New heart pacing technique could offer alternative for heart failure patients

NCT ID NCT04409119

Completed Disease control Sponsor: Rigshospitalet, Denmark Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared a newer pacing method, called HIS or left bundle branch (LBB) pacing, to the standard biventricular pacing in 150 heart failure patients with a specific heart electrical problem (left bundle branch block). The goal was to see if the new method could improve heart function and symptoms as well as or better than the standard approach. Researchers measured changes in heart size and pumping ability after 6 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: HIS/LBB pacing (a device-based pacing procedure)
What this could lead to: If successful, this could offer a more natural pacing method for heart failure patients, potentially improving heart function and symptoms.
What could go wrong: This is a completed study with 150 participants, but it is not a large-scale trial. The new pacing method may not work for everyone and could have implantation challenges or risks like lead dislodgement.

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Conditions

The condition(s) this trial relates to.

heart failure progressive familial heart block, type 1A

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HEART FAILURE LEFT BUNDLE-BRANCH BLOCK

Contacts and locations

Locations

Rigshospitalet

Copenhagen, Capital Region, 2100, Denmark

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