Can a Dual-Chamber device shrink an enlarged heart in AF patients?
NCT ID NCT01994252
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looked at 200 people with both heart failure and permanent atrial fibrillation. Participants received either a standard defibrillator (ICD) or one that also paces both lower heart chambers (CRT/ICD). The goal was to see if the extra pacing reduces heart size and improves pumping function, quality of life, and survival. The trial is now complete, and results will show whether this approach helps this specific group.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Implantable cardioverter-defibrillator (ICD) with or without cardiac resynchronization therapy (CRT)
- What this could lead to
- If successful, this could show that biventricular pacing helps shrink an enlarged heart and improve pumping efficiency in heart failure patients with permanent atrial fibrillation.
- What could go wrong
- This is a completed trial with 200 participants, so results are available but may not apply to all patients. The benefit of CRT in atrial fibrillation is still debated, and device implantation carries risks like infection or lead problems.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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CHUM Centre hospitalier universitaire de Montréal
Montreal, Quebec, Canada
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Hamilton Health Sciences
Hamilton, Ontario, Canada
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Institut universitaire de cardiologie et de pneumologie de Quebec
Québec, Quebec, Canada
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Kingston General Hospital
Kingston, Ontario, Canada
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Le Centre hospitalier universitaire de Sherbrooke
Sherbrooke, Quebec, Canada
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Libin Cardiovascular Institute of Alberta
Calgary, Alberta, Canada
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London Health Sciences Centre
London, Ontario, N6A 5A5, Canada
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McGill Health Science Centre
Montreal, Quebec, Canada
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Montreal Heart Institute
Montreal, Quebec, Canada
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Queen Elizabeth II Health Science
Halifax, Nova Scotia, Canada
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St. Boniface General Hospital
Winnipeg, Manitoba, Canada
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St. Michael's General Hospital
Toronto, Ontario, Canada
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University of Ottawa Heart Institute
Ottawa, Ontario, K1W 4W7, Canada
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Vancouver General Hospital
Vancouver, British Columbia, Canada
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Victoria Cardiac Arrhythmia Trials
Victoria, British Columbia, V8R 4R2, Canada
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Could a new injection tame atrial fibrillation?
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