Tiny heart monitor could unlock secrets of deadly rhythms in amyloidosis

NCT ID NCT04856267

Completed Knowledge-focused Sponsor: Marianna Fontana Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This completed study looked at 110 people with cardiac amyloidosis, a condition where protein deposits build up in the heart. Researchers implanted a small device under the skin to continuously monitor heart rhythms for up to several years. The goal was to learn more about when and why dangerous abnormal heartbeats occur, which could help doctors decide when to use treatments like pacemakers. Participants may not have directly benefited, but the data could improve care for future patients.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: implantable loop recorder (LINQ device)
What this could lead to: If successful, this study could help doctors better predict and prevent dangerous heart rhythms in people with cardiac amyloidosis, potentially saving lives.
What could go wrong: This is an observational study, not a treatment trial. It may not directly benefit participants, and the findings might not change current care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

AL amyloidosis Amyloid Neuropathies, Familial amyloidosis Arrhythmias, Cardiac cardiac rhythm disease Death, Sudden, Cardiac sudden arrhythmia death syndrome sudden cardiac arrest wild type ATTR amyloidosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARRYTHMIA CARDIAC AMYLOIDOSIS SUDDEN CARDIAC DEATH

Contacts and locations

Locations

Royal Free London NHS Foundation Trust

London, NW3 2QG, United Kingdom

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