Cardiac rhythm disease

After cardiac arrest, the brain often suffers from low oxygen even when the heart is restarted. This pilot trial tests whether using a non-invasive forehead sensor to monitor brain oxygen and adjust ICU treatments can keep oxygen levels above a target. Adults who remain in a coma…

This study tests whether the drug THRV-1268 can safely shorten the heart's electrical recovery time (QT interval) in people with Long QT Syndrome Type 2, a genetic condition that raises the risk of dangerous heart rhythms and sudden cardiac arrest. About 64 participants will take…

This study is testing a new, wire-free pacemaker called LivIQ in 325 people who need a pacemaker for a slow heartbeat. The goal is to see if it is safe and works well to keep the heart beating at the right pace. Participants will be followed for several months to check the device…

Researchers compare two procedures for people with persistent atrial fibrillation that has not responded to at least one antiarrhythmic drug. One group receives standard catheter ablation, which burns or freezes small areas inside the heart. The other receives a hybrid procedure …

This study looks at whether combining a heart procedure called ablation with a 12-week home exercise program can improve how well the body uses oxygen in people with a type of heart failure (HFpEF) and a common heart rhythm problem (atrial fibrillation). About 40 participants wil…

This study tests if a catheter-based device that closes a small pouch in the heart (left atrial appendage) can prevent strokes or blood clots in people with atrial fibrillation who are already taking blood thinners. About 4000 participants at high risk of stroke will be enrolled.…

Researchers are studying the SPIKE FLOW endocardial lead, a temporary wire placed inside the heart to keep it beating during surgery or while doctors check a slow heart rhythm. The study enrolls 131 adults who need short-term cardiac pacing. Doctors implant the lead, measure how …

This study compares newer blood thinners (DOACs) to the standard drug warfarin in patients who need anticoagulation after open-heart surgery. About 3500 adults with atrial fibrillation will be randomly assigned to receive either a DOAC or warfarin for 30 days. The main goal is to…

This study tests a new device (Sphere-9 catheter and Affera system) to treat ventricular tachycardia, a fast, dangerous heart rhythm, in 260 adults who have had a heart attack. Participants must have had repeated episodes despite medication or a defibrillator. The goal is to see …

This study tests two experimental drugs, REGN7508 and REGN9933, to prevent strokes in people with atrial fibrillation (an irregular heartbeat) who cannot or choose not to take standard blood thinners. About 2,628 participants will receive one of the drugs or a placebo to see if t…

This trial tests whether cooling patients to 33°C (therapeutic hypothermia) improves survival and brain function compared to keeping them at normal body temperature after an in-hospital cardiac arrest. About 788 comatose adults who had a cardiac arrest in the hospital will be ran…

This large phase 3 trial tests an experimental drug, REGN7508, against the standard blood thinner apixaban for preventing strokes in people with atrial fibrillation (an irregular heartbeat). The study will enroll over 15,000 participants to compare how well each drug prevents str…

This study tests whether cooling the brain quickly after a cardiac arrest (using a special nasal device) and then keeping the body cool for 24 hours helps more people survive with full brain function. About 1,000 adults aged 18-79 who have a shockable heart rhythm will be randoml…

This study looks at the best time to start blood thinners in people with atrial fibrillation who had a stroke and then emergency treatment to remove a clot. Some patients develop bleeding in the brain after the procedure, and doctors want to know if starting blood thinners early …

This study compares the safety of the drug flecainide against standard treatments (sotalol or amiodarone) in about 988 adults with atrial fibrillation and stable coronary artery disease. Participants will be randomly assigned to one treatment and followed for at least a year to t…

This study tests a new catheter called VARIPULSE against an already approved one, FARAWAVE, for people with persistent atrial fibrillation (a long-lasting irregular heartbeat). About 466 participants will receive one of the two treatments to see which is safer and better at resto…

This study tests a new device called the SpherePVI catheter, which uses heat to isolate the veins that trigger atrial fibrillation. About 100 adults with symptomatic AF who haven't responded to medication will be enrolled. The main goals are to see if the procedure is safe and ca…

This study tests two experimental drugs, REGN7508 and REGN9933, in about 1,200 people with atrial fibrillation (an irregular heartbeat). The goal is to see if these drugs can prevent blood clots and strokes with less bleeding compared to the standard blood thinner apixaban. Parti…

This study tests a new catheter system called SpherePVI that uses heat to destroy tiny areas of heart tissue causing atrial fibrillation (an irregular heartbeat). About 150 people with symptomatic atrial fibrillation will undergo the procedure. The goal is to see if the device ca…

Researchers are testing whether reducing alcohol intake after catheter ablation helps people with atrial fibrillation. The trial enrolls 184 patients who regularly drink more than five alcoholic drinks per week and are scheduled for their first ablation. Participants are asked to…

This trial tests a procedure called TEER, which uses a clip to repair a leaky heart valve (mitral regurgitation) caused by an irregular heartbeat (atrial fibrillation). The study will include 400 people with moderate-to-severe or severe leakage who still have symptoms despite tak…

This study compares two approaches for people with permanent atrial fibrillation and heart failure with preserved ejection fraction. One group gets a pacemaker plus a procedure to ablate (destroy) the heart's AV node, while the other group continues with standard heart rate medic…

This study is testing whether it is safe and effective to perform two heart procedures at the same time in people with atrial fibrillation (AF). The first procedure uses pulsed field ablation to correct the heart's rhythm, and the second closes off a small pouch in the heart to r…

Researchers compare two imaging strategies for planning left atrial appendage closure in adults with nonvalvular atrial fibrillation. Participants are randomly assigned to have their heart anatomy assessed either by transesophageal echocardiography or by cardiac CT angiography be…

This study tests whether closing a small pouch in the heart (left atrial appendage) with a device, along with blood thinners, can prevent another stroke better than blood thinners alone. It includes 482 adults with atrial fibrillation who had a recent stroke despite taking antico…

This study tests a new device that uses electrical pulses to treat atrial fibrillation (an irregular heartbeat) while patients undergo other heart surgery. About 135 adults aged 18-85 with a history of AFib will participate. The goal is to see if the device safely restores normal…

After an out-of-hospital cardiac arrest, doctors often aim to keep mean arterial pressure at or above 65 mmHg, but no one knows the best target. The METAPHORE trial compares a standard target of 65 mmHg with a higher target of 90 mmHg for the first 24 hours, using norepinephrine …

This study tests different lengths of body cooling in children who remain unconscious after a cardiac arrest outside the hospital. The goal is to see if longer cooling helps protect the brain and improve recovery. The trial will enroll 900 children and follow them for one year.

This study tests two different ways to program an implantable defibrillator (ICD) to stop dangerous fast heartbeats. About 4,000 people with heart disease who need an ICD will be assigned to one of two pacing patterns (burst or ramp) and followed for up to 10 years. The goal is t…

This study tests whether a short course of amiodarone can reduce the return and burden of atrial fibrillation (AF) in 400 adults who develop new AF after heart surgery. Participants receive either standard care or amiodarone for 4 weeks. The goal is to see if this approach is pra…

This study compares a new, tailored ablation approach to the standard treatment for people with paroxysmal atrial fibrillation (AFib), a common heart rhythm problem. About 556 adults with AFib will be randomly assigned to either standard pulmonary vein isolation or a procedure th…

This pilot study compares two ablation techniques for treating ventricular tachycardia, a fast and dangerous heart rhythm that can occur after a heart attack. Researchers will randomly assign 40 adults with ischemic heart disease and an implantable defibrillator to receive either…

This study is testing a new device called the Sphere-9 catheter, used with the Affera mapping system, to treat ventricular tachycardia (VT) — a fast, dangerous heart rhythm. The procedure uses heat to destroy small areas of scarred heart tissue that cause the abnormal rhythm. The…

This trial tests whether finerenone, a drug that reduces inflammation and scarring, can lower the chance of atrial fibrillation returning after a catheter ablation. About 40 adults with atrial fibrillation will receive finerenone or usual care for 12 months after their first abla…

This study is tracking 1000 people with atrial fibrillation who receive the WATCHMAN FLX Pro device, a small implant that closes off a part of the heart to prevent blood clots from causing strokes. The goal is to see how safe and effective the device is in everyday medical practi…

This study compares two approaches to blood thinning after a heart attack in patients with atrial fibrillation. One group gets two blood thinners (a DOAC plus clopidogrel), while the other gets only one (a DOAC alone). The goal is to see if using just one drug reduces bleeding ri…

This study looks at whether low-dose beta-blockers can reduce dangerous heart rhythms in people who have survived a cardiac arrest with no clear cause. About 218 participants will receive one of several beta-blockers and be followed for up to 3 years. The goal is to see if this t…

This study is checking the long-term safety and effectiveness of the VARIPULSE catheter, a device already approved by the FDA, for treating people with a type of irregular heartbeat called paroxysmal atrial fibrillation. About 276 participants who have symptoms and haven't respon…

This trial investigates whether a new dual energy catheter system can safely and effectively treat ventricular arrhythmias—abnormal heart rhythms that can be life-threatening. The system uses both radiofrequency and pulsed field energy to ablate the heart tissue causing the probl…

This study is testing the FARAPULSE Pulsed Field Ablation system in 376 people with persistent atrial fibrillation (AFib) who have already had a prior ablation. The device uses electrical pulses to destroy the heart tissue causing the abnormal rhythm. The goal is to see if it is …

This study compares two stomach-acid-lowering drugs—tegoprazan and rabeprazole—in about 3,300 heart disease patients who take blood thinners and are at high risk for stomach bleeding. The goal is to see if tegoprazan works as well as rabeprazole at preventing serious gut problems…

This phase 2 trial tests budiodarone, an experimental drug, in about 100 people with non-permanent atrial fibrillation, especially the paroxysmal form. Researchers want to see if the drug can safely reduce or eliminate long episodes of irregular heartbeat that last five hours or …

This study tests a new device called FARAFLEX that uses electrical pulses to treat atrial fibrillation (AF), a condition where the heart beats irregularly. About 571 adults with AF that hasn't improved with medication will get this procedure. The goal is to see if it safely resto…

This study is testing a new system (VARIPULSE catheter and TRUPULSE generator) with updated software to treat atrial fibrillation, a condition where the heart beats irregularly. The goal is to see how well the system works in a real-world setting, measuring procedure times and sa…

This study is testing a new device called the VARIPULSE catheter system to treat persistent atrial fibrillation, a type of irregular heartbeat. The device uses pulsed field ablation to isolate specific heart veins and may be combined with a procedure to close off a heart pouch to…

This study tests a new system (VARIPULSE catheter and TRUPULSE generator) with updated software for treating persistent atrial fibrillation, a long-lasting irregular heartbeat. About 50 adults aged 18-75 who have not responded to medication will undergo a heart ablation procedure…

This study tests new waveforms delivered by the FARAPULSE PFA system to treat atrial fibrillation, a common heart rhythm problem. About 200 adults with paroxysmal or persistent atrial fibrillation will receive the procedure. The goal is to see if these new waveforms are safe and …

This trial tests whether combining two advanced heart-mapping technologies can make ablation for ventricular tachycardia (VT) more accurate and effective. The approach merges a non-invasive 3D electrical map of the heart with detailed scar imaging from an MRI, aiming to better ta…

This study tests a procedure called pulsed field ablation (PFA) for people with early-stage atrial fibrillation (AFib) diagnosed within the last 3 years. The procedure uses a balloon to deliver energy that isolates the pulmonary veins, aiming to stop abnormal heart rhythms. Resea…

This trial is testing whether a higher dose of targeted radiation to the heart can reduce the return of ventricular tachycardia, a dangerous fast heart rhythm, in people with structural heart disease. The treatment, called stereotactic arrhythmia radioablation, aims to create sca…

This trial tests whether extending the compression pause from 3 to 5 seconds during mechanical CPR helps rescuers deliver two effective breaths more often. It includes adults who had a cardiac arrest outside the hospital and were treated with a LUCAS device. The study compares th…

This study tests whether placing a balloon in the main artery (aorta) during CPR helps restart the heart more often than standard CPR alone. The balloon is inserted through the leg and inflated to block blood flow below the chest, potentially sending more blood to the heart and b…

This trial is investigating whether a combination of left bundle branch area pacing (a new way to pace the heart) and atrioventricular node ablation (a procedure to disrupt faulty electrical signals) can improve outcomes for people with symptomatic atrial fibrillation who haven't…

This study tests whether implanting small filters in the carotid arteries (the main neck arteries) can prevent repeat strokes in people with atrial fibrillation who have already had a stroke. Participants will receive the filters plus standard blood thinners, or blood thinners al…

This trial compares two ways of guiding a heart procedure called pulsed field ablation, used to treat paroxysmal atrial fibrillation (an irregular heartbeat that comes and goes). About 292 people scheduled for this ablation will be randomly assigned to have the procedure guided b…

This study is testing a pacemaker lead placed in a specific area of the heart called the left bundle branch area. The goal is to see if this placement is safe and helps the heart beat more naturally in people with slow heart rates. About 140 participants will get the lead and be …

This trial tests whether a non-invasive mapping system called VIVO can help doctors locate the source of a dangerous heart rhythm called ventricular tachycardia (VT) before an invasive procedure. Patients with structural heart disease who need catheter ablation will be randomly a…

This study tests a new device that uses extreme cold to destroy small areas of heart tissue causing a dangerous fast heartbeat called ventricular tachycardia. The trial will include 100 adults with this condition who have not responded to medication. Researchers will check if the…

This study tests whether taking semaglutide (Wegovy) for at least three months before a first-time atrial fibrillation ablation can improve heart rhythm outcomes. 200 overweight or obese adults scheduled for ablation will be randomly assigned to either standard care or semaglutid…

This trial compares two blood thinners, edoxaban and apixaban, in people who have both atrial fibrillation (an irregular heartbeat) and coronary artery disease (narrowed heart arteries). Both drugs help prevent blood clots, but they are taken differently and may have different ri…

This trial asks whether cooling the body to 33-34°C after a cardiac arrest treated with ECMO improves survival and brain function compared to keeping a normal temperature. It includes adults aged 18-75 who had an out-of-hospital cardiac arrest with certain heart rhythms. Particip…

This study tests whether moving cardiac arrest survivors to a specialized hospital improves their recovery. About 1,600 adults who were revived after an out-of-hospital cardiac arrest will be randomly assigned to either stay at the nearest hospital or be transferred to a specialt…

This trial asks whether people with permanent atrial fibrillation (AF) can continue drinking caffeinated coffee without worsening their heart rate control. Half of the participants will keep their usual coffee habit, while the other half will switch to decaf for a month, then swa…

This study tests a new catheter system (Sphere-9) for a repeat heart ablation procedure in 400 people whose atrial fibrillation came back after an earlier ablation. The procedure uses radiofrequency and pulsed field energy to correct faulty heart signals. Participants will be fol…

This study looks at a new way to treat an irregular heartbeat (atrial fibrillation) that can happen after heart surgery. It uses low-energy electrical shocks and special pacing to try to restore a normal rhythm. The goal is to see if this approach is safe and effective, and if it…

After a cardiac arrest, some patients develop seizures that do not respond to standard treatment. This trial tests whether putting the brain into a deeper state of electrical silence — called burst suppression — can stop those seizures better than the usual approach of only suppr…

This trial compares two ways to guide ablation for ventricular tachycardia, a dangerous fast heart rhythm. One method uses standard voltage mapping to burn away all low-voltage scar tissue. The other uses a newer technique called ILAM that targets specific zones where the electri…

This trial investigates whether isolating the superior vena cava, in addition to the standard pulmonary vein isolation, improves success rates for treating atrial fibrillation. Using a newer, safer energy source called pulsed field ablation, the study compares the two procedures …

This study tests a new procedure using pulsed field energy to treat atrial fibrillation (AFib), a common heart rhythm problem. The procedure isolates the pulmonary veins and the back wall of the left atrium to stop abnormal signals. About 442 adults with symptomatic AFib will be …

This trial investigates whether cardiac ablation — a procedure that destroys tiny areas of heart tissue causing irregular rhythms — can improve exercise capacity in endurance athletes with atrial fibrillation. One hundred athletes who train at least four hours per week will have …

This trial compares two catheter ablation strategies for people with persistent atrial fibrillation (AF). One group receives standard pulmonary vein isolation using pulsed-field ablation; the other receives radiofrequency ablation followed by additional map-guided targeting of ab…

This study tests whether adding a vein-injected alcohol treatment to the usual heart ablation procedure can better control dangerous heart rhythms in people with prior heart attacks. About 156 adults with an implanted defibrillator and recent episodes of rapid heartbeat will be r…

This study compares two pacemaker methods for people with a slow heart rate: standard right ventricular pacing and a newer 'physiological pacing' that targets the heart's natural conduction system. Researchers will track 2,600 participants over time to see which method better pre…

This trial tests whether using two defibrillators in rapid succession, rather than one, can improve survival in people whose hearts stop outside a hospital. The procedure, called double sequential external defibrillation (DSED), is normally tried only after several failed attempt…

This study looks at whether pulsed field ablation (PFA), a standard treatment for atrial fibrillation, creates lasting changes in the heart's electrical pathways. Researchers will check this during a follow-up procedure to close the left atrial appendage, and may do extra ablatio…

This trial tests whether the position of the electrodes on the chest — front-to-back versus front-to-side — and applying manual pressure to the electrodes improve the success of electrical cardioversion for atrial fibrillation. About 1750 adults scheduled for non-urgent cardiover…

This study tests whether destroying small areas of heart muscle that cause dangerous rhythms (ventricular tachycardia ablation) during LVAD implant surgery can reduce the number of these rhythms after surgery. About 100 adults with advanced heart failure who are getting an LVAD w…

This study tests a new mapping system (CoreMap) to help doctors treat persistent atrial fibrillation (AFib), a type of irregular heartbeat. About 245 adults with persistent AFib will have a standard procedure called ablation, but with the CoreMap system guiding the treatment. The…

This study compares two ablation methods for people with persistent atrial fibrillation (AFib), a heart rhythm problem. One group gets standard treatment (isolating the pulmonary veins), while the other gets that plus extra ablation on the back wall of the heart and a nearby vein…

This study tests doing two procedures at once for people with atrial fibrillation (AFib): a catheter ablation to restore normal heart rhythm and a device implant to close off a part of the heart where clots form. The goal is to see if this combined approach is safe and effective …

This study tests an experimental drug called CRD-4730 in 12 adults with a rare inherited heart condition (CPVT) that can cause dangerous heart rhythms during exercise or stress. Participants will receive two different doses of the drug and a placebo in random order to see if it s…

This registry tracks 20,000 people with atrial fibrillation or ventricular arrhythmias who undergo catheter ablation using advanced CARTO mapping technologies. The goal is to see how safe and effective these procedures are in everyday medical practice. Researchers will monitor he…

This pilot study tests whether using a noninvasive global mapping system to guide catheter ablation can improve outcomes for people with persistent atrial fibrillation. Thirty participants will receive standard pulmonary vein isolation plus personalized ablation of up to three ad…

This study compares two implantable heart devices—Cardiac Contractility Modulation (CCM) and Cardiac Resynchronization Therapy (CRT)—in people with Chagas heart disease and advanced heart failure. The goal is to see which device better improves quality of life and heart function.…

This study tests whether repeatedly inflating and deflating a blood pressure cuff on a leg can reduce brain damage in people who survive a cardiac arrest outside the hospital. The procedure, called remote ischemic post-conditioning (RIPOST), is started within 4 hours after the he…

This study tests whether a two-month hormone pretreatment (GnRH agonist plus letrozole) before standard frozen embryo transfer can improve live birth rates in women with adenomyosis. About 222 participants will be randomly assigned to either the new regimen or standard care. The …

This study tests whether a pacemaker plus a heart ablation procedure is better than standard medications for controlling heart rate in 600 people with both atrial fibrillation and heart failure. Participants will either get a pacemaker implant and ablation, or continue with optim…

This study is tracking 10,000 people with atrial fibrillation who are having a heart ablation procedure. The goal is to see how well the procedure works and how safe it is in everyday medical practice. Researchers will measure how much AF burden patients have 6 months after the p…

This study looks at whether adding a blood thinner to standard antiplatelet therapy helps prevent strokes and blood clots in people who develop a new, temporary irregular heartbeat after coronary artery bypass surgery. About 3,200 adults who had bypass surgery and then experience…

This study tests two ways to treat a slow heart rate caused by overactive nerves, without using a permanent pacemaker. One method uses freezing (cryoablation) and the other uses burning (radiofrequency) to calm the nerves. Sixty adults aged 18 to 60 with symptoms like fainting or…

This study tests a new two-step procedure for people with long-standing persistent atrial fibrillation (AFib), a type of irregular heartbeat. The procedure combines a minimally invasive surgery on the outside of the heart with a standard catheter ablation inside the heart. Resear…

This study tests whether adding an implantable cardioverter defibrillator (ICD) to standard medication helps people with variant angina who have survived a sudden cardiac arrest. About 140 adults will be randomly assigned to get either an ICD plus medication or medication alone. …

This study will test an AI software called Volta AF-Xplorer II during catheter ablation for atrial fibrillation. About 150 adults will be treated in real-world clinics, and researchers will track how well the AI helps guide the procedure. The goal is to see if the AI improves saf…

This study will compare two widely used blood thinners, apixaban (Eliquis) and rivaroxaban (Xarelto), in about 10,000 veterans with atrial fibrillation (an irregular heartbeat). The goal is to see which drug better prevents strokes and major bleeding. Participants must already be…

This trial tests whether a special alert system called ICU Beacon can help doctors in intensive care units detect early signs of organ failure. The study includes about 1,962 adult ICU patients and compares units using the software plus standard care to those using standard care …

This trial tests a new way to treat typical atrial flutter, a heart rhythm problem. Instead of the standard linear ablation, doctors use a special catheter with tiny sensors to map and target only the high-voltage areas causing the flutter. The goal is to see if this approach is …

This study looks at whether using a CPAP machine for sleep apnea after a heart procedure (catheter ablation) can help prevent atrial fibrillation from coming back. About 658 adults with both conditions will be randomly assigned to use CPAP for a year or receive usual care. The go…

This study tests a new way to guide catheter ablation for atrial fibrillation (AF), a common heart rhythm problem. The technique uses unipolar voltage mapping to find specific electrical signals (QS potentials) that may help keep AF going. Researchers will compare this personaliz…

This study looks at people with heart devices that detect short bursts of irregular heartbeats (atrial high-rate episodes lasting 6 minutes to 24 hours) but no diagnosed atrial fibrillation. It tests whether starting rhythm-control drugs early, along with managing heart risk fact…

This study tests whether a two-drug combination of dabigatran and ticagrelor can lower bleeding risk compared to the standard three-drug therapy (dabigatran, clopidogrel, and aspirin) in people with atrial fibrillation who have had a heart stent after a heart attack. About 1,200 …

This study compares two blood thinner strategies after left atrial appendage closure (LAAC) in people with atrial fibrillation. Sixty participants will receive either aspirin alone or aspirin plus clopidogrel for three months. The goal is to see which approach better prevents sma…

This Phase 2 trial tests whether the experimental drug AP31969 can reduce the amount of time people with atrial fibrillation spend in an irregular heart rhythm. Two hundred adults with paroxysmal or persistent AF will receive either AP31969 or a placebo twice daily for several we…

This study is testing a new procedure called pulsed-field ablation to treat persistent atrial fibrillation, a common heart rhythm problem. The procedure uses non-thermal energy to isolate the pulmonary veins, aiming to stop abnormal heart signals. Researchers will follow 60 parti…

This study compares two treatment strategies for elderly frail patients with atrial fibrillation (AF) who are at high risk for both stroke and bleeding. One group receives catheter ablation plus a device to close the left atrial appendage (LAAO), while the other receives ablation…

This study tests whether using special brain monitors (near-infrared light, ultrasound, and brain wave tracking) can help doctors better manage oxygen levels in the brain for people on life support after a cardiac arrest. The goal is to see if this approach increases the number o…

This study looks at whether people with atrial fibrillation (AF) can safely stop taking blood thinners after a successful catheter ablation procedure. About 3,160 adults who have been free of AF for 6 to 12 months after ablation will be randomly assigned to either continue or sto…

This study looks at people over 65 who recently had a stroke with no clear cause. Doctors suspect they may have hidden atrial fibrillation (an irregular heartbeat) not caught in the hospital. The trial compares two treatments: a blood thinner (apixaban) or aspirin, to see which b…

This study tests a pre-set treatment plan for managing heart rhythm issues that can occur after transcatheter aortic valve replacement (TAVR). The goal is to reduce the number of patients who receive a permanent pacemaker while ensuring no one is put at risk of sudden cardiac dea…

This study tests whether a structured cardiac rehabilitation program with exercise and lifestyle coaching, started after a standard catheter ablation procedure, can help obese patients with atrial fibrillation stay free from the heart rhythm disorder longer. Researchers will foll…

This study looks at two ways to treat a fast, dangerous heart rhythm called ventricular tachycardia in people with coronary artery disease and relatively good heart function. One treatment uses a catheter to burn the tiny area causing the problem (radiofrequency ablation), and th…

This study looks at whether it is safer to stop or continue taking direct oral anticoagulants (blood thinners) during planned heart procedures like angiography or stent placement. About 1,270 adults with atrial fibrillation and coronary artery disease will be randomly assigned to…

This study looks at whether starting rhythm control early—using drugs or procedures like ablation—can improve outcomes for people with both atrial fibrillation and tricuspid regurgitation (a leaky heart valve). About 5,800 participants will be randomly assigned to early rhythm co…

This study compares a new procedure called pulsed field ablation (PFA) to standard treatment for atrial fibrillation, a common heart rhythm problem that raises stroke risk. About 1,574 adults who need catheter ablation will be randomly assigned to receive PFA or standard care. Th…

This study is tracking 300 people with paroxysmal or persistent atrial fibrillation (AFib) who are treated with the Volt PFA System, a balloon-based device that uses pulsed field ablation to correct irregular heart rhythms. Researchers are monitoring safety—looking for serious si…

This study tests a newer pacing method called Conduction System Pacing (CSP) against standard right ventricular pacing in 1,260 adults with heart block. The goal is to see if CSP reduces heart failure events, hospitalizations, and need for additional procedures, while also improv…

This early study tests a new device called the Append System in 15 adults with atrial fibrillation (a type of irregular heartbeat). The device is threaded through a blood vessel to close off a small pouch in the heart called the left atrial appendage, where clots often form. The …

This study looks at whether it's safe to wait 5-9 days before treating a sudden episode of atrial fibrillation or flutter, instead of treating it right away in the emergency room. About 500 patients who are stable enough to go home will be randomly assigned to either immediate tr…

This study looks at whether the blood thinner warfarin can safely reduce stroke risk in people with end-stage kidney disease on dialysis who also have atrial fibrillation (an irregular heartbeat). About 718 adults will be randomly assigned to take warfarin or not, and researchers…

This study tests whether starting heart rhythm control therapy soon after a stroke can prevent future strokes, heart-related deaths, or hospital stays in people with atrial fibrillation. About 1,746 participants will receive either early comprehensive treatment or usual care. The…

This study compares a new pacing method called conduction system pacing (CSP) to standard pacing for people with a slow heart rate and a wide QRS pattern on their ECG. The goal is to see if CSP better preserves the heart's pumping ability over one year. About 120 adults who need …

This study tests whether enavogliflozin, a drug originally for diabetes, can prevent atrial fibrillation (AF) from returning after a catheter ablation procedure in people with AF and heart failure. About 390 adults will receive either the drug or a placebo daily for a year. The m…

This study looks at people with paroxysmal atrial fibrillation (a type of irregular heartbeat) that came back after a previous treatment. It compares two approaches during a repeat procedure: isolating the superior vena cava alone versus also adding ethanol (alcohol) infusion int…

This study looks at whether people with atrial fibrillation can safely stop taking long-term blood thinners after a procedure that closes off a part of the heart called the left atrial appendage. Participants will get a reduced dose of the blood thinner apixaban for just 3 months…

This study compares two medicines—apixaban (a blood thinner) and aspirin—in people who have had a brain bleed (intracerebral hemorrhage) and also have an irregular heartbeat (atrial fibrillation). The goal is to see which drug better prevents future strokes or death. About 700 pa…

This study tests a personalized approach to catheter ablation for persistent atrial fibrillation (AF), a common heart rhythm disorder. Researchers will identify specific areas in the heart that drive AF and target them with ablation, aiming to improve success rates. The trial inv…

This study tests a new approach for people with atrial fibrillation who have just received a coronary stent. Instead of taking multiple blood thinners together for months, the experimental group takes only one antiplatelet drug for the first month, then switches to a single antic…

This study compares two types of CPR for people who have a cardiac arrest outside a hospital: hands-only CPR (chest compressions without rescue breaths) versus standard CPR (compressions plus rescue breaths). The trial will include over 3,000 adults whose cardiac arrest is witnes…

This phase 2 trial tests whether giving high-dose vitamin C and thiamine early after cardiac arrest can help patients recover from shock. About 234 adults who remain unconscious after cardiac arrest and need blood pressure support will be randomly assigned to get either standard …

This study compares two approaches to taking blood thinners after a common heart procedure for atrial fibrillation. One group takes blood thinners every day as usual, while the other takes them only when a small implanted monitor detects an irregular heartbeat. The goal is to see…

This study tests a new device called MAGiC that uses magnets to help doctors treat abnormal heart rhythms. About 150 adults who need a standard heart ablation procedure will take part. The goal is to see if the device is safe and works well, both right after the procedure and ove…

This study tests a new device called the CellFX nsPFA catheter, which uses short electrical pulses instead of heat to treat paroxysmal atrial fibrillation (a type of irregular heartbeat). The goal is to see if it is safe and effective at restoring normal rhythm in 215 adults who …

This study looks at whether a procedure called catheter ablation (using heat or cold to fix faulty heart signals) is better than standard medications for people with both atrial fibrillation and heart failure. About 1,200 adults will be randomly assigned to receive either ablatio…

This study compares two approaches for treating atrial tachycardia that occurs after atrial fibrillation ablation or heart surgery. One group gets standard ablation targeting all abnormal heart circuits, while the other gets a more focused ablation guided by a new ultra-high-dens…

This study tests whether treating extra scar tissue in the heart's upper chamber, along with the standard vein isolation, can better control atrial fibrillation (AF) in people with persistent AF. About 204 adults with moderate scarring will be randomly assigned to standard treatm…

This study follows 50 patients with ventricular tachycardia that hasn't responded to standard treatments. They receive a single, high-dose radiation treatment (STAR) aimed at the heart tissue causing the abnormal rhythm. Researchers will track how well the treatment controls the …

This study tests whether emergency responders can safely use a special cooling vest on adults who have had a cardiac arrest and regained a pulse but remain unconscious. The vest is designed to cool the body quickly in the ambulance, which might protect the brain. The goal is to s…

This study tests a new approach for people with a life-threatening fast heart rhythm called ventricular tachycardia (VT) that keeps coming back after standard treatment. It compares a single, targeted radiation dose (cardiac radioablation) to a repeat catheter ablation, which is …

This study tests a new step-by-step care plan for paramedics to use after an adult's heart is restarted following a cardiac arrest outside the hospital. The plan includes careful monitoring of oxygen, blood pressure, and fluids to prevent the heart from stopping again. About 318 …

This study compares two blood thinners, rivaroxaban and apixaban, to see which causes less bleeding in people with atrial fibrillation (an irregular heartbeat). About 3,000 adults who need to start blood thinners will take one of the two drugs. The goal is to find which medicatio…

This study tests a digital toolkit called the Corrie Virtual Atrial Fibrillation Management Program, designed to help people with atrial fibrillation learn about treatment options, stick to therapies, and manage episodes. Researchers will enroll 248 adults with AFib and a BMI of …

This study tests whether colchicine, a common anti-inflammatory drug, can help people with chronic heart muscle inflammation (inflammatory cardiomyopathy). About 80 adults with this condition will receive either colchicine or a placebo to see if it prevents worsening heart failur…

This study is testing a procedure called pulsed field ablation (PFA) to treat atrial fibrillation, a common heart rhythm problem, in patients from racial and ethnic minority groups. About 275 participants will receive the standard PFA treatment using FDA-approved catheters, and r…

This study tests a newer pacing method called left bundle branch area pacing against standard pacing in people who need a pacemaker after a TAVI procedure. About 266 participants will be enrolled to see if the new method reduces heart-related deaths, hospitalizations for heart fa…

This study is testing a new catheter that uses real-time MRI to guide treatment for a common heart rhythm problem called type I atrial flutter. About 91 adults who need this procedure will receive radiofrequency ablation to block abnormal electrical signals. The main goals are to…

This trial tests whether a new app and device can help community first responders give better CPR during out-of-hospital cardiac arrests. The enhanced system allows two-way audio and one-way video communication with dispatchers, plus real-time feedback on chest compressions. Rese…

This study tests a new method called decrement evoked potential (DeEP) mapping to guide catheter ablation for ventricular tachycardia (VT) in people with structural heart disease. VT is a fast, dangerous heart rhythm that can cause sudden cardiac arrest. The standard ablation pro…

This study tests whether a single procedure that combines two heart treatments—pulmonary vein isolation (to correct irregular heartbeat) and left atrial appendage occlusion (to block a clot-prone area)—can prevent future strokes and major bleeding better than standard blood thinn…

This study looks at people with an irregular heartbeat (atrial fibrillation) who have had a brain bleed. Doctors are unsure if blood thinners are safe for them. The trial compares two options: the blood thinner apixaban or a procedure to close a part of the heart (left atrial app…

This study compares two procedures—pulsed field ablation and cryoballoon ablation—for treating atrial fibrillation (an irregular heartbeat). About 104 people having their first ablation will be randomly assigned to one method. The goal is to see which technique creates better sca…

This study tests whether Qidong Yixin Granules, an herbal medicine, can reduce the chance of atrial fibrillation returning within a year after a standard heart ablation procedure. About 846 adults with persistent atrial fibrillation will be randomly assigned to receive either the…

This study compares two types of pacemaker settings in people who need a pacemaker after a TAVI procedure (a minimally invasive heart valve replacement). The two methods are 'physiological pacing' (which tries to mimic natural heart activation) and standard 'right ventricular pac…

This study is testing whether people aged 70 and older with heart failure and a weak heart pump live just as long with only medication as they do with an implanted defibrillator (ICD). The trial will randomly assign 730 participants to receive either an ICD plus medication or med…

This study looks at whether a heart procedure called left atrial occlusion can help patients who have both atrial fibrillation (an irregular heartbeat) and radiation cystitis (bladder inflammation from cancer treatment). These patients often take blood thinners to prevent strokes…

This study tests doing two heart procedures at the same time for people with atrial fibrillation (AFib) who cannot take long-term blood thinners. The first procedure uses pulse field ablation to fix the heart's faulty electrical signals. The second closes off a small pouch in the…

This study tests whether adding an AI-powered heart mapping system (vMap) to the standard ablation procedure helps treat atrial fibrillation (AF) better than ablation alone. About 423 adults with persistent or recurrent AF will be randomly assigned to either standard treatment or…

This study tests whether a catheter ablation procedure can reduce severe mitral valve leakage in people with persistent atrial fibrillation (a type of irregular heartbeat). About 146 adults aged 18-80 with both conditions will either get the ablation plus standard care or just st…

This study compares two ways of placing a pacemaker lead in people who need frequent pacing. One method (left bundle branch pacing) aims to activate the heart more naturally than the standard method. The goal is to see if it reduces the time the heart spends in fast, irregular rh…

This study compares two ways to place a pacemaker in people with heart block (a condition where the heart's electrical signals slow or stop). One method uses standard right ventricular pacing, the other uses conduction system pacing (targeting the heart's natural electrical pathw…

This study looks at whether people with atrial fibrillation (AF) can safely stop taking blood thinners after a successful heart ablation procedure. About 4,100 adults aged 18-80 who have been on blood thinners for at least 2 months after ablation and have no signs of AF recurrenc…

This study tests a single, precise dose of radiation to the heart to treat dangerous arrhythmias in 60 patients who haven't improved with medication or standard procedures. Researchers will monitor changes in heart rhythm events and medication use over 18 months. The goal is to s…

This study looks at whether starting treatment early for atrial fibrillation (AF) that is only detected by heart devices can help control the condition. About 520 adults with these hidden AF episodes will be randomly assigned to either early rhythm control therapy (medication, sh…

This study is testing a device called LambrE that is implanted in the heart to close off a small pouch (the left atrial appendage) where blood clots often form in people with atrial fibrillation. The goal is to prevent strokes in patients who cannot take blood thinners due to ble…

This study tests whether using remote monitoring devices after a heart valve procedure (TAVI) allows patients to safely go home the same day instead of staying in the hospital. 216 adults who are eligible for same-day discharge will be randomly assigned to either standard care or…

This study tests whether a 12-month personalized exercise and diet program can reduce the amount of time spent in atrial fibrillation (an irregular heartbeat) and decrease fat around the heart in overweight or obese adults. About 158 participants will either follow the lifestyle …

This study tests whether heart failure patients who fully recover after treatment for a fast heart rhythm (like atrial fibrillation) can safely stop their heart failure medications. 348 participants will be randomly assigned to either gradually stop their drugs or continue them a…

This study compares two types of pacemaker placement after a procedure called AV node ablation for people with atrial fibrillation and normal heart function. One method uses standard right ventricular pacing, while the other targets the left bundle branch area. The goal is to see…

This study tests a new way to treat persistent atrial fibrillation (AFib) by targeting specific high-frequency areas in the heart that may be driving the condition. Researchers will compare this new ablation method to standard treatment in 78 adults with long-lasting AFib or recu…

This study compares a single dose of targeted radiation (SBRT) to the standard catheter ablation procedure for reducing dangerous heart rhythms in people with advanced heart disease. Sixty participants will be randomly assigned to one of the two treatments. The main goal is to se…

This study compares a new type of heart pacing (His-bundle pacing) to standard pacing in 120 adults with heart failure and right bundle-branch block. The goal is to see if the new method better improves the heart's pumping ability over 6 months. Participants will receive one of t…

This study looks at 60 adults with rapid atrial fibrillation who already have a pacemaker and recently had a heart ablation procedure. Researchers want to see if pacing the heart's natural electrical system (left bundle branch) helps patients exercise better compared to standard …

This study compares two types of repeat catheter ablation for people with symptomatic atrial fibrillation (AF) whose first treatment didn't work. 200 participants will be randomly assigned to receive either dual-energy ablation or standard contact force-guided ablation. The goal …

This study compares reprocessed (cleaned and re-sterilized) ablation catheters to brand-new ones in 200 adults with atrial fibrillation undergoing pulmonary vein isolation. The goal is to see if the reused catheters are just as safe and effective, while also being cheaper and bet…

This pilot study is testing a new procedure called electroporation ablation (using the FARAPULSE system) to treat atrial fibrillation in 200 people who also have heart failure with preserved ejection fraction. Half will get the procedure, half will get standard medical care. The …

This study tests a new device that uses short bursts of energy (pulsed field ablation) to treat atrial fibrillation, a common heart rhythm problem. The device maps the heart and then delivers energy to specific areas to correct the rhythm. Researchers will enroll 175 people to se…

This study compares a new pacing method (left bundle branch pacing) with a standard pacemaker-defibrillator in 30 people who have hypertrophic cardiomyopathy and a specific heart block after myectomy surgery. The goal is to see if the new method better prevents heart failure wors…

This study tests a pharmacy-led program for low-income patients with multiple chronic conditions like diabetes, heart disease, and depression. After leaving the hospital, participants get their medications with no copay, delivery to their bedside and home, and help from a pharmac…

This study is testing two different procedures—AF catheter ablation and AV node ablation—in 70 people who have heart failure, atrial fibrillation, and a CRT device that isn't pacing enough. The goal is to see which procedure better improves heart function and quality of life afte…

This study tests whether adding a small valve (PEEP) to the breathing bag during CPR helps restart the heart and improve survival in adults whose heart stops outside a hospital. About 132 participants will be randomly assigned to receive CPR with or without PEEP. The goal is to s…

This study tests a device called AtriLASH that closes a small heart pouch (the left atrial appendage) during planned heart surgery in 200 people with atrial fibrillation. The goal is to prevent blood clots that cause strokes, potentially reducing the need for blood-thinning medic…

This study tests a new, smaller pacemaker called Micra AV2 in 150 adults with heart block (a condition where the heart's electrical signals are blocked). The pacemaker is designed to better match the heart's natural rhythm, especially during exercise, and lasts over 15 years. Res…

This study tests a single, high-dose radiation treatment aimed at the area of the heart causing dangerous rapid rhythms (ventricular tachycardia). It includes 12 adults with an implanted defibrillator who have not been helped by medications or standard procedures. The goal is to …

This study tests whether using a heart-lung machine (ECMO) right at the scene of a cardiac arrest can improve survival and brain function. Researchers will compare how quickly ECMO can be started on-site versus in the hospital. The trial involves 100 adults who have a witnessed c…

This study tests a telemedicine-based care model for heart failure patients who are frequently readmitted to hospital and cannot join standard rehab. Researchers will provide on-demand video and chat support from cardiologists to general practitioners and community health workers…

This study tests whether blood thinners (NOACs) can prevent stroke in people who develop atrial fibrillation only during stressful events like surgery or serious illness. About 2,270 participants will be randomly assigned to take a blood thinner or not, and researchers will track…

This phase 2 study at the Cleveland Clinic will test whether the weight-loss drug tirzepatide (Zepbound) can help people with obesity and atrial fibrillation (AFib). About 100 participants will receive weekly injections of tirzepatide or a placebo for up to 12 months. The main go…

This study tests a new catheter (Vision-MR 2.0) to treat ventricular tachycardia, a fast, dangerous heart rhythm, in people with ischemic heart disease. About 64 adults will undergo a procedure to burn small areas of heart tissue causing the abnormal rhythm. The goal is to stop t…

This pilot study tests whether a non-invasive global mapping system can help doctors personalize catheter ablation for people with persistent atrial fibrillation (AF). The standard approach isolates the pulmonary veins, but this study adds up to three extra targets based on where…

This study looks at 240 adults with septic shock who develop a new, fast heart rhythm problem. It compares three treatment approaches: controlling heart rate with low-dose amiodarone, restoring normal rhythm with high-dose amiodarone or electric shock, or managing risk factors wi…

This study compares two pacemaker strategies for people with sick sinus syndrome and AV conduction delay. Participants will be randomly assigned to receive either left bundle branch area pacing (LBBAP) or minimized ventricular pacing (MVP). The goal is to see which method leads t…

This early study tests a new catheter that changes shape to better treat persistent atrial fibrillation (AF), a type of irregular heartbeat. The catheter can switch between a large 'petal' shape for quick vein isolation and a small 'bud' shape for precise linear ablation. Forty a…

This study tests whether giving the heart medication amiodarone for 72 hours can reduce death and prevent life-threatening heart rhythms in critically ill patients who survived a cardiac arrest with a shockable rhythm. About 674 adults in intensive care will receive either amioda…

This study tests whether giving the heart medication amiodarone one cycle earlier than usual during cardiac arrest can improve survival. About 585 adults with a shockable heart rhythm will be enrolled. The goal is to see if this change in timing helps restore a normal heartbeat f…

This study tests whether adding a special pacing test during heart ablation can lower the chance of atrial fibrillation coming back. About 240 adults with paroxysmal AF (short, self-stopping episodes) will be randomly assigned to standard ablation or standard ablation plus extra …

This study looks at whether a lower daily dose of the heart medication amiodarone can keep the heart in a normal rhythm as well as the standard dose, but with fewer side effects. About 312 adults with persistent atrial fibrillation who have had a successful electrical shock to re…

This study compares a low cumulative dose of epinephrine (adrenaline) to the standard dose during resuscitation for out-of-hospital cardiac arrest. About 3,790 adults with a shockable heart rhythm will be enrolled. The goal is to see if using less epinephrine improves survival to…

This study tests whether adding a kidney nerve-zapping procedure (renal artery denervation) to the standard heart ablation procedure can better control persistent atrial fibrillation (AF). About 50 adults with persistent AF and controlled or no high blood pressure will be randoml…

This study tests whether a newer, two-step hybrid ablation procedure works better than standard catheter ablation for people with persistent atrial fibrillation (a type of irregular heartbeat) and heart failure. About 120 participants will be randomly assigned to one of the two p…

This trial compares two ways to help patients breathe during a cardiac arrest in the hospital: a supraglottic airway (a tube placed in the throat) versus endotracheal intubation (a tube placed into the windpipe). About 1,060 adults who suffer cardiac arrest while hospitalized wil…

This trial tests two ways to treat ventricular tachycardia (a fast, dangerous heart rhythm) in people who have had a heart attack and have an implanted defibrillator. One method uses standard ablation inside the heart; the other also ablates outside the heart. The study will trac…

This study tests a new, non-invasive radiation treatment against the standard catheter procedure for ventricular tachycardia, a dangerous fast heartbeat. About 244 adults with heart failure and an implanted defibrillator will be randomly assigned to one of the two treatments. The…

This study tests a new device called NEURESCUE, a balloon catheter inserted into the leg artery that inflates to redirect blood to the heart and brain during cardiac arrest. Researchers will compare standard CPR plus the device against CPR alone in 84 adults with witnessed cardia…

This study tests whether a group of treatments (like controlling body temperature, oxygen levels, blood pressure, and blood sugar) can improve brain function in adults who remain unconscious after a cardiac arrest. About 1,000 participants will be randomly assigned to receive eit…

This study tests whether semaglutide, a medication used for weight loss, can help control atrial fibrillation (AFib) in people who are overweight or have obesity. About 200 adults aged 18-75 with AFib and a BMI of 30 or higher will receive semaglutide plus standard AFib care. Res…

This study tests a device called CoolCryo that freezes small areas of heart tissue to stop atrial fibrillation (an irregular heartbeat). It is being used in 20 people who are already having mitral valve surgery. The goal is to see if the freezing treatment can keep the heart in n…

This phase 2 trial tests whether breathing a mix of argon gas and oxygen soon after a cardiac arrest can reduce brain damage. Researchers will enroll 120 comatose patients who were resuscitated from a witnessed cardiac arrest. The main goal is to see if argon lowers a brain injur…

This trial compares three different catheter ablation strategies for people with persistent atrial fibrillation (AFib), a heart rhythm problem. Sixty adults aged 18-80 will be randomly assigned to one of three approaches using a special catheter that can switch between two energy…

This study tests whether a newer pacing method called left bundle branch pacing (LBBP) works better than the standard biventricular pacing for people with chronic heart failure and reduced pumping ability. About 60 adults with heart failure and a specific electrical delay in the …

This study tests a new approach for treating paroxysmal atrial fibrillation (a type of irregular heartbeat). It combines two procedures: pulsed-field ablation to isolate the pulmonary veins, plus targeted thermal ablation of a nerve cluster near the heart. The goal is to see if a…

This study compares two procedures for treating persistent atrial fibrillation (AF): catheter ablation (which scars tiny areas in the heart to block faulty signals) and DC cardioversion (an electric shock to restore normal rhythm). Researchers want to see which one better prevent…

Mitral valve prolapse is common and usually harmless, but a small group of patients develop dangerous heart rhythms that can cause sudden cardiac arrest. Researchers at Oslo University Hospital are building and testing a risk prediction model that combines clinical exams, electro…

This study tests whether a chest-strap ECG wearable, the Frontier X Plus, can accurately detect heart rhythm problems compared to the standard MoMe ARC patch monitor. About 15 active adults who are already prescribed a heart monitor will wear both devices at the same time. Resear…

This study will test new ultrasound techniques, combined with artificial intelligence, to more accurately measure heart filling pressure in patients who have both heart failure and atrial fibrillation. Current methods are unreliable for these patients, making diagnosis and treatm…

Researchers at Ohio State University are testing whether high-resolution contrast-enhanced MRI can show the scar tissue in the heart that matches the electrical rotors targeted during FIRM-guided ablation for atrial fibrillation. About 20 adults with symptomatic paroxysmal or per…

This study compares two types of portable heart monitors in people who have symptoms of an irregular heartbeat (arrhythmia) but whose standard heart test was normal. About 588 participants will wear either a continuous ECG patch or use a handheld ECG device for one month. The goa…

This trial tests whether a smartphone app using the camera's light sensor can detect atrial fibrillation (AF), a common heart rhythm disorder that raises stroke risk. About 554 adults with heart conditions will have their heart rhythm measured simultaneously by a standard 12-lead…

This trial tests whether an artificial intelligence tool can help doctors detect undiagnosed atrial fibrillation and structural heart disease from routine electrocardiograms (ECGs). About 1,000 healthcare providers are randomly assigned to either receive AI-generated risk alerts …

This trial tests whether a machine-learning algorithm can detect atrial fibrillation (AF) early by analyzing pulse wave signals from a wearable sensor. The study involves 200 adults with heart failure, comparing the algorithm's readings against standard ECG results. If it works, …

This study aims to develop a new clinical test to diagnose Calcium Release Deficiency Syndrome (CRDS), a rare inherited heart condition that increases the risk of sudden cardiac arrest. Researchers will use a pacing procedure to measure heart wave changes in 400 participants, inc…

This study is testing a cloud-based artificial intelligence platform called Willem that analyzes ECG recordings to detect heart rhythm problems and abnormal patterns. Researchers will compare the AI's readings to those of board-certified cardiologists in over 5,300 high-risk card…

This trial tests a wearable bracelet called Stroke Alarm that detects when a stroke causes arm weakness. People aged 50 and older with certain high-risk conditions (like recent mini-stroke, atrial fibrillation, or artery disease) wear the device for 3 months. The goal is to see i…

This study looks at whether a specific antibody in the blood can help diagnose and predict the course of a rare, life-threatening heart condition called short-coupled ventricular fibrillation (SCVF). Researchers will test 300 adults with SCVF for these antibodies and study how th…

This study compares a new wearable armband called HeartWatch to the standard Holter monitor for detecting heart rhythm problems like atrial fibrillation. About 300 adults who need a Holter test will wear both devices at the same time. The goal is to see if the HeartWatch can accu…

This study tests whether a special CT scan done in the emergency department can quickly check for blood clots in people with atrial fibrillation or atrial flutter. If no clot is found, doctors can proceed with a procedure to restore normal heart rhythm (cardioversion) right away.…

This study is testing whether a computer program (machine learning) can help doctors diagnose severe heart attacks in patients who have a heart condition called left bundle branch block (LBBB). LBBB can hide the usual signs of a heart attack on an ECG, making it hard to tell if a…

This study tests an artificial intelligence program that analyzes heart rhythm data from a small, wearable patch to estimate how well the heart pumps blood. Researchers will compare the AI's results to standard ultrasound in 2,000 adults. If accurate, this could offer a simpler, …

This study is looking for markers in blood and saliva that can quickly tell if a person is having a stroke, and what kind. Researchers will collect samples from 650 adults with suspected stroke within 24 hours of symptoms. The goal is to develop a fast, accurate test to help emer…

This study aims to improve how doctors diagnose a rare heart condition where a coronary artery starts in the wrong place (AAOCA), which can cause sudden cardiac death in young athletes. Researchers will use artificial intelligence and 3D computer models to analyze CT scans and pr…

This study tests a new, noninvasive method to quickly determine if critically ill children need intravenous fluids. The method uses gentle abdominal pressure and a device that measures blood flow. If accurate, it could help doctors avoid giving unnecessary fluids, which can be ha…

This study tests whether wearing a portable ECG monitor for 30 days after a heart valve replacement (TAVI) can detect dangerous heart rhythm problems better than the usual 1-2 days of hospital monitoring. 250 patients will be randomly assigned to either the extended monitoring gr…

This study is testing whether a small implantable heart monitor (Reveal LINQ) can detect serious heart block in people who develop a new electrical problem (left bundle branch block) after having their aortic valve replaced (TAVI). About 80 participants will get the monitor and b…

This study tests whether a smartwatch (Withings ScanWatch) can diagnose atrial fibrillation that occurs after heart surgery better than standard monitoring. About 324 adults who had on-pump heart surgery will either use the smartwatch or receive usual care. The goal is to catch s…

This study compares a new wireless heart sensor patch to standard hospital monitoring for detecting atrial fibrillation (an irregular heartbeat) in people who recently had a stroke. About 450 adults will be randomly assigned to wear the patch for up to 14 days or receive usual ca…

This study tests a new CT scan method that checks for blocked heart arteries in people who survive a cardiac arrest, without needing extra medication or heart monitoring. About 30 adults who have been revived after a cardiac arrest will get this special CT scan, and the results w…

This study is testing whether certain heart ultrasound findings can identify people who might have hidden atrial fibrillation (AF), a common heart rhythm problem that raises stroke risk. Researchers will enroll 3000 participants with abnormal ultrasound results and randomly assig…

This study tests whether an artificial intelligence (AI) system can help doctors spot hidden atrial fibrillation (AF) — a common heart rhythm disorder that raises stroke risk — by flagging suspicious electrocardiograms (ECGs). About 14,700 patients will be randomly assigned to ha…

This Stanford study is testing computer algorithms to better map the heart's electrical activity in people with atrial fibrillation (AF), a common heart rhythm disorder. Researchers will compare different methods to see which best identifies problem areas in the heart. The study …

Researchers compare two ways of placing a pacemaker lead in people with atrioventricular block, a condition where the heart's electrical signal is blocked. One method, left bundle branch area pacing, aims to mimic the heart's natural activation; the other, right ventricular pacin…

Researchers are testing a device called the Append System to close off the left atrial appendage, a small pouch in the heart, in people with non-valvular atrial fibrillation. The procedure uses a catheter to fold and tie off the pouch, with the goal of reducing the risk of blood …

After a cardiac arrest, many survivors develop seizures that can worsen brain injury. This trial tests whether giving the drug perampanel soon after resuscitation can prevent those seizures. About 52 adults who are comatose after a cardiac arrest will receive either perampanel or…

This trial investigates whether a short course of atorvastatin, a widely used statin, can prevent atrial fibrillation—a rapid, irregular heartbeat—in adults aged 60 and older undergoing lung surgery. Participants are randomly assigned to receive either atorvastatin or a placebo f…

This trial tests whether making a small opening in the sac around the heart (posterior pericardiotomy) during heart surgery can prevent a common complication called atrial fibrillation. About 650 adults in China having surgery on the heart's valves, coronary arteries, or aorta wi…

This study tests whether giving fish oil through a vein during heart surgery can prevent a common complication called atrial fibrillation (irregular heartbeat) and help patients recover faster. About 550 high-risk adults having elective heart surgery will receive either fish oil …

This large study tests whether a smartphone app can help prevent strokes by detecting atrial fibrillation (an irregular heartbeat) early. Adults aged 65 and older in Austria are randomly assigned to use the 'Pulskontrolle' app for pulse checks or to receive usual care. If the app…

This study is testing whether a home-based screening kit can identify hidden heart risks better than standard doctor visits. 45,000 adults in Sweden aged 50-75 will either receive a home blood pressure monitor, a finger-prick blood test, and a health questionnaire, or continue wi…

This study tests whether a newer pacemaker method (conduction system pacing) can better prevent heart muscle weakening compared to the standard method. Researchers will enroll 200 adults who need a pacemaker for a slow heart rhythm. The goal is to see which approach reduces the r…

This study looks at whether closing a small pouch in the heart (the left atrial appendage) during open-heart surgery can help prevent strokes in people with atrial fibrillation. Researchers will analyze heart tissue, blood, and ECG recordings from 1000 participants to find out wh…

This study tests whether placing a biodegradable patch soaked with the drug amiodarone on the heart during surgery can prevent atrial fibrillation (a common irregular heartbeat) afterward. About 500 adults having elective heart surgery will be randomly assigned to get either the …

Researchers are testing whether a pacing technique called left bundle branch area pacing, guided by detailed imaging and electrical data, can improve outcomes for people with heart failure and left bundle branch block. The trial enrolls 100 adults with non-ischemic cardiomyopathy…

Researchers are testing a targeted ablation method for people with structural heart disease who have ventricular tachycardia, a dangerous fast heart rhythm. The procedure maps conducting channels inside heart scar tissue by pacing many sites, then uses radiofrequency energy to bl…

This study tests an experimental medicine called BAY 3670549 in 360 adults with atrial fibrillation (an irregular heartbeat). Participants receive a single IV dose of the drug or a placebo to see if it can restore normal heart rhythm without needing an electrical shock procedure.…

This study tests an investigational nasal spray called etripamil for people with atrial fibrillation (AFib) who experience episodes of dangerously fast heart rate. About 750 adults will be randomly assigned to use either the real spray or a placebo at home when symptoms start. Th…

This study tests if using a camera inside the heart (intracardiac echocardiography) is as safe and effective as the standard throat camera (transesophageal echocardiography) for guiding a procedure to close a heart pouch. The goal is to prevent strokes in people with an irregular…

This study tests whether adding lidocaine to the Custodiol solution used during heart bypass surgery can reduce dangerous heart rhythms that often occur after the heart is restarted. About 70 adults having planned coronary bypass surgery will be randomly assigned to receive eithe…

This study tests a new exercise approach for people aged 60 and older who have both atrial fibrillation (an irregular heartbeat) and a type of heart failure called HFpEF. Instead of starting with aerobic exercise like walking, participants will first do 2 months of progressive re…

This study tests whether low-intensity focused ultrasound (LIFU) applied to a nerve cluster in the neck can improve sleep quality and heart rate control in people recovering from heart surgery. 200 participants will receive either real or sham ultrasound daily for 3-7 days after …

This trial is testing whether a mild sedation combination of remimazolam and fentanyl can be used instead of general anesthesia during a pulsed-field ablation procedure for atrial fibrillation. The study will enroll 20 adults with paroxysmal or persistent AF and monitor how well …

This pilot study tests a program called Heartsight, which provides educational modules to caregivers of children who have had a cardiac arrest. The goal is to see if the program is feasible and acceptable, and whether it can reduce caregivers' uncertainty, anxiety, depression, an…

This study tests whether a sedative called dexmedetomidine can help people in the ICU who have a life-threatening heart rhythm problem called electrical storm. About 192 adults will receive either the sedative or a placebo for 2-3 days. The goal is to see if it reduces deaths and…

This study looks at whether a procedure called catheter ablation can improve quality of life for people aged 80 and older who have a heart rhythm problem called atrial fibrillation. Half of the 182 participants will get the real procedure, and half will get a fake one (sham) to s…

This study compares electrical cardioversion—a procedure that delivers a shock to restore normal heart rhythm—to a sham version where no shock is given. Researchers want to see if the real procedure truly improves quality of life in people with persistent atrial fibrillation, a c…

This study tests whether having a trained peer mentor—someone who also has atrial fibrillation—can improve mental well-being in patients who are more vulnerable due to low income or education. About 290 participants will either receive usual care or be paired with a mentor for 16…

This study tests a modified imaging catheter (ViewFlex X ICE) to help doctors see heart structures during procedures for irregular heartbeats. About 500 adults who are already scheduled for a heart procedure using ultrasound will be enrolled. The goal is to see if the new cathete…

This study compares a simple nasal swab to the standard Valsalva maneuver for stopping a common rapid heartbeat condition called supraventricular tachycardia (SVT). About 60 adults with SVT in the emergency room will be randomly assigned to one of the two methods. The goal is to …

This study tests whether a smartwatch and text message system can encourage people with paroxysmal atrial fibrillation (a type of irregular heartbeat) to be more physically active. The trial has two phases: first, a small group will help design the messages and test the smartwatc…

This study looks at how a child's quality of life changes after a procedure called transcatheter ablation, which treats abnormal heart rhythms. Researchers will ask 200 children aged 5 to 17 and their parents to fill out questionnaires about physical, emotional, social, and schoo…

This study tests whether using a brain activity monitor (BIS) to guide sedation during a procedure that shocks the heart back to normal rhythm leads to faster recovery and fewer side effects. About 60 adults with atrial fibrillation will be randomly assigned to receive sedation g…

This study tests whether keeping a special chest tube in place for up to 3 days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart surgery will be randomly assigned to get the tube p…

This study tests whether a 12-week home walking program can improve daily activity and quality of life in people who have an implantable cardioverter defibrillator (ICD). Researchers will enroll 210 adults who can walk without help and have had an ICD placed to prevent sudden car…

This study looks at whether using a CPAP machine in a personalized way can reduce the amount of time people with atrial fibrillation (AFib) spend in an irregular heart rhythm. Twenty adults with both moderate-to-severe sleep apnea and AFib will alternate two weeks on and two week…

This study tests whether a web-based program can improve quality of life for people who survived a cardiac arrest outside the hospital. The program includes educational sessions, brain games, and tips on physical activity and nutrition. Researchers will enroll 106 survivors and m…

This study compares two types of supervised exercise programs—high-intensity interval training (HIIT) and moderate-intensity continuous exercise—against standard care alone in 132 adults with persistent or permanent atrial fibrillation. Participants will exercise twice weekly for…

This study tests a special closure device (VASCADE MVP) to stop bleeding after a heart ablation for atrial fibrillation. The goal is to see if it helps patients get up and walk sooner compared to standard manual compression. One hundred adults undergoing ablation will be randomly…

This trial compares two defibrillators—one delivering a maximum of 200 joules and the other 360 joules—to see which is better at restoring normal heart rhythm in people with persistent atrial fibrillation. About 376 adults scheduled for elective cardioversion will be randomly ass…

This study compares two types of nerve blocks—M-TAPA and TAP block—for pain relief after open inguinal hernia repair. Sixty adults undergoing elective surgery will receive one of the two blocks with the same numbing medicine. Researchers will measure pain scores and patient satis…

Researchers compare two hand positions for chest compressions: the standard interlocked-finger technique and an overlapped-hands technique. Adults with and without medical training perform two minutes of compressions on a manikin. The study measures compression depth, rate, and r…

After a cardiac arrest, the brain can suffer from dangerous pressure changes. This pilot study at National Taiwan University Hospital is testing a method to directly monitor brain pressure and blood flow in 50 patients who remain in a coma after their heart is restarted. Research…

This study is a registry that collects information on the safety and effectiveness of Medtronic medical devices already on the market. It will include up to 100,000 people who have or will receive a Medtronic product for conditions like heart, nerve, or digestive disorders. The g…

People admitted for acute coronary syndrome, which includes heart attacks and unstable angina, face a higher risk of dangerous heart rhythms such as sustained ventricular tachycardia and ventricular fibrillation. Hospitals monitor these patients, but the exact rate of these rhyth…

This study is observing 900 adults in Greece who have both chronic obstructive pulmonary disease (COPD) and at least one heart condition. Researchers will track their health for two years, recording lung flare-ups, heart complications, hospital visits, and quality of life. The go…

This study is testing a new 3D imaging system that helps doctors see inside the heart during a procedure to treat atrial flutter and atrial fibrillation. About 50 adults who are already scheduled for a catheter ablation will have their procedure guided by this system. The goal is…

Researchers are studying people with arrhythmia-induced cardiomyopathy, a condition where a fast or irregular heartbeat weakens the heart muscle. The study checks whether these patients carry more harmful gene variants than people with other types of cardiomyopathy or the general…

This study tests a new imaging system called VERAFEYE that helps doctors see inside the heart during a common procedure called catheter ablation. The procedure treats irregular heartbeats like atrial fibrillation. About 50 adults will take part to see if the system works well and…

This study collects blood and tissue samples from 2,000 people with or without heart rhythm problems. Researchers will analyze the samples to find genetic differences linked to arrhythmias. The goal is to better understand the causes of these conditions, not to test a new treatme…

This study will look at 40 people with both hypertrophic cardiomyopathy (HCM) and atrial fibrillation (AF) to understand why AF is more common and harder to treat in HCM. Researchers will measure electrical signals in the heart and use advanced imaging. The goal is to find clues …

This study is observing 4,500 people who need pacemakers or similar heart devices. The goal is to create a tool that predicts who is at risk of developing a weakened heart from the device itself. By identifying high-risk patients early, doctors can choose better pacing methods to…

This study will observe 253 adults with heart rhythm problems who are scheduled for procedures like pacemakers or ablation. Researchers will use advanced imaging and AI tools to understand why some patients respond well to treatment while others do not. The goal is to find better…

Researchers at Wroclaw Medical University are studying what factors are linked to slow heartbeats, called bradycardia, in patients recovering from pulsed field ablation for atrial fibrillation. The study enrolls about 100 people who have this procedure, which uses pulsed energy t…

Researchers at the Heart Center Bad Berka run a registry that collects data on adults treated for heart rhythm problems. The registry follows people who receive medication, procedures such as ablation, or implanted cardiac devices. It tracks how safe and effective these treatment…

This study is collecting information from 280 people who need a heart rhythm procedure using BIOTRONIK catheters, external devices, or sheaths. The goal is to track how well the devices work and any problems that may happen during or shortly after the procedure. It is a routine s…

This study tests whether the Apple Watch's AFib History feature can accurately measure the amount of time spent in atrial fibrillation after a type of heart surgery called the Cox-Maze IV procedure. Researchers will compare the watch's readings to those from a standard medical de…

Researchers at the Cleveland Clinic are testing a prototype 4D intracardiac echocardiography (ICE) catheter that provides real-time ultrasound images from inside the heart. The study involves 20 adults scheduled for a left atrial appendage closure procedure, a common treatment fo…

This observational study will follow 200 adults with Brugada Syndrome who need anesthesia for surgery or other procedures. Researchers want to see how often dangerous heart rhythms occur during and up to 30 days after anesthesia. They will also check if certain anesthetic drugs o…

This study follows 700 cancer patients who take blood thinners and are scheduled for surgery or medical procedures. Researchers will track how often major bleeding or clotting events occur within 30 days after the procedure. The goal is to see if current blood thinner management …

This study tests whether showing real-time visual feedback to EMS responders helps them deliver the right amount of air during simulated CPR. 80 rescuers will give breaths to a mannequin with and without feedback, using two different CPR strategies. The goal is to see if feedback…

This study explores whether drones can deliver automated external defibrillators (AEDs) to people experiencing cardiac arrest in rural areas faster than traditional emergency responders. Researchers will compare arrival times and see if drone delivery is practical enough to test …

This trial is testing a medical device that has not been approved by the U.S. FDA. The purpose is to gather information about how the device works and its safety in people. Participants will be monitored closely, but the device is not yet proven to treat or cure any condition.

This study will screen 3,000 adults with heart disease (coronary artery disease, atrial fibrillation, or heart failure) to see how many also have COPD, a serious lung condition. Doctors and patients will receive education on managing both heart and lung problems together. The goa…

This study is testing a new paddle-shaped catheter designed to map the heart's electrical signals in people with various heart rhythm disorders like atrial fibrillation and ventricular tachycardia. The device has many sensors to create a detailed map of the heart's chambers. The …

This study tests whether artificial intelligence can use continuous ECG data to predict and detect life-threatening heart arrhythmias in patients admitted with acute cardiac illness. Researchers will analyze stored ECG data from 3000 adult patients to see if AI models can forecas…

This study will enroll 100 people who have already had a heart procedure (pulsed field ablation) for atrial fibrillation. Participants will wear a BodyGuardian monitor for a period after the procedure to see if it catches any return of irregular heartbeats. The study also asks pa…

This trial tests whether mailing a sleep apnea home-testing device to people with atrial fibrillation can improve their quality of life. About 936 participants will either receive the device and possible treatment, or no test at all. Researchers will track symptoms, activity, and…

This trial tests whether an augmented reality (AR) system can help healthcare providers deliver high-quality chest compressions during a simulated pediatric cardiac arrest. Participants, who are nurses or technicians with pediatric life support certification, will perform CPR for…

This observational study aims to uncover clinical and genetic risk factors for sudden cardiac arrest and death in patients with coronary artery disease (CAD). Researchers will follow about 4,000 participants who have been diagnosed with CAD, collecting data from surveys, ECG reco…

This study is a national registry in France that will follow young people aged 12 to 35 who experience sudden cardiac arrest or death during sports. Researchers will perform thorough medical investigations, including autopsies and whole exome genetic testing, to try to find the u…

This study is observing 1,500 people with coronary artery disease to find better ways to predict who is at risk of sudden cardiac arrest. Researchers are looking at genetic, electrical, and biological markers, as well as psychological factors. The goal is to identify high-risk pa…

This study looks at whether specific proteins released into the blood after a traumatic brain injury or cardiac arrest can help doctors assess damage and predict recovery. Researchers will collect blood samples from patients starting in the ambulance or emergency department and c…

This study will compare two newer pacemaker technologies—left bundle branch area pacing and leadless pacing—to see how they affect heart function and the tricuspid valve. Twenty adults with certain heart block conditions will receive both types temporarily during their routine pa…

This study is collecting blood and other samples from 5,000 children and young adults (under 21) who are already taking certain medications as part of their regular care. The goal is to understand how these drugs move through and affect children's bodies, so doctors can prescribe…

This study will test a new imaging system called CHORUS IDx in 200 people scheduled for a heart ablation procedure. The system takes pictures inside the heart to help doctors see better during the procedure. The main goal is to check if the device is safe and to collect images th…

This study looks at whether certain fat molecules in the blood, called lipids and ceramides, are linked to atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from people with atrial fibrillation to those with other heart conditions but no a…

This study observes how core body temperature changes in adults who experience cardiac arrest outside the hospital. Researchers will measure temperature using a probe inserted into the esophagus during resuscitation and transport to the hospital. They will also track environmenta…

This study looks at whether using a special heart ultrasound (called TEE) during emergencies helps doctors make better decisions and improves patient outcomes. Researchers will track 1,000 critically ill adults in the ER or ICU who receive this test as part of their care. The goa…

This study looks at how blood levels of common blood thinners (apixaban, dabigatran, edoxaban, and rivaroxaban) change over time in Chinese patients with atrial fibrillation. Researchers will take blood samples before and after stopping the medication for medical procedures. The …

This study tests a new software module that analyzes heart signals during a procedure called pulsed field ablation, used to treat atrial fibrillation. The goal is to see if the software can accurately tell doctors when the targeted heart veins are fully isolated. One hundred adul…

This study looks at whether people with heart rhythm problems after a TAVI procedure can safely leave the hospital early if they wear a non-invasive heart monitor at home. About 100 adults who had a successful TAVI for severe aortic stenosis and have certain conduction disorders …

This study aims to create a better way to predict stroke risk in people with atrial fibrillation (an irregular heartbeat) who are already taking direct oral anticoagulants (DOACs), a type of blood thinner. Even with these medications, some patients still have strokes. Researchers…

This observational study investigates whether blood clotting markers and heart ultrasound measurements can help assess stroke risk in people with device-detected atrial fibrillation—a brief, symptomless irregular heart rhythm picked up by pacemakers or similar implants. Researche…

This registry tracks 2,000 adults with congenital heart disease who are on the waiting list for a heart or heart-lung transplant. The goal is to understand why some patients get worse or die while waiting, while others improve enough to be removed from the list. By collecting dat…

This study tests whether a live video connection between paramedics and pediatric emergency doctors improves care for critically ill children. Paramedics will treat infant mannequins in simulated ambulance scenarios, with some getting video support and others only audio. The goal…

This study tests whether an artificial intelligence algorithm can predict survival and complications in people who have had a cardiorespiratory arrest and been revived. Researchers will analyze hospital records from 300 to 500 patients treated in intensive care units in France be…

This study tests whether advanced MRI scans that map the brain's structural and functional connections can better predict neurological recovery in coma patients after cardiac arrest than standard methods. Researchers will scan 263 adults who remain unconscious at least 72 hours a…

This study observes 50 adult organ donors to measure oxygen levels in the blood when the heart stops during a Maastricht III donation procedure. Researchers take blood samples at key moments to understand how low oxygen gets. The goal is to gather knowledge, not to test a treatme…

This observational study at Brigham and Women's Hospital will use advanced MRI scans to see if brain activity and structure can predict recovery in 50 people who are comatose after a cardiac arrest. Participants will have a special MRI during their standard scan and be followed f…

This study looks at 300 people with rapid atrial fibrillation (a fast, irregular heartbeat) to understand why some have heart damage. Researchers will use blood tests and heart scans to see if blocked arteries are the cause. The goal is to improve how doctors diagnose and manage …

This study is not testing a drug or treatment. Instead, researchers are using artificial intelligence to analyze electrocardiogram (ECG) data from over 127,000 people. The goal is to create computer models that can quickly and accurately predict life-threatening heart rhythm prob…

This study looks at whether a person's genetic makeup can help spot undiagnosed atrial fibrillation (AF), an irregular heartbeat that raises stroke risk. About 800 adults with symptoms or risk factors will wear a heart monitor for 7 days and use a handheld ECG device at home for …

This study will use a special X-ray technique called fluoroscopy to check how often the diaphragm becomes temporarily paralyzed after pulsed field ablation, a newer treatment for atrial fibrillation. Researchers will monitor 250 adults before and after the procedure to detect any…

This study aims to find unique substances in the blood (biomarkers) that are only present in people with atrial fibrillation, a common heart rhythm problem. Researchers will compare blood samples from 400 patients with AF to those without, and track changes over time. The goal is…

This study aims to create a North American registry of sudden unexplained death in epilepsy (SUDEP) cases. Researchers will interview family members and review medical records of people with epilepsy who died suddenly. By comparing these cases with living epilepsy patients, they …

This study is a registry that will follow 4,000 people in China who are having a procedure called catheter ablation to treat atrial fibrillation or ventricular tachycardia. The goal is to see how well the procedure works over the long term and how safe it is. Participants will be…

This study follows 2000 adults who are in a coma or have disorders of consciousness after serious brain injuries like stroke, cardiac arrest, or trauma. Researchers collect medical records and later interview survivors or their caregivers about physical and emotional recovery. No…

This study uses 3D echocardiography to track changes in the tricuspid valve of 66 people with atrial fibrillation (AF) who do not yet have significant valve leakage. Researchers want to see if the valve's shape changes as AF becomes more persistent. The goal is to better understa…

This study looks at people who had a heart attack and also developed a dangerous heart rhythm (ventricular arrhythmia) while still in the hospital. Researchers want to learn more about how these patients are treated and how many die after leaving the hospital. The study does not …

This study looks at whether measuring the function of the right upper heart chamber using ultrasound can help predict a common irregular heartbeat (atrial fibrillation) that often occurs after heart surgery. About 334 adults scheduled for bypass surgery will have their heart func…

This study is developing an AI system that tracks tumors and organs during radiation therapy without needing physical markers. Researchers will use existing patient data to train and test the AI. If it works, it could help doctors target radiation more accurately. The study invol…

This study is testing whether a Samsung smartwatch and heart MRI scans can detect early signs of heart muscle damage (atrial myopathy) in 360 people with atrial fibrillation or at high risk for heart disease. Participants wear the watch for up to 9 months while researchers track …

This study tests whether paramedics can safely place a small tube in the leg artery of people having a cardiac arrest outside the hospital. The tube allows continuous blood pressure monitoring, which may help doctors give the right amount of medication to keep the heart pumping. …

This study looks at how artificial intelligence (AI) can help emergency call operators quickly identify life-threatening situations like cardiac arrest, stroke, or severe breathing problems. Researchers will analyze millions of past emergency calls to train AI models to recognize…

This study looks at how much pain people feel after a cardiac arrest while they are in the intensive care unit. Researchers will track pain using special scales, even in patients who are unconscious or on a breathing machine. The goal is to understand how pain affects recovery, s…

This study looks at whether checking pupils and brain oxygen levels right before starting ECMO can help predict neurological recovery in cardiac arrest patients. Researchers will measure these in 45 adults being evaluated for ECMO, before and after the procedure. The goal is to s…

This study is testing different treatments to reduce major complications and improve survival in 600 adults who need ECMO—a machine that does the work of the heart and lungs. Researchers will compare how well these treatments work in the first 28 days. The goal is to find safer, …

This study is building a registry of 1,211 people in Brazil who have inherited heart conditions like cardiomyopathy, arrhythmias, and Marfan syndrome. Researchers will collect DNA samples and medical information to discover which genes are most commonly affected and how often the…

This study follows 24 people who had a stroke and were recently diagnosed with atrial fibrillation (AF), a heart rhythm problem. Researchers want to see how AF changes over two years by monitoring heart activity, blood markers, and heart structure. The goal is to better understan…

This study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…

This registry is tracking 2,000 people with atrial fibrillation who are taking blood thinners for a long time. The goal is to see how often serious bleeding or clotting events happen. Researchers will also look at genetic factors that might affect risk. This is an observational s…

This study looks at whether long-term stress, measured by cortisol levels in hair, is linked to cardiac arrest. Researchers will take a small hair sample from 136 patients who had a cardiac arrest or heart attack. The goal is to see if higher stress levels over the past three mon…

This study tests whether a mixed reality (MR) system called HEROS 4.0 can teach CPR as effectively as traditional instructor-led classes. 120 adults who haven't had CPR training in the last year will be split into two groups: one using MR and one using standard video and in-perso…

This study aims to find genetic causes of out-of-hospital cardiac arrest in people aged 18–50 in Lombardy, Italy. Researchers will analyze blood samples from 1,725 patients and also check family members for inherited heart risks. The goal is to better understand why cardiac arres…

This study follows 750 people with atrial fibrillation (an irregular heartbeat) who are getting a procedure called catheter ablation. The main goal is to learn why the heart rhythm problem returns in up to 45% of patients within a year after the procedure. Researchers will track …

This study is creating a biological bank of blood samples from 1,000 people with atrial fibrillation (AF) and stroke. Researchers will collect DNA and plasma to study the genetic roots of these conditions. The goal is to better understand why AF leads to stroke and find new drug …

This study watches 600 adults on a heart-lung machine (ECMO) for severe shock to see how often they develop heart rhythm problems like atrial fibrillation. It tracks complications and recovery times. The goal is to learn more, not to test a new treatment.

This study aims to create a tool that uses stress heart MRI and routine medical data to predict which patients with dilated cardiomyopathy (a weakened, enlarged heart) are at highest risk for serious problems like heart failure or sudden cardiac death. Researchers will follow 2,0…

People with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…

This study looks at whether combining blood tests and brain ultrasound can better predict how well someone recovers from a cardiac arrest. Researchers will enroll 50 adults and check their blood for proteins linked to inflammation and use ultrasound to measure brain blood flow an…

This observational study at Imperial College London will enroll 70 people undergoing heart catheterization to understand why some patients tolerate ventricular tachycardia (VT) better than others. Researchers will measure blood pressure and blood flow in the heart during simulate…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study follows people who survived a cardiac arrest and received ultra-rapid cooling treatment in a previous study. Researchers will check their health and survival status over 5 years through phone interviews and medical records. The goal is to understand the long-term effec…

This study is looking for proteins, metabolites, and platelet changes in the blood that could predict whether a person will survive after receiving ECPR, a machine that takes over heart and lung function during cardiac arrest. Researchers will study blood samples from 130 adults …

This study is collecting cervical mucus from 476 women undergoing IVF or frozen embryo transfer. Researchers will analyze the proteins in the mucus to find markers that indicate when the uterus is most receptive to an embryo. By comparing samples from women who become pregnant wi…

This study aims to uncover the molecular causes of secondary brain injury in patients who survive cardiac arrest. Researchers will analyze cerebrospinal fluid from 60 participants using advanced techniques to identify changes in genes, proteins, and other molecules. The goal is t…

This study tracks 774 adults who develop a new type of irregular heartbeat (atrial fibrillation) while hospitalized for a heart attack. Researchers will use continuous electronic monitoring to measure how much time patients spend in this abnormal rhythm. The goal is to see if the…

This study tests whether combining detailed heart scans (MRI/CT) with electrical mapping can help doctors better target and treat scar-related ventricular tachycardia (VT), a dangerous heart rhythm. Twenty people with VT who already have an implanted defibrillator will undergo ex…

This study looks at how belly pressure changes during a heart procedure called pulsed field ablation for atrial fibrillation. Researchers will use a special catheter to measure pressure in the abdomen while patients are under different types of anesthesia. The goal is to see if t…

This study follows 50 adults with paroxysmal atrial fibrillation (AFib) who are scheduled for catheter ablation. Researchers will use exercise tests, heart MRIs, and echocardiograms to measure how well the heart's left atrium works during exercise before and 5-6 months after the …

This study examines whether special pacemakers can effectively treat a common type of fast heart rhythm (atrial tachycardia) in people born with heart defects. Researchers will review medical records from up to 300 patients over 10 years to see if the pacemaker reduces the need f…

This study is a registry that will collect information on how a new balloon-in-basket device (VOLT PFA) is used in real-world hospitals to treat atrial fibrillation (AFib). Researchers will track procedure details, safety, and how well it stops abnormal heart rhythms. About 1,000…

This study will have up to 10,000 adults wear a smartwatch for one year to collect health data like heart rate and activity. Participants will also answer questions through a phone app. The goal is to see if smartwatch data can help doctors spot heart problems earlier. No drugs o…

This study will implant a small heart monitor (loop recorder) in 20 young adults aged 18-60 who have a heart condition called mitral annular disjunction and mild or no symptoms. The goal is to detect hidden dangerous heart rhythms that could lead to sudden cardiac death. Particip…

This study looks at why the airway sometimes closes during CPR for people who have a cardiac arrest outside the hospital. Researchers will analyze breathing data from 150 adults to see how common this closure is and whether it affects the chances of restarting the heart. The goal…

This study tests an AI system that reads blood pressure signals during CPR to tell rescuers if they are compressing the wrong part of the chest. In about half of cardiac arrest patients, standard chest compressions accidentally press on a valve in the heart, reducing blood flow. …

This study follows 100 people who had atrial fibrillation (AF) during a hospital stay for surgery or illness. Participants get a small heart monitor implanted to track AF over 12 months. The goal is to see how often AF returns and whether the cause (heart surgery, other surgery, …

This study explores using drones to quickly deliver automated external defibrillators (AEDs) to people helping someone having a cardiac arrest outside a hospital. Researchers will test the delivery process with training manikins and interview people with and without cardiac arres…

This study is a registry that will collect detailed information from 400 people who had a cardiac arrest outside of a hospital. The goal is to better understand what happens before, during, and after the event, so doctors can improve care and survival rates. Participants are foll…

This study is testing whether a special heart ultrasound can predict who will develop atrial fibrillation after heart surgery. Researchers will measure how well the heart's upper chambers work together before surgery in 138 patients. They will then track patients during recovery …

This study looks at how well the Micra AV2 pacemaker can detect atrial fibrillation (AFib) in people who already have a history of paroxysmal AFib. Researchers will monitor 50 patients using the pacemaker's signals and a special Holter monitor. The goal is to understand how often…

This study tests whether a connected watch can better detect returning atrial fibrillation (an irregular heartbeat) in 106 adults who had heart surgery and developed a temporary irregular rhythm. Participants will wear the watch for 12 months, and doctors will compare how well it…

This study looks at whether certain medications known to affect the heart's electrical activity (QT-prolonging drugs) actually cause major heart problems in hospitalized adults. Researchers will analyze data from over 990,000 patients across Ontario hospitals, comparing those who…

This study explores a gentler way to screen embryos for genetic problems during IVF. Instead of taking a cell from the embryo (biopsy), researchers will analyze the fluid the embryo grows in. They want to see if this non-invasive method can predict which embryos are most likely t…

This study watches 40 adults with atrial fibrillation who get a new type of heart treatment called pulsed field ablation. The goal is to see if the procedure causes tiny, symptom-free brain spots that show up on MRI scans. Researchers want to know how often these spots happen and…

This study follows 1,125 adults with atrial fibrillation who have had or will have a catheter ablation procedure. Over one year, participants use a smartphone app to report symptoms, lifestyle habits, and quality of life, and provide ECG readings. The goal is to identify factors …

This study follows 1500 people who already have an implantable cardioverter-defibrillator (ICD) to prevent sudden cardiac death. Researchers will track heart function, genetics, and blood markers to find better ways to predict who is at highest risk. The goal is to improve how do…

This study is testing whether sending a portable ECG monitor to people with elevated NT-proBNP (a heart stress marker) can catch hidden atrial fibrillation and reduce strokes. 4,000 adults aged 40+ without known AF will be randomly assigned to either 7 days of home monitoring or …

This study follows 250 atrial fibrillation patients who received a left atrial appendage closure device to prevent strokes. The procedure blocks a small pouch in the heart where clots often form, allowing patients to avoid long-term blood thinners. Researchers will track how many…

This observational study enrolls 5,000 adults hospitalized with acute coronary syndrome in Italy. Researchers will track how often doctors follow European quality indicators, like timely artery-opening procedures and proper discharge medications. Participants are followed for 12 …

This study compares a 7-day AI-enhanced single-lead ECG patch against routine 12-lead ECGs to detect new atrial fibrillation in 15,360 adults aged 60+ in rural China. The goal is to see if longer, smarter monitoring catches more cases and reduces deaths, strokes, and heart failur…

This study compares a continuous heart-monitoring patch with standard electrocardiograms (ECGs) in 60 adults receiving cancer drugs that can cause dangerous heart rhythm changes. The goal is to see if the patch detects problems more accurately and consistently. Participants will …

This study is a registry that collects information on 2,000 people with atrial fibrillation who have heart surgery to treat it. The goal is to see how well the surgery works in everyday medical practice and what complications occur. No new treatment is being tested; instead, rese…

This study looks at a better way to predict recovery in people who remain unconscious after a cardiac arrest. Doctors often struggle to know who will wake up, which can lead to early decisions to stop life support. The study will follow 600 patients in the US, Brazil, and Italy, …

This study tests a new tool called PRECOM that uses brain wave signals to predict whether coma patients after cardiac arrest will wake up within three months. Researchers will enroll 100 adults in French ICUs and compare the tool's predictions to actual outcomes. The goal is to i…

This study looks at whether avoiding alcohol reduces the chance of an atrial fibrillation (AFib) episode in people with paroxysmal AFib. One hundred participants will be randomly assigned each day to either avoid or be allowed to drink alcohol. They will wear heart monitors, fitn…

This study is watching 400 US patients who have a procedure to fix atrial fibrillation (a type of irregular heartbeat). Doctors will use an AI system to help guide the procedure. The goal is to see if using AI leads to better outcomes, like fewer heart rhythm problems after treat…

This study looks at how early menopause (premature ovarian insufficiency) affects the heart's electrical signals, which can raise the risk of dangerous heart rhythms. Researchers will compare 120 women with and without this condition, and also check how hormone replacement therap…

This study follows 198 people with symptomatic atrial fibrillation (AF) who decided not to join a larger trial comparing aggressive risk management plus ablation versus ablation alone. Researchers will track their hospital visits, emergency department stays, and AF episodes over …

This study looks at sleep quality in 100 people with atrial fibrillation (AFib) who are scheduled for a heart procedure called pulmonary vein isolation. Participants will have four non-invasive sleep tests—two before and two after the procedure—to measure breathing, heart rate, a…

This study compares different scoring systems to predict brain damage in patients admitted to the ICU after cardiac arrest. Researchers will calculate early prognosis scores using clinical and lab values to see which system best identifies patients at risk. The goal is to help do…

This study is a registry that collects information from 1,000 adults who have conditions like fainting, rapid heartbeat, or low blood pressure and have received a procedure that adjusts nerve signals to the heart. Researchers will track whether symptoms return within a year. The …

This study will follow 10,000 people who come to a clinic in Davos, Switzerland for cardiac rehabilitation after a heart attack, surgery, or other heart problem. Researchers will collect health data, blood samples, and genetic information to understand what helps people recover b…

This study is testing whether a smartwatch, combined with artificial intelligence and remote doctor check-ins, can help detect heart issues like atrial fibrillation and unstable angina earlier than usual. Researchers at the University of Sao Paulo will enroll 520 adults with hear…

This study will follow 90 people with mitral valve prolapse who are already scheduled for mitral valve surgery. Researchers will use heart scans and 7-day rhythm monitors before and 6 months after surgery to see if the procedure reduces dangerous heart rhythms and scarring. The g…

This study tests whether a simpler, single-step thawing method for frozen embryos works as well as or better than the standard multi-step method. About 816 women undergoing IVF will have their embryos thawed using one of the two methods. The main goal is to see if the simpler met…