Cardiac rhythm disease

This study tested a device called the Amplatzer Amulet, which is implanted to close a part of the heart and reduce stroke risk in people with non-valvular atrial fibrillation who cannot take blood thinners. The study enrolled 50 participants in China and tracked safety and effect…

This trial tests a special pacemaker called the Moderato System in people who need a pacemaker and have high blood pressure that is hard to control with medication. The device is implanted like a regular pacemaker and may help lower blood pressure by adjusting the heart's pacing.…

This trial tests a special pacemaker-like device, the Moderato System, designed to lower blood pressure in people who have resistant hypertension and already need a dual-chamber pacemaker. Participants are randomly assigned to have the device's blood-pressure-lowering feature tur…

This study tested a dramatic approach: rapidly cooling trauma patients whose hearts had stopped from severe bleeding. Doctors flushed ice-cold saline into the aorta to induce deep hypothermia, then performed emergency surgery to stop the bleeding before slowly rewarming the patie…

This study aimed to see if combining surgical and catheter ablation (hybrid therapy) works better than standard catheter ablation alone for people with persistent atrial fibrillation. The trial was terminated after enrolling only 7 participants, so no meaningful conclusions can b…

This study tested an experimental drug called CRD-4730 in people with a rare inherited heart rhythm disorder (CPVT) that can cause dangerous fast heartbeats. Seven adults received two different doses of the drug and a placebo to check safety and how the body processes it. The stu…

This study compared two types of heart ablation for people with paroxysmal atrial fibrillation (AFib). One group received standard pulmonary vein isolation, while the other also had the back wall of the left atrium isolated. Both used a newer technique called pulsed-field ablatio…

This study compared two approaches to reduce shocks in people with an implantable defibrillator (ICD) who had dangerous heart rhythms. One group received antiarrhythmic drugs, the other had a catheter ablation procedure. The trial was a small pilot with only 3 participants and wa…

This study looked at whether a procedure called renal denervation could help people with recurrent atrial fibrillation (an irregular heartbeat) that keeps coming back even after standard treatment. The procedure uses energy to calm certain nerves near the kidneys. Only 6 people t…

This study tested a drug called CardiolRx in 90 hospitalized COVID-19 patients who also had heart disease or risk factors like diabetes or high blood pressure. The goal was to see if the drug could lower the chance of death, needing intensive care, or having heart problems. The t…

This study tested a medical device that freezes small areas of heart tissue to treat atrial fibrillation (AFib) and related irregular heartbeats. The goal was to see if the procedure safely stops abnormal rhythms for at least 12 months. The study enrolled 91 people, but was termi…

This trial tested whether giving two quick electrical shocks instead of one could better restore a normal heart rhythm in people with atrial fibrillation. It focused on patients with factors that make standard shock treatment less likely to work, such as obesity or lung disease. …

This study looked at how well the DiamondTemp ablation system controls atrial fibrillation (a type of irregular heartbeat) over three years. It included 84 adults with paroxysmal AF who had not responded to medication. The study was terminated early, so the full results are not a…

This pilot study compared a heart ablation procedure (pulmonary vein isolation) to standard medications for managing atrial fibrillation in people with heart failure with preserved ejection fraction. Only 13 participants were enrolled before the study was terminated early. The ma…

This study looked at two types of implantable cardioverter defibrillator (ICD) leads in children and patients with congenital heart disease. The goal was to see which lead type lasts longer without breaking and is easier to remove if needed. The trial was terminated early, so res…

This study tested whether checking blood clotting levels every week with a small finger-prick device is better than the usual monthly lab test for elderly nursing home residents on blood thinners. The goal was to see which method keeps patients in the safe therapeutic range longe…

This study tested whether a single high dose (2000 mg) of the heart medication amiodarone, taken by mouth, could safely and quickly restore normal heart rhythm in people with acute atrial fibrillation. The trial planned to include both hospital and outpatient settings, but was te…

This study tested a device called Efferon LPS that filters blood during heart surgery when a heart-lung machine is used. The goal was to see if it could prevent multiple organ failure, especially kidney damage. Only 14 people took part before the study was stopped, so the results…

This study looked at whether the drug dronedarone could prevent atrial fibrillation (AFib) from coming back after a heart ablation procedure. About 22 adults with AFib who had ablation were randomly given either dronedarone or a placebo. The goal was to see if the drug reduced ir…

This study looked at whether giving less oxygen (aiming for 90-94% oxygen in the blood) right after a cardiac arrest outside the hospital helps more people survive to leave the hospital. It included 428 unconscious adults who had been revived and were on a breathing tube. The tri…

This small pilot study tested whether a special oral appliance (like a mouthguard) could reduce episodes of atrial fibrillation, a common heart rhythm problem. Only 3 people participated, and the study was ended early. The device is already used for snoring and sleep apnea, but i…

This study looked at whether using a positive airway pressure (PAP) machine at night can reduce the return of atrial fibrillation (an irregular heartbeat) in people who also have obstructive sleep apnea. About 129 participants with both conditions were assigned to receive either …

This study looked at using the WATCHMAN FLX device, a small plug placed in the heart, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who also had serious gastrointestinal (GI) bleeding. The device is meant to close off a part of the heart where clo…

This study tested whether wearing a small, waterproof heart monitor (ePatch) for 7 days finds more treatable heart rhythm problems than the usual 24-hour Holter monitor in people who have fainted. About 55 adults with fainting symptoms were randomly assigned to either the 7-day e…

This study tested whether a mindfulness program (including meditation, body scans, and gentle yoga) could help people with implanted heart devices like ICDs or pacemakers feel less anxious, stressed, and depressed. The study planned to enroll 34 adults who had recently received s…

This study compared two types of nerve blocks (serratus anterior plane block and erector spinae plane block) using the same dose of ropivacaine to manage pain after hybrid arrhythmia ablation surgery. It enrolled 28 adults aged 18-80. The trial was terminated early, so findings a…

This study looked at whether letting patients manage their own recovery precautions after heart surgery leads to a better quality of life compared to following standard sternal precautions. Ten adults who had heart surgery were followed for up to a year. Researchers checked pain,…

This study looks at how high blood sugar combined with a medication called moxifloxacin (an antibiotic known to affect heart rhythm) impacts the heart's electrical activity in people with insulin-resistant type 2 diabetes. Researchers will measure changes in heart tracings (ECGs)…

This study looked at how two common pain relievers—celecoxib (a Coxib) and naproxen (an NSAID)—affect blood clotting in people with rheumatoid arthritis who also have heart disease or are at high risk for it. All participants took low-dose aspirin daily. The goal was to see if on…

This study looked at whether pain-relief drugs given during labor (ropivacaine and sufentanil) can pass into the mother's blood and cause abnormal heart rhythms in the baby. It involved 40 first-time mothers with a single baby in head-first position. The goal was to measure drug …

This study aimed to understand why some people with genetic early-onset atrial fibrillation (AF) are at risk for a dangerous heart rhythm called ventricular tachycardia (VT). Researchers used special heart mapping during a standard AF ablation procedure in 32 adults. The goal was…

This study looked at 212 patients who woke up after a cardiac arrest outside the hospital. Researchers compared getting a heart angiogram right away versus waiting 12-24 hours. The goal was to see if immediate imaging reduces the risk of death, shock, or another cardiac arrest. T…

This study looked at whether a new anti-shivering protocol helped reduce the need for muscle relaxants in patients cooled after cardiac arrest. Researchers reviewed records of 165 patients treated between 2017 and 2021. The study was terminated early, so results are limited.

This study looked at a common heart rhythm problem called atrial fibrillation (AF). The goal was to find better ways to predict which patients would benefit from a procedure called ablation, which creates scar tissue in the heart to stop abnormal rhythms. Researchers planned to u…

This study looked at how Medtronic heart devices detect and manage atrial fibrillation (AF) in Indian patients. It tracked whether the condition became persistent over time. The study enrolled 79 people over 55 with heart devices. It was terminated early, so results are limited.

This study looked at whether using ultrasound to guide vein puncture reduces complications like bleeding or false aneurysms in people undergoing ablation for atrial fibrillation. Over 1,000 adults scheduled for the procedure were enrolled. The study was terminated early, so resul…

This study aimed to find out how many people experience short-term and long-term pain after a specific type of heart surgery called one-stage hybrid arrhythmia ablation. Researchers surveyed patients who had the procedure at UZ Brussels to see what factors, like medications or ge…

This pilot study aimed to see if antiseizure drugs like phenobarbital and levetiracetam change brain connectivity patterns in people with severe acute brain injury and reduced consciousness. Only 5 participants were enrolled before the study was terminated. Researchers used resti…