Cardiac rhythm disease

This study tests a device that freezes small areas of heart tissue to treat paroxysmal atrial fibrillation (AFib), a condition where the heart beats irregularly. About 200 people with AFib that hasn't responded to medication will receive the procedure. Researchers will track safe…

This study tested whether starting ECMO (a heart-lung bypass machine) right at the location of a cardiac arrest, rather than waiting until the patient reaches the hospital, could improve survival with good brain function. Researchers enrolled 65 adults with refractory cardiac arr…

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This study tests whether a three-month smartphone-supported walking program can improve daily step counts, psychological well-being, and body composition in adults with cardiovascular disease or type 2 diabetes. Participants use the Walk15 app to set personalized step goals and t…

This study tested a coaching program called MACRO-I for adults aged 70 and older who had a heart event. The program used coaches to guide patients through starting cardiac rehab, either at a center, at home, or a mix of both. 416 participants were split into the coaching group or…

This study looked at 9 people with atrial fibrillation (AFib) that came back after an initial cryoballoon ablation. It compared two repeat ablation methods: another cryoballoon procedure versus radiofrequency ablation guided by a high-fidelity mapping system (Rhythmia). Participa…

This study tested two different catheters (lattice-tip vs standard irrigated-tip) for a heart procedure called ablation, which treats a fast heartbeat (atrial flutter). 102 adults received the procedure to see which catheter works better and faster with fewer side effects. The go…

This study tested whether adding vasopressin to the standard drug epinephrine helps more people survive a cardiac arrest that happens outside the hospital. Over 2,400 adults were enrolled. The main goal was to see how many patients were alive when they reached the hospital.

This study tested whether giving a more powerful antiplatelet drug (prasugrel or ticagrelor) for one month after a heart attack, along with a standard blood thinner, could reduce heart attacks, strokes, and deaths in people with atrial fibrillation. The 602 participants were then…

This completed study tested a new catheter and generator system designed to treat paroxysmal atrial fibrillation (AFib) — a common heart rhythm problem. The device uses pulsed field ablation (PFA) to target and destroy tiny areas of heart tissue causing the irregular rhythm. 188 …

This study tested whether placing the left ventricle lead of a cardiac resynchronization therapy (CRT) device at the heart's latest electrical activation spot improves outcomes. It included 1,000 heart failure patients with bundle branch block. The goal was to see if this targete…

This study tested a procedure called radiofrequency catheter ablation in 20 people with Brugada syndrome, a heart condition that can cause dangerous heart rhythms. Half received the real ablation, which uses heat to destroy small areas of heart tissue thought to cause the problem…

This study tested a new type of pacemaker that doesn't use wires (leads) to help both the upper and lower chambers of the heart beat in sync. It involved 464 people with slow heart rhythms who needed a pacemaker. The main goals were to see if the device was safe and worked well a…

This study tested whether using a CT scan before heart ablation can make the procedure faster and safer for people with ventricular tachycardia, a fast heart rhythm that can be life-threatening. 119 adults who had a prior heart attack and an implanted defibrillator were randomly …

This study tested a new type of pacemaker that doesn't need wires (leads) to connect to the heart. It was implanted directly into the heart in over 1,200 people with slow heart rhythms. The goal was to see if it is safe and works well. The study found that most patients had no se…

This study tested whether a newer blood thinner, rivaroxaban (Xarelto), is as safe and effective as the older drug warfarin for preventing strokes in people who develop atrial fibrillation after heart surgery. About 100 adults who had open-heart surgery and then experienced a new…

This study tested whether using a 3D electroanatomic mapping system (FARAVIEW) during pulsed field ablation helps create more precise lesions in the pulmonary veins of people with atrial fibrillation. Thirty-two participants were randomly assigned to receive ablation with or with…

This study tested whether a smartphone app that reminds patients to take their medication can improve how consistently people with atrial fibrillation take their blood thinner (rivaroxaban). Over 600 adults with AF and other health issues like high blood pressure or diabetes used…

This early study tested a new device called the FieldForce™ Ablation System in 34 people with ventricular arrhythmias (dangerous heart rhythms). The device uses pulsed electric fields to destroy the small areas of heart tissue causing the problem. The main goal was to see if the …

This study tested a new way to treat paroxysmal atrial fibrillation (a type of irregular heartbeat) using pulsed field energy instead of standard radiofrequency. 292 adults with drug-resistant AF took part. The goal was to see if the new method is faster, safer, and more effectiv…

This study tested whether using a smartphone app to alert nearby volunteers (called 'heart runners') to bring an automated external defibrillator (AED) to a suspected cardiac arrest can improve survival. Over 2,000 emergency calls were randomly assigned to either activate these v…

This study tested whether catheter ablation (a procedure to fix irregular heart rhythm) is better than standard rate-control medication for people with both atrial fibrillation and heart failure. Over 400 participants were randomly assigned to either ablation or medication. The m…

This completed study looked at whether two different blood thinners—dabigatran (Pradaxa) and warfarin (Coumadin)—could help prevent memory loss and dementia in people over 65 with atrial fibrillation (an irregular heartbeat). A total of 101 participants were randomly assigned to …

This study tested a new device called the Volt PFA System, which uses pulsed field ablation to treat atrial fibrillation (AF), a common heart rhythm problem. Researchers enrolled 392 people with symptomatic AF that didn't respond to medication. The goal was to see if the procedur…

This study tested a combination of two drugs, rivaroxaban and ticagrelor, in 40 patients with atrial fibrillation who had a stent placed. The goal was to see if this combo causes less bleeding and prevents heart attacks or strokes better than current treatments. Patients took the…

This study tested whether it is safe and feasible to perform two heart procedures—MitraClip to repair a leaky mitral valve and Watchman to close off a part of the heart linked to stroke risk—in one session. The trial enrolled 25 adults with both severe mitral regurgitation and at…

This study looked at 200 people with both heart failure and permanent atrial fibrillation. Participants received either a standard defibrillator (ICD) or one that also paces both lower heart chambers (CRT/ICD). The goal was to see if the extra pacing reduces heart size and improv…

This study tested whether low doses of digoxin, an old and cheap heart drug, can reduce hospitalizations and death in 982 heart failure patients. Participants received either digoxin or a placebo pill. The goal is to see if keeping digoxin levels low in the blood improves outcome…

This study tested a wearable defibrillator patch (the Jewel) in 18 adults who were already scheduled for a heart procedure. The patch was used to deliver a shock to stop dangerous heart rhythms that could lead to sudden cardiac arrest. The goal was to see how often the patch coul…

This study tested a wearable defibrillator called the Jewel P-WCD in 322 adults at high risk for sudden cardiac arrest. The device is designed to automatically deliver a shock to restore normal heart rhythm if a dangerous heart rhythm occurs. The main goals were to see how often …

This study looked at whether Vidaza, a drug used for acute leukemia, could also help treat atrial fibrillation (an irregular heartbeat). The idea was that Vidaza might reverse certain DNA changes that lower the activity of a gene important for heart function. Only one person took…

This study tested a once-daily pill called orforglipron against insulin glargine in nearly 2,750 adults with type 2 diabetes, obesity or overweight, and increased cardiovascular risk. The main goal was to see if orforglipron could reduce major heart events like heart attacks or s…

This study compared two hormone protocols for women with high ovarian response undergoing IVF. One used progesterone (dydrogesterone) and the other used a GnRH antagonist. The goal was to see which approach leads to more eggs retrieved and higher pregnancy rates. 200 women partic…

This trial tested a new ablation catheter (DiamondTemp) against the current standard (Tacticath/Tactiflex) for treating ventricular tachycardia (VT), a life-threatening fast heart rhythm. 61 adults with VT who needed ablation took part. The goal was to see if the new catheter is …

This study tested the WATCHMAN device, a small implant that closes off a part of the heart where clots often form, in 481 people with atrial fibrillation who cannot take blood thinners. The goal was to see if the device is safe and effective at reducing stroke risk. Participants …

This study tested two new devices that use energy pulses to treat persistent atrial fibrillation (a type of irregular heartbeat). 89 adults who had not responded to medication received a heart ablation procedure. The goal was to see if the devices are safe and can stop abnormal h…

This study compared two ways to treat paroxysmal atrial fibrillation (AFib) — a heart rhythm problem. One method uses a freezing balloon (cryoballoon), the other uses heat (radiofrequency). About 769 patients took part. The goal was to see if the freezing method works as well and…

This study tested a device called iCLAS™ that uses extreme cold to destroy tiny areas of heart tissue causing persistent atrial fibrillation (AFib). 215 adults with AFib lasting more than 7 days but less than a year received the procedure. Researchers tracked safety issues like h…

This early study tested whether placing a thin layer of human amniotic membrane on the heart during bypass surgery could reduce inflammation and prevent post-operative atrial fibrillation (an irregular heartbeat). Twenty-seven patients were randomly assigned to receive either the…

This study tested two ways of managing breathing during heart bypass surgery to see which better prevents lung complications. Over 1,500 adults having planned heart surgery were randomly assigned to either no breathing support or gentle, low-volume breaths while on the heart-lung…

This study tested whether taking an oral progesterone pill (Seidigestan) can prevent early ovulation during IVF as well as the standard daily injections (Astarté). 150 healthy egg donors participated. If the pill works just as well, it could make IVF more convenient and less pain…

This study tested a systematic 12-step workflow for a newer type of heart ablation (pulsed-field ablation) in 118 adults with atrial fibrillation. The goal was to see if this approach could better isolate the pulmonary veins and reduce the chance of the heart rhythm problem retur…

This study tested whether removing the ligament of Marshall during coronary artery bypass surgery could prevent a common complication: atrial fibrillation. 220 high-risk patients were randomly assigned to get the extra procedure or standard surgery alone. The goal was to see if t…

This study tested a new device called the OMNYPULSE catheter with the TRUPULSE generator to treat paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal was to see if it is safe and effective at isolating the veins that carry blood from the lungs to the heart. 1…

This study looked at whether giving a higher dose of vaginal progesterone (800 mg vs 1200 mg daily) can improve pregnancy rates in women with low progesterone levels on the day of embryo transfer. It involved 87 women undergoing a single frozen embryo transfer. The goal was to se…

This study tested a ready-to-use calcium ionophore medium (GM508 CultActive) on eggs from 68 IVF patients who had low fertilization rates, poor embryo quality, or were over 40. The medium was applied shortly after sperm injection to try to improve fertilization and embryo develop…

This study tested whether using a 3D-printed model of a heart chamber helps doctors better plan a procedure to close off a small pouch in the heart. This pouch, called the left atrial appendage, is a common source of blood clots that can cause stroke in people with atrial fibrill…

This pilot study tested whether community pharmacists can manage blood thinner therapy for older adults (60+) with atrial fibrillation who are at high risk for stroke but not on optimal treatment. Fourteen participants received pharmacist-led care for 3 months, then were followed…

This study tested a new freezing method (cryoablation) to treat a fast, dangerous heart rhythm called ventricular tachycardia. 64 adults who had not responded well to medication took part. The goal was to see if freezing the small area causing the problem could safely stop the rh…

This study tested whether permanent pacemakers can be safely implanted using only ultrasound (transthoracic echocardiography) instead of traditional X-ray guidance. Thirty-one adults with arrhythmias who needed a pacemaker took part. The goal was to see if the procedure could be …

This study tested whether a single dose of dantrolene, a muscle relaxant, could reduce the risk of dangerous heart rhythms in 68 people with structural heart disease who were scheduled for a procedure to treat ventricular tachycardia. Participants received either dantrolene or a …

This study tested a new device that uses short electrical pulses to treat a type of irregular heartbeat called paroxysmal atrial fibrillation. Ten patients received the procedure to see if it was safe and could stop the heart rhythm problem for at least 12 months. The goal was to…

This study tested whether the anti-inflammatory drug colchicine can reduce complications like irregular heartbeat, heart sac inflammation, and heart damage after coronary artery bypass surgery. 100 patients who had a recent heart attack and needed bypass surgery were randomly ass…

This study followed 364 people with paroxysmal atrial fibrillation (a type of irregular heartbeat) who had already received ablation treatment in a previous trial. Researchers compared a newer pulsed field ablation system with traditional thermal ablation to see how well each met…

This study tested a device called Amplatzer Amulet that closes a small pouch in the heart (left atrial appendage) in people with atrial fibrillation. The goal was to see if it safely reduces stroke risk without long-term blood thinners. 104 adults at high stroke risk took part ac…

This study compared a newer pacing method, called HIS or left bundle branch (LBB) pacing, to the standard biventricular pacing in 150 heart failure patients with a specific heart electrical problem (left bundle branch block). The goal was to see if the new method could improve he…

This study tested whether intensive dental cleaning and oral hygiene advice can improve gum health and also affect markers of heart disease and type 2 diabetes. About 200 adults with gum disease and either heart disease or diabetes (or prediabetes) took part. Researchers measured…

This study compares two types of ablation (pulsed-field vs cryoballoon) for treating atrial fibrillation in people with heart failure and reduced pumping function. Researchers looked back at 700 patients who had their first ablation to see which method works better and is safer. …

This study tests a device called the Farawave catheter, which uses electrical pulses to destroy heart tissue causing long-standing atrial fibrillation. Twenty adults with this condition for over a year will undergo the procedure. The goal is to see if it stops abnormal heart rhyt…

This study looked at whether a combination drug (sacubitril/valsartan) can stop atrial fibrillation from returning after a heart procedure called catheter ablation. The study included 320 older adults (ages 55-80) with high blood pressure and atrial fibrillation. Participants too…

This study tested whether a generic version of dronedarone hydrochloride tablets works the same as the brand-name drug MULTAQ in healthy adults. Fifty-one healthy male volunteers took a single dose of either the generic or brand drug under fasting conditions. The results showed t…

This pilot study tested a procedure called bilateral sympathectomy, which cuts certain nerves to the heart, in 45 Chagas disease patients with implantable defibrillators (ICDs) who had frequent dangerous heart rhythms. Participants were randomly assigned to receive the nerve-cutt…

This small completed study looked at a blood filtering procedure called double-filtration plasmapheresis (DFPP) in 5 kidney dialysis patients with very high levels of lipoprotein(a), a fatty substance linked to heart disease and blood clots. The goal was to see if DFPP could lowe…

This study tested a new system that uses electrical pulses to treat a type of irregular heartbeat called paroxysmal atrial fibrillation (AF). The system includes a special catheter and generator designed to safely and effectively stop the faulty signals causing the condition. 150…

This study tested a device called the Lariat to close off a small pouch in the heart (the left atrial appendage) in people with atrial fibrillation who cannot take blood thinners. The goal was to reduce the risk of stroke. Nine participants were enrolled, and the study measured h…

This study tested a new computer simulation, called a 'virtual heart,' to help doctors find the best spots to burn heart tissue (ablation) in patients with ventricular tachycardia (VT) caused by prior heart attacks. Ten adults with VT and scarred heart muscle were enrolled. The a…

This study tested a procedure that blocks certain nerves to the heart in 18 people with life-threatening, uncontrollable heart rhythm problems (called electrical storm). The goal was to see if it could reduce dangerous heart episodes and the need for defibrillator shocks. The app…

This study tested whether using a CO2-based algorithm to guide treatment of high lactate in patients with acute circulatory failure works better than standard care. 180 adults in intensive care were randomly assigned to either usual treatment or treatment guided by CO2 measuremen…

This study tested a new type of catheter (a thin tube) that uses heat to destroy tiny areas of heart tissue causing irregular heartbeats in people with paroxysmal atrial fibrillation (AFib). The catheter has a cooling system to prevent overheating. The trial involved 415 particip…

This study looked at whether rebamipide, a stomach-protecting drug, can prevent bleeding and ulcers in people with atrial fibrillation who take blood thinners (DOACs). 210 adults were randomly assigned to receive rebamipide, pantoprazole, or both for 24 weeks. The goal was to see…

This study tested a voltage-guided stepwise ablation strategy against the standard circumferential approach for treating atrial fibrillation. 130 adults with AF undergoing their first catheter ablation were randomly assigned to one of the two methods. The goal was to see if the s…

This study tested a special catheter system to treat people with a type of irregular heartbeat called paroxysmal atrial fibrillation (PAF) that didn't get better with medication. The treatment uses heat energy to isolate the veins that trigger the abnormal rhythm. The study inclu…

This study looked at whether using a CPAP machine at night can reduce episodes of atrial fibrillation (a type of irregular heartbeat) in people who also have obstructive sleep apnea. Twenty-five adults with both conditions were enrolled. Half used CPAP while the other half were o…

This completed study tested a multi-discipline care program for 343 adults with atrial fibrillation. Led by an electrophysiologist, the team aimed to uncover hidden risk factors and improve treatment. Researchers monitored AF burden and major cardiovascular events like stroke and…

This early-phase trial tested a single dose of the investigational drug THRV-1268 in 16 healthy obese adults to see if it is safe and tolerable. The drug is being developed as a potential treatment for heart failure. The study did not test effectiveness, only safety and how the d…

This study tested whether a drug called alirocumab, which lowers cholesterol, can reduce heart disease risk in people with HIV. The trial involved 118 adults aged 40 and older with well-controlled HIV and high heart disease risk. Participants received either alirocumab or a place…

This study tested a new device that uses electrical pulses to treat a type of irregular heartbeat called paroxysmal atrial fibrillation. 142 people who had not been helped by standard medications took part. The goal was to see if the procedure could keep their heart rhythm normal…

This completed trial looked at whether taking two cholesterol-lowering drugs (rosuvastatin and ezetimibe) is more effective and safer than taking just one (rosuvastatin) for people with heart disease. 66 adults with high cholesterol were randomly assigned to one of the two treatm…

This study tested a newer pacing method (left bundle branch area pacing) against the standard method (right ventricular pacing) in 486 adults with atrioventricular block, a condition where the heart's electrical signals are delayed. The goal was to see if the newer method better …

This study tested whether starting a portable heart-lung machine (ECPR) right at the scene of a cardiac arrest could save more lives and protect brain function. It included 221 adults aged 18-50 with witnessed cardiac arrest that didn't respond to standard CPR. The goal was to se…

This study tested whether a stellate ganglion block (a nerve injection) before coronary artery bypass surgery can prevent new atrial fibrillation, a common complication. 108 patients were included. The approach aims to calm the nervous system and reduce inflammation. Results coul…

This study tested whether using cardiac MRI to guide ablation (a procedure that destroys small areas of heart tissue) can improve outcomes for people with ventricular tachycardia, a dangerous fast heart rhythm. 104 adults with structural heart disease were randomly assigned to on…

This study tested the FARAPULSE system, a device that uses short electrical pulses to destroy small areas of heart tissue causing abnormal rhythms in people with persistent atrial fibrillation (AFib). The trial enrolled 669 adults with drug-resistant, symptomatic persistent AFib.…

This study tested a new tool called VISITAG that helps doctors track where they apply heat during a heart procedure for atrial fibrillation (AFib). The goal was to see if it makes the procedure safer and more effective at preventing irregular heartbeats for a year. 200 adults hav…

This study tested a procedure to close a small pouch in the heart (left atrial appendage) in people with atrial fibrillation who are at high risk for both stroke and bleeding. The goal was to see if this procedure works better than standard blood-thinning medications at preventin…

This study tested a single hybrid procedure that combines keyhole surgery with a catheter-based approach to treat complex atrial fibrillation (AF) in 12 patients. The goal was to see if this combined method could completely isolate the abnormal electrical signals in the heart. Th…

This study tested a special catheter and generator system to treat people with paroxysmal atrial fibrillation (AFib), a condition where the heart beats irregularly. The goal was to safely isolate the veins that trigger AFib and restore normal rhythm. 135 participants were treated…

This study tested a new type of wire (lead) for implantable heart devices that deliver shocks to stop dangerous fast heart rhythms. Researchers checked how safe and effective the lead was in 998 people who needed a defibrillator or heart failure device. The lead was placed in a s…

This study looked at how tissue covers the WATCHMAN FLX Pro device after it is placed in the heart to prevent strokes in people with atrial fibrillation. 43 participants received the implant and had follow-up CT scans and echocardiograms to check for any thickening on the device …

This study tested a high dose of a fertility drug called follitropin delta, mixed with another hormone (hCG), in 118 women undergoing IVF. The goal was to see if this combination could improve the number of good-quality embryos. The study was completed and focused on women aged 1…

This study tested a new approach for repeat catheter ablation in people with atrial fibrillation (AF) whose symptoms returned after a previous ablation. Doctors used a special software algorithm (VX1) to guide the procedure. The study included 96 adults and measured how many stay…

This study tested a two-part approach to prevent a common complication called atrial fibrillation after heart surgery. About 242 people having coronary bypass surgery received a preventive dose of the drug amiodarone and a surgical technique called posterior pericardiotomy. The g…

This study looked at how safe and effective a freezing treatment (cryoablation) is for people with a type of irregular heartbeat called paroxysmal atrial fibrillation (AFib). The treatment uses a device called POLARx to freeze heart tissue and stop the faulty signals causing AFib…

This study looked at whether stopping coffee helps prevent atrial fibrillation (AFib) from returning after a heart shock treatment called cardioversion. Two hundred coffee drinkers with AFib were randomly assigned to either keep drinking coffee or avoid it for six months. Researc…

This phase 3 trial tested whether high doses of epoetin alpha, a drug that boosts red blood cells and may protect the brain, could improve recovery in 500 comatose adults who survived a cardiac arrest. Half received the drug plus standard care, half got standard care alone. The m…

This study looked at whether giving ulinastatin during heart surgery can lower the chance of lung complications like infections or breathing failure. Researchers analyzed data from over 4,500 patients and also used computer models to understand how the drug works. The results sug…

This study tested a procedure called left atrial appendage occlusion (LAAO) against standard blood-thinning medications in 81 people with atrial fibrillation who were also getting a new heart valve (TAVI). The goal was to see if LAAO could prevent strokes and bleeding better than…

This pilot study tested a procedure to close the left atrial appendage—a small pouch in the heart where clots often form—in 58 patients with atrial fibrillation who had a prior brain bleed and cannot take standard blood thinners. The goal was to see if this approach could reduce …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study looked at 320 adults with paroxysmal atrial fibrillation (a type of irregular heartbeat) to compare two cryoballoon ablation techniques: freezing only the pulmonary veins versus freezing both the veins and the back wall of the heart's left upper chamber. The goal was t…

This study tested whether adding ablation of the left atrial posterior wall to standard pulmonary vein isolation reduces the return of atrial fibrillation in people with persistent AF. A total of 110 adults having their first catheter ablation took part. The goal was to see if th…

This study tracked 949 patients with non-valvular atrial fibrillation who received the WATCHMAN FLX Pro device, a small implant that closes off a part of the heart to reduce stroke risk. The goal was to see how well the device works in everyday medical practice, focusing on safet…

This study tested a device called the DiamondTemp system, which uses heat energy to destroy tiny areas of heart tissue causing irregular heartbeats in people with persistent atrial fibrillation. 376 adults with drug-resistant symptoms took part. The goal was to see if the procedu…

This phase 3 trial tested a special balloon catheter that uses radiofrequency energy to destroy tiny areas of heart tissue causing irregular heartbeats in people with symptomatic paroxysmal atrial fibrillation. The study enrolled 397 adults who had not responded to medication. Th…

This study tested a new device called NEURESCUE in 6 adults experiencing in-hospital cardiac arrest. The device is a balloon catheter inserted through the leg artery that inflates to redirect blood flow to the heart and brain. The goal was to see if it could be deployed quickly a…

This study tested whether adding a personalized, computer-model-guided ablation (OPTIMA) to the standard pulmonary vein isolation (PVI) procedure improves outcomes for people with persistent atrial fibrillation. 67 participants were randomly assigned to receive either PVI alone o…

This trial tested two blood thinners—rivaroxaban (Xarelto) and aspirin—in over 1,200 people with atrial fibrillation who had a successful ablation procedure. The goal was to see which one better prevents strokes and silent brain clots. Participants were followed for three years w…

This study tested whether sending mild electrical pulses just under the skin could help control heart rate in people with atrial fibrillation (AFib). 46 adults with symptomatic paroxysmal AFib who didn't respond to standard drugs were given a device implant. For two weeks, some r…

This study looked at whether metformin, a drug usually used for diabetes, can help prevent atrial fibrillation (an irregular heartbeat) from coming back after a standard procedure called catheter ablation. About 117 non-diabetic adults with a higher body weight took metformin or …

This study tested two different defibrillator waveforms—Zoll's 200J rectilinear biphasic shock and Lifepak's 360J biphasic truncated exponential shock—to see which restores normal heart rhythm better in people with atrial fibrillation. Over 500 adults were randomly assigned to re…

This completed study in Algeria followed 398 adults with atrial fibrillation who were taking the blood thinner Trombix (Rivaroxaban). The goal was to see how safe and effective the drug is in everyday medical practice, and how it affects quality of life. Researchers tracked serio…

This study looked at whether a three-month diet and exercise program before IVF could improve live birth rates in overweight and obese women. 197 women were randomly assigned to either the weight loss group or a control group. The goal was to see if losing weight beforehand leads…

This study tested a pacemaker feature called AutoAdapt that automatically adjusts timing settings to help the heart pump better. It involved 198 people with heart failure who needed a special pacemaker. The goal was to see if this smart feature improves symptoms, reduces hospital…

This study tested whether a device called WATCHMAN FLX, which closes a small pouch in the heart, is a good alternative to blood thinners for preventing strokes in people with atrial fibrillation (AF) after a heart procedure called ablation. About 1,600 high-risk patients were enr…

This study tested two non-thermal ablation systems in 100 people with paroxysmal atrial fibrillation to see which works better and is safer. Patients were randomly assigned to one of the two devices, and their heart rhythms were monitored for a year. The goal was to find out whic…

This study tested a new mapping feature (FARAVIEW™) used with a pulsed field ablation catheter (FARAWAVE NAV™) to treat atrial fibrillation. Fifty patients with symptomatic AFib that didn't respond to medication were included. The goal was to see how well doctors could isolate th…

This study compared two treatments for persistent atrial fibrillation (an irregular heartbeat): cryoablation (freezing tiny areas of heart tissue) and antiarrhythmic drugs. 196 patients were randomly assigned to one treatment and monitored for over a year. The goal was to see whi…

This study tested a device called the Laminar Left Atrial Appendage Closure System in 29 people with atrial fibrillation who cannot take blood thinners. The device is implanted to seal off a small pouch in the heart where clots often form. The goal was to see if it is safe and ef…

This study tested two ways to treat persistent atrial fibrillation (a type of irregular heartbeat) using catheter ablation. In one group, doctors aimed to stop the abnormal rhythm during the procedure. In the other, they followed a preset plan and used electrical shock if needed.…

This study tested a procedure called cryoballoon ablation in 1,420 people with atrial fibrillation (an irregular heartbeat) and severe heart failure. The goal was to see if freezing the veins that trigger the irregular rhythm could reduce recurrence of the heart rhythm problem an…

This study tested whether a tailored ablation approach, which targets specific abnormal areas in the heart, works better than the standard anatomical ablation for people with persistent atrial fibrillation (AFib). 377 adults with AFib that didn't respond to medication were includ…

This study tested whether a special type of dialysis (high-permeability hemodialysis) could help people in shock after being revived from cardiac arrest. The idea was to filter out inflammatory substances from the blood to improve blood pressure and reduce the need for strong med…

This study tested a new catheter system that uses pulsed field energy to treat atrial fibrillation and related arrhythmias. In 141 patients, doctors used the VARIPULSE catheter with a 3D mapping system to destroy the heart tissue causing the irregular rhythm. The goal was to see …

This completed study tested a new type of implantable defibrillator (EV ICD) in 14 Japanese patients with dangerous heart rhythms. The device is placed under the skin, outside the heart and blood vessels, to deliver a shock if a life-threatening rhythm occurs. Researchers checked…

This study tested whether wearing a small heart monitor (MEMO Patch PLUS) for 8 to 14 days finds more cases of hidden atrial fibrillation than wearing it for just 1 day. About 1,000 adults aged 75 or older (or with other stroke risk factors) wore the patch. The goal was to see if…

This study tested how well a small, portable device (LumiraDx) measures blood clotting (INR) compared to standard lab tests. Researchers collected blood from 420 adults, some taking warfarin and some not, using both a fingerstick and a vein draw. The goal was to see if the device…

This study tested whether two wearable devices—the Apple Watch and the Skylab CART-I ring—can accurately detect atrial fibrillation and other irregular heart rhythms compared to the standard 12-lead ECG. Researchers recruited 500 adults from UK cardiology clinics. Each participan…

This study looked at whether a special eye scan (SS-OCTA) can detect signs of cardiovascular disease. Researchers compared retinal blood vessel changes to results from a standard carotid ultrasound in 42 adults. The goal was to see if the eye scan could predict the presence or se…

This study tested a non-invasive mapping system (Cardioinsight®) to help doctors treat heart rhythm disorders. It included 492 patients who needed ablation, pacemaker implantation, or risk assessment for sudden death. The goal was to see if the mapping system improves outcomes co…

This study tested whether an iPhone ECG device (AliveCor) can accurately measure the QT interval of the heart compared to a standard 12-lead ECG. Researchers studied 29 hospitalized patients starting medications that can affect the QT interval. The goal was to see if the iPhone r…

This study tested whether a special algorithm in a pacemaker can accurately diagnose sleep apnea in people with heart problems. Researchers compared the pacemaker's readings to a standard overnight sleep test in 66 participants. They also looked for a link between sleep apnea sev…

This study tested whether a simple scoring system (ATE score) can safely rule out dangerous blood clots in the heart before a procedure for atrial fibrillation. Over 3,000 adults participated. The goal was to see if the score could replace a more uncomfortable ultrasound test, po…

This study tested whether an AI-powered smart stethoscope can accurately detect structural heart disease in over 6,600 students aged 10-18 in China. Trained staff used the device to listen to heart sounds, and the AI flagged potential issues. Students with positive results, plus …

This study tested a new non-invasive tool called ECG-Imaging that uses many electrodes on the body to create a 3D map of the heart's electrical activity. The goal was to see if it can more accurately locate the source of heart rhythm problems compared to a standard ECG. 362 parti…

This study tested whether a Withings device (BeamO with ECG app) can accurately detect atrial fibrillation, a common heart rhythm problem. Over 370 adults each had a 30-second ECG with the device and a standard 12-lead ECG for comparison. The goal was to see how well the device i…

This study tested a wearable heart monitor called Cardea SOLO against a standard 12-lead EKG to see if it could better detect paroxysmal atrial fibrillation (a temporary irregular heartbeat) in people who had a stroke of unknown cause and have an enlarged heart. 257 participants …

This study tested a new contrast agent called NH002 in 36 adults with heart disease. The agent is used during heart ultrasound to make the heart's chambers and borders clearer. The main goal was to check safety by monitoring vital signs, heart activity, and allergic reactions aft…

This study tested a new device called Masimo INVSENSOR00057 that records a single-lead ECG, similar to a standard lead I. Researchers compared its heart rate and atrial fibrillation detection against standard measurements in 365 adults, including healthy people and those with AFi…

This study tested whether an artificial intelligence algorithm (ZywieAI) can accurately analyze heart rhythm data collected from a wearable sensor (ZywieZ3) worn for 24 hours. The sensor was placed in non-traditional positions on the chest. Researchers compared the AI's findings …

This study tested whether an Apple Watch can detect atrial fibrillation (a heart rhythm problem) faster than usual methods in people aged 65 and older with high stroke risk. Over 400 participants wore the watch, which uses light sensors and an ECG to check heart rhythm. The goal …

This study tested whether making a small opening in the lining around the heart (called a left posterior pericardiotomy) can prevent new atrial fibrillation after coronary artery bypass surgery. 270 adults having bypass surgery were randomly assigned to get this extra cut or not.…

This study tested whether colchicine, an anti-inflammatory drug used for gout, can prevent new-onset atrial fibrillation and the need for a permanent pacemaker in people undergoing transcatheter aortic valve replacement (TAVI). About 120 older adults with severe aortic stenosis w…

This study tested an online psychological program designed to prevent depression in people with atrial fibrillation (AF), a common heart rhythm problem. The program combined phone or video sessions with online modules and exercises over 4-12 weeks. The trial included 28 adults wi…

This study looked at how often older adults with heart disease risk factors should exercise to improve fitness and blood pressure. Twenty-two participants did combined training either twice or three times a week for 12 weeks. The goal was to see which frequency worked better for …

This study tested whether a low-dose infusion of landiolol, a short-acting beta-blocker, could prevent atrial fibrillation in 400 non-Asian patients after cardiac surgery. Participants received either landiolol or a placebo for up to 48 hours after surgery. The goal was to see if…

This study tested an 8-week digital lifestyle program called MYCardio-PEER for low-income adults at risk of heart disease. Participants received weekly videos and infographics on healthy eating and exercise, plus group chats with peer leaders. The goal was to see if the program i…

This study tested whether making a small cut in the sac around the heart (posterior pericardiotomy) during open-heart surgery can prevent a common complication called atrial fibrillation. 210 adults having elective heart surgery in Yemen were randomly assigned to receive either t…

This study looked at whether a home-based physical activity program and computer-based cognitive training could help prevent memory loss in older women with heart disease. 253 women aged 65 and older participated. The goal was to see if these lifestyle changes could improve memor…

This completed study tested whether sending behavioral nudges through Denmark's official electronic letter system could increase flu vaccination among adults aged 18-64 with chronic diseases. Over 300,000 participants were randomly assigned to receive different types of letters o…

This study tested a computer algorithm called CartoFinder to help doctors better identify and treat complex heart rhythm problems (arrhythmias). 70 adults with persistent atrial fibrillation (a type of irregular heartbeat) took part. The goal was to see if the algorithm could imp…

This study tested whether an 8-week cardiac rehabilitation program using a stationary bike could improve cardiorespiratory fitness in 20 adults with atrial fibrillation. Participants exercised for 6 minutes, three times a week. The goal was to see if exercise capacity could incre…

This study tested whether wearing a virtual reality headset during heart device implantation (like pacemakers) could reduce patients' anxiety and pain. 111 adults were randomly assigned to use VR or standard care. The goal was to see if distraction through VR lowers stress and di…

This study looked at two methods to reduce pain after heart surgery through a cut in the chest bone. 120 adults received either a nerve block near the breastbone, pain medicine injected into the wound, or standard painkillers. Researchers measured pain levels using a saliva test …

This study tested a nasal spray called etripamil for people with a condition that causes sudden rapid heartbeats (PSVT). Participants, who had been in earlier studies, used the spray themselves at home to stop an episode. The main goal was to see if it was safe and easy to use ou…

This completed trial tested an 8-week program called Healing Hearts Together (HHT) for couples where one partner has heart disease. 474 couples attended weekly group sessions focused on communication, emotional support, and heart health. The goal was to see if the program improve…

This study tested whether a 20-minute session of nurse-led spiritual care, including prayer and relaxation techniques, could help heart surgery patients feel less anxious and have more stable blood pressure and heart rate before their operation. 248 adults in Indonesia took part.…

This study tested whether a commercial meal replacement weight loss programme could reduce atrial fibrillation (AF) symptoms in overweight adults aged 60-85 with persistent AF. 119 participants were randomly assigned to either the weight loss programme or usual care for 32-36 wee…

This study looked at whether a 12-week virtual exercise program could help women with cardiac implantable electronic devices (CIEDs) improve their physical fitness, quality of life, and mental health. Twenty women took part, doing either high-intensity interval training (HIIT) or…

This study tested whether a 3-month yoga program could improve physical and mental health in adults over 65 who had recently finished cardiac rehab. Participants attended yoga twice a week. Researchers measured balance, muscle strength, anxiety, and mood. The goal was to see if y…

This study tested whether showing patients with atrial fibrillation (AF) simple visual charts of common post-ablation symptoms could help them decide more confidently about undergoing the procedure. 75 adults with symptomatic AF who were considering catheter ablation used these d…

This study tested three different drug combinations to keep patients comfortable and still during a heart procedure called pulsed field ablation for atrial fibrillation. 240 adults were randomly assigned to one of three sedation groups. The goal was to see which method achieved t…

This study tested whether adding a tramadol injection to a continuous local anesthetic (levobupivacaine) delivered through a wound catheter can reduce the need for morphine after heart surgery via sternotomy. 160 adults undergoing various heart surgeries were enrolled. The goal w…

This completed study looked at 90 people with lower back pain from conditions like herniated discs or spinal stenosis. Researchers compared two different target areas for injecting numbing medicine during a lumbar spine block to see which provides better pain relief and blood flo…

This study tested a breathing exercise called the active cycle breathing technique in 120 adults who had just had heart surgery. The exercise combines controlled breathing, deep breaths, and huffing or coughing to help clear the lungs and improve breathing. Researchers measured w…

This study tested a 9-week internet-based cognitive behavioral therapy (CBT) program designed to reduce stress, anxiety, and depression in people with stable heart disease. 215 adults with heart disease and elevated stress or mood symptoms took part. The program was personalized …

This study tested whether a website called Heartsight could help close family members of cardiac arrest patients feel less uncertain, anxious, and burdened. Fifty-three family members were given access to the website or usual care. The goal was to see if the website was easy to u…

This study tested whether giving calcium before the drug diltiazem can prevent a sudden drop in blood pressure in people with a fast heart rate due to atrial fibrillation or flutter. 92 adults took part. The goal was to make the treatment safer and more comfortable.

This study tested a short mindfulness and exposure therapy program in 13 adults with atrial fibrillation who also had high anxiety sensitivity. The goal was to see if the therapy could reduce heart-related anxiety, symptom burden, and AFib episodes. Participants attended 4-5 indi…

This study tested a mind-body program called 'Recovering Together after Cardiac Arrest' for survivors and their caregivers. 14 pairs (survivor and caregiver) took part to see if the program was feasible and helpful. The goal was to reduce emotional distress and improve well-being…

This study tested a remote magnetic catheter ablation technique for treating atrial fibrillation, a common heart rhythm problem. Researchers followed 804 patients to see how safe the procedure was, how much radiation it used, and how well it worked. The goal was to improve routin…

This study tested whether adding virtual reality (VR) driving simulations to standard cardiac rehabilitation helps heart surgery patients feel less anxious and depressed. Sixty adults recovering from heart surgery took part. The results suggest VR can improve emotional well-being…

This study tested whether online group exercise training could help children aged 6-18 with pacemakers become more active and improve their strength and quality of life. 36 children were split into two groups: one did online exercise sessions three times a week for eight weeks, w…

This study explored how family members share health information about genetic diseases like sickle cell, diabetes, and cancer. Over 1,000 adults completed surveys or interviews about their family health history and support. The goal was to understand social and relational factors…

This study followed 601 adults who survived a cardiac arrest outside the hospital. Researchers wanted to learn how many survive long-term and how their quality of life and daily functioning are affected. The goal is to better understand what helps people recover and live well aft…

This study looks at medical records from France to see how doctors prescribe blood thinners to people with atrial fibrillation (an irregular heartbeat) who also have a high risk of stomach bleeding. The goal is to understand which treatments are used and how often serious bleedin…

This study looks at why people on dialysis for kidney failure often have dangerous heart rhythms. Researchers implanted a small heart monitor in 18 patients to track their heartbeats for up to three years. They also used CT scans and ultrasound to see if the dialysis procedure it…

This pilot study looked at whether it's possible to run a larger trial comparing two types of exercise—moderate steady exercise and high-intensity interval training—on symptoms of atrial fibrillation (AF), a common heart rhythm problem. Researchers enrolled 25 men and women with …

This study follows 340 people with atrial fibrillation who are having their first ablation procedure. Researchers will track heart rhythm using remote monitoring, along with imaging and blood tests, to find which factors—like patient health, heart structure, or electrical signals…

This study looked at 70 people aged 75 and older with atrial fibrillation who were taking a Xaban blood thinner (dabigatran, rivaroxaban, or apixaban) during an unplanned hospital stay. Researchers wanted to see if certain clinical or lab factors were linked to higher drug levels…

This study looked at over 2,100 patients aged 80 and older with atrial fibrillation who were taking the blood thinner warfarin. Researchers wanted to see if having multiple other health conditions (comorbidities) made it harder to keep their blood thinning levels stable. The goal…

This study looked at two ways to improve CPR during cardiac arrest: changing how often rescuers switch (every 2 vs. 4 minutes) and using a device called CPRmeter that gives real-time feedback on chest compressions. Researchers measured the quality of compressions in 51 patients. …

This small, completed study tested whether special pacing signals from a pacemaker could help control blood pressure in people with slow heartbeats. Five adults who needed a pacemaker or similar device took part. Researchers measured blood pressure and heart function during brief…

This study looks at how inherited heart rhythm problems (like Long QT Syndrome) and heart muscle diseases (like Hypertrophic Cardiomyopathy) affect the quality of life and physical activity of children aged 6 to 18. Researchers will compare 107 children with these conditions to 1…

This study looked at 130 adults who survived a cardiac arrest outside the hospital and were treated with cooling therapy. Researchers measured two simple tests—a blood protein level and a motor response score—to see if they could predict brain function 6 months later. The goal is…

This study reviewed records of 630 adults who survived a cardiac arrest and were treated in an ICU in Italy over 14 years. Researchers compared outcomes across three time periods when different official treatment guidelines were in use. The goal was to see if newer guidelines led…

This pilot study tested whether giving inhaled nitric oxide gas during laparoscopic surgery could protect blood vessels and organs in 40 adults with heart disease. Half received the gas through their breathing tube during surgery, and half received standard care. Researchers meas…

This study tested a new tool called a linear cognitive aid to help emergency medical teams treat children during critical situations like cardiac arrest. The tool gives simple, step-by-step instructions based on the child's age and emergency type. Researchers compared teams using…

This study tracked 883 adults with atrial fibrillation to see how consistently they took their direct oral anticoagulants (blood thinners). Researchers used pharmacy refill records and a simple questionnaire to measure adherence. The goal was to find patterns that could help iden…

This completed study observed 528 adults who had heart surgery and were admitted to the intensive care unit (ICU). Researchers tracked deaths, serious complications like stroke or infection, and patient details to identify risk factors. The goal is to use this information to impr…

This study looked at whether it's safe to skip the defibrillation test when implanting a subcutaneous implantable cardioverter-defibrillator (S-ICD). The test involves purposely triggering a dangerous heart rhythm to make sure the device can stop it. About 965 people took part. T…

This study tested if using the lower leg to push on the chest during CPR works as well as the standard hand method. About 99 paramedic and nursing students performed two minutes of chest compressions on a manikin, either with their hands or their dominant foot. The goal was to se…

This study tested whether individually adjusting the timing (atrioventricular delay) of a pacemaker improves heart function in 39 adults with conduction system pacing. Researchers used echocardiography to optimize settings and measured changes in heart strain, pumping ability, an…

This study enrolled 91 people with atrial fibrillation to see if computer simulations can identify the main electrical problem causing their irregular heartbeat. Participants had heart imaging, mapping, and symptom tracking before and after a standard ablation procedure. The goal…

This study measured how two common blood thinners (rivaroxaban and apixaban) behave in 193 adults with active cancer who also had blood clots or atrial fibrillation. Researchers aimed to understand factors like age, weight, and kidney function that affect drug levels. The goal wa…

This study tested whether a CT scan before a heart procedure could help doctors better target the source of a dangerous heart rhythm called ventricular tachycardia. 23 people who had a prior heart attack and needed catheter ablation took part. The approach aimed to see if using C…

This study looked at 636 older Italian patients with a type of irregular heartbeat called non-valvular atrial fibrillation (NVAF). Researchers wanted to understand why some patients start taking blood thinners and others do not, and how long they stay on their treatment. The goal…

This study looks at 250 people with atrial fibrillation who are having a hybrid ablation procedure. Researchers want to find out which factors—like clinical history, blood markers, and genetics—are linked to the procedure failing. The goal is to create a risk profile that helps d…

This study looked at 150 Caribbean Hispanic adults with heart disease or stroke risk who take the blood thinner clopidogrel. Researchers wanted to see if certain gene variants affect how well the drug works. The goal is to understand why some people get less benefit and to pave t…

This study tested a new catheter designed to measure the heart's electrical signals in people with irregular heartbeats (atrial fibrillation, ventricular fibrillation, or junctional tachycardia). Researchers enrolled 42 adults to see if the device could better identify abnormal e…

This study collected medical and social information from 111 patients having their first ablation for atrial fibrillation, a common heart rhythm problem. Researchers wanted to understand how factors like income, education, location, and ethnicity might affect who receives this tr…

This completed study looked at how rising temperatures affect people with chronic conditions like heart disease, diabetes, and depression. Researchers in Germany and Italy surveyed 176 patients to see what symptoms they experienced during heat and what protective steps they took.…

This early-phase study in 17 healthy male volunteers examines how a natural sugar modification on the heart hormone ANP changes its effects on blood pressure and fluid balance. Participants receive intravenous infusions of both the sugar-modified and unmodified forms of the hormo…

This study tested a new way to predict dangerous heart rhythm problems after a common heart valve procedure called TAVR. Researchers combined ECG results with CT scan measurements and implant depth to see if they could safely identify low-risk patients. The study looked back at 2…

This study looked at 200 adults having a cardiac arrest outside the hospital to see how long it takes paramedics to get a working IV or IO line. The goal was to find out what causes delays or failures when trying to start an IV first and then switching to an IO if needed. The res…

This study looked at whether a special mapping tool called vMap can help doctors perform heart ablations more efficiently for people with irregular heartbeats (arrhythmias). Researchers tracked 112 patients to see if using vMap reduced procedure time and improved success rates. T…

This study examines how often patients and their relatives develop post-traumatic stress disorder (PTSD) after a sudden cardiac arrest. Researchers interviewed 45 people (20 survivors and 20 relatives) within a week of the event and again at 3 months using standard questionnaires…

This study checked how well over 5,000 heart patients follow their prescribed medicine routine. Researchers asked patients about their medication habits and any side effects. The goal was to understand how many patients do not take their medicines as directed.

This study followed 268 adults with end-stage kidney disease on dialysis. Each participant wore a Holter heart monitor for 7 days to track irregular heartbeats. Researchers then looked for links between those heart patterns and serious outcomes like sudden cardiac death, heart at…

This study looked at how well a new heart monitor (Assert-IQ) detects atrial fibrillation (an irregular heartbeat) in people who have had a heart ablation procedure. 151 participants wore the monitor as part of their normal care. Researchers compared the monitor's readings to a s…

This study used computer simulations to compare three types of radiation (photons, protons, and carbon ions) for treating a dangerous heart rhythm called ventricular tachycardia. Researchers created treatment plans for 23 patients who were already scheduled for standard catheter …

This study gathered information from routine medical care for 198 adults with atrial fibrillation who had a prior procedure to close a small heart pouch (left atrial appendage occlusion) and later needed a heart ablation. Researchers looked at patient details, procedure steps, bl…

This study aimed to create a new questionnaire that measures how atrial fibrillation (AF) affects a person's quality of life. Researchers worked with 206 adults who have AF to develop and test this tool. The goal was to better understand the real-world impact of AF beyond just me…

This study looked at 468 Italian adults who take blood thinners (anticoagulants) to understand their health knowledge, quality of life, and confidence in managing their condition. Researchers used questionnaires to measure these factors and see how they relate to age, education, …

This study looked at how well a procedure called catheter ablation works for treating fast heart rhythms in people with congenital heart disease. Researchers treated 40 patients and followed them for one year to see if the abnormal heart rhythm came back. The goal was to understa…

This study looked at 300 women undergoing frozen embryo transfer as part of IVF treatment. Researchers measured progesterone levels in the blood to understand how the body processes the hormone. The goal was to find out if low progesterone on transfer day leads to higher failure …

This study aimed to make heart rate monitors more accurate for people with heart conditions. Researchers collected data from 138 participants, including cardiac patients and athletes, using Fitbit and Polar devices over 13 weeks. The goal was to remove false readings and develop …

This study looked back at the medical records of 168 adults who survived a cardiac arrest and were treated in the intensive care unit. Researchers wanted to find early signs that could predict which patients were more likely to die within 30 days or six months. By analyzing lab r…

This study looked at 155 people with early-onset atrial fibrillation to see if genetic testing can help doctors choose better treatments. Participants had heart imaging and ECG tests to find hidden heart muscle or rhythm disorders. The goal is to learn how genetics influence the …

This study examined how the Impella heart pump changes platelet function in 30 patients with cardiogenic shock or cardiac arrest. Researchers measured markers of platelet activation and aggregation before and during pump support. The goal was to understand why some patients devel…

This study tested whether a small, band-aid-like heart monitor (Zio patch) can be worn by children for up to 14 days. It involved 36 kids aged 1 to 17 years. The goal was to see if the patch sticks well and gives clear heart signals. The study did not test any treatment, only the…

This study tracked 1,826 people who received a small implantable heart monitor (Confirm Rx) to check for irregular heartbeats. Over 12 months, researchers recorded how often the device caused serious problems and how well it worked in daily life. The goal was to see if the monito…

This study looked at 321 people with pacemakers or heart monitors who had short, symptomless episodes of atrial fibrillation (silent AF). Researchers measured certain proteins in the blood to see if they could predict who might later have a stroke or other heart problems. The goa…

This study looked at 200 people with atrial fibrillation to see if treatments like catheter ablation or exercise training change levels of a brain chemical called BDNF. Researchers also checked if these changes relate to mood and quality of life. The goal was to gather knowledge,…

This study tested a 12-week virtual education program for primary care providers in North Carolina to improve how they manage atrial fibrillation (AFib). 70 providers joined online sessions to learn about AFib care and EKG interpretation. Researchers measured changes in provider …

This study tested whether a special pacing technique in the heart's right ventricle can more accurately predict where certain rapid heartbeats originate, compared to standard ECG criteria. Researchers enrolled about 200 patients undergoing catheter ablation for ventricular arrhyt…

This study tested a six-session virtual education program called 'AF at Home' for adults with atrial fibrillation. Participants attended Zoom classes over three weeks to learn about self-monitoring and managing their condition. The goal was to see if the program improved quality …

This study tested a program where doctors refer inactive people with chronic diseases (like diabetes, heart disease, or obesity) to an exercise professional for personalized counseling. The goal was to see if this referral scheme helps people become more active compared to just g…

This study looked at whether ultrasound measurements of the vena cava and femoral artery can predict which sepsis patients with low blood pressure will benefit from extra fluids. 90 spontaneously breathing adults in intensive care were studied. The goal is to avoid giving too muc…

This study tested whether using a video call (telemedicine) to guide bystanders in CPR is better than standard phone-only instructions. Researchers studied 108 adults with suspected cardiac arrest in Bangkok, Thailand. The goal was to see if video help leads to more people receiv…

This study looked at 346 adults who had a cardiac arrest outside the hospital. Doctors used an ultrasound within the first 12 minutes of CPR to see if a still heart (no movement) meant the heart would not restart. The goal was to help decide on next steps like ECMO or organ donat…

This study examined 297 adults who had a cardiac arrest outside the hospital and were treated by emergency services. Researchers wanted to see if placing a breathing tube before arriving at the hospital helped more people survive for 28 days and have better brain function. They a…

This study checked whether the Turkish version of the Cardiac Depression Scale (CDS) works well for people with heart disease. Researchers tested 360 Turkish adults with various heart conditions to see if the scale accurately measures depression. The goal is to give doctors a rel…

This completed study looked at 400 people with both heart disease and a mental health condition (like depression or anxiety). Researchers used questionnaires, blood tests, and imaging to find shared risk factors and biological markers. The goal was to better understand how these …

This study looks at how a cardiac arrest affects brain function, including memory, thinking, and emotions. Researchers will follow 48 survivors for one year, using cognitive tests and brain scans (fMRI) to track changes. Their results will be compared to a healthy control group t…

This study looked at whether a low-field MRI (0.23-T) is safe and practical for patients who are on a heart-lung machine after a cardiac arrest. The goal was to see if doctors could use this MRI to find brain injuries early without causing harm. 36 unconscious patients took part,…

This study looked at 1,003 people who had a cardiac arrest outside the hospital and were revived. It compared getting a coronary angiogram (an X-ray of the heart's arteries) within 2 hours versus waiting 3 days. The goal was to see if early imaging improves survival at 30 days. P…

This completed study looked at 309 adults with heart failure to see if increased pressure in the brain is linked to atrial fibrillation (an irregular heartbeat). Researchers measured eye nerve sheath diameter as a sign of brain pressure and used echocardiography to check heart fu…

This study looked at whether giving CPR instructions over the phone before help arrives increases the number of bystanders who perform CPR. Researchers tracked 274 adults who had a cardiac arrest outside the hospital. The goal was to see if simple instructions could save more liv…

This study tested a wearable smart textile sensor system called SimpleSense in 334 people. The device uses special sensors in a harness to record heart signals, breathing, and body movement. Researchers compared its readings to standard hospital monitors to see if it works just a…

This study observed how emergency medical teams give breaths to adults suffering cardiac arrest outside the hospital. Using a portable device, researchers measured the volume, frequency, and pressure of ventilations during CPR. The goal was to describe current practices, not to t…

This completed trial compared two ways to start CPR in a simulated child cardiac arrest: starting with chest compressions (AHA method) versus starting with rescue breaths (ERC method). Researchers used a manikin to measure how much air reached the lungs in the first minute. 28 he…

This pilot study looked at whether giving extra oxygen during heart surgery (when a heart-lung machine is used) affects kidney function afterward. 104 adults having elective heart surgery were randomly assigned to receive either high or normal oxygen levels. The main goal was to …

This completed study looked at 60 heart failure patients with reduced pumping function and dangerous heart rhythms. Researchers compared metabolic profiles between those with ischemic (blocked arteries) and non-ischemic (other causes) heart disease. By analyzing blood samples, th…

This study looked at whether sending alerts to pharmacists instead of doctors helps improve how blood thinners (anticoagulants) are prescribed. Researchers tested two types of alerts with 306 healthcare providers. The goal was to see which method leads to faster and safer prescri…

This study compared two heart-mapping systems, RHYTHMIA and CARTO, in 49 adults undergoing a repeat procedure for atrial fibrillation (AF). The goal was to see which system better finds gaps from previous ablations. The study did not test a new treatment but aimed to improve unde…

This study looked at 44 people with persistent atrial fibrillation who had a second heart procedure 2 months after their first ablation. Doctors checked for reconnections in the pulmonary veins and treated them again to see if this improves outcomes. The goal was to better unders…

This early-stage study tested whether giving regular insulin as nose drops is safe and tolerable in 24 healthy adults. Researchers aimed to find the highest dose that does not cause dangerously low blood sugar. The study was completed and focused on safety, not on treating any di…

This study looked at whether measuring venous lactate (a waste product in the blood) during CPR can help predict if a person's heart will start beating again after a cardiac arrest outside the hospital. Researchers tested lactate levels in 77 adults when emergency teams arrived. …

This study looked at how the blood thinner edoxaban behaves in 150 Chinese adults with non-valvular atrial fibrillation (an irregular heartbeat). The goal was to see if current dosing models fit Chinese patients and to create a more personalized dosing plan to improve effectivene…

This study looked at whether wearing an activity monitor (like a Fitbit) after heart surgery helps patients get moving sooner and return to their normal activity levels faster. Researchers tracked motivation, length of hospital stay, and readmission rates in 12 adults who had car…

This study tested a machine learning algorithm to predict if a patient being cared for at home would deteriorate. Researchers used data from over 500 patients to train the algorithm and compared its alerts to traditional vital sign alarms. The goal is to catch problems earlier an…

This completed study tracked 832 heart attack patients in China who developed new-onset atrial fibrillation during their hospital stay. Researchers used continuous heart monitoring to see how the amount of AFib affected risks like death, another heart attack, or heart failure. Th…

This study looked at data from 372 patients to see if a computer program could predict who would need to be readmitted to the hospital within 30 days. Researchers used information like age and health history to train the computer model. The goal was to find patterns that could he…

This study looked at 537 people with myotonic dystrophy type 1 to understand their risk of serious heart rhythm problems, including sudden cardiac arrest. Researchers tracked participants for two years to see how often these events happened and what factors might predict them. Th…

This completed pilot study looked at how moderate exercise affects heart function and dangerous heart rhythms in 20 adults with arrhythmogenic cardiomyopathy (ACM). Participants did different types of exercise while doctors measured heart pressures and electrical activity. The go…

This study developed an artificial intelligence system that combines patient medical records and doctors' notes to predict whether atrial fibrillation (an irregular heartbeat) will return after a common treatment called ablation. Researchers analyzed data from over 2,500 patients…

This completed registry study followed over 5,000 people with heart rhythm disorders who received Abbott devices during standard procedures. The goal was to collect real-world data on safety and how well the devices work. No new treatments were tested; instead, the study observed…

This completed study looked at how the heart medication amiodarone behaves in children aged 0 to 18 with heart rhythm disorders. Researchers took blood samples from 57 children to measure drug levels and understand how the body processes it. The goal was to find the best dose for…

This small pilot study explored whether advanced heart imaging can detect hidden strokes in people who have never had atrial fibrillation but are at high risk due to conditions like diabetes or heart failure. Researchers used brain MRIs to find silent, symptom-free strokes and li…

This study followed 167 people with atrial fibrillation or flutter who had a catheter ablation procedure. Researchers measured changes in stroke and bleeding risk scores before and 3, 6, and 12 months after ablation. They also compared different monitoring methods, including impl…

This study tested whether special communication training for pharmacists and general practitioners helps them involve older patients in decisions to stop or lower medications for heart disease and diabetes. Researchers enrolled 310 patients aged 75 and older who were taking certa…

This study tested a new hands-free device called RescueDoppler that uses ultrasound to monitor blood flow in the carotid artery during cardiac arrest. Researchers attached the device to 285 patients experiencing sudden cardiac arrest, both in and out of the hospital. The goal was…

This study looked at 172 people with atrial fibrillation who had a heart procedure guided by a special ultrasound. Researchers found a common harmless imaging artifact, called the 'Floating Lotus' sign, that can look like a dangerous blood clot. By learning to tell the difference…

This study tested whether a theory-based motivational letter mailed six months in advance could increase attendance at a one-year post-cardiac rehabilitation check-up. Researchers compared 102 adults who received the letter to those who got usual care. The goal was to see if a si…

This study looked at 91 Chinese patients with atrial fibrillation who had a stroke while taking blood thinners (NOACs). The goal was to understand why these strokes happen and whether not taking the medication as prescribed played a role. Researchers hope this knowledge will help…

This study measured the amount of common blood thinners (dabigatran, apixaban, and rivaroxaban) in the blood of 308 Chinese adults with atrial fibrillation who had been taking the medication for at least 3 months. The goal was to establish normal reference ranges for these drugs …

This study examined the DNA of over 2,300 adults who experienced sudden cardiac arrest outside the hospital. Researchers looked for specific genetic variations that might increase the risk of sudden death. The goal is to better identify people at high risk so that future preventi…

This pilot study enrolled 5 people with hypertrophic cardiomyopathy who needed an implantable cardioverter defibrillator (ICD) but did not require pacing. Participants were randomly assigned to receive either a subcutaneous ICD (placed under the skin) or a transvenous ICD (with l…

This study tested a special breathing technique during atrial fibrillation ablation to see if it reduces catheter movement. Fifty-two adults with atrial fibrillation were given both standard and high-frequency, low-volume ventilation during their procedure. The goal was to see if…

This study looked at blood clots from 380 people who had a heart attack or sudden cardiac death. Researchers wanted to see if the age and makeup of the clot could explain why some people die suddenly while others survive. They compared clots from sudden death victims, heart attac…

This study looked back at medical records of 65 adults who had a cardiac arrest that did not respond to usual treatments and were placed on a heart-lung machine (ECLS). The goal was to find factors that might help predict who is more likely to survive. Researchers checked things …

This study tested whether an augmented reality (AR) tool, accessed via a QR code on a smartphone, could help heart patients better understand their discharge instructions. 303 adults hospitalized for heart attack, heart failure, atrial fibrillation, or pacemaker implantation took…

This study tested whether a generic version of dronedarone hydrochloride (400 mg tablets) works the same as the brand-name drug MULTAQ in 48 healthy Chinese adults. Participants took a single dose under fed conditions, and researchers measured drug levels in the blood to check fo…

This study tested two heart monitoring methods in 516 people who had a transient ischemic attack (TIA or mini-stroke). The goal was to see which method better detects hidden atrial fibrillation, a heart rhythm problem that raises stroke risk. Participants received either a small …

This study tested a new imaging system called VERAFEYE in 18 people already scheduled for standard heart procedures like ablation or closure. Doctors used the device during the procedure and gave feedback via a questionnaire. The goal was to gather information to improve the syst…

This study tested whether a computer program (Clinical Decision Support System) helps doctors follow official treatment guidelines for patients with both high blood pressure and atrial fibrillation (an irregular heartbeat). Researchers compared clinics using the program to those …

This study looked at whether MRI scans can help doctors predict if a coma patient will recover brain function after a cardiac arrest. Researchers followed 94 comatose patients in the ICU, scanning their brains at different times. The goal was to improve how doctors identify patie…

This completed study tested a new algorithm that automatically measures the cycle length and complexity of atrial fibrillation (AF) signals during a heart ablation procedure. Researchers collected data from 21 people with persistent AF undergoing ablation. The goal was to see if …

This study looked at how Chinese Americans talk about advance care planning—decisions about end-of-life care—with their families. Researchers interviewed religious leaders, patients with chronic diseases, and family caregivers in Chicago to understand their needs and readiness. T…

This study tested a noninvasive monitor that uses light to measure oxygen levels in the liver of children with heart conditions. Researchers wanted to see if this method could replace the usual needle-based blood draw. The study included 100 children undergoing heart catheterizat…

This study examined how well medical teams perform both technical skills (like chest compressions) and non-technical skills (like communication and leadership) during real cardiac arrest situations. Researchers video-recorded 36 ICU team members and used a validated tool to measu…

This completed study looked at 110 people with cardiac amyloidosis, a condition where protein deposits build up in the heart. Researchers implanted a small device under the skin to continuously monitor heart rhythms for up to several years. The goal was to learn more about when a…

This study looked at 9 people with persistent atrial fibrillation (a type of irregular heartbeat) to see if different treatments affect thinking skills differently. Participants were given standard care and had their cognitive function measured with questionnaires and brain scans…

This study aimed to find the best marker for measuring how well heart rate is controlled in people with atrial fibrillation. Researchers tested 13 adults using exercise tests with different doses of heart rate medication. The goal was to see which marker best reflects rate contro…

This study compared two methods for a key step in atrial fibrillation ablation—puncturing the wall between heart chambers—without using any X-rays. Both techniques used ultrasound instead. The trial involved 28 patients and measured how long each method took, whether X-rays were …

This completed early-stage study looked at whether a single dose of HSK3486, an anesthesia drug, changes the heart's electrical activity in 48 healthy adults aged 18 to 45. The main goal was to measure any effects on heart repolarization (QTc interval) and check for side effects.…

This study looked at 80 people having a heart procedure called ablation to treat irregular heartbeats. Doctors wanted to see if a CT scan could accurately show the location of a nerve near the heart that can be accidentally injured. They compared the CT images with a standard met…

This study looked at whether using short, mobile-friendly lessons (micro-learning) can improve critical care nurses' self-confidence, motivation, and stress levels after performing CPR. One hundred nurses with at least one year of ICU experience took part. The goal was to see if …

This study looked at how wearing full firefighter protective gear affects chest compressions during CPR. 38 healthy firefighters performed 12 minutes of CPR in teams, switching every 1 or 2 minutes. The goal was to see which interval leads to better compression depth and quality.

This study looked at how well a daily low-dose aspirin works in people who have both immune thrombocytopenia (low platelets) and heart disease. Only 4 adults took part. Researchers measured platelet function after aspirin to see if the standard dose is enough to prevent blood clo…

This study tested whether a systematic phone call from a medical student, supervised by a general practitioner, could reduce hospitalizations in patients with chronic heart or mental health conditions during the COVID-19 lockdown in France. Over 22,000 patients aged 70 and older …

This study looked at 320 adults who had heart surgery to see how well two different risk scores (EuroSCORE-II and POSPOM) predict the chance of dying in the hospital. Researchers calculated each patient's scores before surgery and compared them to what actually happened. The goal…

This completed study analyzed data from over 2 million people in France with atrial fibrillation (an irregular heart rhythm) to compare outcomes between those who took blood thinners and those who did not. Researchers looked at rates of stroke, major bleeding, and death between 2…

This study looked at whether orienteering (a navigation-based walk) is as good as regular walking for heart rehab. 40 people with stable heart disease took part. Researchers measured heart rate and enjoyment during both activities. The goal was to see if orienteering could be a f…

This study looked at whether a 6-minute stepper test (ST6) can accurately measure exercise tolerance in people with heart conditions undergoing rehabilitation. Researchers compared the stepper test results with the standard 6-minute walk test and a cardiac stress test in 60 patie…

This study looked at 116 people with paroxysmal atrial fibrillation (AFib) who were scheduled for a heart ablation procedure. Researchers measured baroreflex sensitivity—a non-invasive test of the autonomic nervous system—before the procedure. They wanted to see if this measureme…

This study gathered information from 100 people undergoing a standard heart procedure called left atrial appendage closure. Researchers used the data to test a software tool that measures heart structures from echocardiograms. No new treatments or procedures were given—only routi…

This study looked at 175 adults with atrial fibrillation who had radiofrequency ablation. Researchers wanted to see if a special map of the heart's electrical signals (called an isochron map) could predict whether patients would stay free of atrial fibrillation 18 months later. T…

This study looks at how cardiac arrest affects thinking, memory, emotions, and sleep over time. About 200 survivors will take detailed brain tests 7 and 24 months after their cardiac arrest. Their results will be compared to heart attack patients who did not have a cardiac arrest…

This study used a special brain imaging technique called near-infrared spectroscopy to see how the brain responds to pain and sounds while people are under general anesthesia. 44 healthy volunteers aged 12-30 were given either a painkiller (remifentanil) or a placebo. The goal wa…

This study looked at whether keeping a diary during intensive care can lower the risk of post-traumatic stress disorder (PTSD) in people who survived a sudden cardiac arrest and in their family members. About 173 patients and their relatives took part. Researchers measured PTSD s…

This study tested a new computer algorithm that analyzes heart signals during a procedure called ablation for persistent atrial fibrillation (a type of irregular heartbeat). The goal was to see if the system could collect and process these signals to help doctors better understan…

This pilot study involved 9 people with atrial fibrillation undergoing a first-time pulsed field ablation procedure. Researchers collected heart signal data to test a new algorithm that automatically measures local electrical activity. The goal was to see if the automated measure…

This study looked at 74 people who received emergency ECMO (a heart-lung machine) after their heart stopped outside a hospital. Researchers measured their quality of life, anxiety, and depression 30 days later. The goal was to understand how well survivors recover physically and …

This study looked at 58 adults who had a cardiac arrest and were cooled to 33°C to protect their brains. Researchers compared two rewarming speeds (slow at 0.25°C per hour vs. fast at 0.50°C per hour) to see how it affected inflammation levels in the blood. The goal was to gather…

This study tested a larger 31 mm cryoballoon in 20 patients with paroxysmal atrial fibrillation to see how much heart tissue it could freeze. Researchers used 3D maps before and after the procedure to measure the size of the treated area. The goal was to gather data to improve fu…

This study looked at 212 critically ill adults in one ICU to see if three blood test ratios could predict death. The ratios compare lactate, CRP, and procalcitonin to albumin levels. Researchers will check if these ratios are linked to survival and find cut-off values to help doc…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This study looked at 60 patients who were resuscitated after a cardiac arrest but remained unconscious. Researchers took blood samples at the hospital and on days 1 and 3 to analyze the activity of all genes (the transcriptome). The goal was to see if these gene patterns could pr…

This study looked at over 12,500 people in Korea with atrial fibrillation (an irregular heartbeat) to see how their condition and health outcomes changed over time. Researchers used existing hospital and national insurance records, not new patient visits. The goal was to better u…

This study looked at 300 critically ill adults in the ICU who were receiving drugs to raise their blood pressure. Researchers measured blood pressure at the upper arm and the wrist to see if there was a difference. They wanted to find out how often this difference happens and if …

This study tested a device that gives paramedics real-time feedback on how well they are breathing for a patient during CPR after a cardiac arrest. Researchers compared breathing quality before and after using the device in over 400 patients. The goal was to see if the device hel…

This study tested an indoor air pollution intervention called AIRWISE in 20 adults aged 55 and older with heart disease. Participants received personal air cleaners, a color-changing air quality monitor, and educational materials. The goal was to see if they would use these tools…

This study looked at whether silent myocardial ischemia (reduced blood flow to the heart without chest pain) increases the risk of heart problems or death in people with coronary heart disease. Researchers followed participants for one to three years. The goal was to better under…

This completed study tested whether healthcare claims data can predict the results of a major heart trial (SURPASS-CVOT) comparing two diabetes drugs, tirzepatide and dulaglutide. Researchers analyzed records from over 44,000 people with type 2 diabetes and heart disease to see i…

This study aimed to find out if certain genes make people more likely to die suddenly from a heart problem. Researchers looked at the DNA of 2,500 people to see if specific gene variations were linked to sudden cardiac death. No treatments or interventions were given; the goal wa…

This study looked at 18 heart failure patients with a specific heart block to find the best spots for pacing the heart's natural electrical system. Doctors used a 3D mapping system during device implant to see where pacing corrects the heart's rhythm. The goal was to gather infor…

This pilot study tested whether using two defibrillators early, instead of one, is feasible and safe for people whose hearts stop outside a hospital and don't respond to the first shock. Researchers enrolled 40 adults with a shockable heart rhythm. The goal was to see if emergenc…

This study looked at 72 healthy male triathletes aged 20-54 who competed in a long-distance triathlon. Researchers checked heart function and rhythm before, during, and after the race to see if intense exercise causes temporary heart strain or irregular beats. The goal was to bet…

This study looked at 17 adults with persistent atrial fibrillation (a long-lasting heart rhythm problem) to find specific areas in the heart that may keep the condition going. Researchers used special mapping to identify stable high-frequency electrical signals. The goal was to b…

This study looked at how safe and effective the blood thinner edoxaban is for preventing strokes in people aged 80 or older with a common heart rhythm problem called atrial fibrillation. Researchers followed over 1,200 patients in Korea who were already prescribed edoxaban by the…

This study looked at 40 adults with atrial fibrillation (an irregular heartbeat) to compare two ways of performing a common treatment called pulmonary vein isolation. One method uses advanced 3D heart mapping, while the other relies on standard X-ray guidance. The goal was to see…

This completed study looked at nearly 1,000 people aged 80 and older with atrial fibrillation (an irregular heartbeat) who were newly prescribed the blood thinner apixaban. Researchers tracked bleeding events and how well the dose matched each patient's needs. The goal was to gat…

This study followed 214 children born from two different fertility treatments—CAPA-IVM and conventional IVF—to see if their development and behavior at age 5 were similar. Researchers used parent questionnaires to assess communication, motor skills, problem-solving, and emotional…

This completed study from the University of São Paulo measured physical activity levels and quality of life in 100 adults with cardiac arrhythmias. Researchers used questionnaires to see how active patients were and how they felt physically and mentally. The goal was to understan…

This study looked at 87 women who had no eggs retrieved during their first IVF cycle. Researchers wanted to see if a second round of ovulation-inducing medication could lead to successful egg retrieval. The goal was to understand which factors might predict failure and how to imp…

This study tested whether video calls with emergency dispatchers help bystanders perform CPR better than phone-only instructions, especially in tough conditions like darkness. 157 healthy volunteers managed a simulated cardiac arrest alone, with some using video and others just a…

This study followed 50 atrial fibrillation patients for 12 months to see if advanced heart imaging and ECG tests can predict whether the drug flecainide will keep their heart in normal rhythm. Researchers collected data during four clinic visits and analyzed it against outcomes l…

This study looked at 116 people who had a cardiac arrest outside the hospital and were treated with a machine called ECMO (which pumps and oxygenates blood). Researchers measured how well the heart was pumping at 28 days and 90 days after the arrest. The goal was to understand if…

This study looked at two ways to assign care coordinators to older adults (65+) with heart disease or risk factors. One method used patients' own reports of difficulty coordinating care, while the other used usual triggers like hospital discharge. The goal was to see which approa…

This completed study enrolled 164 adults with chronic heart failure, some also with permanent atrial fibrillation. Researchers measured blood markers of inflammation and certain microRNAs (genetic molecules) and used echocardiograms to look at heart structure. The goal was to und…