New heart device aims to cut stroke risk without lifelong pills

NCT ID NCT07278869

Recruiting now Disease control Sponsor: Append Medical Ltd. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early study tests a new device called the Append System in 15 adults with atrial fibrillation (a type of irregular heartbeat). The device is threaded through a blood vessel to close off a small pouch in the heart called the left atrial appendage, where clots often form. The goal is to see if the procedure is safe and can reduce stroke risk, potentially offering an alternative to long-term blood thinners.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Append System (a catheter-based device that closes the left atrial appendage by turning it inside out and tying it off)
What this could lead to: If this device works safely, it could offer a new way to lower stroke risk in people with atrial fibrillation who cannot take blood thinners long-term.
What could go wrong: This is a very early feasibility study with only 15 people, so results may not apply broadly. The procedure carries risks like stroke, bleeding, or heart sac inflammation.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-VALVULAR ATRIAL FIBRILLATION

Contacts and locations

Locations

Arrhythmia Research Group
RECRUITING

Jonesboro, Arkansas, 72401, United States
Cedars-Sinai Medical Center
RECRUITING

Los Angeles, California, 90048, United States
Icahn School of Medicine at Mount Sinai
RECRUITING

New York, New York, 10029, United States

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