New heart ablation method aims to beat atrial fibrillation
NCT ID NCT04101539
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether adding a personalized, computer-model-guided ablation (OPTIMA) to the standard pulmonary vein isolation (PVI) procedure improves outcomes for people with persistent atrial fibrillation. 67 participants were randomly assigned to receive either PVI alone or PVI plus OPTIMA ablation. The goal was to see if the extra ablation could increase the chance of staying free from atrial arrhythmias for one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
catheter ablation (OPTIMA-guided)
What this could lead to
If successful, this approach could improve the success rate of ablation for persistent atrial fibrillation, reducing the need for repeat procedures.
What could go wrong
This is a small, early-phase study (67 participants) and prior similar strategies have failed to show benefit. Results may not be generalizable.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Johns Hopkins Hospital
Baltimore, Maryland, 21287, United States