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Can a forehead sensor save brains after cardiac arrest?

NCT ID NCT07829887

NEW Disease control Sponsor: University of Calgary Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 21, 2026 · Last updated Sep 21, 2026

Summary

After cardiac arrest, the brain often suffers from low oxygen even when the heart is restarted. This pilot trial tests whether using a non-invasive forehead sensor to monitor brain oxygen and adjust ICU treatments can keep oxygen levels above a target. Adults who remain in a coma after resuscitation are randomly assigned to either usual care or a protocol that raises blood pressure, adjusts breathing support, improves heart function, or gives blood transfusions when brain oxygen drops. Researchers will measure how often brain oxygen falls too low and whether blood markers of brain injury are lower with the sensor-guided approach.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
cerebral oximetry-guided treatment, a protocol that adjusts blood pressure, breathing support, heart function, and other ICU care based on forehead oxygen readings
What this could lead to
If it works, this approach could give ICU teams a way to protect the brain after cardiac arrest and improve the chances of waking up with better neurological function.
What could go wrong
This is a small pilot trial, so it may not show a clear benefit or may not be large enough to prove that the approach changes outcomes. Adjusting blood pressure, breathing, and heart support carries risks, and the brain damage from cardiac arrest may be too severe to reverse.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 44 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

May 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age \>= 18 years * Cardiac arrest (in- or out-of-hospital) lasting \>= 5 minutes * Glasgow Coma Scale score \<= 8 and motor score \<= 5 Exclusion Criteria: * Cardiac arrest cause was any form of brain injury * Cannot be enrolled within 6 hours * Unsupportable physiology * CT scan (not mandated) showing diffuse loss of grey-white differentiation

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest Hypoxia, Brain Out-of-Hospital Cardiac Arrest post-cardiac arrest syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hypoxic-ischemic brain injury Post cardiac arrest brain injury Post-cardiac arrest syndrome

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Foothills Medical Center

    RECRUITING

    Calgary, Alberta, T3Z 3L7, Canada

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