates a new multichannel ECG system designed to detect early signs of cardiovascular disease (CVD) in people who may have no symptoms yet. The system uses advanced algorithms to analyze electrical signals from the heart, looking for subtle abnormalities that could …

This study compares electrical cardioversion—a procedure that delivers a shock to restore normal heart rhythm—to a sham version where no shock is given. Researchers want to see if the real procedure truly improves quality of life in people with persistent atrial fibrillation, a c…

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study compares two types of supervised exercise programs—high-intensity interval training (HIIT) and moderate-intensity continuous exercise—against standard care alone in 132 adults with persistent or permanent atrial fibrillation. Participants will exercise twice weekly for…

This study is testing a new paddle-shaped catheter designed to map the heart's electrical signals in people with various heart rhythm disorders like atrial fibrillation and ventricular tachycardia. The device has many sensors to create a detailed map of the heart's chambers. The …

This study tests a new software module that analyzes heart signals during a procedure called pulsed field ablation, used to treat atrial fibrillation. The goal is to see if the software can accurately tell doctors when the targeted heart veins are fully isolated. One hundred adul…

This study will collect ECG recordings from 600 people using the HeartBeam 3-Lead ECG recorder. The goal is to build a database of heart rhythm information for future research and regulatory use. Participants will have their ECG taken as part of routine care, and their de-identif…

This study tests a new imaging system called VERAFEYE that helps doctors see inside the heart during a common procedure called catheter ablation. The procedure treats irregular heartbeats like atrial fibrillation. About 50 adults will take part to see if the system works well and…

This study is testing a new 3D imaging system that helps doctors see inside the heart during a procedure to treat atrial flutter and atrial fibrillation. About 50 adults who are already scheduled for a catheter ablation will have their procedure guided by this system. The goal is…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This Stanford study looks at 200 people with persistent atrial fibrillation (AF) who are scheduled for ablation or Maze surgery. Researchers will map the heart's electrical activity to see if the size of organized areas predicts whether the procedure works. The goal is to better …

This study looks at whether MRI scans can help predict serious heart events in people who have implanted heart devices like pacemakers or defibrillators. Researchers will scan 1,500 adults before they get their device and track their health for years. The goal is to see if MRI fi…

This study at St Bartholomew's Hospital is enrolling 160 people with persistent atrial fibrillation (AFib) who are scheduled for their first catheter ablation. Researchers will create detailed 3D electrical maps of the heart during the procedure to understand why AFib persists an…

This study is testing a special heart monitor, the BIOMONITOR IV, in 300 people with heart failure who also have irregular heartbeats. The device tracks heart activity, fluid levels, and breathing patterns to see if it can predict when heart failure gets worse. Researchers hope t…