New heart device aims to cut stroke risk without lifelong pills
NCT ID NCT07278869
First seen Jan 09, 2026 · Last updated Jun 23, 2026 · Updated 26 times
Summary
This early study tests a new device called the Append System in 15 adults with atrial fibrillation (a type of irregular heartbeat). The device is threaded through a blood vessel to close off a small pouch in the heart called the left atrial appendage, where clots often form. The goal is to see if the procedure is safe and can reduce stroke risk, potentially offering an alternative to long-term blood thinners.
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Arrhythmia Research Group
RECRUITINGJonesboro, Arkansas, 72401, United States
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Cedars-Sinai Medical Center
RECRUITINGLos Angeles, California, 90048, United States
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10029, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Append System (a catheter-based device that closes the left atrial appendage by turning it inside out and tying it off)
What this could lead to
If this device works safely, it could offer a new way to lower stroke risk in people with atrial fibrillation who cannot take blood thinners long-term.
What could go wrong
This is a very early feasibility study with only 15 people, so results may not apply broadly. The procedure carries risks like stroke, bleeding, or heart sac inflammation.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.