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Spinal fluid and blood may reveal how the brain suffers after cardiac arrest

NCT ID NCT07090577

Knowledge-focused Sponsor: Chungnam National University Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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Status unknown
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First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Researchers at Chungnam National University Hospital are studying blood and cerebrospinal fluid from adults who had an out-of-hospital cardiac arrest and received post-resuscitation care. The goal is to map molecular changes over time and see how they relate to the severity of brain injury and neurological outcomes. The study uses samples already stored in a biobank and does not test any treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If the molecular patterns line up with brain injury severity, this could help doctors predict outcomes and point toward treatments that protect the brain after cardiac arrest.
What could go wrong
This is a small observational study of 15 people, so it cannot prove cause and effect. The findings may not apply to all cardiac arrest patients, and no treatment is being tested.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

15 people

The number who actually took part.

Started

Jul 2025

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Adult patients with an out-of-hospital cardiac arrest who underwent post-resuscitation care

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years old * Out-of-hospital cardiac arrest (OHCA) * Patients who have received post-resuscitation care including temperature control due to unconsciousness (Glasgow Coma Score \< 8) after sustained ROSC. * Patients who consented to the placement of lumbar catheter for storing cerebrospinal fluid and blood samples in a human biobank. Exclusion Criteria: * Patients diagnosed with a central nervous system-related disease before cardiac arrest * Patients who have undergone extracorporeal circulatory membrane oxygenation therapy * Patients who died within 24 hours from post-resuscitation care

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Conditions

The condition(s) this trial relates to.

brain hypoxia - ischemia cardiac arrest post-cardiac arrest syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cardiac arrest (CA) Hypoxic-ischemic brain injury Post-resuscitation syndrome

Contacts and locations

Locations

  • Chungnam National University Hospital

    Daejeon, 35015, South Korea

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