New drug aims to tame dangerous heart rhythms in genetic disorder

NCT ID NCT07277582

Recruiting now Disease control Sponsor: Thryv Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jul 23, 2026 · Updated 3 times

Summary

This study tests whether the drug THRV-1268 can safely shorten the heart's electrical recovery time (QT interval) in people with Long QT Syndrome Type 2, a genetic condition that raises the risk of dangerous heart rhythms and sudden cardiac arrest. About 64 participants will take the drug twice daily at different doses for 6 weeks, with heart monitoring and clinic visits. The goal is to find a dose that works best and is safe, with the possibility of continuing treatment for up to a year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: THRV-1268
What this could lead to: If it works, this could provide a new treatment option to control heart rhythm and reduce the risk of dangerous events in people with Long QT Syndrome Type 2.
What could go wrong: This is an early-to-mid-stage trial with only 64 participants, so results may not apply to everyone. The drug may cause side effects or fail to shorten the QT interval effectively.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

long QT syndrome long QT syndrome 2

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

LONG QT SYNDROME (LQTS) 2

Contacts and locations

Locations

Heart Center Clinical Research Program | MGH
RECRUITING

Boston, Massachusetts, 02114, United States
Honor Health Research and Innovation Institute
RECRUITING

Scottsdale, Arizona, 85258, United States
Mayo Clinic
RECRUITING

Rochester, Minnesota, 55905, United States
NYU Langone Health
NOT_YET_RECRUITING

New York, New York, 10016, United States
Oregon Health & Science University
NOT_YET_RECRUITING

Portland, Oregon, 97239, United States
University of California San Francisco
RECRUITING

San Francisco, California, 94143, United States
University of Illinois Chicago
RECRUITING

Chicago, Illinois, 60612, United States
University of Michigan
NOT_YET_RECRUITING

Arbor, Michigan, 48109, United States
Wilmington Health
RECRUITING

Wilmington, North Carolina, 28401, United States