New hope for stroke survivors: closing a heart pouch may cut stroke risk
NCT ID NCT05976685
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking anticoagulants. Participants are randomly assigned to get the procedure plus blood thinners or just blood thinners, and are followed for up to 4 years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Left atrial appendage occlusion (a procedure to close a heart pouch) plus direct oral anticoagulants (blood thinners)
What this could lead to
If it works, this could offer a new way to reduce the risk of another stroke in people with atrial fibrillation who still have strokes despite taking blood thinners.
What could go wrong
This is a mid-sized trial, and the procedure carries risks like bleeding or device complications. It may not prove superior to blood thinners alone, and results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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AZ Sint Jan Brugge
RECRUITINGBruges, 8000, Belgium
Contact Email: •••••@•••••
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Asklepios Klinik Altona
RECRUITINGHamburg, 22763, Germany
Contact
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Brussels University Hospital
RECRUITINGBrussels, 1090, Belgium
Contact Email: •••••@•••••
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CHU Liège Sart-Tilman
RECRUITINGLiège, 4000, Belgium
Contact Email: •••••@•••••
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Centre Hospitalier Universitaire Vaudois
RECRUITINGLausanne, Vaude, 1011, Switzerland
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Charité-Universitätsmedizin Berlin
RECRUITINGBerlin, 12203, Germany
Contact Email: •••••@•••••
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Christchurch Hospital
RECRUITINGChristchurch, 8011, New Zealand
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Ente Ospedaliero Cantonale
RECRUITINGLugano, Canton Ticino, 6900, Switzerland
Contact
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HUmani CHU Charleroi-Chimay
RECRUITINGCharleroi, 6000, Belgium
Contact Email: •••••@•••••
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Hosp. Barcelona Santa Creu y Sant Pau
RECRUITINGBarcelona, 08025, Spain
Contact Email: •••••@•••••
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Hosp. Clínic of Barcelona
RECRUITINGBarcelona, 08036, Spain
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Hôpitaux universitaires de Genève
NOT_YET_RECRUITINGGeneva, 1211, Switzerland
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Inselspital, University Hospital Bern
RECRUITINGBern, 3010, Switzerland
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Kantonsspital St. Gallen
RECRUITINGSankt Gallen, 9007, Switzerland
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Luzerner Kantonsspital
NOT_YET_RECRUITINGLucerne, 6000, Switzerland
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St Bartholomew's Hospital
RECRUITINGLondon, EC1A 7BE, United Kingdom
Contact Email: •••••@•••••
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St Thomas' Hospital
RECRUITINGLondon, United Kingdom
Contact Email: •••••@•••••
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UCLouvain - Cliniques universitaires Saint-Luc
RECRUITINGBrussels, 1200, Belgium
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UKSH, Campus Lübeck
RECRUITINGLübeck, Schleswig-Holstein, 26538, Germany
Contact Email: •••••@•••••
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Universitair Ziekenhuis (UZ) Leuven
RECRUITINGLeuven, 3000, Belgium
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University Hospital Basel
RECRUITINGBasel, 4031, Switzerland
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University Hospital Heidelberg
RECRUITINGHeidelberg, 69120, Germany
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University Hospitals Sessex NHS Trust
RECRUITINGWorthing, United Kingdom
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Universitätsklinikum Bonn
RECRUITINGBonn, 53127, Germany
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Universitätsklinikum Leipzig
RECRUITINGLeipzig, 04103, Germany
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Universitätsklinikum Tübingen
RECRUITINGTübingen, 72076, Germany
Contact Email: •••••@•••••
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Universitätsmedizin Göttingen
RECRUITINGGöttingen, 37075, Germany
Contact Email: •••••@•••••
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Universitätsmedizin Mannheim
RECRUITINGMannheim, 68167, Germany
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Vall d'Hebron University Hospital
RECRUITINGBarcelona, 08035, Spain
Contact Email: •••••@•••••