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New hope for stroke survivors: closing a heart pouch may cut stroke risk

NCT ID NCT05976685

Recruiting now Disease control Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 24, 2026 · Updated 2 times

Summary

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking anticoagulants. Participants are randomly assigned to get the procedure plus blood thinners or just blood thinners, and are followed for up to 4 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Left atrial appendage occlusion (a procedure to close a heart pouch) plus direct oral anticoagulants (blood thinners)
What this could lead to
If it works, this could offer a new way to reduce the risk of another stroke in people with atrial fibrillation who still have strokes despite taking blood thinners.
What could go wrong
This is a mid-sized trial, and the procedure carries risks like bleeding or device complications. It may not prove superior to blood thinners alone, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation ischemic stroke stroke disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION ISCHEMIC STROKE

Contacts and locations

Locations

  • AZ Sint Jan Brugge

    RECRUITING

    Bruges, 8000, Belgium

  • Asklepios Klinik Altona

    RECRUITING

    Hamburg, Free and Hanseatic City of Hamburg, 22763, Germany

  • Brussels University Hospital

    RECRUITING

    Brussels, 1090, Belgium

  • CHU Liège Sart-Tilman

    RECRUITING

    Liège, 4000, Belgium

  • Centre Hospitalier Universitaire Vaudois

    RECRUITING

    Lausanne, Vaude, 1011, Switzerland

  • Charité-Universitätsmedizin Berlin

    RECRUITING

    Berlin, State of Berlin, 12203, Germany

  • Christchurch Hospital

    RECRUITING

    Christchurch, Christchurch, 8011, New Zealand

  • Ente Ospedaliero Cantonale

    RECRUITING

    Lugano, Canton Ticino, 6900, Switzerland

  • HUmani CHU Charleroi-Chimay

    RECRUITING

    Charleroi, 6000, Belgium

  • Hosp. Barcelona Santa Creu y Sant Pau

    RECRUITING

    Barcelona, 08025, Spain

  • Hosp. Clínic of Barcelona

    RECRUITING

    Barcelona, 08036, Spain

  • Hospital Clínico San Carlos (HCSC)

    RECRUITING

    Madrid, 28040, Spain

  • Hôpitaux universitaires de Genève

    NOT_YET_RECRUITING

    Geneva, Canton of Geneva, 1211, Switzerland

  • Inselspital, University Hospital Bern

    RECRUITING

    Bern, Canton of Bern, 3010, Switzerland

  • Kantonsspital St. Gallen

    RECRUITING

    Sankt Gallen, Canton of St. Gallen, 9007, Switzerland

  • Luzerner Kantonsspital

    NOT_YET_RECRUITING

    Lucerne, Canton of Lucerne, 6000, Switzerland

  • St Bartholomew's Hospital

    RECRUITING

    London, EC1A 7BE, United Kingdom

  • St Thomas' Hospital

    RECRUITING

    London, United Kingdom

  • UCLouvain - Cliniques universitaires Saint-Luc

    RECRUITING

    Brussels, Brussels Capital, 1200, Belgium

  • UKSH, Campus Lübeck

    RECRUITING

    Lübeck, Schleswig-Holstein, 26538, Germany

  • Universitair Ziekenhuis (UZ) Leuven

    RECRUITING

    Leuven, 3000, Belgium

  • University Hospital Basel

    RECRUITING

    Basel, Basel, 4031, Switzerland

  • University Hospital Heidelberg

    RECRUITING

    Heidelberg, 69120, Germany

  • University Hospitals Sessex NHS Trust

    RECRUITING

    Worthing, United Kingdom

  • Universitätsklinikum Bonn

    RECRUITING

    Bonn, 53127, Germany

  • Universitätsklinikum Leipzig

    RECRUITING

    Leipzig, Leipzig, 04103, Germany

  • Universitätsklinikum Tübingen

    RECRUITING

    Tübingen, 72076, Germany

  • Universitätsmedizin Göttingen

    RECRUITING

    Göttingen, 37075, Germany

  • Universitätsmedizin Mannheim

    RECRUITING

    Mannheim, Mannheim, 68167, Germany

  • Vall d'Hebron University Hospital

    RECRUITING

    Barcelona, 08035, Spain

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