New ablation technique tested against standard in heart failure patients

NCT ID NCT07181291

Completed Disease control Sponsor: St. Josefs-Hospital Wiesbaden GmbH Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two types of ablation (pulsed-field vs cryoballoon) for treating atrial fibrillation in people with heart failure and reduced pumping function. Researchers looked back at 700 patients who had their first ablation to see which method works better and is safer. The goal is to find out if the newer pulsed-field method is as good as the standard cryoballoon method.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pulmonary vein isolation (PVI) procedure
What this could lead to: If successful, this could show that pulsed-field ablation is as safe and effective as cryoballoon ablation for controlling atrial fibrillation in heart failure patients.
What could go wrong: This is a retrospective study, not a randomized trial, so results may be biased. The non-inferiority margin is wide, and the study may not prove one method is better.

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Conditions

The condition(s) this trial relates to.

atrial fibrillation heart failure systolic heart failure

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ATRIAL FIBRILLATION HEART FAILURE WITH REDUCED EJECTION FRACTION

Contacts and locations

Locations

Evangelisches Krankenhaus Düsseldorf

Düsseldorf, Germany
Evangelisches Krankenhaus Hagen-Haspe

Hagen, Germany
Kerckhoff-Klinik Bad Nauheim

Bad Nauheim, Germany
Klinikum Fürth

Fürth, Germany
Medizinische Hochschule Hannover

Hanover, Germany
Montreal Heart Institute

Montreal, Quebec, Canada
St. Josefs-Hospital Wiesbaden

Wiesbaden, Germany
Universitätsklinikum Frankfurt am Main

Frankfurt am Main, Germany
Universitätsklinikum Hamburg-Eppendorf

Hamburg-Eppendorf, Germany
Universitätsklinikum Heidelberg

Heidelberg, Germany
Vancouver General Hospital

Vancouver, British Columbia, Canada
Vivantes Klinikum am Urban

Berlin, Germany

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